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E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,639) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 55,385 136,880 244
Proteins 35,379 103,754 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000058010.000000005652Least InformativeDirect
Biological Process (BP)biological regulation0.00000065790.00000000004136Least InformativeDirect
Biological Process (BP)cell communication0.0000056030.00000000000002124Moderately InformativeDirect
Biological Process (BP)single organism signaling0.00061080.00000000001305Moderately InformativeDirect
Biological Process (BP)immune system process0.000080870.379Moderately InformativeInherited
Biological Process (BP)organic substance transport0.000079321Moderately InformativeInherited
Biological Process (BP)cellular localization0.4661Moderately InformativeInherited
Biological Process (BP)single-organism transport0.0034640.9329Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0000000056920.3573Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.54460.7337Moderately InformativeInherited
Biological Process (BP)lipid localization00.000002915InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway0.0072690.00000000146InformativeInherited
Biological Process (BP)immune response0.053390.8724InformativeInherited
Biological Process (BP)single-organism intracellular transport0.0076080.7759InformativeInherited
Biological Process (BP)hemostasis0.0000000030590.00007914Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport00.000000001517Highly InformativeDirect
Biological Process (BP)coagulation0.00000040170.00001232Highly InformativeDirect
Biological Process (BP)wound healing0.000027270.05226Highly InformativeInherited
Biological Process (BP)innate immune response0.0080490.07603Highly InformativeInherited
Molecular Function (MF)binding0.0010180.0003366Least InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.038640.1799Moderately InformativeInherited
Molecular Function (MF)molecular function regulator0.00000026070.002316Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.35711Moderately InformativeInherited
Molecular Function (MF)enzyme binding0.0049710.03459InformativeInherited
Molecular Function (MF)steroid binding00.00000000002199Highly InformativeDirect
Molecular Function (MF)GTPase regulator activity00.0000000006092Highly InformativeDirect
Molecular Function (MF)small GTPase binding0.000000010780.000003732Highly InformativeDirect
Molecular Function (MF)alcohol binding0.00000004730.00009075Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.000000005652 Least Informative Direct
Biological Process (BP) biological regulation 0.00000000004136 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7793 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000634 Moderately Informative Direct
Biological Process (BP) cell communication 0.00000000000002124 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000005199 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000005535 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.00000000001305 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000001577 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.7337 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.01328 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5766 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5778 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2168 Moderately Informative Inherited
Biological Process (BP) ion transport 0.001358 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1408 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7386 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) system development 0.06568 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4137 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.04336 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8229 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2426 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.4306 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3573 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.379 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9576 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2939 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.06224 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9329 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02883 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.03949 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9398 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.1604 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.1246 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.6948 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.000000000001687 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0006409 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00000000146 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000411 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000001485 Informative Direct
Biological Process (BP) lipid localization 0.000002915 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000004173 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) actin filament-based process 0.000753 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000012 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00000000000003469 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001094 Informative Direct
Biological Process (BP) locomotion 0.00000000000008519 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000000000001059 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0000001541 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.00000003639 Informative Direct
Biological Process (BP) protein oligomerization 0.000003644 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.2289 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05889 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.1334 Informative Inherited
Biological Process (BP) negative regulation of transport 0.07579 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5023 Informative Inherited
Biological Process (BP) cell development 0.6265 Informative Inherited
Biological Process (BP) tissue development 0.3697 Informative Inherited
Biological Process (BP) transmembrane transport 0.8453 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.174 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.3188 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.7297 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01015 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.8653 Informative Inherited
Biological Process (BP) positive regulation of transport 0.885 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01954 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.07516 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.9468 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.8724 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.57 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.6236 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.8168 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.3965 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.01886 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.4895 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.9261 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.7759 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.7286 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.03298 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.7303 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02341 Informative Inherited
Biological Process (BP) generation of neurons 0.7983 Informative Inherited
Biological Process (BP) system process 0.7869 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.4544 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.01673 Informative Inherited
Biological Process (BP) secondary metabolic process 0.09699 Informative Inherited
Biological Process (BP) pigment metabolic process 0.02669 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.3731 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3749 Informative Inherited
Biological Process (BP) circulatory system development 0.8166 Informative Inherited
Biological Process (BP) cell cycle process 0.9084 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2658 Informative Inherited
Biological Process (BP) angiogenesis 0.0006229 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.000000008884 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00002107 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0008644 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0002226 Highly Informative Direct
Biological Process (BP) hemostasis 0.00007914 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00000000001533 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.000000000000001945 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0002765 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0004044 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.000000001517 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000000001219 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0000001959 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000000915 Highly Informative Direct
Biological Process (BP) regulation of DNA-templated transcription in response to stress 0.0002215 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0.0002813 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.000000006134 Highly Informative Direct
Biological Process (BP) coagulation 0.00001232 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.0001892 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00005109 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0000001932 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000003818 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.2105 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.03371 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.03026 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.007011 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.001387 Highly Informative Inherited
Biological Process (BP) calcium-mediated signaling 0.02596 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.212 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.007014 Highly Informative Inherited
Biological Process (BP) wound healing 0.05226 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.3466 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1152 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.06231 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001938 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.3656 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.0092 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.04097 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.3926 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.05618 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.8275 Highly Informative Inherited
Biological Process (BP) neurological system process 0.1144 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.1003 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.4733 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.1561 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.4215 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.656 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.03116 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.5184 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.6118 Highly Informative Inherited
Biological Process (BP) innate immune response 0.07603 Highly Informative Inherited
Biological Process (BP) gene silencing 0.05222 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.2141 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular amide metabolic process 0.06818 Highly Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.0156 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.2664 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.8831 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1045 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.05793 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.01125 Highly Informative Inherited
Biological Process (BP) positive regulation of nucleotide metabolic process 0.3284 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.7597 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.2594 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3499 Highly Informative Inherited
Biological Process (BP) neuron development 0.004714 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.002792 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.01053 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.01764 Highly Informative Inherited
Molecular Function (MF) binding 0.0003366 Least Informative Direct
Molecular Function (MF) transferase activity 0.6074 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.00002094 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.1799 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.002316 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.01021 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.01173 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.4768 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0.0003859 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.0009544 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0000266 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.00001452 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0.9745 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.5573 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.03459 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.01729 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 0.1414 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0257 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.0000008038 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0.00000000002199 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0002629 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0000002271 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0000000587 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.0000000006092 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000003732 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00009075 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.5282 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.007838 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.3134 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.001535 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.2669 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.2371 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.2228 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.000003429 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.4879 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.007741 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.05346 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.2053 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) transporter complex 0.01792 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.007846 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.0388 Informative Inherited
Cellular Component (CC) cytoplasmic region 0.3851 Informative Inherited
Cellular Component (CC) sarcolemma 0.0001291 Highly Informative Direct
Cellular Component (CC) tethering complex 0.0003877 Highly Informative Direct
Cellular Component (CC) spindle 0.3654 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.936 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.02349 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase0.000000000000004856Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.00000000000005029Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.0000000001199Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.07663Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5316Moderately InformativeInherited
Disease Ontology (DO)bullous skin disease0.01636InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.01487Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2102Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2287Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4266Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8225Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.05072Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.08165Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.1996Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.2082Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.3754Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0.4187Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.5225Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.5893Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.5953Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.01566InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.1215InformativeInherited
Phenotypic Abnormality (PA)Abnormality of ion homeostasis0.3172InformativeInherited
Phenotypic Abnormality (PA)Abnormal jaw morphology0.7587InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0.8689InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.0002227Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.0003266Highly InformativeDirect
Phenotypic Abnormality (PA)Encephalocele0.0009535Highly InformativeDirect
Phenotypic Abnormality (PA)Short long bone0.02955Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of bones of the lower limbs0.03529Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0124Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3394Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.372Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.453Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.04038Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.05762Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.09441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1435Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3036Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.3048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000008847InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.006306InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.08061InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.09059InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00005419Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.000367Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.4863Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6473Least InformativeInherited
Worm Phenotype (WP)cell development variant0.7516Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2405Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4256Moderately InformativeInherited
Worm Phenotype (WP)pesticide response variant0.02537InformativeInherited
Worm Phenotype (WP)cell stress response variant0.4322InformativeInherited
Worm Phenotype (WP)paraquat hypersensitive0.000501Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.01216Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.3389Least InformativeInherited
Fly Anatomy (FA)circulatory system0.06786InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.00003426Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.9265Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9952Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)midgut0.0009249Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.05568Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003635Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02595Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06133Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.009004Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.000000000000001954Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00003431Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.02158Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.7528Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.03089InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.1156InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.7933InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen0.0000000000001519Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.000000000007677Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.000009016Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000001352Least InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processIon transport0.000000000002808Moderately InformativeDirect
Biological processTranscription regulation0.00000000004996Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processmRNA processing0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid transport0.00000000000003731InformativeDirect
Biological processViral immunoevasion0.00001225InformativeDirect
Biological processBiological rhythms0.000676InformativeDirect
Biological processSteroid metabolism0.00704InformativeInherited
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision0.0000000000009702Highly InformativeDirect
Biological processNotch signaling pathway0.00000004166Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000002132Highly InformativeDirect
Biological processOxygen transport0.0000007469Highly InformativeDirect
Biological processCholesterol metabolism0.0002541Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0003744Highly InformativeDirect
Biological processExocytosis0.0005329Highly InformativeDirect
Cellular componentMembrane0.00000000000001907Least InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000005025Moderately InformativeDirect
Cellular componentCell projection0.0002449Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentSpliceosome0.0006442InformativeDirect
Cellular componentLysosome0.0009327InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentCoated pit0.0000001107Highly InformativeDirect
DiseaseProto-oncogene0.00000000000002799Moderately InformativeDirect
DiseaseAutoimmune uveitis0.0000000002748Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.2516Least InformativeInherited
DomainANK repeat0.00002006InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.08649Moderately InformativeInherited
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD0.0005546InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding9.917e-16Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.09104Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease0.00000000000003643Moderately InformativeDirect
Post-translational modificationReceptor0.0000000002859Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000005125Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation0.00000001575InformativeDirect
Post-translational modificationProtease inhibitor0.00000001716InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00000000003838Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0.0000000001519Highly InformativeDirect
Post-translational modificationViral ion channel0.000002795Highly InformativeDirect
Post-translational modificationViral nucleoprotein0.0001684Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.000000000002703Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.000000001128InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002713Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation1InformativeInherited
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)glycogen degradation0Highly InformativeDirect
UniPathway (UP)beta-glucan biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]