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Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001

	GO term	FDR (singleton)	FDR (all)	IC level	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	purine nucleotide biosynthetic process	2.568e-09	0.0004057	1.62	--	DIRECT
Biological Process (BP)	nucleoside phosphate metabolic process	1.552e-05	0.0003952	1.194	--	DIRECT
Biological Process (BP)	ATP biosynthetic process	1.399e-13	4.746e-06	2.398	--	DIRECT
Biological Process (BP)	transport	0.0008859	1.605e-07	0.7747	--	DIRECT
Biological Process (BP)	cation transport	1.391e-06	0	1.319	--	DIRECT
Biological Process (BP)	nucleoside metabolic process	3.201e-06	1.744e-05	1.444	--	DIRECT
Biological Process (BP)	nucleotide metabolic process	1.281e-05	0.0003486	1.222	--	DIRECT
Biological Process (BP)	purine nucleoside triphosphate metabolic process	4.123e-07	2.443e-06	1.921	--	DIRECT
Biological Process (BP)	purine nucleoside triphosphate biosynthetic process	2.759e-12	4.102e-06	2.222	--	DIRECT
Biological Process (BP)	purine ribonucleotide metabolic process	1.325e-06	1.751e-05	1.62	--	DIRECT
Biological Process (BP)	purine ribonucleotide biosynthetic process	9.819e-10	0.0004566	1.745	--	DIRECT
Biological Process (BP)	nucleoside biosynthetic process	6.688e-09	6.137e-08	1.62	--	DIRECT
Biological Process (BP)	ribonucleoside triphosphate metabolic process	3.206e-07	2.232e-06	2	--	DIRECT
Biological Process (BP)	ribonucleoside triphosphate biosynthetic process	1.323e-12	4.703e-06	2.222	--	DIRECT
Biological Process (BP)	purine ribonucleoside triphosphate biosynthetic process	1.323e-12	3.463e-06	2.222	--	DIRECT
Biological Process (BP)	ribonucleotide metabolic process	1.735e-06	2.886e-05	1.62	--	DIRECT
Biological Process (BP)	ribonucleotide biosynthetic process	2.778e-09	0.0008617	1.745	--	DIRECT
Biological Process (BP)	energy coupled proton transport, down electrochemical gradient	7.046e-14	0.0005483	2.398	--	DIRECT
Biological Process (BP)	ATP synthesis coupled proton transport	7.046e-14	3.878e-12	2.398	--	DIRECT
Biological Process (BP)	proton transport	6.932e-12	0	2.222	--	DIRECT
Biological Process (BP)	purine nucleoside biosynthetic process	1.851e-09	4.442e-05	1.658	--	DIRECT
Biological Process (BP)	ribonucleoside biosynthetic process	4.477e-09	0.0003749	1.62	--	DIRECT
Biological Process (BP)	ATP metabolic process	5.652e-11	3.537e-08	2.398	--	DIRECT
Biological Process (BP)	purine ribonucleoside metabolic process	1.547e-06	8.459e-06	1.553	--	DIRECT
Biological Process (BP)	purine ribonucleoside biosynthetic process	1.774e-09	0.0001351	1.658	--	DIRECT
Biological Process (BP)	ribose phosphate biosynthetic process	2.995e-09	1.784e-05	1.699	--	DIRECT
Biological Process (BP)	establishment of localization	0.0009575	2.579e-07	0.7696	--	DIRECT
Biological Process (BP)	purine-containing compound metabolic process	3.91e-06	5.807e-05	1.357	--	DIRECT
Biological Process (BP)	organophosphate biosynthetic process	3.417e-06	0.0004761	1.155	--	DIRECT
Biological Process (BP)	carbohydrate derivative biosynthetic process	4.837e-06	0.0008458	1.222	--	DIRECT
Biological Process (BP)	nucleoside phosphate biosynthetic process	8.348e-08	0.0001062	1.444	--	DIRECT
Biological Process (BP)	glycosyl compound metabolic process	5.682e-06	4.079e-05	1.377	--	DIRECT
Biological Process (BP)	organic substance biosynthetic process	0.006624	0.5642	0.5376	--	INHERITED FROM: carbohydrate derivative biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || purine ribonucleotide biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || organophosphate biosynthetic process || purine nucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process
Biological Process (BP)	single-organism process	0.03716	0.005736	0.3316	--	INHERITED FROM: transmembrane transport || monovalent inorganic cation transport || hydrogen transport || ATP synthesis coupled proton transport || proton transport || cation transport || energy coupled proton transport, down electrochemical gradient
Biological Process (BP)	organonitrogen compound metabolic process	0.002715	0.07945	0.699	--	INHERITED FROM: purine ribonucleoside metabolic process || purine nucleoside metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleoside biosynthetic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || purine ribonucleotide metabolic process || purine nucleotide biosynthetic process || purine-containing compound metabolic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process
Biological Process (BP)	primary metabolic process	0.1458	1	0.2976	--	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	small molecule metabolic process	0.01051	0.2688	0.6421	--	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	cellular nitrogen compound metabolic process	0.006154	0.512	0.585	--	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine-containing compound metabolic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	nucleobase-containing compound metabolic process	0.001469	0.3093	0.7305	--	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	single-organism transport	0.001791	3.957e-06	0.8013	--	INHERITED FROM: monovalent inorganic cation transport || ATP synthesis coupled proton transport || proton transport || cation transport || transmembrane transport || hydrogen transport || energy coupled proton transport, down electrochemical gradient
Biological Process (BP)	biological_process	1	1	0	--	INHERITED FROM: ribonucleotide metabolic process || ribonucleoside biosynthetic process || transmembrane transport || glycosyl compound metabolic process || purine ribonucleoside metabolic process || purine-containing compound biosynthetic process || purine nucleoside biosynthetic process || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process || nucleoside triphosphate metabolic process || monovalent inorganic cation transport || transport || purine ribonucleoside triphosphate biosynthetic process || hydrogen transport || ATP synthesis coupled proton transport || purine nucleoside triphosphate biosynthetic process || purine nucleotide metabolic process || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || ribose phosphate metabolic process || nucleoside triphosphate biosynthetic process || ATP biosynthetic process || ribonucleotide biosynthetic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || carbohydrate derivative biosynthetic process || nucleobase-containing small molecule metabolic process || purine nucleotide biosynthetic process || nucleoside metabolic process || nucleoside phosphate biosynthetic process || glycosyl compound biosynthetic process || nucleoside biosynthetic process || organophosphate biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || establishment of localization || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || proton transport || purine ribonucleoside biosynthetic process || cation transport || energy coupled proton transport, down electrochemical gradient || ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	cellular process	0.3209	0.7454	0.1415	--	INHERITED FROM: ribonucleotide metabolic process || ribose phosphate metabolic process || nucleoside triphosphate biosynthetic process || ATP biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || transmembrane transport || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine ribonucleoside metabolic process || purine-containing compound biosynthetic process || nucleobase-containing small molecule metabolic process || purine nucleotide biosynthetic process || purine nucleoside biosynthetic process || nucleoside metabolic process || nucleoside phosphate biosynthetic process || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process || nucleoside triphosphate metabolic process || nucleoside biosynthetic process || organophosphate biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || purine ribonucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || purine ribonucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || energy coupled proton transport, down electrochemical gradient || purine nucleotide metabolic process || ribonucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process
Biological Process (BP)	metabolic process	0.2995	1	0.2411	--	INHERITED FROM: ribonucleotide metabolic process || ribose phosphate metabolic process || nucleoside triphosphate metabolic process || nucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || organophosphate biosynthetic process || ATP biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || glycosyl compound metabolic process || carbohydrate derivative biosynthetic process || purine ribonucleoside metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	organic substance metabolic process	0.2169	1	0.2676	--	INHERITED FROM: ribonucleotide metabolic process || ribose phosphate metabolic process || nucleoside triphosphate metabolic process || nucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || organophosphate biosynthetic process || ATP biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || glycosyl compound metabolic process || carbohydrate derivative biosynthetic process || purine ribonucleoside metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	cellular metabolic process	0.1991	1	0.2708	--	INHERITED FROM: ribonucleotide metabolic process || ribose phosphate metabolic process || nucleoside triphosphate metabolic process || nucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || organophosphate biosynthetic process || ATP biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine ribonucleoside metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	cellular biosynthetic process	0.0058	0.5229	0.5498	--	INHERITED FROM: ribonucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process
Biological Process (BP)	phosphorus metabolic process	0.001132	0.1253	0.8013	--	INHERITED FROM: ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || ribose phosphate metabolic process || ribose phosphate biosynthetic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || organophosphate biosynthetic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ATP biosynthetic process || nucleoside triphosphate metabolic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	nucleobase-containing compound biosynthetic process	2.708e-06	0.00367	1.167	--	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process
Biological Process (BP)	biosynthetic process	0.008739	0.6207	0.52	Least Informative	INHERITED FROM: carbohydrate derivative biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || purine ribonucleotide biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || organophosphate biosynthetic process || purine nucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process
Biological Process (BP)	single-organism cellular process	0.03529	0.1946	0.3915	Least Informative	INHERITED FROM: transmembrane transport || ATP synthesis coupled proton transport || energy coupled proton transport, down electrochemical gradient
Biological Process (BP)	cellular aromatic compound metabolic process	0.005125	0.4814	0.6271	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine-containing compound metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	nitrogen compound metabolic process	0.01539	0.7164	0.5171	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine-containing compound metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	organic cyclic compound metabolic process	0.007851	0.575	0.5817	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine-containing compound metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	single-organism metabolic process	0.03032	0.6121	0.5376	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || glycosyl compound metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	heterocycle metabolic process	0.004812	0.4493	0.6308	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine-containing compound metabolic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	localization	0.001725	1.007e-05	0.6946	Least Informative	INHERITED FROM: monovalent inorganic cation transport || ATP synthesis coupled proton transport || transport || establishment of localization || proton transport || cation transport || transmembrane transport || hydrogen transport || energy coupled proton transport, down electrochemical gradient
Biological Process (BP)	nucleobase-containing small molecule metabolic process	3.96e-05	0.0009024	1.086	Moderately Informative	DIRECT
Biological Process (BP)	ion transport	0.005285	8.133e-07	1.194	Moderately Informative	INHERITED FROM: monovalent inorganic cation transport || cation transport || energy coupled proton transport, down electrochemical gradient || proton transport || ATP synthesis coupled proton transport
Biological Process (BP)	organophosphate metabolic process	0.0001051	0.004135	0.9914	Moderately Informative	INHERITED FROM: ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || ribose phosphate metabolic process || ribose phosphate biosynthetic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || organophosphate biosynthetic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ATP biosynthetic process || nucleoside triphosphate metabolic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	phosphate-containing compound metabolic process	0.0009728	0.1101	0.8182	Moderately Informative	INHERITED FROM: ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || ribose phosphate metabolic process || ribose phosphate biosynthetic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ATP biosynthetic process || nucleoside triphosphate metabolic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	carbohydrate derivative metabolic process	0.0001337	0.005426	1.018	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || carbohydrate derivative biosynthetic process || purine ribonucleoside metabolic process || purine ribonucleoside biosynthetic process || purine nucleoside metabolic process || purine ribonucleotide metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribose phosphate metabolic process || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || nucleoside metabolic process || ribonucleoside biosynthetic process || ATP biosynthetic process
Biological Process (BP)	organonitrogen compound biosynthetic process	0.000128	0.00875	0.8861	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process
Biological Process (BP)	heterocycle biosynthetic process	5.768e-05	0.01678	0.9355	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	aromatic compound biosynthetic process	3.184e-05	0.01736	0.9747	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	cellular nitrogen compound biosynthetic process	6.843e-05	0.02019	0.9136	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	organic cyclic compound biosynthetic process	0.0001047	0.0344	0.8928	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	purine nucleotide metabolic process	1.905e-06	2.772e-05	1.553	Informative	DIRECT
Biological Process (BP)	ribonucleoside metabolic process	2.547e-06	1.391e-05	1.495	Informative	DIRECT
Biological Process (BP)	nucleoside triphosphate metabolic process	5.926e-07	3.147e-06	1.745	Informative	DIRECT
Biological Process (BP)	ribose phosphate metabolic process	1.802e-06	3.034e-05	1.585	Informative	DIRECT
Biological Process (BP)	purine nucleoside metabolic process	1.655e-06	8.888e-06	1.553	Informative	DIRECT
Biological Process (BP)	transmembrane transport	3.106e-06	4.194e-09	1.585	Informative	DIRECT
Biological Process (BP)	purine-containing compound biosynthetic process	1.222e-08	1.085e-06	1.523	Informative	DIRECT
Biological Process (BP)	glycosyl compound biosynthetic process	2.591e-08	4.971e-07	1.585	Informative	DIRECT
Biological Process (BP)	nucleotide biosynthetic process	7.757e-08	0.004986	1.444	Informative	INHERITED FROM: ribonucleotide biosynthetic process || ATP biosynthetic process || purine ribonucleotide biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process
Biological Process (BP)	hydrogen transport	1.825e-09	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	nucleoside triphosphate biosynthetic process	9.08e-12	5.403e-07	2.097	Highly Informative	DIRECT
Biological Process (BP)	purine ribonucleoside triphosphate metabolic process	3.206e-07	2.143e-06	2	Highly Informative	DIRECT
Biological Process (BP)	monovalent inorganic cation transport	4.791e-09	3.129e-05	1.796	Highly Informative	DIRECT
Biological Process (BP)	ion transmembrane transport	1.403e-08	0.003586	1.921	Highly Informative	INHERITED FROM: energy coupled proton transport, down electrochemical gradient || ATP synthesis coupled proton transport
Molecular Function (MF)	cation transmembrane transporter activity	1.729e-07	1.176e-10	1.423	--	DIRECT
Molecular Function (MF)	ion transmembrane transporter activity	1.352e-06	5.399e-09	1.336	--	DIRECT
Molecular Function (MF)	primary active transmembrane transporter activity	3.428e-08	6.754e-12	1.775	--	DIRECT
Molecular Function (MF)	P-P-bond-hydrolysis-driven transmembrane transporter activity	3.359e-08	6.511e-12	1.775	--	DIRECT
Molecular Function (MF)	pyrophosphatase activity	1.882e-05	5.428e-06	1.298	--	DIRECT
Molecular Function (MF)	hydrolase activity, acting on acid anhydrides	2.007e-05	5.634e-06	1.281	--	DIRECT
Molecular Function (MF)	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.967e-05	5.565e-06	1.281	--	DIRECT
Molecular Function (MF)	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.505e-08	1.776e-08	1.775	--	DIRECT
Molecular Function (MF)	ATPase activity	1.056e-07	3.619e-08	1.599	--	DIRECT
Molecular Function (MF)	cation-transporting ATPase activity	4.708e-12	6.994e-08	2.377	--	DIRECT
Molecular Function (MF)	substrate-specific transmembrane transporter activity	5.625e-06	3.107e-08	1.281	--	DIRECT
Molecular Function (MF)	ATPase activity, coupled	5.615e-08	5.58e-09	1.637	--	DIRECT
Molecular Function (MF)	ATPase activity, coupled to transmembrane movement of substances	2.505e-08	4.877e-12	1.775	--	DIRECT
Molecular Function (MF)	ATPase activity, coupled to movement of substances	2.505e-08	7.724e-12	1.775	--	DIRECT
Molecular Function (MF)	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	1.445e-13	0	2.679	--	DIRECT
Molecular Function (MF)	proton-transporting ATP synthase activity, rotational mechanism	8.758e-15	0.0005207	2.679	--	DIRECT
Molecular Function (MF)	substrate-specific transporter activity	1.318e-05	0.7126	1.134	--	INHERITED FROM: proton-transporting ATP synthase activity, rotational mechanism || substrate-specific transmembrane transporter activity || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism || ion transmembrane transporter activity || ATPase activity, coupled to transmembrane movement of ions || cation transmembrane transporter activity || inorganic cation transmembrane transporter activity || cation-transporting ATPase activity || hydrogen ion transmembrane transporter activity
Molecular Function (MF)	transmembrane transporter activity	1.553e-05	0.7534	1.231	--	INHERITED FROM: proton-transporting ATP synthase activity, rotational mechanism || substrate-specific transmembrane transporter activity || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism || ion transmembrane transporter activity || hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances || ATPase activity, coupled to transmembrane movement of ions || cation transmembrane transporter activity || active transmembrane transporter activity || inorganic cation transmembrane transporter activity || ATPase activity, coupled to transmembrane movement of substances || cation-transporting ATPase activity || primary active transmembrane transporter activity || P-P-bond-hydrolysis-driven transmembrane transporter activity || hydrogen ion transmembrane transporter activity
Molecular Function (MF)	catalytic activity	0.2136	0.9856	0.2686	--	INHERITED FROM: ATPase activity, coupled || hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || nucleoside-triphosphatase activity || cation-transporting ATPase activity || proton-transporting ATP synthase activity, rotational mechanism || ATPase activity || pyrophosphatase activity || ATPase activity, coupled to transmembrane movement of substances || ATPase activity, coupled to transmembrane movement of ions || hydrolase activity, acting on acid anhydrides || ATPase activity, coupled to movement of substances || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
Molecular Function (MF)	molecular_function	0.9827	1	0	--	INHERITED FROM: ATPase activity, coupled || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || P-P-bond-hydrolysis-driven transmembrane transporter activity || cation-transporting ATPase activity || ATPase activity || pyrophosphatase activity || primary active transmembrane transporter activity || ATPase activity, coupled to transmembrane movement of ions || cation transmembrane transporter activity || active transmembrane transporter activity || ATPase activity, coupled to movement of substances || ion transmembrane transporter activity || hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances || hydrogen ion transmembrane transporter activity || substrate-specific transmembrane transporter activity || nucleoside-triphosphatase activity || proton-transporting ATP synthase activity, rotational mechanism || ATPase activity, coupled to transmembrane movement of substances || hydrolase activity, acting on acid anhydrides || transporter activity || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism || inorganic cation transmembrane transporter activity
Molecular Function (MF)	monovalent inorganic cation transmembrane transporter activity	6.013e-09	0.002066	1.637	--	INHERITED FROM: hydrogen ion transmembrane transporter activity || proton-transporting ATP synthase activity, rotational mechanism
Molecular Function (MF)	hydrolase activity	0.005376	0.02841	0.6657	Least Informative	INHERITED FROM: proton-transporting ATP synthase activity, rotational mechanism || ATPase activity || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || pyrophosphatase activity || ATPase activity, coupled to transmembrane movement of substances || ATPase activity, coupled || ATPase activity, coupled to movement of substances || nucleoside-triphosphatase activity || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism || hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances || ATPase activity, coupled to transmembrane movement of ions || cation-transporting ATPase activity || hydrolase activity, acting on acid anhydrides
Molecular Function (MF)	transporter activity	4.926e-05	1.151e-09	1.087	Moderately Informative	DIRECT
Molecular Function (MF)	nucleoside-triphosphatase activity	9.191e-06	3.008e-06	1.502	Informative	DIRECT
Molecular Function (MF)	active transmembrane transporter activity	3.791e-07	0.0002533	1.532	Informative	DIRECT
Molecular Function (MF)	inorganic cation transmembrane transporter activity	4.168e-08	8.538e-12	1.502	Informative	DIRECT
Molecular Function (MF)	hydrogen ion transmembrane transporter activity	3.57e-10	0	1.98	Highly Informative	DIRECT
Molecular Function (MF)	ATPase activity, coupled to transmembrane movement of ions	5.228e-11	3.759e-09	2.076	Highly Informative	DIRECT
Cellular Component (CC)	intracellular	8.307e-05	4.188e-13	0.1266	--	DIRECT
Cellular Component (CC)	cell	0.000465	9.458e-06	0.08068	--	DIRECT
Cellular Component (CC)	macromolecular complex	0.0001191	7.04e-13	0.4276	--	DIRECT
Cellular Component (CC)	proton-transporting two-sector ATPase complex, proton-transporting domain	1.243e-14	0	2.542	--	DIRECT
Cellular Component (CC)	intracellular part	7.874e-05	3.212e-13	0.1266	--	DIRECT
Cellular Component (CC)	membrane part	8.242e-06	0	0.6842	--	DIRECT
Cellular Component (CC)	cell part	0.0004619	9.331e-06	0.08068	--	DIRECT
Cellular Component (CC)	proton-transporting ATP synthase complex	1.864e-10	0	1.763	--	DIRECT
Cellular Component (CC)	proton-transporting ATP synthase complex, coupling factor F(o)	0	1.207e-14	2.542	--	DIRECT
Cellular Component (CC)	cellular_component	0.08689	9.298e-06	0	--	INHERITED FROM: cell || proton-transporting ATP synthase complex || macromolecular complex || protein complex || cell part || proton-transporting ATP synthase complex, coupling factor F(o) || membrane part || proton-transporting two-sector ATPase complex || intracellular part || intracellular || proton-transporting two-sector ATPase complex, proton-transporting domain
Cellular Component (CC)	protein complex	1.125e-05	0	0.5639	Least Informative	DIRECT
Cellular Component (CC)	membrane	0.001991	4.667e-15	0.5731	Least Informative	INHERITED FROM: proton-transporting ATP synthase complex, coupling factor F(o) || membrane part || proton-transporting two-sector ATPase complex || proton-transporting ATP synthase complex || proton-transporting two-sector ATPase complex, proton-transporting domain
Cellular Component (CC)	proton-transporting two-sector ATPase complex	6.295e-15	0	1.638	Informative	DIRECT

Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001

	GO term	FDR (all)	IC level	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	purine nucleotide biosynthetic process	0.0004057	1.62	--	DIRECT
Biological Process (BP)	nucleoside phosphate metabolic process	0.0003952	1.194	--	DIRECT
Biological Process (BP)	ATP biosynthetic process	4.746e-06	2.398	--	DIRECT
Biological Process (BP)	transport	1.605e-07	0.7747	--	DIRECT
Biological Process (BP)	cation transport	0	1.319	--	DIRECT
Biological Process (BP)	cellular ion homeostasis	2.51e-12	1.377	--	DIRECT
Biological Process (BP)	regulation of pH	0	2.222	--	DIRECT
Biological Process (BP)	vacuole organization	1.584e-10	1.854	--	DIRECT
Biological Process (BP)	nucleoside metabolic process	1.744e-05	1.444	--	DIRECT
Biological Process (BP)	nucleotide metabolic process	0.0003486	1.222	--	DIRECT
Biological Process (BP)	purine nucleoside triphosphate metabolic process	2.443e-06	1.921	--	DIRECT
Biological Process (BP)	purine nucleoside triphosphate biosynthetic process	4.102e-06	2.222	--	DIRECT
Biological Process (BP)	purine ribonucleotide metabolic process	1.751e-05	1.62	--	DIRECT
Biological Process (BP)	purine ribonucleotide biosynthetic process	0.0004566	1.745	--	DIRECT
Biological Process (BP)	nucleoside biosynthetic process	6.137e-08	1.62	--	DIRECT
Biological Process (BP)	ribonucleoside triphosphate metabolic process	2.232e-06	2	--	DIRECT
Biological Process (BP)	ribonucleoside triphosphate biosynthetic process	4.703e-06	2.222	--	DIRECT
Biological Process (BP)	purine ribonucleoside triphosphate biosynthetic process	3.463e-06	2.222	--	DIRECT
Biological Process (BP)	ribonucleotide metabolic process	2.886e-05	1.62	--	DIRECT
Biological Process (BP)	ribonucleotide biosynthetic process	0.0008617	1.745	--	DIRECT
Biological Process (BP)	energy coupled proton transport, down electrochemical gradient	0.0005483	2.398	--	DIRECT
Biological Process (BP)	ATP synthesis coupled proton transport	3.878e-12	2.398	--	DIRECT
Biological Process (BP)	proton transport	0	2.222	--	DIRECT
Biological Process (BP)	cellular homeostasis	5.169e-11	1.284	--	DIRECT
Biological Process (BP)	cellular monovalent inorganic cation homeostasis	7.349e-10	2.222	--	DIRECT
Biological Process (BP)	regulation of cellular pH	0	2.222	--	DIRECT
Biological Process (BP)	regulation of lysosomal lumen pH	3.355e-05	2.398	--	DIRECT
Biological Process (BP)	purine nucleoside biosynthetic process	4.442e-05	1.658	--	DIRECT
Biological Process (BP)	ribonucleoside biosynthetic process	0.0003749	1.62	--	DIRECT
Biological Process (BP)	single-organism transport	3.957e-06	0.8013	--	DIRECT
Biological Process (BP)	ATP metabolic process	3.537e-08	2.398	--	DIRECT
Biological Process (BP)	purine ribonucleoside metabolic process	8.459e-06	1.553	--	DIRECT
Biological Process (BP)	purine ribonucleoside biosynthetic process	0.0001351	1.658	--	DIRECT
Biological Process (BP)	ribose phosphate biosynthetic process	1.784e-05	1.699	--	DIRECT
Biological Process (BP)	chemical homeostasis	3.189e-10	1.208	--	DIRECT
Biological Process (BP)	ion homeostasis	1.229e-11	1.337	--	DIRECT
Biological Process (BP)	establishment of localization	2.579e-07	0.7696	--	DIRECT
Biological Process (BP)	intracellular pH reduction	0	2.398	--	DIRECT
Biological Process (BP)	monovalent inorganic cation homeostasis	1.981e-08	2.222	--	DIRECT
Biological Process (BP)	cation homeostasis	4.21e-14	1.495	--	DIRECT
Biological Process (BP)	cellular chemical homeostasis	5.864e-12	1.357	--	DIRECT
Biological Process (BP)	regulation of biological quality	0.0001171	0.8539	--	DIRECT
Biological Process (BP)	purine-containing compound metabolic process	5.807e-05	1.357	--	DIRECT
Biological Process (BP)	organophosphate biosynthetic process	0.0004761	1.155	--	DIRECT
Biological Process (BP)	carbohydrate derivative biosynthetic process	0.0008458	1.222	--	DIRECT
Biological Process (BP)	nucleoside phosphate biosynthetic process	0.0001062	1.444	--	DIRECT
Biological Process (BP)	glycosyl compound metabolic process	4.079e-05	1.377	--	DIRECT
Biological Process (BP)	organic substance biosynthetic process	0.5642	0.5376	--	INHERITED FROM: carbohydrate derivative biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || purine ribonucleotide biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || organophosphate biosynthetic process || purine nucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process
Biological Process (BP)	biological regulation	0.7066	0.4202	--	INHERITED FROM: cellular chemical homeostasis || cellular cation homeostasis || ion homeostasis || regulation of lysosomal lumen pH || cellular homeostasis || chemical homeostasis || regulation of cellular pH || cation homeostasis || intracellular pH reduction || regulation of biological quality || cellular ion homeostasis || cellular monovalent inorganic cation homeostasis || homeostatic process || vacuolar acidification || regulation of intracellular pH || monovalent inorganic cation homeostasis || pH reduction || regulation of pH
Biological Process (BP)	single-organism process	0.005736	0.3316	--	INHERITED FROM: cellular chemical homeostasis || cellular cation homeostasis || regulation of lysosomal lumen pH || cellular homeostasis || transmembrane transport || ion transport || regulation of cellular pH || intracellular pH reduction || single-organism transport || vacuole organization || cellular ion homeostasis || cellular monovalent inorganic cation homeostasis || monovalent inorganic cation transport || hydrogen transport || ATP synthesis coupled proton transport || proton transport || cation transport || energy coupled proton transport, down electrochemical gradient || vacuolar acidification || regulation of intracellular pH
Biological Process (BP)	organonitrogen compound metabolic process	0.07945	0.699	--	INHERITED FROM: purine ribonucleoside metabolic process || purine nucleoside metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleoside biosynthetic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || purine ribonucleotide metabolic process || purine nucleotide biosynthetic process || purine-containing compound metabolic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process
Biological Process (BP)	primary metabolic process	1	0.2976	--	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	small molecule metabolic process	0.2688	0.6421	--	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	cellular nitrogen compound metabolic process	0.512	0.585	--	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine-containing compound metabolic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	nucleobase-containing compound metabolic process	0.3093	0.7305	--	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	cellular process	0.7454	0.1415	--	INHERITED FROM: ribonucleotide metabolic process || cellular chemical homeostasis || ribose phosphate metabolic process || cellular cation homeostasis || nucleoside triphosphate biosynthetic process || ATP biosynthetic process || regulation of lysosomal lumen pH || cellular homeostasis || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || transmembrane transport || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine ribonucleoside metabolic process || purine-containing compound biosynthetic process || nucleobase-containing small molecule metabolic process || regulation of cellular pH || purine nucleotide biosynthetic process || purine nucleoside biosynthetic process || nucleoside metabolic process || intracellular pH reduction || nucleoside phosphate biosynthetic process || vacuole organization || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process || nucleoside triphosphate metabolic process || nucleoside biosynthetic process || organophosphate biosynthetic process || cellular ion homeostasis || cellular monovalent inorganic cation homeostasis || purine nucleoside metabolic process || ATP metabolic process || purine ribonucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || purine ribonucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || energy coupled proton transport, down electrochemical gradient || purine nucleotide metabolic process || ribonucleoside triphosphate biosynthetic process || vacuolar acidification || nucleoside phosphate metabolic process || regulation of intracellular pH || nucleotide metabolic process || ribonucleoside triphosphate metabolic process
Biological Process (BP)	biological_process	1	0	--	INHERITED FROM: ribonucleotide metabolic process || cellular cation homeostasis || regulation of lysosomal lumen pH || ribonucleoside biosynthetic process || transmembrane transport || glycosyl compound metabolic process || purine ribonucleoside metabolic process || purine-containing compound biosynthetic process || cation homeostasis || purine nucleoside biosynthetic process || single-organism transport || vacuole organization || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process || nucleoside triphosphate metabolic process || regulation of biological quality || cellular ion homeostasis || cellular monovalent inorganic cation homeostasis || monovalent inorganic cation transport || transport || purine ribonucleoside triphosphate biosynthetic process || hydrogen transport || ATP synthesis coupled proton transport || purine nucleoside triphosphate biosynthetic process || purine nucleotide metabolic process || homeostatic process || vacuolar acidification || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || regulation of pH || cellular chemical homeostasis || ribose phosphate metabolic process || ion homeostasis || nucleoside triphosphate biosynthetic process || ATP biosynthetic process || cellular homeostasis || ribonucleotide biosynthetic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || chemical homeostasis || carbohydrate derivative biosynthetic process || ion transport || nucleobase-containing small molecule metabolic process || regulation of cellular pH || purine nucleotide biosynthetic process || nucleoside metabolic process || intracellular pH reduction || nucleoside phosphate biosynthetic process || glycosyl compound biosynthetic process || localization || nucleoside biosynthetic process || organophosphate biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || establishment of localization || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || proton transport || purine ribonucleoside biosynthetic process || cation transport || energy coupled proton transport, down electrochemical gradient || ribonucleoside triphosphate biosynthetic process || regulation of intracellular pH || monovalent inorganic cation homeostasis || pH reduction
Biological Process (BP)	metabolic process	1	0.2411	--	INHERITED FROM: ribonucleotide metabolic process || ribose phosphate metabolic process || nucleoside triphosphate metabolic process || nucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || organophosphate biosynthetic process || ATP biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || glycosyl compound metabolic process || carbohydrate derivative biosynthetic process || purine ribonucleoside metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	organic substance metabolic process	1	0.2676	--	INHERITED FROM: ribonucleotide metabolic process || ribose phosphate metabolic process || nucleoside triphosphate metabolic process || nucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || organophosphate biosynthetic process || ATP biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || glycosyl compound metabolic process || carbohydrate derivative biosynthetic process || purine ribonucleoside metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	cellular metabolic process	1	0.2708	--	INHERITED FROM: ribonucleotide metabolic process || ribose phosphate metabolic process || nucleoside triphosphate metabolic process || nucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || organophosphate biosynthetic process || ATP biosynthetic process || purine nucleoside metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine ribonucleoside metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine-containing compound metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	cellular biosynthetic process	0.5229	0.5498	--	INHERITED FROM: ribonucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process
Biological Process (BP)	phosphorus metabolic process	0.1253	0.8013	--	INHERITED FROM: ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || ribose phosphate metabolic process || ribose phosphate biosynthetic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || organophosphate biosynthetic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ATP biosynthetic process || nucleoside triphosphate metabolic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	nucleobase-containing compound biosynthetic process	0.00367	1.167	--	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside biosynthetic process || purine nucleoside triphosphate biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process
Biological Process (BP)	cellular component organization	0.03067	0.6819	--	INHERITED FROM: vacuole organization || regulation of lysosomal lumen pH
Biological Process (BP)	localization	1.007e-05	0.6946	Least Informative	DIRECT
Biological Process (BP)	biosynthetic process	0.6207	0.52	Least Informative	INHERITED FROM: carbohydrate derivative biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribose phosphate biosynthetic process || purine ribonucleotide biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || organophosphate biosynthetic process || purine nucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process
Biological Process (BP)	single-organism cellular process	0.1946	0.3915	Least Informative	INHERITED FROM: cellular chemical homeostasis || cellular cation homeostasis || cellular ion homeostasis || regulation of lysosomal lumen pH || cellular monovalent inorganic cation homeostasis || cellular homeostasis || transmembrane transport || ATP synthesis coupled proton transport || regulation of cellular pH || energy coupled proton transport, down electrochemical gradient || intracellular pH reduction || vacuolar acidification || vacuole organization || regulation of intracellular pH
Biological Process (BP)	cellular aromatic compound metabolic process	0.4814	0.6271	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine-containing compound metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	nitrogen compound metabolic process	0.7164	0.5171	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine-containing compound metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	organic cyclic compound metabolic process	0.575	0.5817	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine-containing compound metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	single-organism metabolic process	0.6121	0.5376	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine nucleotide metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || ribonucleoside triphosphate biosynthetic process || glycosyl compound biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || glycosyl compound metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	heterocycle metabolic process	0.4493	0.6308	Least Informative	INHERITED FROM: purine ribonucleoside metabolic process || ribonucleoside triphosphate biosynthetic process || purine nucleoside metabolic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine-containing compound biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || nucleoside triphosphate metabolic process || nucleobase-containing small molecule metabolic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || purine nucleotide biosynthetic process || purine-containing compound metabolic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine nucleoside biosynthetic process || nucleoside metabolic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	cellular component organization or biogenesis	0.04584	0.6536	Least Informative	INHERITED FROM: vacuole organization || regulation of lysosomal lumen pH
Biological Process (BP)	ion transport	8.133e-07	1.194	Moderately Informative	DIRECT
Biological Process (BP)	homeostatic process	2.453e-08	1.086	Moderately Informative	DIRECT
Biological Process (BP)	nucleobase-containing small molecule metabolic process	0.0009024	1.086	Moderately Informative	DIRECT
Biological Process (BP)	organophosphate metabolic process	0.004135	0.9914	Moderately Informative	INHERITED FROM: ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || ribose phosphate metabolic process || ribose phosphate biosynthetic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || organophosphate biosynthetic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ATP biosynthetic process || nucleoside triphosphate metabolic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	phosphate-containing compound metabolic process	0.1101	0.8182	Moderately Informative	INHERITED FROM: ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || ribonucleoside triphosphate metabolic process || purine ribonucleotide metabolic process || purine nucleoside triphosphate biosynthetic process || nucleoside phosphate metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || ribose phosphate metabolic process || ribose phosphate biosynthetic process || purine nucleotide metabolic process || purine ribonucleoside triphosphate metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || ribonucleotide biosynthetic process || ATP biosynthetic process || nucleoside triphosphate metabolic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process || nucleotide metabolic process || purine nucleoside triphosphate metabolic process
Biological Process (BP)	carbohydrate derivative metabolic process	0.005426	1.018	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || carbohydrate derivative biosynthetic process || purine ribonucleoside metabolic process || purine ribonucleoside biosynthetic process || purine nucleoside metabolic process || purine ribonucleotide metabolic process || ribonucleotide metabolic process || ATP synthesis coupled proton transport || ribose phosphate metabolic process || ribose phosphate biosynthetic process || ribonucleoside metabolic process || purine ribonucleotide biosynthetic process || ATP metabolic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || nucleoside metabolic process || ribonucleoside biosynthetic process || ATP biosynthetic process
Biological Process (BP)	organonitrogen compound biosynthetic process	0.00875	0.8861	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process
Biological Process (BP)	heterocycle biosynthetic process	0.01678	0.9355	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	aromatic compound biosynthetic process	0.01736	0.9747	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	cellular nitrogen compound biosynthetic process	0.02019	0.9136	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	organic cyclic compound biosynthetic process	0.0344	0.8928	Moderately Informative	INHERITED FROM: nucleoside biosynthetic process || purine ribonucleoside biosynthetic process || ribonucleoside triphosphate biosynthetic process || nucleoside triphosphate biosynthetic process || purine nucleoside triphosphate biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process || purine-containing compound biosynthetic process || purine ribonucleotide biosynthetic process || purine nucleoside biosynthetic process || ribonucleotide biosynthetic process || ribonucleoside biosynthetic process || ATP biosynthetic process || nucleoside phosphate biosynthetic process || purine ribonucleoside triphosphate biosynthetic process
Biological Process (BP)	organelle organization	0.001121	0.8996	Moderately Informative	INHERITED FROM: vacuole organization || regulation of lysosomal lumen pH
Biological Process (BP)	purine nucleotide metabolic process	2.772e-05	1.553	Informative	DIRECT
Biological Process (BP)	ribonucleoside metabolic process	1.391e-05	1.495	Informative	DIRECT
Biological Process (BP)	nucleoside triphosphate metabolic process	3.147e-06	1.745	Informative	DIRECT
Biological Process (BP)	ribose phosphate metabolic process	3.034e-05	1.585	Informative	DIRECT
Biological Process (BP)	cellular cation homeostasis	4.008e-15	1.495	Informative	DIRECT
Biological Process (BP)	purine nucleoside metabolic process	8.888e-06	1.553	Informative	DIRECT
Biological Process (BP)	transmembrane transport	4.194e-09	1.585	Informative	DIRECT
Biological Process (BP)	purine-containing compound biosynthetic process	1.085e-06	1.523	Informative	DIRECT
Biological Process (BP)	glycosyl compound biosynthetic process	4.971e-07	1.585	Informative	DIRECT
Biological Process (BP)	nucleotide biosynthetic process	0.004986	1.444	Informative	INHERITED FROM: ribonucleotide biosynthetic process || ATP biosynthetic process || purine ribonucleotide biosynthetic process || ATP synthesis coupled proton transport || purine nucleotide biosynthetic process
Biological Process (BP)	hydrogen transport	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	nucleoside triphosphate biosynthetic process	5.403e-07	2.097	Highly Informative	DIRECT
Biological Process (BP)	purine ribonucleoside triphosphate metabolic process	2.143e-06	2	Highly Informative	DIRECT
Biological Process (BP)	monovalent inorganic cation transport	3.129e-05	1.796	Highly Informative	DIRECT
Biological Process (BP)	pH reduction	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	regulation of intracellular pH	0	2.222	Highly Informative	DIRECT
Biological Process (BP)	lysosome organization	0.02663	2	Highly Informative	INHERITED FROM: regulation of lysosomal lumen pH
Biological Process (BP)	ion transmembrane transport	0.003586	1.921	Highly Informative	INHERITED FROM: energy coupled proton transport, down electrochemical gradient || ATP synthesis coupled proton transport
Molecular Function (MF)	cation transmembrane transporter activity	1.176e-10	1.423	--	DIRECT
Molecular Function (MF)	ion transmembrane transporter activity	5.399e-09	1.336	--	DIRECT
Molecular Function (MF)	primary active transmembrane transporter activity	6.754e-12	1.775	--	DIRECT
Molecular Function (MF)	P-P-bond-hydrolysis-driven transmembrane transporter activity	6.511e-12	1.775	--	DIRECT
Molecular Function (MF)	pyrophosphatase activity	5.428e-06	1.298	--	DIRECT
Molecular Function (MF)	hydrolase activity, acting on acid anhydrides	5.634e-06	1.281	--	DIRECT
Molecular Function (MF)	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	5.565e-06	1.281	--	DIRECT
Molecular Function (MF)	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.776e-08	1.775	--	DIRECT
Molecular Function (MF)	ATPase activity	3.619e-08	1.599	--	DIRECT
Molecular Function (MF)	cation-transporting ATPase activity	6.994e-08	2.377	--	DIRECT
Molecular Function (MF)	substrate-specific transmembrane transporter activity	3.107e-08	1.281	--	DIRECT
Molecular Function (MF)	ATPase activity, coupled	5.58e-09	1.637	--	DIRECT
Molecular Function (MF)	ATPase activity, coupled to transmembrane movement of substances	4.877e-12	1.775	--	DIRECT
Molecular Function (MF)	ATPase activity, coupled to movement of substances	7.724e-12	1.775	--	DIRECT
Molecular Function (MF)	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	0	2.679	--	DIRECT
Molecular Function (MF)	proton-transporting ATP synthase activity, rotational mechanism	0.0005207	2.679	--	DIRECT
Molecular Function (MF)	substrate-specific transporter activity	0.7126	1.134	--	INHERITED FROM: proton-transporting ATP synthase activity, rotational mechanism || substrate-specific transmembrane transporter activity || proton-transporting ATPase activity, rotational mechanism || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism || ion transmembrane transporter activity || ATPase activity, coupled to transmembrane movement of ions || cation transmembrane transporter activity || inorganic cation transmembrane transporter activity || cation-transporting ATPase activity || hydrogen ion transmembrane transporter activity
Molecular Function (MF)	transmembrane transporter activity	0.7534	1.231	--	INHERITED FROM: proton-transporting ATP synthase activity, rotational mechanism || substrate-specific transmembrane transporter activity || proton-transporting ATPase activity, rotational mechanism || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism || ion transmembrane transporter activity || hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances || ATPase activity, coupled to transmembrane movement of ions || cation transmembrane transporter activity || active transmembrane transporter activity || inorganic cation transmembrane transporter activity || ATPase activity, coupled to transmembrane movement of substances || cation-transporting ATPase activity || primary active transmembrane transporter activity || P-P-bond-hydrolysis-driven transmembrane transporter activity || hydrogen ion transmembrane transporter activity
Molecular Function (MF)	catalytic activity	0.9856	0.2686	--	INHERITED FROM: ATPase activity, coupled || proton-transporting ATPase activity, rotational mechanism || hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || nucleoside-triphosphatase activity || cation-transporting ATPase activity || proton-transporting ATP synthase activity, rotational mechanism || ATPase activity || pyrophosphatase activity || ATPase activity, coupled to transmembrane movement of substances || ATPase activity, coupled to transmembrane movement of ions || hydrolase activity, acting on acid anhydrides || ATPase activity, coupled to movement of substances || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
Molecular Function (MF)	molecular_function	1	0	--	INHERITED FROM: ATPase activity, coupled || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || P-P-bond-hydrolysis-driven transmembrane transporter activity || cation-transporting ATPase activity || ATPase activity || pyrophosphatase activity || primary active transmembrane transporter activity || ATPase activity, coupled to transmembrane movement of ions || cation transmembrane transporter activity || active transmembrane transporter activity || ATPase activity, coupled to movement of substances || ion transmembrane transporter activity || proton-transporting ATPase activity, rotational mechanism || hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances || hydrogen ion transmembrane transporter activity || substrate-specific transmembrane transporter activity || nucleoside-triphosphatase activity || proton-transporting ATP synthase activity, rotational mechanism || ATPase activity, coupled to transmembrane movement of substances || hydrolase activity, acting on acid anhydrides || transporter activity || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism || inorganic cation transmembrane transporter activity
Molecular Function (MF)	monovalent inorganic cation transmembrane transporter activity	0.002066	1.637	--	INHERITED FROM: hydrogen ion transmembrane transporter activity || proton-transporting ATP synthase activity, rotational mechanism || proton-transporting ATPase activity, rotational mechanism
Molecular Function (MF)	hydrolase activity	0.02841	0.6657	Least Informative	INHERITED FROM: proton-transporting ATP synthase activity, rotational mechanism || ATPase activity || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || pyrophosphatase activity || ATPase activity, coupled to transmembrane movement of substances || ATPase activity, coupled || ATPase activity, coupled to movement of substances || nucleoside-triphosphatase activity || proton-transporting ATPase activity, rotational mechanism || ATPase activity, coupled to transmembrane movement of ions, rotational mechanism || hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances || ATPase activity, coupled to transmembrane movement of ions || cation-transporting ATPase activity || hydrolase activity, acting on acid anhydrides
Molecular Function (MF)	transporter activity	1.151e-09	1.087	Moderately Informative	DIRECT
Molecular Function (MF)	nucleoside-triphosphatase activity	3.008e-06	1.502	Informative	DIRECT
Molecular Function (MF)	active transmembrane transporter activity	0.0002533	1.532	Informative	DIRECT
Molecular Function (MF)	inorganic cation transmembrane transporter activity	8.538e-12	1.502	Informative	DIRECT
Molecular Function (MF)	hydrogen ion transmembrane transporter activity	0	1.98	Highly Informative	DIRECT
Molecular Function (MF)	ATPase activity, coupled to transmembrane movement of ions	3.759e-09	2.076	Highly Informative	DIRECT
Cellular Component (CC)	cellular_component	9.298e-06	0	--	DIRECT
Cellular Component (CC)	intracellular	4.188e-13	0.1266	--	DIRECT
Cellular Component (CC)	cell	9.458e-06	0.08068	--	DIRECT
Cellular Component (CC)	cytoplasm	5.138e-05	0.2515	--	DIRECT
Cellular Component (CC)	mitochondrial envelope	1.001e-08	1.094	--	DIRECT
Cellular Component (CC)	mitochondrial inner membrane	5.088e-10	1.219	--	DIRECT
Cellular Component (CC)	vacuolar proton-transporting V-type ATPase complex	0	2.542	--	DIRECT
Cellular Component (CC)	organelle inner membrane	7.885e-07	1.199	--	DIRECT
Cellular Component (CC)	envelope	0.0004223	0.9288	--	DIRECT
Cellular Component (CC)	macromolecular complex	7.04e-13	0.4276	--	DIRECT
Cellular Component (CC)	proton-transporting V-type ATPase complex	1.615e-06	2.542	--	DIRECT
Cellular Component (CC)	proton-transporting two-sector ATPase complex, proton-transporting domain	0	2.542	--	DIRECT
Cellular Component (CC)	organelle	5.091e-10	0.1836	--	DIRECT
Cellular Component (CC)	membrane-bounded organelle	0	0.2912	--	DIRECT
Cellular Component (CC)	organelle part	3.201e-09	0.3713	--	DIRECT
Cellular Component (CC)	intracellular part	3.212e-13	0.1266	--	DIRECT
Cellular Component (CC)	membrane part	0	0.6842	--	DIRECT
Cellular Component (CC)	vacuolar part	0	1.696	--	DIRECT
Cellular Component (CC)	cell part	9.331e-06	0.08068	--	DIRECT
Cellular Component (CC)	proton-transporting ATP synthase complex	0	1.763	--	DIRECT
Cellular Component (CC)	proton-transporting ATP synthase complex, coupling factor F(o)	1.207e-14	2.542	--	DIRECT
Cellular Component (CC)	mitochondrial membrane	0.5178	1.127	--	INHERITED FROM: mitochondrial membrane part || mitochondrial inner membrane || mitochondrial proton-transporting ATP synthase complex
Cellular Component (CC)	mitochondrion	0.02071	0.7422	--	INHERITED FROM: mitochondrial membrane part || mitochondrial inner membrane || mitochondrial envelope || mitochondrial proton-transporting ATP synthase complex
Cellular Component (CC)	intracellular organelle	0.005714	0.1875	--	INHERITED FROM: mitochondrial envelope || intracellular membrane-bounded organelle || intracellular organelle part || vacuolar part || vacuole || vacuolar proton-transporting V-type ATPase complex || mitochondrial membrane part || organelle inner membrane || vacuolar proton-transporting V-type ATPase, V0 domain || mitochondrial inner membrane || vacuolar membrane || mitochondrial proton-transporting ATP synthase complex
Cellular Component (CC)	membrane	4.667e-15	0.5731	Least Informative	DIRECT
Cellular Component (CC)	intracellular membrane-bounded organelle	0	0.2961	Least Informative	DIRECT
Cellular Component (CC)	protein complex	0	0.5639	Least Informative	DIRECT
Cellular Component (CC)	cytoplasmic part	1.379e-09	0.2605	Least Informative	DIRECT
Cellular Component (CC)	intracellular organelle part	0.0001122	0.3893	Least Informative	DIRECT
Cellular Component (CC)	organelle membrane	0	0.8514	Moderately Informative	DIRECT
Cellular Component (CC)	mitochondrial part	0.001258	1.01	Moderately Informative	INHERITED FROM: mitochondrial membrane part || mitochondrial inner membrane || mitochondrial envelope || mitochondrial proton-transporting ATP synthase complex
Cellular Component (CC)	organelle envelope	0.002886	0.9618	Moderately Informative	INHERITED FROM: organelle inner membrane || mitochondrial membrane part || mitochondrial inner membrane || mitochondrial envelope || mitochondrial proton-transporting ATP synthase complex
Cellular Component (CC)	intrinsic to membrane	1	1.18	Moderately Informative	INHERITED FROM: integral to membrane
Cellular Component (CC)	vacuole	0	1.337	Informative	DIRECT
Cellular Component (CC)	integral to membrane	9.287e-07	1.286	Informative	DIRECT
Cellular Component (CC)	proton-transporting two-sector ATPase complex	0	1.638	Informative	DIRECT
Cellular Component (CC)	mitochondrial membrane part	3.145e-05	1.395	Informative	DIRECT
Cellular Component (CC)	mitochondrial proton-transporting ATP synthase complex	1.084e-07	1.843	Highly Informative	DIRECT
Cellular Component (CC)	vacuolar membrane	4.069e-10	1.843	Highly Informative	DIRECT

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.04414	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.007361	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.8388	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.0009133	--	DIRECT
Worm Phenotype (WP)	physiology variant	0	0.01015	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.002746	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.199	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.2107	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6953	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04212	--	DIRECT
Worm Phenotype (WP)	diakinesis progression during oogenesis variant	9.843e-08	2.678	--	DIRECT
Worm Phenotype (WP)	oocytes lack nucleus	1.721e-07	2.377	--	DIRECT
Worm Phenotype (WP)	oocyte physiology variant	1.17e-06	1.473	--	DIRECT
Worm Phenotype (WP)	germ cell compartment nuclei number variant	2.575e-06	1.979	--	DIRECT
Worm Phenotype (WP)	mitosis variant	3.666e-06	1.833	--	DIRECT
Worm Phenotype (WP)	gonad development variant	8.989e-06	1.636	--	DIRECT
Worm Phenotype (WP)	endocytic transport variant	9.709e-06	1.23	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	1.478e-05	1.335	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	2.587e-05	1.297	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	4.219e-05	1.316	--	DIRECT
Worm Phenotype (WP)	oogenesis variant	7.131e-05	1.186	--	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	7.325e-05	1.23	--	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	0.0001323	1.134	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.000147	1.215	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0.0001503	1.186	--	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0.0002041	1.134	--	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.0006385	1.098	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.002977	0.7745	--	INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || cell organization biogenesis variant || oocyte morphology variant || oocytes lack nucleus || germ cell morphology variant || germ cell compartment anucleate || cell membrane organization biogenesis variant || germ cell compartment nuclei number variant || nuclear appearance variant
Worm Phenotype (WP)	cell development variant	0.006652	0.7533	--	INHERITED FROM: meiotic chromosome organization variant || diakinesis progression during oogenesis variant || chromosome condensation variant || germ cell development variant || oocytes lack nucleus || oogenesis variant || meiotic progression during oogenesis variant || meiosis variant || meiotic progression prophase variant || germ cell differentiation variant
Worm Phenotype (WP)	morphology variant	0.9993	0.06908	--	INHERITED FROM: germ cell compartment expansion variant || cell organization biogenesis variant || oocyte morphology variant || germ cell compartment nuclei number variant || nuclear appearance variant || germ cell compartment morphology variant || oocytes lack nucleus || germ cell morphology variant || germ cell compartment anucleate || cell membrane organization biogenesis variant
Worm Phenotype (WP)	organism metabolism processing variant	0	0.5877	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.001063	0.6733	Least Informative	INHERITED FROM: programmed cell death variant || receptor mediated endocytosis defective || chromosome condensation variant || mitosis variant || oocyte physiology variant || endocytic transport defect || endocytic transport variant
Worm Phenotype (WP)	pattern of transgene expression variant	0	0.97	Moderately Informative	DIRECT
Worm Phenotype (WP)	endocytic transport defect	9.186e-06	1.23	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0.0003339	1.121	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.0003563	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0.001082	0.9874	Moderately Informative	INHERITED FROM: meiotic progression during oogenesis variant || meiotic chromosome organization variant || diakinesis progression during oogenesis variant || chromosome condensation variant || germ cell development variant || meiosis variant || meiotic progression prophase variant || oocytes lack nucleus || oogenesis variant || germ cell differentiation variant
Worm Phenotype (WP)	organ system development variant	0.002231	0.8852	Moderately Informative	INHERITED FROM: oocyte septum formation variant || gonad development variant || reproductive system development variant || somatic gonad development variant
Worm Phenotype (WP)	cell death variant	0.01583	1.172	Moderately Informative	INHERITED FROM: programmed cell death variant
Worm Phenotype (WP)	receptor mediated endocytosis defective	1.005e-06	1.502	Informative	DIRECT
Worm Phenotype (WP)	somatic gonad development variant	4.277e-06	1.636	Informative	DIRECT
Worm Phenotype (WP)	meiotic chromosome organization variant	1.419e-05	1.531	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	1.781e-05	1.399	Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.007906	1.399	Informative	INHERITED FROM: chromosome condensation variant || mitosis variant
Worm Phenotype (WP)	germ cell compartment anucleate	1.874e-07	1.979	Highly Informative	DIRECT
Worm Phenotype (WP)	oocyte septum formation variant	5.642e-07	1.979	Highly Informative	DIRECT
Worm Phenotype (WP)	chromosome condensation variant	1.79e-06	1.833	Highly Informative	DIRECT
Worm Phenotype (WP)	cell membrane organization biogenesis variant	6.26e-06	1.775	Highly Informative	DIRECT
Worm Phenotype (WP)	nuclear appearance variant	1.249e-05	1.775	Highly Informative	DIRECT

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular morphology	0	1.209	--	DIRECT
Yeast Phenotype (YP)	cellular processes	0	0.214	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.3122	--	DIRECT
Yeast Phenotype (YP)	oxidative stress resistance	0	2.439	--	DIRECT
Yeast Phenotype (YP)	metal resistance	0	2.439	--	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.7672	--	DIRECT
Yeast Phenotype (YP)	respiratory metabolism	0	1.837	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1361	--	DIRECT
Yeast Phenotype (YP)	utilization of iron source	0	2.439	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1276	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.5942	Least Informative	DIRECT
Yeast Phenotype (YP)	morphology	0	1.078	Moderately Informative	DIRECT
Yeast Phenotype (YP)	nutrient utilization	0	1.138	Moderately Informative	DIRECT
Yeast Phenotype (YP)	chemical compound accumulation	0	1.74	Informative	DIRECT
Yeast Phenotype (YP)	utilization of carbon source	0	1.398	Informative	DIRECT
Yeast Phenotype (YP)	vegetative growth	0	1.36	Informative	DIRECT
Yeast Phenotype (YP)	subcellular morphology	0	1.398	Informative	DIRECT
Yeast Phenotype (YP)	dessication resistance	0	1.74	Informative	DIRECT
Yeast Phenotype (YP)	protein/peptide modification	0	1.962	Highly Informative	DIRECT
Yeast Phenotype (YP)	alkaline pH resistance	0	2.138	Highly Informative	DIRECT
Yeast Phenotype (YP)	respiratory growth	0	1.837	Highly Informative	DIRECT

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	brain	0	0.6917	--	DIRECT
Xenopus ANatomical entity (XAN)	head region	0	0.3355	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.1399	--	DIRECT
Xenopus ANatomical entity (XAN)	cardiovascular system	0	1.276	--	DIRECT
Xenopus ANatomical entity (XAN)	respiratory system	0	1.312	--	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.2252	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.264	--	DIRECT
Xenopus ANatomical entity (XAN)	female genitalia	0	0.7989	--	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.5037	--	DIRECT
Xenopus ANatomical entity (XAN)	dermal system	0	1.312	--	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.426	--	DIRECT
Xenopus ANatomical entity (XAN)	eye	0	1.051	--	DIRECT
Xenopus ANatomical entity (XAN)	connective tissue	0	1.829	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.01024	--	DIRECT
Xenopus ANatomical entity (XAN)	female organism	0	0.7931	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.4921	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.7149	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.01593	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.1399	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.04453	--	DIRECT
Xenopus ANatomical entity (XAN)	germ line cell	0	0.7055	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.4068	--	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.06222	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.02266	--	DIRECT
Xenopus ANatomical entity (XAN)	visual system	0	1.021	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal tissue	0	1.829	--	DIRECT
Xenopus ANatomical entity (XAN)	skeleton	0	1.829	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	1	0	--	INHERITED FROM: trunk region || connective tissue || respiratory system || primary germ layer || brain || germ line cell || endomesoderm || skeletal system || limb || testis || immune system || genital system || heart || skeletal tissue || anatomical group || viscus || visual system || ovary || dermal system || cavitated compound organ || cell || compound organ || anatomical region || bone tissue || male genitalia || male organism || head || female organism || head region || cardiovascular system || trunk || anatomical cluster || female genitalia || gamete || skeleton || musculoskeletal system || surface structure || lung || alimentary system || ectoderm || spleen || nervous system || organism subdivision || skin || eye || portion of tissue || central nervous system || gonad || urogenital system || sensory system
Xenopus ANatomical entity (XAN)	anatomical system	1	0.1237	--	INHERITED FROM: respiratory system || cardiovascular system || female genitalia || brain || gamete || skeleton || germ line cell || musculoskeletal system || skeletal system || testis || immune system || genital system || heart || lung || alimentary system || visual system || spleen || ovary || nervous system || dermal system || skin || male genitalia || bone tissue || eye || central nervous system || urogenital system || sensory system
Xenopus ANatomical entity (XAN)	whole organism	1	0	--	INHERITED FROM: trunk region || connective tissue || respiratory system || primary germ layer || brain || germ line cell || endomesoderm || skeletal system || limb || testis || immune system || genital system || heart || skeletal tissue || anatomical group || viscus || visual system || ovary || dermal system || cavitated compound organ || cell || compound organ || anatomical region || bone tissue || male genitalia || male organism || head || female organism || head region || cardiovascular system || trunk || anatomical cluster || female genitalia || gamete || skeleton || musculoskeletal system || surface structure || lung || alimentary system || ectoderm || spleen || nervous system || organism subdivision || skin || eye || portion of tissue || central nervous system || gonad || urogenital system || sensory system
Xenopus ANatomical entity (XAN)	embryo	0	0.6783	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.7394	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.5008	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.4334	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cell	0	0.6486	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.3355	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.4644	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	portion of tissue	0	0.4725	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.3817	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9258	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0	1.227	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	ovary	0	1.002	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	surface structure	0	1.155	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	endomesoderm	0	1.212	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	gamete	0	0.7989	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	immune system	0	1.118	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	sensory system	0	0.9927	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	skin	0	1.373	Informative	DIRECT
Xenopus ANatomical entity (XAN)	heart	0	1.419	Informative	DIRECT
Xenopus ANatomical entity (XAN)	lung	0	1.332	Informative	DIRECT
Xenopus ANatomical entity (XAN)	spleen	0	1.443	Informative	DIRECT
Xenopus ANatomical entity (XAN)	limb	0	1.633	Informative	DIRECT
Xenopus ANatomical entity (XAN)	skeletal system	0	1.674	Informative	DIRECT
Xenopus ANatomical entity (XAN)	bone tissue	0	1.829	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	unfertilized egg	0	0.1645	--	DIRECT

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.2738	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.2226	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.07669	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.1026	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3284	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6345	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.6447	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.6447	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.08516	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.02574	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: pollen tube cell || phyllome || shoot system || microsporangium || plant cell || multi-tissue plant structure || microgametophyte || sporophyll || sporangium || whole plant || pollen sac || collective plant structure || microsporophyll || pollen || plant organ
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.05844	--	INHERITED FROM: phyllome || shoot system || sporophyll || pollen sac || microsporophyll || pollen
Plant ANatomical entity (PAN)	plant cell	0	0.5989	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.3796	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.6311	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.6447	Least Informative	DIRECT
Plant ANatomical entity (PAN)	pollen tube cell	0	1.423	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	3 flower organ development stage	0	0.09024	--	DIRECT
Plant structure DEvelopment stage (PDE)	androecium development stage	0	1.132	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.04663	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.06738	--	INHERITED FROM: L mature pollen stage || M germinated pollen stage || androecium development stage || pollen development stage || 3 flower organ development stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.06738	--	INHERITED FROM: L mature pollen stage || M germinated pollen stage || androecium development stage || pollen development stage || 3 flower organ development stage
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	1	0.06738	--	INHERITED FROM: L mature pollen stage || M germinated pollen stage || androecium development stage || pollen development stage || 3 flower organ development stage
Plant structure DEvelopment stage (PDE)	pollen development stage	0	1.132	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	L mature pollen stage	0	1.524	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	M germinated pollen stage	0	1.469	Informative	DIRECT