SUPERFAMILY 1.75 HMM library and genome assignments server

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E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,633) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 54,907 136,880 244
Proteins 35,127 103,754 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00001750.00000000002061Least InformativeDirect
Biological Process (BP)localization0.00018660.000006452Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0054160.00007652Least InformativeInherited
Biological Process (BP)regulation of cellular process0.052080.00304Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0091690Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.88290.2408Least InformativeInherited
Biological Process (BP)signal transduction0.0043720.000001975Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.8871Moderately InformativeInherited
Biological Process (BP)immune system process0.0072020.02175Moderately InformativeInherited
Biological Process (BP)cellular localization0.3451Moderately InformativeInherited
Biological Process (BP)organelle organization0.75171Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.00000063191Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00033821Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00074680.71Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.32550.4963Moderately InformativeInherited
Biological Process (BP)response to light stimulus0.0000097650.00006987InformativeDirect
Biological Process (BP)lipid localization00.00001098InformativeDirect
Biological Process (BP)defense response0.002530.01094InformativeInherited
Biological Process (BP)immune response0.0094970.1132InformativeInherited
Biological Process (BP)response to wounding0.0047050.000438InformativeInherited
Biological Process (BP)cytoskeleton organization0.0080170.03394InformativeInherited
Biological Process (BP)actin filament-based process0.010790.00004082InformativeInherited
Biological Process (BP)regulation of body fluid levels0.000072180.0134InformativeInherited
Biological Process (BP)hemostasis0.00000045530.0002612Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.00024220Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.000000000030210.000006421Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport00.0000001313Highly InformativeDirect
Biological Process (BP)coagulation0.000010010.0002672Highly InformativeDirect
Biological Process (BP)humoral immune response0.0076920.01277Highly InformativeInherited
Biological Process (BP)wound healing0.000014310.2165Highly InformativeInherited
Biological Process (BP)innate immune response0.073350.4279Highly InformativeInherited
Molecular Function (MF)binding0.013090.0000000004649Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.000011760.04378Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.0000027760.003881InformativeInherited
Molecular Function (MF)GTPase regulator activity0.000000000020310.03522InformativeInherited
Molecular Function (MF)lipid binding0.000000061620.03069InformativeInherited
Molecular Function (MF)steroid binding0.0000024880.02973Highly InformativeInherited
Molecular Function (MF)alcohol binding0.000000077620.005463Highly InformativeInherited
Molecular Function (MF)antigen binding0.000026060.2905Highly InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.042920.3898Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0.000000008003 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00007652 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000002061 Least Informative Direct
Biological Process (BP) localization 0.000006452 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.2408 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3371 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.00304 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.000005781 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000001975 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0003376 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0001014 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000001023 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1955 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.71 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001144 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.6579 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01389 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.7801 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2039 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2124 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.1086 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.01048 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02175 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8691 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4475 Moderately Informative Inherited
Biological Process (BP) organ development 0.03135 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9522 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4963 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1129 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.0000001078 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0002283 Informative Direct
Biological Process (BP) response to light stimulus 0.00006987 Informative Direct
Biological Process (BP) response to wounding 0.000438 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000000001447 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000000000000003755 Informative Direct
Biological Process (BP) lipid localization 0.00001098 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.00004205 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0002981 Informative Direct
Biological Process (BP) metal ion transport 0.00000000008482 Informative Direct
Biological Process (BP) actin filament-based process 0.00004082 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000000001781 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00000000002985 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000000003696 Informative Direct
Biological Process (BP) locomotion 0.0000000000001751 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000003833 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0005533 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0000000000004717 Informative Direct
Biological Process (BP) negative regulation of transport 0.0004582 Informative Direct
Biological Process (BP) protein oligomerization 0.00001039 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000000000007996 Informative Direct
Biological Process (BP) transmembrane transport 0.00000000006664 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0002842 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.07154 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2906 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8174 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.8912 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03957 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.504 Informative Inherited
Biological Process (BP) gland development 0.4678 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.3317 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.03394 Informative Inherited
Biological Process (BP) muscle structure development 0.9112 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01456 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2379 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2305 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8595 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.9118 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.9404 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.0668 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.3881 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) cell projection organization 0.02884 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6906 Informative Inherited
Biological Process (BP) organelle assembly 0.2709 Informative Inherited
Biological Process (BP) defense response 0.01094 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.006058 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.7129 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.3605 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.4308 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.3953 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3986 Informative Inherited
Biological Process (BP) generation of neurons 0.3675 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) cellular component movement 0.4945 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2237 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.324 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.0134 Informative Inherited
Biological Process (BP) cell cycle process 0.8622 Informative Inherited
Biological Process (BP) protein transport 0.8365 Informative Inherited
Biological Process (BP) secondary metabolic process 0.1317 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1013 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.1132 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5803 Informative Inherited
Biological Process (BP) tube development 0.2978 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.1317 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.08885 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.00001543 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0001992 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0002159 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0004607 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) hemostasis 0.0002612 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.000006421 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0002091 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0000001313 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.000000007796 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.0000644 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.00003083 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0000000001049 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0000003839 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0003422 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.000002083 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) stem cell development 0.000005856 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) coagulation 0.0002672 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0002634 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.00000002019 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0007815 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.004366 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.03341 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.003187 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.001443 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.001354 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.2491 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.8203 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.002501 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.007937 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.01114 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.02781 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.07937 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.04928 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.4534 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.003761 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.08367 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.4518 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1441 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.003898 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.9156 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1147 Highly Informative Inherited
Biological Process (BP) interaction with host 0.07924 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.4317 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.3116 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.1696 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1719 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.9656 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.7194 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.08913 Highly Informative Inherited
Biological Process (BP) cilium organization 0.02343 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.01277 Highly Informative Inherited
Biological Process (BP) wound healing 0.2165 Highly Informative Inherited
Biological Process (BP) innate immune response 0.4279 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01901 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) gene silencing 0.4101 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.9968 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.4204 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1182 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.003891 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.1334 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.005802 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.5234 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.2169 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.4305 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1022 Highly Informative Inherited
Biological Process (BP) sensory perception 0.139 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.6502 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.001795 Highly Informative Inherited
Biological Process (BP) DNA modification 0.144 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.01344 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.003405 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.3345 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.001708 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2617 Highly Informative Inherited
Biological Process (BP) cell division 0.7446 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000004649 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0006739 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.0000004491 Moderately Informative Direct
Molecular Function (MF) anion binding 0.005062 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.003828 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.04378 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0.0000000007243 Informative Direct
Molecular Function (MF) DNA binding 0.0000000007897 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00002043 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0001754 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0005322 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.00079 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.003881 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.004344 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.03522 Informative Inherited
Molecular Function (MF) receptor activity 0.01058 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.009162 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) ligase activity 0.1517 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.1522 Informative Inherited
Molecular Function (MF) lipid binding 0.03069 Informative Inherited
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0001084 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0.0001832 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0.02973 Highly Informative Inherited
Molecular Function (MF) alcohol binding 0.005463 Highly Informative Inherited
Molecular Function (MF) antigen binding 0.2905 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3898 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.01108 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.6258 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.246 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.5418 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.02271 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) protein complex 0.6994 Least Informative Inherited
Cellular Component (CC) membrane 0.02665 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.00000001418 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.004042 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.03516 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.1519 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.1813 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.07838 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.946 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.004723 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.01443 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 0.0008646 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.0003157 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0005993 Highly Informative Direct
Cellular Component (CC) spindle 0.6681 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.006149 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.1957 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase0.000000000000004856Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.00000000000005029Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.0000000001199Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.5189Least InformativeInherited
Disease Ontology (DO)skin disease0.1028Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.6111Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis0.00002317InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5205Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.7498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.3257Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.4611Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.835Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the feet0.04632InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1249InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2642InformativeInherited
Phenotypic Abnormality (PA)Esophageal varix0.0002029Highly InformativeDirect
Phenotypic Abnormality (PA)Portal hypertension0.0002609Highly InformativeDirect
Phenotypic Abnormality (PA)Ascites0.000512Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the metatarsal bones0.006637Highly InformativeInherited
Phenotypic Abnormality (PA)Short long bones0.01386Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03155Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1669Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2965Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2972Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.08627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.08888Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.119Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1759Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.1888Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1984Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.2104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2115Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2362Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2427Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0007913InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.006113InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.05068InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.0587InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.1211InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00002147Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.0003672Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.5618Least InformativeInherited
Fly Anatomy (FA)cell0.5823Least InformativeInherited
Fly Anatomy (FA)circulatory system0.05457InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.00002683Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003623Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02577Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06103Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.006459Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases4.839e-16Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0002456Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.02657Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase4.839e-16InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.02716InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.06954InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen0.00000000000005013Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.000000000005718Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.004304Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processTranscription regulation0.0000000000243Moderately InformativeDirect
Biological processIon transport0.0000008799Moderately InformativeDirect
Biological processProtein transport0.0004441Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid transport0.000000000000002773InformativeDirect
Biological processViral immunoevasion0.000007855InformativeDirect
Biological processBiological rhythms0.0001065InformativeDirect
Biological processInnate immunity0.000603InformativeDirect
Biological processSteroid metabolism0.003782InformativeInherited
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision0.0000000000009425Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00000001172Highly InformativeDirect
Biological processNotch signaling pathway0.00000004055Highly InformativeDirect
Biological processOxygen transport0.00000007157Highly InformativeDirect
Biological processCholesterol metabolism0.0001186Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0001588Highly InformativeDirect
Biological processExocytosis0.0003681Highly InformativeDirect
Cellular componentMembrane0.00000000000003892Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00001048Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentCoated pit0.00000009363Highly InformativeDirect
DiseaseProto-oncogene0.00000000000008904Moderately InformativeDirect
DiseaseAutoimmune uveitis0.0000000003459Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1425Least InformativeInherited
DomainANK repeat0.00001422InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.02159Moderately InformativeInherited
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD0.00004851InformativeDirect
Molecular functionHeme0.000626InformativeDirect
Molecular functionLipid-binding0.0006995InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding0.000000000000164Highly InformativeDirect
Molecular functionViral nucleoprotein0.0001811Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.07173Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease0.0000000000001264Moderately InformativeDirect
Post-translational modificationReceptor0.0000000001146Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000003406Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation0.000000005568InformativeDirect
Post-translational modificationProtease inhibitor0.000000012InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00000000001996Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000000000001191Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.000001248InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002542Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation1InformativeInherited
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)glycogen degradation0Highly InformativeDirect
UniPathway (UP)beta-glucan biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]