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Smc hinge domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Smc hinge domain [ 75552]
Superfamily:   Smc hinge domain [ 75553]
Families:   Smc hinge domain [ 75554]


Superfamily statistics
Genomes (2,100) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,018 13,052 2
Proteins 3,993 13,040 2


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000001903 Least Informative Direct
Biological Process (BP) biological regulation 0.375 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4553 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1769 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1862 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2584 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.3017 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.7269 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.00000000002002 Moderately Informative Direct
Biological Process (BP) reproduction 0.000001095 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signaling 0.02311 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.0191 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01364 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.5235 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.753 Moderately Informative Inherited
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) organelle fission 0 Informative Direct
Biological Process (BP) response to radiation 0.000006291 Informative Direct
Biological Process (BP) DNA metabolic process 0.00002177 Informative Direct
Biological Process (BP) mitotic cell cycle 0.00002466 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.00008183 Informative Direct
Biological Process (BP) regulation of cell cycle 0.0000935 Informative Direct
Biological Process (BP) single organism reproductive process 0.0001581 Informative Direct
Biological Process (BP) intracellular signal transduction 0.04654 Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0 Highly Informative Direct
Biological Process (BP) chromosome organization 0 Highly Informative Direct
Biological Process (BP) mitotic nuclear division 0.0000000000002668 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000003235 Highly Informative Direct
Biological Process (BP) meiotic cell cycle process 0.00008084 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.0002065 Highly Informative Direct
Molecular Function (MF) binding 0.000000000009188 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.007117 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000004816 Moderately Informative Direct
Molecular Function (MF) protein binding 0.05895 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.2099 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.04589 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.04251 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0.0000000001826 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000000007261 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.0007912 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.0008019 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.7033 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.2777 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.04392 Informative Inherited
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00008395 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000000000175 Least Informative Direct
Cellular Component (CC) protein complex 0.0000000112 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.6722 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000000002753 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00001564 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0003583 Informative Direct
Cellular Component (CC) condensed chromosome 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.0000000006692 Highly Informative Direct
Cellular Component (CC) chromatin 0.0000000009557 Highly Informative Direct
Cellular Component (CC) kinetochore 0.00002237 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the oral cavity0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the orbital region0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebral column0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the inner ear0InformativeDirect
Phenotypic Abnormality (PA)Hearing abnormality0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eyelid0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the thorax0InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Vascular skin abnormality0InformativeDirect
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0InformativeDirect
Phenotypic Abnormality (PA)Sensorineural hearing impairment0Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.0002174Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0004342Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.002303Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.000001416Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.00000489Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0009215Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.311Moderately InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.000000002242InformativeDirect
Worm Phenotype (WP)cell migration variant0.000000109InformativeDirect
Worm Phenotype (WP)sick0.0004429InformativeDirect
Worm Phenotype (WP)protruding vulva0.0006852InformativeDirect
Worm Phenotype (WP)no oocytes0.00001716Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.02895Moderately InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.0007061InformativeDirect
Yeast Phenotype (YP)colony sectoring0.000352Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)some die during larval stage0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0.00000000009948Moderately InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processDNA condensation0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentCentromere0Highly InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionDNA-binding0.00000000000007587Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationAcetylation0.000000000000003737Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010935 SSF75553 Protein matches
Abstract

This entry represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction [PubMed12411491].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Smc hinge domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Smc hinge domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]