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E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,642) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 56,240 272,296 244
Proteins 35,744 199,534 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase0.000000000000004856Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.00000000000005029Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.0000000001199Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.07768Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5346Moderately InformativeInherited
Disease Ontology (DO)bullous skin disease0.01658InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1777Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2131Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.09489Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.3726Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.4415Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.5646Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.06364InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.4268InformativeInherited
Phenotypic Abnormality (PA)Metabolic alkalosis0.0002579Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0003455Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.0005301Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0005847Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0005847Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.01192Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.338Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3706Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4513Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0404Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.05659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.09444Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.3023Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3058Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.00000841InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.006244InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.07941InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.09098InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00005456Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.0003678Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.5171Least InformativeInherited
Worm Phenotype (WP)cell development variant0.6756Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.773Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2883Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4516Moderately InformativeInherited
Worm Phenotype (WP)pesticide response variant0.02971InformativeInherited
Worm Phenotype (WP)cell stress response variant0.4078InformativeInherited
Worm Phenotype (WP)paraquat hypersensitive0.0005834Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.01336Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.1048Least InformativeInherited
Fly Anatomy (FA)hemocyte0.005665InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.00001791Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8308Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.8511Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.9104Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.9236Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.548Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.8543Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.9141Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9144Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.9266InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.07657Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0002809Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage0.9528InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003635Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02595Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06133Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000000000005073Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0002818Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.002381Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.05953InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.2081InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.8574InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen0.0000000000004377Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0000000001424Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.00001323Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]