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TGS-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   TGS-like [ 81271] (2)
Families:   TGS domain [ 81270]
  G domain-linked domain [ 82583] (2)


Superfamily statistics
Genomes (3,231) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,560 56,532 6
Proteins 10,558 56,524 6


Functional annotation
General category General
Detailed category Ligand binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.0091 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1933 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.003027 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1515 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.7679 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.008921 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01003 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.02082 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.531 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.0000000003014 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000008171 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000002902 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.000004223 Moderately Informative Direct
Biological Process (BP) gene expression 0.00001524 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0001618 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.4935 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6362 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.5876 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4748 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8632 Moderately Informative Inherited
Biological Process (BP) cell communication 0.3425 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.2198 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 0.00000000002729 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01359 Informative Inherited
Biological Process (BP) epithelium development 0.1038 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.002429 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04571 Informative Inherited
Biological Process (BP) circulatory system development 0.01484 Informative Inherited
Biological Process (BP) angiogenesis 0.000007497 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.0001798 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.008958 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.001972 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.001228 Highly Informative Inherited
Molecular Function (MF) binding 0.3571 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.00000003475 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000001127 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001052 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0.0000000000000123 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000006105 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000000003879 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000000005281 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.0000000000001081 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Threonine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR012676 SSF81271 Protein matches
Abstract

The TGS domain is present in a number of enzymes, for example, in threonyl-tRNA synthetase (ThrRS), GTPase, and guanosine 3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (SpoT) [PubMed10447505]. The TGS domain is also present at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism, including the related spirochaete Borrelia burgdorferi).

TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly beta-sheet structure. There is no direct information on the functions of the TGS domain, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, regulatory role [PubMed10447505]. The TGS domain is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies, and has some similarity to the alpha-L RNA-binding motif.

This entry represents TGS domain-containing proteins, as well as The C-terminal domain of bacterial and fungal YchF, a universally conserved GTPase whose function is unknown [PubMed12837776].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TGS-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the TGS-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]