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Cullin homology domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Cullin homology domain [ 75631]
Superfamily:   Cullin homology domain [ 75632]
Families:   Cullin homology domain [ 75633] (2)


Superfamily statistics
Genomes (505) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,623 10,048 4
Proteins 3,577 9,967 4


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.02116Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.02624Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.2017Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.009905InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.05073InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.09035InformativeInherited
Mammalian Phenotype (MP)abnormal embryo size0.001121Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.002589Highly InformativeInherited
Mammalian Phenotype (MP)abnormal preimplantation embryo morphology0.006917Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000102Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001338Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.008667Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.00000003044Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.000000317Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.000002144Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0001247Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0004042Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0004047Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0009652Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.3319Moderately InformativeInherited
Worm Phenotype (WP)accumulated germline cell corpses0.00000000003793InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.0000000002388InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.0000000000001658Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.000000000001236Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0000006966Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.02783Moderately InformativeInherited
Fly Anatomy (FA)epithelial cell0.00526InformativeInherited
Fly Anatomy (FA)ovariole0.008894InformativeInherited
Fly Anatomy (FA)germline cyst0.01475InformativeInherited
Fly Anatomy (FA)follicle cell0.0003996Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)testis0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin homology domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Cullin homology domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]