SUPERFAMILY 1.75 HMM library and genome assignments server

E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,634) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 55,005 136,880 244
Proteins 35,200 103,754 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000016170.00000000002002Least InformativeDirect
Biological Process (BP)localization0.00028760.00002154Least InformativeDirect
Biological Process (BP)single-organism cellular process0.98640.124Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0067840Least InformativeInherited
Biological Process (BP)positive regulation of biological process10.09159Least InformativeInherited
Biological Process (BP)regulation of cellular process0.089740.0007098Least InformativeInherited
Biological Process (BP)defense response0.0023120.007709Moderately InformativeInherited
Biological Process (BP)immune system process0.0069940.02116Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00022241Moderately InformativeInherited
Biological Process (BP)cellular localization0.44791Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.43810.02896Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.00000037530.9264Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.32580.5048Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.0053210.000009271Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00086680.8197Moderately InformativeInherited
Biological Process (BP)signal transduction0.0033430.00000436Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.87411Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound transport00.00000157InformativeDirect
Biological Process (BP)lipid localization00.00001518InformativeDirect
Biological Process (BP)response to light stimulus0.0000094580.00007055InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00007610.0118InformativeInherited
Biological Process (BP)immune response0.0094380.1108InformativeInherited
Biological Process (BP)single-organism intracellular transport0.10351InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.20280.000000000001221InformativeInherited
Biological Process (BP)sterol transport00.000000000003021Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.00000000001810.000005785Highly InformativeDirect
Biological Process (BP)hemostasis0.00000045120.000259Highly InformativeDirect
Biological Process (BP)coagulation0.000011540.0002931Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus0.00010450.00000000000008989Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.00021690Highly InformativeDirect
Biological Process (BP)wound healing0.000014150.03539Highly InformativeInherited
Biological Process (BP)humoral immune response0.0076410.01258Highly InformativeInherited
Biological Process (BP)innate immune response0.077310.4963Highly InformativeInherited
Molecular Function (MF)binding0.014080.000000000933Least InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.014240.3632Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.12381Moderately InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0000043740.003438Moderately InformativeInherited
Molecular Function (MF)lipid binding0.000000061720.03028InformativeInherited
Molecular Function (MF)alcohol binding0.00000013150.007033Highly InformativeInherited
Molecular Function (MF)steroid binding0.0000016310.0333Highly InformativeInherited
Molecular Function (MF)antigen binding0.000025450.2882Highly InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.19090.3878Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000000002002 Least Informative Direct
Biological Process (BP) localization 0.00002154 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0.000000007565 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0007098 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.124 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1487 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.09159 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6147 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0.00000436 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000009271 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001285 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000003373 Moderately Informative Direct
Biological Process (BP) ion transport 0.0001701 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.496 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5168 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02116 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8197 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.002056 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.8613 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4725 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.04129 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.007709 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.02896 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9632 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02949 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5048 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8712 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9264 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.04092 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4603 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.02309 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.04683 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.00000157 Informative Direct
Biological Process (BP) lipid localization 0.00001518 Informative Direct
Biological Process (BP) response to light stimulus 0.00007055 Informative Direct
Biological Process (BP) actin filament-based process 0.0000007918 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000000818 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000000000001221 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0 Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000000000000003707 Informative Direct
Biological Process (BP) metal ion transport 0.000000000000005526 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000000000001455 Informative Direct
Biological Process (BP) locomotion 0.0000000000001668 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000001291 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000000006542 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000000000685 Informative Direct
Biological Process (BP) ion transmembrane transport 0.00000002456 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0000001022 Informative Direct
Biological Process (BP) protein oligomerization 0.00001045 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0002696 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000289 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0004009 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0004638 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0005331 Informative Direct
Biological Process (BP) negative regulation of transport 0.0008324 Informative Direct
Biological Process (BP) negative regulation of signaling 0.3159 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.07296 Informative Inherited
Biological Process (BP) generation of neurons 0.3735 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.4296 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.005215 Informative Inherited
Biological Process (BP) cell proliferation 0.2806 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.8944 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03435 Informative Inherited
Biological Process (BP) gland development 0.02565 Informative Inherited
Biological Process (BP) epithelium development 0.778 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.3341 Informative Inherited
Biological Process (BP) muscle structure development 0.6277 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3213 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.8822 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4038 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.05124 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8319 Informative Inherited
Biological Process (BP) single-organism cellular localization 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.6855 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7037 Informative Inherited
Biological Process (BP) organelle assembly 0.3066 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.0118 Informative Inherited
Biological Process (BP) immune response 0.1108 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.5483 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.7632 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.4721 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2886 Informative Inherited
Biological Process (BP) regulation of defense response 0.2906 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.8544 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) reproductive structure development 0.9788 Informative Inherited
Biological Process (BP) response to nutrient levels 0.4392 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01475 Informative Inherited
Biological Process (BP) cell projection organization 0.00549 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) cellular component movement 0.2284 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.1671 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.08731 Informative Inherited
Biological Process (BP) neurological system process 0.661 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1145 Informative Inherited
Biological Process (BP) protein transport 0.2881 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1001 Informative Inherited
Biological Process (BP) secondary metabolic process 0.1362 Informative Inherited
Biological Process (BP) DNA repair 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7444 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3105 Informative Inherited
Biological Process (BP) tube development 0.1813 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5953 Informative Inherited
Biological Process (BP) cell division 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.1336 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2777 Informative Inherited
Biological Process (BP) cell cycle process 0.8507 Informative Inherited
Biological Process (BP) sterol transport 0.000000000003021 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.000005785 Highly Informative Direct
Biological Process (BP) hemostasis 0.000259 Highly Informative Direct
Biological Process (BP) coagulation 0.0002931 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000000000008989 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of chemotaxis 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) positive regulation of behavior 0.00000000000002753 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.00000002851 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0000000376 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0000003697 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.000003061 Highly Informative Direct
Biological Process (BP) stem cell development 0.000005689 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.00001262 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.00001508 Highly Informative Direct
Biological Process (BP) hair cycle process 0.00003361 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.0000508 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00005256 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001102 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.0001681 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0001716 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0002816 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0004497 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0007859 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.01728 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.2452 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.8256 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.00254 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.008773 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.004499 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.02797 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.08219 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.05054 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.002047 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.0809 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3609 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.5066 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.9787 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1307 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.05857 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.001423 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0038 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.01331 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.8951 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.00704 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1104 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.8874 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2456 Highly Informative Inherited
Biological Process (BP) regulation of protein targeting 0.1279 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.158 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.1684 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.5075 Highly Informative Inherited
Biological Process (BP) cilium organization 0.002748 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.0829 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.6686 Highly Informative Inherited
Biological Process (BP) wound healing 0.03539 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.01258 Highly Informative Inherited
Biological Process (BP) innate immune response 0.4963 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) DNA modification 0.1289 Highly Informative Inherited
Biological Process (BP) gene silencing 0.3048 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.9737 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1734 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.2407 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.2504 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.6859 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.2091 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.005885 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.1331 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.5313 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.01831 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1116 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3458 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) cytokinesis 0.3575 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.1138 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.02413 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.003553 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.3347 Highly Informative Inherited
Biological Process (BP) epidermis development 0.1581 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.001723 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2639 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000933 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.9017 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0000004353 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0004794 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.3632 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.004948 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.00382 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.003438 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.000166 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0004223 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.0000000007745 Informative Direct
Molecular Function (MF) DNA binding 0.00000000492 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0005488 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.0008017 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) protein complex binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) lipid binding 0.03028 Informative Inherited
Molecular Function (MF) enzyme binding 0.004669 Informative Inherited
Molecular Function (MF) receptor activity 0.006649 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.005713 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.1509 Informative Inherited
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0001044 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000107 Highly Informative Direct
Molecular Function (MF) ubiquitin-protein transferase activity 0.0001627 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.007033 Highly Informative Inherited
Molecular Function (MF) steroid binding 0.0333 Highly Informative Inherited
Molecular Function (MF) antigen binding 0.2882 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.01155 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.2449 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.4529 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3878 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.2353 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.6235 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.02248 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.05099 Highly Informative Inherited
Cellular Component (CC) membrane 0.03207 Least Informative Inherited
Cellular Component (CC) protein complex 0.7135 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.00000000974 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.03562 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.2849 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.01092 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.2257 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.07727 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) integral component of membrane 0.002897 Informative Inherited
Cellular Component (CC) transporter complex 0.01038 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.829 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.004784 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.7852 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.0003287 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000467 Highly Informative Direct
Cellular Component (CC) spindle 0.6469 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.01287 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 0.3569 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.2157 Highly Informative Inherited
Cellular Component (CC) cytoplasmic ribonucleoprotein granule 0.1117 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase0.000000000000004856Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.00000000000005029Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.0000000001199Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.5189Least InformativeInherited
Disease Ontology (DO)skin disease0.1028Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.6111Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis0.00002317InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5205Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.7498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.3257Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.4611Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.835Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the feet0.04632InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1249InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2642InformativeInherited
Phenotypic Abnormality (PA)Esophageal varix0.0002029Highly InformativeDirect
Phenotypic Abnormality (PA)Portal hypertension0.0002609Highly InformativeDirect
Phenotypic Abnormality (PA)Ascites0.000512Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the metatarsal bones0.006637Highly InformativeInherited
Phenotypic Abnormality (PA)Short long bones0.01386Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03155Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1669Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2965Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2972Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.08627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.08888Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.119Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1759Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.1888Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1984Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.2104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2115Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2362Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2427Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0007913InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.006113InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.05068InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.0587InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.1211InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00002147Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.0003672Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.5618Least InformativeInherited
Fly Anatomy (FA)cell0.5823Least InformativeInherited
Fly Anatomy (FA)circulatory system0.05457InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.00002683Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003623Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02577Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06103Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.006459Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases4.839e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0002456Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.02657Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase4.839e-16InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.02716InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.06954InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen0.00000000000005013Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.000000000005718Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.05517Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.1436Least InformativeInherited
Drugbank ATC_code (DB)blood and blood forming organs0.2002Least InformativeInherited
Drugbank ATC_code (DB)genito urinary system and sex hormones0.00003664Moderately InformativeDirect
Drugbank ATC_code (DB)drugs used in diabetes0.0002305Moderately InformativeDirect
Drugbank ATC_code (DB)stomatological preparations0.003216Moderately InformativeInherited
Drugbank ATC_code (DB)other analgesics and antipyretics0.01094Moderately InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)drugs used in erectile dysfunction0.000000009186InformativeDirect
Drugbank ATC_code (DB)glibenclamide0.000000996InformativeDirect
Drugbank ATC_code (DB)acetylsalicylic acid0.0000139InformativeDirect
Drugbank ATC_code (DB)acetylsalicylic acid0.0000139InformativeDirect
Drugbank ATC_code (DB)other agents for local oral treatment0.00003913InformativeDirect
Drugbank ATC_code (DB)yohimbine0.0000000004306Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.004304Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processTranscription regulation0.0000000000243Moderately InformativeDirect
Biological processIon transport0.0000008799Moderately InformativeDirect
Biological processProtein transport0.0004441Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid transport0.000000000000002773InformativeDirect
Biological processViral immunoevasion0.000007855InformativeDirect
Biological processBiological rhythms0.0001065InformativeDirect
Biological processInnate immunity0.000603InformativeDirect
Biological processSteroid metabolism0.003782InformativeInherited
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision0.0000000000009425Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00000001172Highly InformativeDirect
Biological processNotch signaling pathway0.00000004055Highly InformativeDirect
Biological processOxygen transport0.00000007157Highly InformativeDirect
Biological processCholesterol metabolism0.0001186Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0001588Highly InformativeDirect
Biological processExocytosis0.0003681Highly InformativeDirect
Cellular componentMembrane0.00000000000003892Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00001048Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentCoated pit0.00000009363Highly InformativeDirect
DiseaseProto-oncogene0.00000000000008904Moderately InformativeDirect
DiseaseAutoimmune uveitis0.0000000003459Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1425Least InformativeInherited
DomainANK repeat0.00001422InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.02159Moderately InformativeInherited
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD0.00004851InformativeDirect
Molecular functionHeme0.000626InformativeDirect
Molecular functionLipid-binding0.0006995InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding0.000000000000164Highly InformativeDirect
Molecular functionViral nucleoprotein0.0001811Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.07173Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease0.0000000000001264Moderately InformativeDirect
Post-translational modificationReceptor0.0000000001146Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000003406Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation0.000000005568InformativeDirect
Post-translational modificationProtease inhibitor0.000000012InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00000000001996Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000000000001191Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.000001248InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002542Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation1InformativeInherited
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)glycogen degradation0Highly InformativeDirect
UniPathway (UP)beta-glucan biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]