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Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (556) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 79,708 220,865 43
Proteins 78,352 217,479 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6315Least InformativeInherited
Disease Ontology (DO)disease of mental health0.000001169Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0001955Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.006447Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.03275Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.04464Moderately InformativeInherited
Disease Ontology (DO)brain disease0.07114Moderately InformativeInherited
Disease Ontology (DO)asthma0.0000003944InformativeDirect
Disease Ontology (DO)overnutrition0.000005816InformativeDirect
Disease Ontology (DO)migraine0.0000229InformativeDirect
Disease Ontology (DO)arthritis0.0007326InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2291InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3289InformativeInherited
Disease Ontology (DO)anxiety disorder0.000008357Highly InformativeDirect
Disease Ontology (DO)eating disorder0.00001815Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.002818Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3777Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.8737Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.9422Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.003529Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.2199Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.3943Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.8214Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.8666Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.01147InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.1074InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.2606InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.875InformativeInherited
Phenotypic Abnormality (PA)Abnormality of color vision0.002912Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.006299Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.03057Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.05636Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.06001Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4598Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9884Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.00000005518Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.000009749Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.05766Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.06862Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.08654Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1103Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.19Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2109Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3416Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7285Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7324Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.81Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.9552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9585Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.000000005768InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00000281InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.00001052InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0.00001305InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.00006652InformativeDirect
Mammalian Phenotype (MP)increased body weight0.00006906InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.0001473InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0004InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.003247InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.01029InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.05734InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.2053InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2423InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.5202InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.5911InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.6519InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.8375InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8438InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.9446InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9799InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.000001491Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.000009721Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.00001316Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.00002044Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00002324Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0001404Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0002494Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.0002545Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.00041Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.0004409Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.0007122Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0007922Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.00292Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgE level0.003155Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.08301Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nose morphology0.1255Highly InformativeInherited
Mammalian Phenotype (MP)decreased immunoglobulin level0.2422Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.3972Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant1Moderately InformativeInherited
Worm Phenotype (WP)pharyngeal pumping variant0.5059InformativeInherited
Worm Phenotype (WP)egg laying variant0.829InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)serotonin response variant0.03856Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping rate variant0.1772Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.000005389Moderately InformativeDirect
Fly Phenotype (FP)mating defective0.000003815Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3783Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system1InformativeInherited
Xenopus ANatomical entity (XAN)surface structure1InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.1096Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000001409Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Family A G protein-coupled receptor-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Family A G protein-coupled receptor-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Internal database links ]