SUPERFAMILY 1.75 HMM library and genome assignments server


E set domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Families:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)
  E-set domains of sugar-utilizing enzymes [ 81282] (20)
  Other IPT/TIG domains [ 89191]
  Arthropod hemocyanin, C-terminal domain [ 81283]
  Class II viral fusion proteins C-terminal domain [ 81284] (2)
  Cytomegalovirus protein US2 [ 81285]
  Molybdenum-containing oxidoreductases-like dimerisation domain [ 81286]
  ML domain [ 81287] (2)
  RhoGDI-like [ 81288] (2)
  Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)
  Transglutaminase N-terminal domain [ 81289]
  Filamin repeat (rod domain) [ 81290] (4)
  Arrestin/Vps26-like [ 81291]
  Gingipain R (RgpB), C-terminal domain [ 81292]
  Copper resistance protein C (CopC, PcoC) [ 81969]
  Cellulosomal scaffoldin protein CipC, module x2.1 [ 81293]
  Quinohemoprotein amine dehydrogenase A chain, domains 4 and 5 [ 81294]
  Internalin Ig-like domain [ 81295] (3)
  SoxZ-like [ 141027]
  Enterochelin esterase N-terminal domain-like [ 141030]
  AMPK-beta glycogen binding domain-like [ 158886] (3)
  Sec63 C-terminal domain-like [ 158893]
  SVA-like [ 158896]


Superfamily statistics
Genomes (2,592) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 51,884 89,367 244
Proteins 33,132 67,275 232


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus2.312e-053.075e-10Least InformativeDirect
Biological Process (BP)localization0.00012424.056e-06Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0064993.746e-15Least InformativeInherited
Biological Process (BP)single-organism cellular process0.004390.0001605Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.83870.1449Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0690.002852Least InformativeInherited
Biological Process (BP)immune system process0.0048180.02126Moderately InformativeInherited
Biological Process (BP)cellular localization0.30561Moderately InformativeInherited
Biological Process (BP)organelle organization0.71721Moderately InformativeInherited
Biological Process (BP)macromolecule localization5.132e-070.9537Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00034991Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00048520.7032Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.28150.8064Moderately InformativeInherited
Biological Process (BP)signal transduction0.009625.537e-06Moderately InformativeInherited
Biological Process (BP)lipid localization01.257e-05InformativeDirect
Biological Process (BP)response to light stimulus8.614e-060.000103InformativeDirect
Biological Process (BP)defense response0.0020810.01251InformativeInherited
Biological Process (BP)response to wounding0.0055450.0005828InformativeInherited
Biological Process (BP)immune response0.007670.1217InformativeInherited
Biological Process (BP)cytoskeleton organization0.008250.02178InformativeInherited
Biological Process (BP)actin filament-based process0.0099571.556e-05InformativeInherited
Biological Process (BP)regulation of body fluid levels7.27e-050.01148InformativeInherited
Biological Process (BP)organic hydroxy compound transport01.387e-07Highly InformativeDirect
Biological Process (BP)detection of light stimulus3.595e-115.291e-06Highly InformativeDirect
Biological Process (BP)hemostasis4.849e-070.0002786Highly InformativeDirect
Biological Process (BP)coagulation1.139e-050.0002355Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.00045850Highly InformativeDirect
Biological Process (BP)wound healing1.43e-050.1415Highly InformativeInherited
Biological Process (BP)humoral immune response0.0093280.009305Highly InformativeInherited
Biological Process (BP)innate immune response0.074370.5637Highly InformativeInherited
Molecular Function (MF)binding0.005165.632e-11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity1.601e-060.02198Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding3.49e-060.003781InformativeInherited
Molecular Function (MF)GTPase regulator activity8.188e-130.01457InformativeInherited
Molecular Function (MF)lipid binding1.265e-070.02993InformativeInherited
Molecular Function (MF)alcohol binding8.983e-080.004675Highly InformativeInherited
Molecular Function (MF)steroid binding3.316e-060.02981Highly InformativeInherited
Molecular Function (MF)antigen binding4.106e-050.2514Highly InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.023410.301Highly InformativeInherited
Cellular Component (CC)extracellular region part1.178e-050.0009775Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 3.075e-10 Least Informative Direct
Biological Process (BP) localization 4.056e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001605 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.746e-15 Least Informative Direct
Biological Process (BP) developmental process 1.832e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1449 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3752 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.002852 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 5.537e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00019 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.552e-09 Moderately Informative Direct
Biological Process (BP) ion transport 6.51e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 8.648e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0001178 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.04964 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.175 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7032 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5112 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.013 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.5976 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1298 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3576 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.9983 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.1844 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.007619 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02126 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7969 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.7472 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.03366 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9537 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9224 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8064 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.09992 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.9379 Moderately Informative Inherited
Biological Process (BP) lipid localization 1.257e-05 Informative Direct
Biological Process (BP) response to light stimulus 0.000103 Informative Direct
Biological Process (BP) response to wounding 0.0005828 Informative Direct
Biological Process (BP) actin filament-based process 1.556e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.432e-10 Informative Direct
Biological Process (BP) positive regulation of gene expression 2.112e-14 Informative Direct
Biological Process (BP) regulation of cellular component movement 1.189e-13 Informative Direct
Biological Process (BP) locomotion 1.545e-13 Informative Direct
Biological Process (BP) regulation of locomotion 5.119e-12 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1.332e-11 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.545e-11 Informative Direct
Biological Process (BP) metal ion transport 5.391e-11 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 9.834e-11 Informative Direct
Biological Process (BP) transmembrane transport 2.23e-10 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 6.859e-10 Informative Direct
Biological Process (BP) polysaccharide metabolic process 7.076e-06 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 9.254e-05 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0006776 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04563 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.8248 Informative Inherited
Biological Process (BP) protein localization to organelle 0.793 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.7861 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.02711 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3601 Informative Inherited
Biological Process (BP) gland development 0.4248 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.02178 Informative Inherited
Biological Process (BP) protein complex assembly 0.8517 Informative Inherited
Biological Process (BP) muscle structure development 0.8079 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.004236 Informative Inherited
Biological Process (BP) epithelium development 0.9898 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3019 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.33 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9524 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.8846 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.9266 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.07715 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.3293 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) cell projection organization 0.02052 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6247 Informative Inherited
Biological Process (BP) organelle assembly 0.1869 Informative Inherited
Biological Process (BP) defense response 0.01251 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004565 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.1459 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.7095 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.413 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1657 Informative Inherited
Biological Process (BP) regulation of defense response 0.3332 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.006668 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.001514 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1397 Informative Inherited
Biological Process (BP) generation of neurons 0.3948 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) cellular component movement 0.4294 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) central nervous system development 0.9798 Informative Inherited
Biological Process (BP) regulation of cell development 0.1716 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.063 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01148 Informative Inherited
Biological Process (BP) cell cycle process 0.8619 Informative Inherited
Biological Process (BP) protein transport 0.8343 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) immune response 0.1217 Informative Inherited
Biological Process (BP) cell activation 0.377 Informative Inherited
Biological Process (BP) cardiovascular system development 0.539 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.395 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 1.387e-07 Highly Informative Direct
Biological Process (BP) detection of light stimulus 5.291e-06 Highly Informative Direct
Biological Process (BP) hemostasis 0.0002786 Highly Informative Direct
Biological Process (BP) coagulation 0.0002355 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1.328e-13 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 3.951e-11 Highly Informative Direct
Biological Process (BP) mesenchyme development 7.191e-09 Highly Informative Direct
Biological Process (BP) cell cycle phase 7.207e-08 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 1.336e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 3.036e-06 Highly Informative Direct
Biological Process (BP) stem cell development 3.416e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.127e-05 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0001259 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001566 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0001703 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.00024 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0002746 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0004867 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0008152 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.0008842 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0008987 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.002358 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.08027 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.001781 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.001704 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.9164 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.002076 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.005158 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.01121 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01506 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.06846 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.0277 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.06938 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.003481 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.4056 Highly Informative Inherited
Biological Process (BP) protein homooligomerization 0.0862 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1238 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.4371 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.001716 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.8799 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1131 Highly Informative Inherited
Biological Process (BP) interaction with host 0.02986 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1617 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.1632 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.29 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.4591 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.9112 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.9638 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.07172 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.6102 Highly Informative Inherited
Biological Process (BP) wound healing 0.1415 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.009305 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5637 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.007487 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) gene silencing 0.3792 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.9784 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1091 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.4804 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.8728 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.9368 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.00262 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.1379 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.005086 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.419 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.2647 Highly Informative Inherited
Biological Process (BP) adult behavior 0.09341 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.4378 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1532 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.6842 Highly Informative Inherited
Biological Process (BP) DNA modification 0.1337 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.01291 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.003146 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.6685 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cell division 0.7336 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.005824 Highly Informative Inherited
Molecular Function (MF) binding 5.632e-11 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 2.229e-07 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0007509 Moderately Informative Direct
Molecular Function (MF) cation binding 0.002317 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.003851 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.02198 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.0001044 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 3.766e-05 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) DNA binding 1.687e-09 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 5.153e-09 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0003305 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.003781 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.01105 Informative Inherited
Molecular Function (MF) enzyme binding 0.001502 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.02239 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.01457 Informative Inherited
Molecular Function (MF) receptor activity 0.03082 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.02794 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.004302 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.2074 Informative Inherited
Molecular Function (MF) lipid binding 0.02993 Informative Inherited
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0001255 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0.0005994 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.0008055 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.0009214 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.004675 Highly Informative Inherited
Molecular Function (MF) steroid binding 0.02981 Highly Informative Inherited
Molecular Function (MF) antigen binding 0.2514 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.301 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.6836 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.2175 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.5081 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.04071 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) protein complex 0.5876 Least Informative Inherited
Cellular Component (CC) membrane 0.01653 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.0009775 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 2.582e-08 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.006714 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.1766 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.2019 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.8374 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.9863 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.0752 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.9303 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.04106 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.01372 Informative Inherited
Cellular Component (CC) transcription factor complex 4.335e-10 Highly Informative Direct
Cellular Component (CC) actin filament 3.844e-05 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.0002055 Highly Informative Direct
Cellular Component (CC) cilium 0.0002722 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0004994 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0.0006773 Highly Informative Direct
Cellular Component (CC) spindle 0.6794 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.005849 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.9213 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.185 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0003008Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01838Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.002849Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.02963Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.04627Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Sulfite oxidase0Highly InformativeDirect
Enzyme Commission (EC)Togavirin0Highly InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Monophenol monooxygenase4.856e-15Highly InformativeDirect
Enzyme Commission (EC)Pullulanase5.029e-14Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase1.199e-10Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)4.944e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.3936Least InformativeInherited
Disease Ontology (DO)skin disease0.05115Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4525Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis8.279e-07InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.5818Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.7491Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.7162Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.8365Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the lower limbs0.08733InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1308InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2664InformativeInherited
Phenotypic Abnormality (PA)Esophageal varix0.0001987Highly InformativeDirect
Phenotypic Abnormality (PA)Portal hypertension0.0002653Highly InformativeDirect
Phenotypic Abnormality (PA)Ascites0.0005235Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the metatarsal bones0.006434Highly InformativeInherited
Phenotypic Abnormality (PA)Short long bones0.01435Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.1949Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2519Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3391Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1025Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1256Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.2041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2164Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.2167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2261Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2424Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.2656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0007835InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.03432InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.03752InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.05875InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.111InformativeInherited
Mammalian Phenotype (MP)abnormal thymus medulla morphology2.132e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.0003691Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.6841Least InformativeInherited
Fly Anatomy (FA)cell0.743Least InformativeInherited
Fly Anatomy (FA)circulatory system0.07172InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte9.383e-05Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003623Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.02577Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06103Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.007046Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0002648Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.03153Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase7.202e-16InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.02827InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.07246InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen5.636e-14Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor5.347e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.006173Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processTranscription regulation1.283e-11Moderately InformativeDirect
Biological processIon transport4.926e-07Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid transport2.365e-16InformativeDirect
Biological processViral immunoevasion9.014e-06InformativeDirect
Biological processInnate immunity0.0005034InformativeDirect
Biological processSteroid metabolism0.003435InformativeInherited
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processVision1.055e-12Highly InformativeDirect
Biological processCilium biogenesis/degradation7.75e-09Highly InformativeDirect
Biological processNotch signaling pathway4.098e-08Highly InformativeDirect
Biological processOxygen transport5.905e-08Highly InformativeDirect
Biological processVirus endocytosis by host1.635e-05Highly InformativeDirect
Biological processCholesterol metabolism0.0001006Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0001415Highly InformativeDirect
Biological processExocytosis0.00037Highly InformativeDirect
Cellular componentMembrane3.303e-14Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle7.33e-06Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentCoated pit8.356e-08Highly InformativeDirect
DiseaseProto-oncogene6.298e-14Moderately InformativeDirect
DiseaseAutoimmune uveitis3.256e-10Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.143Least InformativeInherited
DomainANK repeat1.514e-05InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.02022Moderately InformativeInherited
Molecular functionCopper0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFAD4.415e-05InformativeDirect
Molecular functionLipid-binding0.0003834InformativeDirect
Molecular functionHeme0.000519InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functionChitin-binding3.799e-14Highly InformativeDirect
Molecular functionViral nucleoprotein0.0001811Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0.06591Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationProtease9.112e-14Moderately InformativeDirect
Post-translational modificationReceptor1.098e-10Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.271e-07Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGTPase activation9.107e-10InformativeDirect
Post-translational modificationProtease inhibitor9.554e-09InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor1.629e-11Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation4.014e-12Moderately InformativeDirect
Post-translational modificationS-nitrosylation7.116e-07InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002579Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation0.9263InformativeInherited
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR014756 SSF81296 Protein matches
Abstract

The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PubMed7932691]. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin and/or fibronectin type III Ig-like protein superfamilies. Ig-like E set domains include:

  • C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [PubMed15380510].
  • Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).
  • C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.
  • C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.
  • Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [PubMed14671122].
  • Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.
  • ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.
  • Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [PubMed15513926].
  • Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.
  • N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [PubMed15290350].
  • Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [PubMed15516996].
  • Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [PubMed15102497].
  • C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis.
  • Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [PubMed12651950].
  • Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [PubMed14756796].
  • Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.
  • Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 107 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 107 hidden Markov models representing the E set domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]