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Cap-Gly domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Cap-Gly domain [ 74924]
Families:   Cap-Gly domain [ 74925] (10)


Superfamily statistics
Genomes (502) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,818 10,435 22
Proteins 3,026 8,264 22


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000002098 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.004771 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1593 Least Informative Inherited
Biological Process (BP) biological regulation 0.01414 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9656 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.2248 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9553 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.3316 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.000000000000921 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000004095 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00002928 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00006895 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000182 Moderately Informative Direct
Biological Process (BP) defense response 0.0002357 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.1158 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08548 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1524 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.126 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9531 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.5296 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9563 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3008 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.02585 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9232 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4079 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.647 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.7916 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1743 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.4367 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000000000007296 Informative Direct
Biological Process (BP) regulation of cellular localization 0.00000000001354 Informative Direct
Biological Process (BP) regulation of protein localization 0.00000000007583 Informative Direct
Biological Process (BP) organelle localization 0.000000002175 Informative Direct
Biological Process (BP) protein transport 0.00005169 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.00005413 Informative Direct
Biological Process (BP) positive regulation of transport 0.0001341 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001887 Informative Direct
Biological Process (BP) proteolysis 0.0002827 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0003692 Informative Direct
Biological Process (BP) mitotic cell cycle 0.3238 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.07569 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02701 Informative Inherited
Biological Process (BP) generation of neurons 0.007125 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.002919 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.09665 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01187 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.04653 Informative Inherited
Biological Process (BP) negative regulation of transport 0.001285 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01099 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.02398 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2246 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.02939 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.01085 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.6699 Informative Inherited
Biological Process (BP) regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0000000000002783 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.00000000007397 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0000000001087 Highly Informative Direct
Biological Process (BP) protein folding 0.0000000002092 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0000001867 Highly Informative Direct
Biological Process (BP) protein lipidation 0.000001288 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.00003735 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.00008596 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0001341 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0002509 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.0004501 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0006736 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0007365 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0008657 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0.0009412 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.00248 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.3055 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.8002 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.004569 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.02192 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.516 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.001098 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.02868 Highly Informative Inherited
Molecular Function (MF) binding 0.000002289 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.0001 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0003303 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.005333 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1335 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.000003132 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.00002313 Informative Direct
Molecular Function (MF) amide binding 0.0007799 Informative Direct
Molecular Function (MF) protein dimerization activity 0.05033 Informative Inherited
Molecular Function (MF) identical protein binding 0.1089 Informative Inherited
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.00000000003396 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0000131 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00000000000002005 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000007531 Least Informative Direct
Cellular Component (CC) protein complex 0.0000003515 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01359 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00002673 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0003309 Moderately Informative Direct
Cellular Component (CC) cell projection 0.004844 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.03268 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.03198 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0000000003511 Informative Direct
Cellular Component (CC) endosome 0.000002242 Informative Direct
Cellular Component (CC) membrane region 0.00004129 Informative Direct
Cellular Component (CC) nuclear envelope 0.0008856 Informative Direct
Cellular Component (CC) chromosome 0.4293 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.001732 Informative Inherited
Cellular Component (CC) cilium 0.00989 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.05084 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.06138 Informative Inherited
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) spindle 0 Highly Informative Direct
Cellular Component (CC) kinetochore 0.000000000002691 Highly Informative Direct
Cellular Component (CC) midbody 0.0000000001977 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.000009673 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.0002326 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.003335 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.0000008989Moderately InformativeDirect
Biological processUbl conjugation pathway0.00003755Moderately InformativeDirect
Biological processCell cycle0.00005914Moderately InformativeDirect
Biological processWnt signaling pathway0.0000000005474InformativeDirect
Biological processMitosis0.000000003294InformativeDirect
Biological processInnate immunity0.00000002649InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.00000000001264Moderately InformativeDirect
Cellular componentGolgi apparatus0.0001467Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
DomainRepeat0.0000002393Least InformativeDirect
DomainCoiled coil0.00000000000009592Moderately InformativeDirect
DomainLeucine-rich repeat0.00000000002751InformativeDirect
DomainANK repeat0.0000001571InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationProtease0.003021Moderately InformativeInherited
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationThiol protease0.0000002051InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cap-Gly domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Cap-Gly domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]