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Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (556) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 79,708 0 43
Proteins 78,352 0 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6315Least InformativeInherited
Disease Ontology (DO)disease of mental health0.000001169Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0001955Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.006447Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.03275Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.04464Moderately InformativeInherited
Disease Ontology (DO)brain disease0.07114Moderately InformativeInherited
Disease Ontology (DO)asthma0.0000003944InformativeDirect
Disease Ontology (DO)overnutrition0.000005816InformativeDirect
Disease Ontology (DO)migraine0.0000229InformativeDirect
Disease Ontology (DO)arthritis0.0007326InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2291InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3289InformativeInherited
Disease Ontology (DO)anxiety disorder0.000008357Highly InformativeDirect
Disease Ontology (DO)eating disorder0.00001815Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.002818Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3647Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.8682Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.931Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.003227Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.2041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.3955Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.8065Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.8566Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.01041InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.1023InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.2579InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.8656InformativeInherited
Phenotypic Abnormality (PA)Abnormality of color vision0.002397Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.006327Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.03065Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.05625Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.06022Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4604Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9885Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.000000056Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.000009799Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.05533Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.05765Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.06874Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.08653Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1105Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2113Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2681Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3416Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5727Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7285Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7327Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.8104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.9554Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9585Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.000000005773InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00000281InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.00001056InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0.00001305InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.00006697InformativeDirect
Mammalian Phenotype (MP)increased body weight0.00006911InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.0001473InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0004InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.003247InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.01031InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.05739InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.2053InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2423InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.5202InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.5912InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.6521InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.8375InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8438InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.9447InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9798InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.000001491Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.000009722Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.00001317Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.00002044Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00002327Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0001406Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0002497Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.0002554Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0004109Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.0004411Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.0007124Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0007931Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.002924Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgE level0.003155Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.08301Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nose morphology0.1255Highly InformativeInherited
Mammalian Phenotype (MP)decreased immunoglobulin level0.2421Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.3972Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant1Moderately InformativeInherited
Worm Phenotype (WP)pharyngeal pumping variant0.5065InformativeInherited
Worm Phenotype (WP)egg laying variant0.8136InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)serotonin response variant0.03868Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping rate variant0.178Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.00000594Moderately InformativeDirect
Fly Phenotype (FP)mating defective0.000004177Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.2648Least InformativeInherited
Zebrafish Anatomy (ZA)endothelial cell0.0009858Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3708Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.08245InformativeInherited
Xenopus ANatomical entity (XAN)dermal system1InformativeInherited
Xenopus ANatomical entity (XAN)surface structure1InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000000084Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processChemotaxis0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processHemostasis0.0000000000000845InformativeDirect
Biological processBiological rhythms0.000000000004303InformativeDirect
Biological processAngiogenesis0.00000001347InformativeDirect
Biological processInflammatory response0.0000001467InformativeDirect
Biological processBlood coagulation0.00000000000007325Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell junction0.0000000009104Moderately InformativeDirect
Cellular componentSynapse0.01322InformativeInherited
Cellular componentPostsynaptic cell membrane0.00000708Highly InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionLectin0.0003382InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationPhotoreceptor protein0.0000000000003785Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationSulfation0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Family A G protein-coupled receptor-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Family A G protein-coupled receptor-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]