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E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,642) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 56,240 0 244
Proteins 35,744 0 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase0.000000000000004856Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.00000000000005029Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.0000000001199Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.07768Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5346Moderately InformativeInherited
Disease Ontology (DO)bullous skin disease0.01658InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1699Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1917Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4665Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2495Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.3674Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.4464Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.4976Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.0674InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.4217InformativeInherited
Phenotypic Abnormality (PA)Metabolic alkalosis0.0002681Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0003603Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.0005592Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.000609Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000609Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.01196Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3386Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3705Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.452Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.04048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.05671Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.09446Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.3027Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3057Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000008432InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.006253InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.07954InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.09099InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00005467Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.0003684Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.5133Least InformativeInherited
Worm Phenotype (WP)cell development variant0.6494Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.7688Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2845Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4474Moderately InformativeInherited
Worm Phenotype (WP)pesticide response variant0.02744InformativeInherited
Worm Phenotype (WP)cell stress response variant0.4055InformativeInherited
Worm Phenotype (WP)paraquat hypersensitive0.0005806Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.01331Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.09637Least InformativeInherited
Fly Anatomy (FA)anatomical space0.005195InformativeInherited
Fly Anatomy (FA)circulatory system0.07162InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.00001841Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8066Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.8485Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.9069Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.907Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.4759Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.8375Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.904Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9152Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.9159InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.07346Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0003025Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)late tailbud stage0.2345InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003635Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02595Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06133Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000000000005067Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0003403Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003151Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.8708Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.05808InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.2017InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.8603InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen0.0000000000004677Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.00000000001772Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.00001359Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000002645Least InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processIon transport0.000000000003341Moderately InformativeDirect
Biological processTranscription regulation0.00000000002111Moderately InformativeDirect
Biological processImmunity0.08072Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processmRNA processing0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processSensory transduction0.000000000000002877InformativeDirect
Biological processLipid transport0.0000000000002469InformativeDirect
Biological processViral immunoevasion0.000000001797InformativeDirect
Biological processInnate immunity0.0005222InformativeDirect
Biological processBiological rhythms0.0007413InformativeDirect
Biological processSteroid metabolism0.008777InformativeInherited
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processInhibition of host STAT2 by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision0.0000000003433Highly InformativeDirect
Biological processNotch signaling pathway0.00000004514Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000003853Highly InformativeDirect
Biological processOxygen transport0.0000007888Highly InformativeDirect
Biological processCholesterol metabolism0.0003398Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0004482Highly InformativeDirect
Biological processExocytosis0.0005848Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0.00000001345Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000003946Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentSpliceosome0.0009915InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentHost mitochondrion0Highly InformativeDirect
Cellular componentCoated pit0.0000001496Highly InformativeDirect
DiseaseProto-oncogene0.00000000000000186Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.06191Least InformativeInherited
DomainANK repeat0.00001196InformativeDirect
Molecular functionCalcium4.964e-16Moderately InformativeDirect
Molecular functionFlavoprotein0.1106Moderately InformativeInherited
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD0.000878InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding0.000000000000002701Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.01303Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.0000000009264Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000001056Moderately InformativeDirect
Post-translational modificationMultifunctional enzyme0.000003166Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.5972Moderately InformativeInherited
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation0.00000002116InformativeDirect
Post-translational modificationProtease inhibitor0.00000002947InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSuppressor of RNA silencing0Highly InformativeDirect
Post-translational modificationStorage protein2.247e-16Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00000000004722Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0.000000000298Highly InformativeDirect
Post-translational modificationViral ion channel0.00000259Highly InformativeDirect
Post-translational modificationViral nucleoprotein0.0002732Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00000000008344InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002803Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]