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Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (556) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 79,708 220,865 43
Proteins 78,352 217,479 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6031Least InformativeInherited
Disease Ontology (DO)disease of mental health0.0000009864Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0001812Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.00612Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.03055Moderately InformativeInherited
Disease Ontology (DO)brain disease0.07142Moderately InformativeInherited
Disease Ontology (DO)asthma0.0000003615InformativeDirect
Disease Ontology (DO)overnutrition0.000005412InformativeDirect
Disease Ontology (DO)migraine0.00002323InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2292InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3293InformativeInherited
Disease Ontology (DO)anxiety disorder0.000008472Highly InformativeDirect
Disease Ontology (DO)eating disorder0.00001837Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.002833Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.386Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.8952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9958Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.3061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.3656Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.8096Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.8279Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.9085Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.002792InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.1432InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.2176InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.2306InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.403InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.6184InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.868InformativeInherited
Phenotypic Abnormality (PA)Abnormal spermatogenesis0.0003482Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplasia of the ovary0.0005864Highly InformativeDirect
Phenotypic Abnormality (PA)Color vision defect0.001721Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the penis0.2985Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.3826Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00637Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.03011Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.05654Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05945Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4564Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9886Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.00000005758Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.00000948Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.05569Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.05619Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.068Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.0859Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.11Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1915Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2105Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2707Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5738Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7285Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7325Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.8104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.9552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.000000005624InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00000274InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.00001033InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0.0000126InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.00006626InformativeDirect
Mammalian Phenotype (MP)increased body weight0.00006847InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.0001433InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0004011InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.003142InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.01029InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.05699InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.2047InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2423InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.5192InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.5905InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.6512InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.8408InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8453InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.9451InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.98InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.000001494Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.000009724Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.00001319Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.00002197Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00002314Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0001399Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0002492Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.000254Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0004097Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.0004399Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.0007236Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0007869Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.0007915Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.0029Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgE level0.00316Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.08301Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nose morphology0.1252Highly InformativeInherited
Mammalian Phenotype (MP)decreased immunoglobulin level0.2422Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.3974Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant1Moderately InformativeInherited
Worm Phenotype (WP)pharyngeal pumping variant0.5379InformativeInherited
Worm Phenotype (WP)egg laying variant0.8493InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)serotonin response variant0.04501Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping rate variant0.1823Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0000009686Moderately InformativeDirect
Fly Phenotype (FP)hypoactive0.000000000002444Highly InformativeDirect
Fly Phenotype (FP)mating defective0.00004678Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.5572Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.07452InformativeInherited
Xenopus ANatomical entity (XAN)dermal system1InformativeInherited
Xenopus ANatomical entity (XAN)surface structure1InformativeInherited
Xenopus ANatomical entity (XAN)neural nucleus0.000001587Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.7889Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000007794Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Family A G protein-coupled receptor-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Family A G protein-coupled receptor-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]