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E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,642) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 56,240 219,641 244
Proteins 35,744 161,408 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0000015330.000000000031Least InformativeDirect
Biological Process (BP)response to stimulus0.0000230.000000005293Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00064840.00000001967Least InformativeDirect
Biological Process (BP)cell communication0.0000092520.0000000000005484Moderately InformativeDirect
Biological Process (BP)single organism signaling0.00060080.000000000253Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.014140.00000005994Moderately InformativeInherited
Biological Process (BP)immune system process0.0000063730.3121Moderately InformativeInherited
Biological Process (BP)defense response0.0010910.02463Moderately InformativeInherited
Biological Process (BP)organic substance transport0.000064141Moderately InformativeInherited
Biological Process (BP)cellular localization0.46761Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0000000047020.4725Moderately InformativeInherited
Biological Process (BP)single-organism transport0.002840.9697Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.53240.6581Moderately InformativeInherited
Biological Process (BP)lipid localization00.000004044InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway0.0089310.00000000179InformativeInherited
Biological Process (BP)regulation of defense response0.0096880.0005621InformativeInherited
Biological Process (BP)regulation of immune response0.38841InformativeInherited
Biological Process (BP)response to wounding0.003630.09337InformativeInherited
Biological Process (BP)immune response0.0083590.7682InformativeInherited
Biological Process (BP)single-organism cellular localization0.013080.769InformativeInherited
Biological Process (BP)intracellular transport0.26831InformativeInherited
Biological Process (BP)organic hydroxy compound transport00.000000003104Highly InformativeDirect
Biological Process (BP)hemostasis0.000000003280.00009652Highly InformativeDirect
Biological Process (BP)coagulation0.00000030910.00002162Highly InformativeDirect
Biological Process (BP)wound healing0.000050880.0607Highly InformativeInherited
Biological Process (BP)innate immune response0.001060.02271Highly InformativeInherited
Molecular Function (MF)binding0.0033960.001101Least InformativeInherited
Molecular Function (MF)small molecule binding0.32141Moderately InformativeInherited
Molecular Function (MF)molecular function regulator0.00000034880.006727Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.085270.5341Moderately InformativeInherited
Molecular Function (MF)enzyme binding0.0041940.02603InformativeInherited
Molecular Function (MF)steroid binding00.00000000002132Highly InformativeDirect
Molecular Function (MF)GTPase regulator activity00.000000001379Highly InformativeDirect
Molecular Function (MF)small GTPase binding0.000000010150.000006077Highly InformativeDirect
Molecular Function (MF)alcohol binding0.000000050040.00009255Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000000000031 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000005293 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000001967 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8505 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0.0000000000005484 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000000253 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000005994 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000004558 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000002078 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.00001943 Moderately Informative Direct
Biological Process (BP) ion transport 0.000924 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.6581 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3373 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.2218 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1389 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9647 Moderately Informative Inherited
Biological Process (BP) reproduction 0.8396 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.2951 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8969 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.5324 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.06193 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2496 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1891 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02405 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9444 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.08461 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4164 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.3121 Moderately Informative Inherited
Biological Process (BP) defense response 0.02463 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5537 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2656 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2369 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4725 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9697 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.09276 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.01259 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9653 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.08161 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.05158 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.000004044 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00000000179 Informative Direct
Biological Process (BP) regulation of defense response 0.0005621 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00000000000002436 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0000000000001218 Informative Direct
Biological Process (BP) locomotion 0.0000000000001511 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000000000003545 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.00000001482 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0000000237 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00000004077 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000000555 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0000001776 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000000593 Informative Direct
Biological Process (BP) protein oligomerization 0.000006897 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000259 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00003617 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0006814 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.3127 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03948 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.06526 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1048 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8531 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.156 Informative Inherited
Biological Process (BP) generation of neurons 0.905 Informative Inherited
Biological Process (BP) response to wounding 0.09337 Informative Inherited
Biological Process (BP) cell development 0.6337 Informative Inherited
Biological Process (BP) transmembrane transport 0.9508 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.4081 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1417 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.02846 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.005102 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.8955 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1105 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9057 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002192 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.09352 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) protein transport 0.9366 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) immune response 0.7682 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.5875 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.3846 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.1189 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.6506 Informative Inherited
Biological Process (BP) epithelium development 0.001959 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.845 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1903 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.9769 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.769 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.8319 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1757 Informative Inherited
Biological Process (BP) system process 0.9146 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.007231 Informative Inherited
Biological Process (BP) pigment metabolic process 0.02973 Informative Inherited
Biological Process (BP) secondary metabolic process 0.1016 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.3851 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3647 Informative Inherited
Biological Process (BP) circulatory system development 0.8525 Informative Inherited
Biological Process (BP) cell cycle process 0.9379 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.3042 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.000000003104 Highly Informative Direct
Biological Process (BP) hemostasis 0.00009652 Highly Informative Direct
Biological Process (BP) coagulation 0.00002162 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0001836 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000000002935 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.000000000000001925 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.000000000001146 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0000000007714 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00000001014 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.00000002383 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00000005709 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.000000138 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.0000007673 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00009021 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.0001164 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001887 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0.0003408 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0003895 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.000479 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00065 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.09539 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01914 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.003226 Highly Informative Inherited
Biological Process (BP) second-messenger-mediated signaling 0.5578 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.003293 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.2259 Highly Informative Inherited
Biological Process (BP) viral process 0.168 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.338 Highly Informative Inherited
Biological Process (BP) kidney development 0.005102 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1504 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.07701 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.002748 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.01144 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter in response to stress 0.01465 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.3779 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.04923 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.4418 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.1347 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.6082 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.03835 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.4008 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.9224 Highly Informative Inherited
Biological Process (BP) nervous system process 0.1292 Highly Informative Inherited
Biological Process (BP) neuron development 0.002549 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.04952 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.03036 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.008675 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.05682 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.121 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1859 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5096 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.6142 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.6597 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.6862 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.8216 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.548 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.7367 Highly Informative Inherited
Biological Process (BP) wound healing 0.0607 Highly Informative Inherited
Biological Process (BP) innate immune response 0.02271 Highly Informative Inherited
Biological Process (BP) negative regulation of translation 0.03536 Highly Informative Inherited
Biological Process (BP) gene silencing 0.05836 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.2368 Highly Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.01928 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1454 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.381 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.9336 Highly Informative Inherited
Biological Process (BP) positive regulation of nucleotide metabolic process 0.3539 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.01285 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.7286 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.204 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.4754 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.002928 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.01106 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.01741 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.001101 Least Informative Inherited
Molecular Function (MF) transferase activity 0.4686 Least Informative Inherited
Molecular Function (MF) transporter activity 0.000001162 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.01498 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.006727 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.5341 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.01933 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.4813 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.00001805 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00005138 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.0001245 Informative Direct
Molecular Function (MF) DNA binding 0.0005865 Informative Direct
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.5897 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.02603 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.008561 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 0.2098 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.008398 Informative Inherited
Molecular Function (MF) steroid binding 0.00000000002132 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.000000001379 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000006077 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00009255 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00000004163 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0000003736 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.000001039 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0001014 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.0003227 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.3561 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.5781 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.008206 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.4051 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.4208 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.2203 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.000001101 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.01517 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.08932 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.4705 Moderately Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.2223 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) transporter complex 0.02406 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.009562 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.0399 Informative Inherited
Cellular Component (CC) cytoplasmic region 0.4691 Informative Inherited
Cellular Component (CC) tethering complex 0.0005474 Highly Informative Direct
Cellular Component (CC) spindle 0.4009 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.03547 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase0.000000000000004856Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.00000000000005029Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.0000000001199Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000152Least InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processIon transport0.000000000002534Moderately InformativeDirect
Biological processTranscription regulation0.00000000005437Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processmRNA processing0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid transport0.00000000000009024InformativeDirect
Biological processViral immunoevasion0.00001449InformativeDirect
Biological processBiological rhythms0.000673InformativeDirect
Biological processSteroid metabolism0.007456InformativeInherited
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processInhibition of host STAT2 by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision0.0000000000009216Highly InformativeDirect
Biological processNotch signaling pathway0.00000004075Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000002193Highly InformativeDirect
Biological processOxygen transport0.0000007464Highly InformativeDirect
Biological processCholesterol metabolism0.0002838Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000374Highly InformativeDirect
Biological processExocytosis0.0005483Highly InformativeDirect
Cellular componentMembrane0.00000000000002165Least InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000001672Moderately InformativeDirect
Cellular componentCell projection0.000278Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentSpliceosome0.0006332InformativeDirect
Cellular componentLysosome0.0009797InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentCoated pit0.0000001064Highly InformativeDirect
DiseaseProto-oncogene0.00000000000002404Moderately InformativeDirect
DiseaseAutoimmune uveitis0.0000000002634Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.2477Least InformativeInherited
DomainANK repeat0.00001901InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.08686Moderately InformativeInherited
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD0.0005682InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding0.000000000000001482Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.08838Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease0.00000000000003843Moderately InformativeDirect
Post-translational modificationReceptor0.0000000002959Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000005175Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation0.00000001641InformativeDirect
Post-translational modificationProtease inhibitor0.00000002246InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00000000003986Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0.0000000002237Highly InformativeDirect
Post-translational modificationViral ion channel0.000002773Highly InformativeDirect
Post-translational modificationViral nucleoprotein0.0001678Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000000001335Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.000000000006721InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.000257Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]