SUPERFAMILY 1.75 HMM library and genome assignments server


Siroheme synthase middle domains-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Siroheme synthase middle domains-like [ 75614]
Superfamily:   Siroheme synthase middle domains-like [ 75615]
Families:   Siroheme synthase middle domains-like [ 75616] (2)


Superfamily statistics
Genomes (1,427) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,781 11,961 3
Proteins 1,781 11,961 3


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 8.412e-05 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0005502 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.002362 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.003231 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.00227 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.00198 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 3.629e-10 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 3.141e-09 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.603e-05 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 2.879e-05 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 3.138e-05 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 6.773e-05 Moderately Informative Direct
Biological Process (BP) pigment metabolic process 1.72e-09 Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 5.596e-09 Highly Informative Direct
Biological Process (BP) heme metabolic process 0.0001701 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionS-adenosyl-L-methionine0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)heterocycle metabolism0Moderately InformativeDirect
UniPathway (UP)cofactor biosynthesis0Moderately InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis0InformativeDirect
UniPathway (UP)siroheme biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Siroheme synthase middle domains-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Siroheme synthase middle domains-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]