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Smc hinge domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Smc hinge domain [ 75552]
Superfamily:   Smc hinge domain [ 75553]
Families:   Smc hinge domain [ 75554]


Superfamily statistics
Genomes (2,107) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 4,080 17,318 2
Proteins 4,055 17,219 2


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000002808 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.7509 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1347 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1435 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2108 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.2475 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.8458 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.00000006178 Moderately Informative Direct
Biological Process (BP) reproduction 0.000002848 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.09019 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.05521 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02253 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4236 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.8664 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9196 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) DNA metabolic process 0.000005209 Informative Direct
Biological Process (BP) response to radiation 0.00002077 Informative Direct
Biological Process (BP) single organism reproductive process 0.0003666 Informative Direct
Biological Process (BP) mitotic cell cycle 0.06412 Informative Inherited
Biological Process (BP) nuclear division 0 Highly Informative Direct
Biological Process (BP) nuclear chromosome segregation 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000004909 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000001319 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.0005649 Highly Informative Direct
Molecular Function (MF) binding 0.0000000003293 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.0002769 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000000002621 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.1735 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.05587 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.06891 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0.000000001081 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.6755 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.3132 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.03822 Informative Inherited
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0001276 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.000000002643 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.812 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00000001229 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00007874 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.001644 Informative Inherited
Cellular Component (CC) kinetochore 0.00002927 Highly Informative Direct
Cellular Component (CC) spindle 0.08961 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.005466 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0.0000000000133Moderately InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processDNA repair0.000000000007816InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentCentromere0Highly InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010935 SSF75553 Protein matches
Abstract

This entry represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction [PubMed12411491].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Smc hinge domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Smc hinge domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]