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E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,635) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 54,681 136,880 244
Proteins 35,074 103,754 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.00000014870.0000000000007044Least InformativeDirect
Biological Process (BP)response to stimulus0.000026780.00000000007125Least InformativeDirect
Biological Process (BP)single-organism cellular process10.8078Least InformativeInherited
Biological Process (BP)signaling0.0000010470.00000000000001409Moderately InformativeDirect
Biological Process (BP)cell communication0.0000011660Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.0063520.00000007818Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.87171Moderately InformativeInherited
Biological Process (BP)response to stress11Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00005271Moderately InformativeInherited
Biological Process (BP)cellular localization0.32831Moderately InformativeInherited
Biological Process (BP)single-organism transport0.0013770.9381Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0000000057520.3237Moderately InformativeInherited
Biological Process (BP)immune system process0.0000077890.1287Moderately InformativeInherited
Biological Process (BP)lipid localization00.000004419InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway0.013330.000000003192InformativeInherited
Biological Process (BP)regulation of immune response0.32021InformativeInherited
Biological Process (BP)regulation of defense response0.00086850.0228InformativeInherited
Biological Process (BP)positive regulation of immune system process0.0056360.9718InformativeInherited
Biological Process (BP)single-organism intracellular transport0.016280.5124InformativeInherited
Biological Process (BP)immune response0.028870.7129InformativeInherited
Biological Process (BP)organic hydroxy compound transport00.0000000007156Highly InformativeDirect
Biological Process (BP)hemostasis0.00000010630.00003899Highly InformativeDirect
Biological Process (BP)humoral immune response0.00000040060.0004693Highly InformativeDirect
Biological Process (BP)coagulation0.0000096880.0000456Highly InformativeDirect
Biological Process (BP)wound healing0.0002640.07191Highly InformativeInherited
Biological Process (BP)innate immune response0.01320.1101Highly InformativeInherited
Biological Process (BP)innate immune response-activating signal transduction0.000000048060.003267Highly InformativeInherited
Molecular Function (MF)binding0.00054850.00004052Least InformativeDirect
Molecular Function (MF)protein binding0.92890.3423Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.27531Moderately InformativeInherited
Molecular Function (MF)molecular function regulator0.00000026150.007502Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.040510.2131Moderately InformativeInherited
Molecular Function (MF)enzyme binding0.0050730.02548InformativeInherited
Molecular Function (MF)steroid binding00.00000000003293Highly InformativeDirect
Molecular Function (MF)GTPase regulator activity00.0000000005771Highly InformativeDirect
Molecular Function (MF)small GTPase binding0.000000011190.000002873Highly InformativeDirect
Molecular Function (MF)alcohol binding0.000000038190.00006552Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.0000000000007044 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000007125 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.7457 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8078 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) signaling 0.00000000000001409 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000007818 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000005845 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000003547 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.0006921 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.09257 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4854 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.04531 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1911 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.6482 Moderately Informative Inherited
Biological Process (BP) system development 0.175 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.5453 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.07259 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1737 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3606 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3237 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.5028 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2206 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9381 Moderately Informative Inherited
Biological Process (BP) ion transport 0.001064 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.4805 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1287 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3708 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.3403 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.000004419 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000000003192 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000000000000788 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000000000000007239 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) locomotion 0.00000000000001243 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0000000003677 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000006453 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0000009974 Informative Direct
Biological Process (BP) protein oligomerization 0.000001179 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000002402 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000006199 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000008696 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00003394 Informative Direct
Biological Process (BP) epithelium development 0.0004992 Informative Direct
Biological Process (BP) generation of neurons 0.1353 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.1962 Informative Inherited
Biological Process (BP) negative regulation of transport 0.08475 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2468 Informative Inherited
Biological Process (BP) cell development 0.944 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.026 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03625 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.06403 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.76 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.8753 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4094 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003873 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.4577 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.3084 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8364 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.04591 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.4991 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1922 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.8614 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.893 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.8242 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.4334 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.7939 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.9868 Informative Inherited
Biological Process (BP) regulation of defense response 0.0228 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.9718 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.5124 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.5954 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.005436 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.03217 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8277 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05806 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03025 Informative Inherited
Biological Process (BP) system process 0.9379 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) immune response 0.7129 Informative Inherited
Biological Process (BP) pigment metabolic process 0.02362 Informative Inherited
Biological Process (BP) secondary metabolic process 0.09044 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.3386 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.617 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.8018 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.0000000007156 Highly Informative Direct
Biological Process (BP) hemostasis 0.00003899 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0004693 Highly Informative Direct
Biological Process (BP) coagulation 0.0000456 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0001858 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000000001549 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.000000000000003692 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00000000008109 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00000004336 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000001923 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0000006901 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00003621 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000425 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00005331 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00007031 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0001116 Highly Informative Direct
Biological Process (BP) neuron development 0.0001755 Highly Informative Direct
Biological Process (BP) cell projection organization 0.0001818 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.0003003 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0003909 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.0006451 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0007021 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.2908 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.06238 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.03155 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.00678 Highly Informative Inherited
Biological Process (BP) calcium-mediated signaling 0.01598 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.1909 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.00613 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1075 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.005595 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.4711 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.00435 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.3635 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.001248 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.9451 Highly Informative Inherited
Biological Process (BP) sensory perception 0.04704 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.1341 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.1152 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.6265 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.761 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.02819 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.4402 Highly Informative Inherited
Biological Process (BP) wound healing 0.07191 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1101 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.004013 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2507 Highly Informative Inherited
Biological Process (BP) negative regulation of translation 0.08639 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.1651 Highly Informative Inherited
Biological Process (BP) gene silencing 0.06399 Highly Informative Inherited
Biological Process (BP) innate immune response-activating signal transduction 0.003267 Highly Informative Inherited
Biological Process (BP) maintenance of location in cell 0.002441 Highly Informative Inherited
Biological Process (BP) endocytosis 0.2986 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.006618 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.03988 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.1425 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) positive regulation of nucleotide metabolic process 0.2275 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.4395 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.7335 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.2343 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3125 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.001866 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.008784 Highly Informative Inherited
Biological Process (BP) cell cycle phase transition 0.01325 Highly Informative Inherited
Molecular Function (MF) binding 0.00004052 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.887 Least Informative Inherited
Molecular Function (MF) transporter activity 0.00001253 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.3423 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.004081 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.007502 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.005346 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.2131 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.4479 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.00002381 Informative Direct
Molecular Function (MF) DNA binding 0.00006048 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.0001969 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0009968 Informative Direct
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.5509 Informative Inherited
Molecular Function (MF) enzyme binding 0.02548 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.01799 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 0.134 Informative Inherited
Molecular Function (MF) ATPase activity 0.8408 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.1377 Informative Inherited
Molecular Function (MF) steroid binding 0.00000000003293 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.0000000005771 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000002873 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00006552 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.000000007044 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0000001263 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.000001712 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0002122 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.3071 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.5159 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.006392 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.01879 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.1079 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.08725 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0000003923 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.3476 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.01985 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.0171 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) transporter complex 0.01104 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.001375 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.1786 Informative Inherited
Cellular Component (CC) cytoplasmic region 0.3133 Informative Inherited
Cellular Component (CC) tethering complex 0.0002893 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0.0005833 Highly Informative Direct
Cellular Component (CC) spindle 0.3403 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.2302 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 0.07678 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.01983 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase0.000000000000004856Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.00000000000005029Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.0000000001199Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4291Least InformativeInherited
Disease Ontology (DO)skin disease0.06293Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5283Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.0002954InformativeDirect
Disease Ontology (DO)bullous skin disease0.01483InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.02072Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1705Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1778Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2226Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4499Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7893Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.03965Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.06811Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.2013Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.2076Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.3743Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0.3808Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.5919Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.6033Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.6913Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.01322InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.1171InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mandible0.1437InformativeInherited
Phenotypic Abnormality (PA)Abnormality of ion homeostasis0.2803InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0.9352InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.0002064Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.0002536Highly InformativeDirect
Phenotypic Abnormality (PA)Encephalocele0.0008672Highly InformativeDirect
Phenotypic Abnormality (PA)Short long bone0.0268Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of bones of the lower limbs0.03536Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.00986Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2412Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2434Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3213Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.04428Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.09231Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1416Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2436Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2726Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3099Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000008295InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.005579InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.05805InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.08948InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00005186Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.0003565Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.555Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6756Least InformativeInherited
Worm Phenotype (WP)cell development variant0.8686Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1761Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.3428Moderately InformativeInherited
Worm Phenotype (WP)cell stress response variant0.3445InformativeInherited
Worm Phenotype (WP)lineage variant0.01059Highly InformativeInherited
Worm Phenotype (WP)paraquat response variant0.01304Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.5415Least InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.00003541Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.9696Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9925Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)midgut0.000934Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.1014Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003635Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02595Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06133Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.003619Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.000000000000001941Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00003682Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01587Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.02711InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.09023InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.8004InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen0.0000000000001059Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.000000000006578Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.000008369Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.03748Least InformativeInherited
Drugbank ATC_code (DB)blood and blood forming organs0.1274Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.1876Least InformativeInherited
Drugbank ATC_code (DB)genito urinary system and sex hormones0.00007495Moderately InformativeDirect
Drugbank ATC_code (DB)drugs used in diabetes0.0001366Moderately InformativeDirect
Drugbank ATC_code (DB)stomatological preparations0.007102Moderately InformativeInherited
Drugbank ATC_code (DB)analgesics0.01632Moderately InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)drugs used in erectile dysfunction0.00000001906InformativeDirect
Drugbank ATC_code (DB)glibenclamide0.000001569InformativeDirect
Drugbank ATC_code (DB)acetylsalicylic acid0.00002123InformativeDirect
Drugbank ATC_code (DB)salicylic acid and derivatives0.00002123InformativeDirect
Drugbank ATC_code (DB)other agents for local oral treatment0.00003774InformativeDirect
Drugbank ATC_code (DB)yohimbine0.0000000009324Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000001438Least InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processIon transport0.000000000002827Moderately InformativeDirect
Biological processTranscription regulation0.00000000004155Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processmRNA processing0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid transport0.00000000000003093InformativeDirect
Biological processViral immunoevasion0.0000808InformativeDirect
Biological processBiological rhythms0.0006556InformativeDirect
Biological processSteroid metabolism0.006671InformativeInherited
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision0.0000000000009048Highly InformativeDirect
Biological processNotch signaling pathway0.00000004297Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000001228Highly InformativeDirect
Biological processOxygen transport0.0000007799Highly InformativeDirect
Biological processCholesterol metabolism0.0002275Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0003458Highly InformativeDirect
Biological processExocytosis0.0005324Highly InformativeDirect
Cellular componentMembrane0.00000000000001396Least InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000002862Moderately InformativeDirect
Cellular componentCell projection0.0001126Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentLysosome0.0005922InformativeDirect
Cellular componentSpliceosome0.0006537InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentCoated pit0.0000001159Highly InformativeDirect
DiseaseProto-oncogene0.00000000000002925Moderately InformativeDirect
DiseaseAutoimmune uveitis0.0000000002764Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.2323Least InformativeInherited
DomainANK repeat0.00001903InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD0.0005237InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding9.32e-16Highly InformativeDirect
Molecular functionViral nucleoprotein0.0001948Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.08946Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease0.0000000000000267Moderately InformativeDirect
Post-translational modificationReceptor0.0000000002867Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000004047Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation0.00000001603InformativeDirect
Post-translational modificationProtease inhibitor0.00000001786InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00000000002717Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0.0000000001631Highly InformativeDirect
Post-translational modificationViral ion channel0.000003081Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000000000008277Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.000000001127InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002757Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation1InformativeInherited
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)glycogen degradation0Highly InformativeDirect
UniPathway (UP)beta-glucan biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]