SUPERFAMILY 1.75 HMM library and genome assignments server


E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,633) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 54,907 136,880 244
Proteins 35,127 103,754 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.65e-057.681e-11Least InformativeDirect
Biological Process (BP)localization0.00017937.767e-06Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0054235.423e-05Least InformativeInherited
Biological Process (BP)regulation of cellular process0.050510.003091Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0090211.931e-15Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.87740.2234Least InformativeInherited
Biological Process (BP)signal transduction0.004751.954e-06Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.88251Moderately InformativeInherited
Biological Process (BP)immune system process0.0071960.02209Moderately InformativeInherited
Biological Process (BP)cellular localization0.34531Moderately InformativeInherited
Biological Process (BP)organelle organization0.751Moderately InformativeInherited
Biological Process (BP)macromolecule localization6.852e-071Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00036391Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00073610.7882Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.32460.4533Moderately InformativeInherited
Biological Process (BP)lipid localization01.134e-05InformativeDirect
Biological Process (BP)response to light stimulus9.615e-066.532e-05InformativeDirect
Biological Process (BP)defense response0.0024410.009828InformativeInherited
Biological Process (BP)response to wounding0.0047460.0008053InformativeInherited
Biological Process (BP)immune response0.0096850.1054InformativeInherited
Biological Process (BP)cytoskeleton organization0.0080980.0336InformativeInherited
Biological Process (BP)actin filament-based process0.010864.228e-05InformativeInherited
Biological Process (BP)regulation of body fluid levels7.385e-050.01304InformativeInherited
Biological Process (BP)organic hydroxy compound transport01.218e-07Highly InformativeDirect
Biological Process (BP)detection of light stimulus3.041e-116.715e-06Highly InformativeDirect
Biological Process (BP)hemostasis4.568e-070.0002608Highly InformativeDirect
Biological Process (BP)coagulation1.013e-050.0002525Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.0002290Highly InformativeDirect
Biological Process (BP)wound healing1.349e-050.158Highly InformativeInherited
Biological Process (BP)humoral immune response0.0076780.01289Highly InformativeInherited
Biological Process (BP)innate immune response0.075140.4342Highly InformativeInherited
Molecular Function (MF)binding0.012795.906e-10Least InformativeInherited
Molecular Function (MF)enzyme regulator activity1.147e-050.04274Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding2.82e-060.003776InformativeInherited
Molecular Function (MF)GTPase regulator activity2.058e-110.03499InformativeInherited
Molecular Function (MF)lipid binding6.323e-080.02848InformativeInherited
Molecular Function (MF)alcohol binding7.824e-080.005238Highly InformativeInherited
Molecular Function (MF)steroid binding2.519e-060.02937Highly InformativeInherited
Molecular Function (MF)antigen binding2.65e-050.2905Highly InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.042970.3905Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 7.681e-11 Least Informative Direct
Biological Process (BP) localization 7.767e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.423e-05 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.931e-15 Least Informative Direct
Biological Process (BP) developmental process 2.111e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.2234 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3517 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.003091 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 1.954e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001964 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.324e-09 Moderately Informative Direct
Biological Process (BP) ion transport 4.659e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 9.102e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0005723 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.03945 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.188 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7882 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.588 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.02287 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.715 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.171 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2843 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.1788 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.008921 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02209 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8644 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.442 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.03777 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9486 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4533 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.09309 Moderately Informative Inherited
Biological Process (BP) lipid localization 1.134e-05 Informative Direct
Biological Process (BP) response to light stimulus 6.532e-05 Informative Direct
Biological Process (BP) response to wounding 0.0008053 Informative Direct
Biological Process (BP) actin filament-based process 4.228e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.736e-10 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.772e-14 Informative Direct
Biological Process (BP) regulation of cellular component movement 7.974e-14 Informative Direct
Biological Process (BP) locomotion 2.002e-13 Informative Direct
Biological Process (BP) regulation of locomotion 3.428e-12 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 5.204e-12 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.826e-11 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.008e-11 Informative Direct
Biological Process (BP) metal ion transport 6.677e-11 Informative Direct
Biological Process (BP) transmembrane transport 7.142e-11 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 5.105e-10 Informative Direct
Biological Process (BP) polysaccharide metabolic process 1.045e-07 Informative Direct
Biological Process (BP) protein oligomerization 9.224e-06 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 4.248e-05 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0002351 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000295 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0003577 Informative Direct
Biological Process (BP) negative regulation of transport 0.0003597 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0005388 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1005 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2553 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8099 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05424 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4897 Informative Inherited
Biological Process (BP) gland development 0.4403 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.3272 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.0336 Informative Inherited
Biological Process (BP) muscle structure development 0.8912 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01289 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3307 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3408 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9513 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.9231 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.9453 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06735 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.3845 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) cell projection organization 0.02878 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6459 Informative Inherited
Biological Process (BP) organelle assembly 0.2583 Informative Inherited
Biological Process (BP) defense response 0.009828 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.005195 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.7886 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.4711 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2824 Informative Inherited
Biological Process (BP) regulation of defense response 0.3829 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) generation of neurons 0.3588 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) cellular component movement 0.505 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2807 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.06713 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01304 Informative Inherited
Biological Process (BP) cell cycle process 0.8652 Informative Inherited
Biological Process (BP) protein transport 0.839 Informative Inherited
Biological Process (BP) pigment metabolic process 0.09969 Informative Inherited
Biological Process (BP) secondary metabolic process 0.1296 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) immune response 0.1054 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5567 Informative Inherited
Biological Process (BP) tube development 0.285 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.1301 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.08851 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 1.218e-07 Highly Informative Direct
Biological Process (BP) detection of light stimulus 6.715e-06 Highly Informative Direct
Biological Process (BP) hemostasis 0.0002608 Highly Informative Direct
Biological Process (BP) coagulation 0.0002525 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.229e-10 Highly Informative Direct
Biological Process (BP) cell cycle phase 7.581e-09 Highly Informative Direct
Biological Process (BP) mesenchyme development 1.615e-08 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 3.882e-07 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 2.101e-06 Highly Informative Direct
Biological Process (BP) stem cell development 6.114e-06 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 1.553e-05 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.608e-05 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 5.276e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000198 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000241 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.000267 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0003489 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0004604 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0005462 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0008527 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.004312 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.03559 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.002978 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.001102 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002135 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.2308 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.8366 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.00229 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.007252 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.01012 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01924 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.0796 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.04763 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.4542 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.00406 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.08499 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1447 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.4526 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.003782 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.9117 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1121 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2258 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.1722 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1809 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.3108 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.4444 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.9667 Highly Informative Inherited
Biological Process (BP) cilium organization 0.01895 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.08353 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.6882 Highly Informative Inherited
Biological Process (BP) wound healing 0.158 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.01289 Highly Informative Inherited
Biological Process (BP) innate immune response 0.4342 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01521 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) gene silencing 0.4056 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 1 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1145 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.4262 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.003912 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.1337 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.005818 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.5264 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.227 Highly Informative Inherited
Biological Process (BP) adult behavior 0.09801 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.445 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1448 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.6567 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.001661 Highly Informative Inherited
Biological Process (BP) DNA modification 0.1443 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.01277 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.003239 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.3323 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.001642 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2627 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cell division 0.7482 Highly Informative Inherited
Molecular Function (MF) binding 5.906e-10 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 4.589e-07 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0003391 Moderately Informative Direct
Molecular Function (MF) anion binding 0.007338 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.006114 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.04274 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.0001733 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 2.087e-05 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) DNA binding 6.091e-10 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 6.248e-10 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0005168 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.0007736 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.003776 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.003937 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.005358 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.03499 Informative Inherited
Molecular Function (MF) receptor activity 0.01048 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.008907 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.1489 Informative Inherited
Molecular Function (MF) lipid binding 0.02848 Informative Inherited
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000114 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0.0001833 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.005238 Highly Informative Inherited
Molecular Function (MF) steroid binding 0.02937 Highly Informative Inherited
Molecular Function (MF) antigen binding 0.2905 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3905 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.01134 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.6325 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.2428 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.5388 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.02248 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) protein complex 0.7525 Least Informative Inherited
Cellular Component (CC) membrane 0.03338 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 1.59e-08 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.003868 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.03408 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.1818 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.1549 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.08161 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.9495 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.004927 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.01452 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.0003017 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0005489 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0.0008673 Highly Informative Direct
Cellular Component (CC) spindle 0.6587 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.005883 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.197 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase4.856e-15Highly InformativeDirect
Enzyme Commission (EC)Pullulanase5.029e-14Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase1.199e-10Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)4.944e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.5141Least InformativeInherited
Disease Ontology (DO)skin disease0.1023Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.6069Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis2.314e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5211Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.7497Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.3259Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.4611Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.835Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.08302InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1251InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2644InformativeInherited
Phenotypic Abnormality (PA)Esophageal varix0.0002053Highly InformativeDirect
Phenotypic Abnormality (PA)Portal hypertension0.0002639Highly InformativeDirect
Phenotypic Abnormality (PA)Ascites0.0005172Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the metatarsal bones0.00667Highly InformativeInherited
Phenotypic Abnormality (PA)Short long bones0.01392Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02917Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1638Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.287Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2921Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.08791Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.09283Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1132Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1152Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1783Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.1893Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.2118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2382Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0007387InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.005822InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.05125InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.05851InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.1196InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology2.132e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.0003667Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.5611Least InformativeInherited
Fly Anatomy (FA)cell0.5831Least InformativeInherited
Fly Anatomy (FA)circulatory system0.05473InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte2.691e-05Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003623Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02577Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06103Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.006587Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases4.824e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0002544Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.02728Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase4.824e-16InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.02742InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0706InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen5.09e-14Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor5.794e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.006572Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processTranscription regulation2.296e-11Moderately InformativeDirect
Biological processIon transport4.672e-07Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid transport2.088e-15InformativeDirect
Biological processViral immunoevasion8.148e-06InformativeDirect
Biological processInnate immunity0.0005962InformativeDirect
Biological processSteroid metabolism0.003791InformativeInherited
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision1.125e-12Highly InformativeDirect
Biological processCilium biogenesis/degradation9.863e-09Highly InformativeDirect
Biological processNotch signaling pathway3.986e-08Highly InformativeDirect
Biological processOxygen transport5.772e-08Highly InformativeDirect
Biological processCholesterol metabolism0.0001177Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0001567Highly InformativeDirect
Biological processExocytosis0.0003644Highly InformativeDirect
Cellular componentMembrane7.099e-14Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle9.391e-06Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentCoated pit8.924e-08Highly InformativeDirect
DiseaseProto-oncogene9.998e-14Moderately InformativeDirect
DiseaseAutoimmune uveitis3.507e-10Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1726Least InformativeInherited
DomainANK repeat1.393e-05InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.02075Moderately InformativeInherited
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD4.6e-05InformativeDirect
Molecular functionHeme0.000592InformativeDirect
Molecular functionLipid-binding0.0006815InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding1.615e-13Highly InformativeDirect
Molecular functionViral nucleoprotein0.0001794Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.06124Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease1.15e-13Moderately InformativeDirect
Post-translational modificationReceptor1.066e-10Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.315e-07Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation8.816e-10InformativeDirect
Post-translational modificationProtease inhibitor1.155e-08InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor1.711e-11Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation7.343e-14Moderately InformativeDirect
Post-translational modificationS-nitrosylation1.223e-06InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002508Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism3.363e-09Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]