SUPERFAMILY 1.75 HMM library and genome assignments server


E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,627) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 53,031 136,880 244
Proteins 34,137 103,754 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus9.621e-062.191e-10Least InformativeDirect
Biological Process (BP)localization0.00014038.394e-06Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0056520.000117Least InformativeInherited
Biological Process (BP)regulation of cellular process0.060890.004118Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0074831.922e-15Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.84570.164Least InformativeInherited
Biological Process (BP)signal transduction0.0048372.568e-06Moderately InformativeInherited
Biological Process (BP)immune system process0.0065890.03606Moderately InformativeInherited
Biological Process (BP)cellular localization0.34471Moderately InformativeInherited
Biological Process (BP)organelle organization0.75491Moderately InformativeInherited
Biological Process (BP)macromolecule localization6.365e-070.9819Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00037651Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00085880.8137Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.32220.6201Moderately InformativeInherited
Biological Process (BP)lipid localization01.141e-05InformativeDirect
Biological Process (BP)response to light stimulus9.783e-064.985e-05InformativeDirect
Biological Process (BP)defense response0.0022880.0161InformativeInherited
Biological Process (BP)response to wounding0.0050880.0006263InformativeInherited
Biological Process (BP)immune response0.010680.1651InformativeInherited
Biological Process (BP)cytoskeleton organization0.0079740.02648InformativeInherited
Biological Process (BP)actin filament-based process0.010622.926e-05InformativeInherited
Biological Process (BP)regulation of body fluid levels7.333e-050.01265InformativeInherited
Biological Process (BP)organic hydroxy compound transport01.139e-07Highly InformativeDirect
Biological Process (BP)detection of light stimulus3.181e-117.426e-06Highly InformativeDirect
Biological Process (BP)hemostasis4.168e-070.0002288Highly InformativeDirect
Biological Process (BP)coagulation9.351e-060.0002155Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.00024770Highly InformativeDirect
Biological Process (BP)wound healing1.263e-050.148Highly InformativeInherited
Biological Process (BP)humoral immune response0.0075660.008372Highly InformativeInherited
Biological Process (BP)innate immune response0.081520.5994Highly InformativeInherited
Molecular Function (MF)binding0.010486.129e-11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity1.146e-050.03682Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding3.142e-060.004115InformativeInherited
Molecular Function (MF)GTPase regulator activity2.034e-110.03084InformativeInherited
Molecular Function (MF)lipid binding7.294e-080.02986InformativeInherited
Molecular Function (MF)alcohol binding8.055e-080.005076Highly InformativeInherited
Molecular Function (MF)steroid binding2.855e-060.03111Highly InformativeInherited
Molecular Function (MF)antigen binding2.949e-050.2962Highly InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.040870.3728Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 2.191e-10 Least Informative Direct
Biological Process (BP) localization 8.394e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000117 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.922e-15 Least Informative Direct
Biological Process (BP) developmental process 1.642e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.164 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2789 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.004118 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 2.568e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001493 Moderately Informative Direct
Biological Process (BP) regulation of localization 4.112e-09 Moderately Informative Direct
Biological Process (BP) ion transport 7.888e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0001042 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0003691 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.04331 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2002 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8137 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.02236 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1659 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3003 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.1472 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.007518 Moderately Informative Inherited
Biological Process (BP) immune system process 0.03606 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8434 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.5806 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.03521 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9788 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.05248 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9819 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.8644 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6201 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.08121 Moderately Informative Inherited
Biological Process (BP) lipid localization 1.141e-05 Informative Direct
Biological Process (BP) response to light stimulus 4.985e-05 Informative Direct
Biological Process (BP) response to wounding 0.0006263 Informative Direct
Biological Process (BP) actin filament-based process 2.926e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.328e-10 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.253e-14 Informative Direct
Biological Process (BP) regulation of cellular component movement 6.65e-14 Informative Direct
Biological Process (BP) locomotion 1.352e-13 Informative Direct
Biological Process (BP) regulation of locomotion 3.041e-12 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 4.619e-12 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.337e-11 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 3.647e-11 Informative Direct
Biological Process (BP) metal ion transport 7.557e-11 Informative Direct
Biological Process (BP) transmembrane transport 4.22e-10 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 4.509e-10 Informative Direct
Biological Process (BP) polysaccharide metabolic process 8.387e-07 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 9.896e-05 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0003077 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.08859 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.8389 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2572 Informative Inherited
Biological Process (BP) protein localization to organelle 0.7999 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.8726 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.04811 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4624 Informative Inherited
Biological Process (BP) gland development 0.4538 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.3061 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.02648 Informative Inherited
Biological Process (BP) protein complex assembly 0.8284 Informative Inherited
Biological Process (BP) muscle structure development 0.872 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01144 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3074 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.313 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9392 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.9108 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.9463 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06646 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.3843 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) cell projection organization 0.02616 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6056 Informative Inherited
Biological Process (BP) organelle assembly 0.1909 Informative Inherited
Biological Process (BP) defense response 0.0161 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.005889 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.7328 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.411 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1516 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.001824 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.001452 Informative Inherited
Biological Process (BP) generation of neurons 0.3722 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) cellular component movement 0.4948 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2878 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.06132 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01265 Informative Inherited
Biological Process (BP) cell cycle process 0.8724 Informative Inherited
Biological Process (BP) protein transport 0.8265 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) immune response 0.1651 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5521 Informative Inherited
Biological Process (BP) tube development 0.2909 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.1994 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.08925 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 1.139e-07 Highly Informative Direct
Biological Process (BP) detection of light stimulus 7.426e-06 Highly Informative Direct
Biological Process (BP) hemostasis 0.0002288 Highly Informative Direct
Biological Process (BP) coagulation 0.0002155 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 6.294e-13 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 3.701e-11 Highly Informative Direct
Biological Process (BP) interphase 1.153e-08 Highly Informative Direct
Biological Process (BP) mesenchyme development 1.219e-08 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 1.302e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 2.205e-06 Highly Informative Direct
Biological Process (BP) stem cell development 4.629e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.666e-05 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 4.933e-05 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 6.275e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001908 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0002562 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0003313 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000447 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0008294 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.0009529 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0009554 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.004443 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.03837 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002359 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.8599 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.00192 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.005792 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.009999 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01851 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.07704 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.04349 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.4443 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.003771 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.08736 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1223 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.4629 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.003357 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.9062 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1144 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.1393 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.1618 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1961 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.2954 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.4341 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.5759 Highly Informative Inherited
Biological Process (BP) cilium organization 0.01646 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.07441 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.649 Highly Informative Inherited
Biological Process (BP) wound healing 0.148 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.008372 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5994 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01336 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.9861 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1072 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.459 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.8427 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.9564 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.003725 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.132 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.005505 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.4833 Highly Informative Inherited
Biological Process (BP) axon development 0.3837 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1003 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.4161 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1485 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.6644 Highly Informative Inherited
Biological Process (BP) DNA modification 0.1379 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.01238 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.003128 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.001538 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2706 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cell division 0.738 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.005369 Highly Informative Inherited
Molecular Function (MF) binding 6.129e-11 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 4.079e-07 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0003159 Moderately Informative Direct
Molecular Function (MF) anion binding 0.005362 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.003349 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.03682 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.0001638 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 2.175e-05 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) DNA binding 4.203e-10 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 9.789e-10 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0003336 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.004115 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.002404 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.005963 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.01493 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.03084 Informative Inherited
Molecular Function (MF) receptor activity 0.01421 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.0121 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.001667 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.2109 Informative Inherited
Molecular Function (MF) lipid binding 0.02986 Informative Inherited
Molecular Function (MF) actin binding 6.358e-06 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0001133 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0.000252 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.005076 Highly Informative Inherited
Molecular Function (MF) steroid binding 0.03111 Highly Informative Inherited
Molecular Function (MF) antigen binding 0.2962 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3728 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.01096 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.6101 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.2153 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.5074 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.04138 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) protein complex 0.6884 Least Informative Inherited
Cellular Component (CC) membrane 0.01057 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 1.615e-08 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.002973 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.01834 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.1122 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.1417 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.07807 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.9664 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.004023 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.01318 Informative Inherited
Cellular Component (CC) transcription factor complex 3.948e-10 Highly Informative Direct
Cellular Component (CC) actin filament 6.325e-05 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.0002746 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0006576 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0.0007712 Highly Informative Direct
Cellular Component (CC) spindle 0.6652 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.006424 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.969 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.1912 Highly Informative Inherited
Cellular Component (CC) nonmotile primary cilium 0.06239 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase4.856e-15Highly InformativeDirect
Enzyme Commission (EC)Pullulanase5.029e-14Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase1.199e-10Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)4.944e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.3906Least InformativeInherited
Disease Ontology (DO)skin disease0.05086Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.449Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis8.27e-07InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5255Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.749Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.716Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.8366Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.0872InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1304InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2665InformativeInherited
Phenotypic Abnormality (PA)Esophageal varix0.0001982Highly InformativeDirect
Phenotypic Abnormality (PA)Portal hypertension0.0002652Highly InformativeDirect
Phenotypic Abnormality (PA)Ascites0.0005212Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the metatarsal bones0.006411Highly InformativeInherited
Phenotypic Abnormality (PA)Short long bones0.01431Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02961Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2161Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2915Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3683Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.09052Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.09219Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1131Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1235Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.2014Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.2134Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2336Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2386Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.259Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0007617InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.01234InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.03747InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.05766InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.1165InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology2.203e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.0003768Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.7605Least InformativeInherited
Fly Anatomy (FA)cell0.8515Least InformativeInherited
Fly Anatomy (FA)circulatory system0.04914InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte5.134e-05Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003623Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02577Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06103Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00666Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1.434e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0002243Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.02623Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase4.81e-16InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.02639InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.06862InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen4.997e-14Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor5.704e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.005964Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processTranscription regulation2.202e-11Moderately InformativeDirect
Biological processIon transport4.865e-07Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid transport2.315e-15InformativeDirect
Biological processViral immunoevasion8.288e-06InformativeDirect
Biological processInnate immunity0.0005951InformativeDirect
Biological processSteroid metabolism0.003526InformativeInherited
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision1.123e-12Highly InformativeDirect
Biological processCilium biogenesis/degradation9.738e-09Highly InformativeDirect
Biological processNotch signaling pathway3.943e-08Highly InformativeDirect
Biological processOxygen transport5.923e-08Highly InformativeDirect
Biological processCholesterol metabolism0.0001151Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0001553Highly InformativeDirect
Biological processExocytosis0.0003618Highly InformativeDirect
Cellular componentMembrane5.207e-14Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle9.381e-06Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentCoated pit9.138e-08Highly InformativeDirect
DiseaseProto-oncogene9.998e-14Moderately InformativeDirect
DiseaseAutoimmune uveitis3.507e-10Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1654Least InformativeInherited
DomainANK repeat1.432e-05InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.0198Moderately InformativeInherited
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD4.229e-05InformativeDirect
Molecular functionHeme0.0005664InformativeDirect
Molecular functionLipid-binding0.0006762InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding1.615e-13Highly InformativeDirect
Molecular functionViral nucleoprotein0.0001794Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.06748Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease1.103e-13Moderately InformativeDirect
Post-translational modificationReceptor1.065e-10Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.307e-07Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation8.807e-10InformativeDirect
Post-translational modificationProtease inhibitor1.085e-08InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor1.709e-11Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation3.949e-14Moderately InformativeDirect
Post-translational modificationS-nitrosylation1.171e-06InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002493Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation1InformativeInherited
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)glycogen degradation0Highly InformativeDirect
UniPathway (UP)beta-glucan biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]