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Smc hinge domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Smc hinge domain [ 75552]
Superfamily:   Smc hinge domain [ 75553]
Families:   Smc hinge domain [ 75554]


Superfamily statistics
Genomes (2,098) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,002 13,052 2
Proteins 3,977 13,040 2


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000000000000003741 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000001105 Least Informative Direct
Biological Process (BP) developmental process 0.004457 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2635 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.05733 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4458 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000000000359 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0004362 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.3966 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.005021 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.6623 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1806 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.448 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2276 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02114 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01706 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.9117 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.2553 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.5959 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.09593 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.07027 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8464 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.02016 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.00000000000003117 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0002065 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0004483 Informative Direct
Biological Process (BP) microtubule-based process 0.0007976 Informative Direct
Biological Process (BP) organ morphogenesis 0.3131 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.02783 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.02656 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.00665 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.02647 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02759 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01936 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.002926 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.003913 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.001715 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.002329 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 0.001472 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.003744 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) chromosome segregation 0 Highly Informative Direct
Biological Process (BP) mitosis 0.00000000004038 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00000000233 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.0000001316 Highly Informative Direct
Biological Process (BP) meiosis 0.0000004226 Highly Informative Direct
Biological Process (BP) stem cell development 0.000006094 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0001685 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0.0002168 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0005568 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0.0008965 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.1004 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.004652 Highly Informative Inherited
Biological Process (BP) gene silencing 0.004905 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.06047 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.001129 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.001218 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000001379 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.384 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.001431 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.2156 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0.0000000000004867 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00009438 Informative Direct
Molecular Function (MF) nucleotide binding 0.0001368 Informative Direct
Molecular Function (MF) DNA binding 0.0005123 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0008988 Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000000000009613 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00004245 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.004069 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00000542 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0109 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00001532 Informative Direct
Cellular Component (CC) kinetochore 0.000001078 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.00003541 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebral column0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the globe0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eyelid0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hair0InformativeDirect
Phenotypic Abnormality (PA)Hearing impairment0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eyelashes0Highly InformativeDirect
Phenotypic Abnormality (PA)Edema0Highly InformativeDirect
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0002382Least InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0000005725Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0001374Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.000713Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0009456Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.3032Moderately InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.000000001668InformativeDirect
Worm Phenotype (WP)sick0.0004025InformativeDirect
Worm Phenotype (WP)protruding vulva0.0006985InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.02012Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.00005931InformativeDirect
Yeast Phenotype (YP)cell cycle progression0.0006617InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0InformativeDirect
Fly Phenotype (FP)some die during larval stage0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0.00000000778Moderately InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentCentromere0Highly InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionDNA-binding0.00000000000007141Moderately InformativeDirect
Post-translational modificationAcetylation9.083e-16Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010935 SSF75553 Protein matches
Abstract

This entry represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction [PubMed12411491].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Smc hinge domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Smc hinge domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]