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Transmembrane di-heme cytochromes superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Heme-binding four-helical bundle [ 81344] (3)
Superfamily:   Transmembrane di-heme cytochromes [ 81342] (2)
Families:   Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [ 81642] (2)
  Formate dehydrogenase N, cytochrome (gamma) subunit [ 75645]


Superfamily statistics
Genomes (1,903) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,449 167,695 8
Proteins 6,447 167,592 8


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.18840.001554Least InformativeInherited
Biological Process (BP)single-organism cellular process0.85651Least InformativeInherited
Biological Process (BP)oxidation-reduction process0.00001260.00000000000002741Moderately InformativeDirect
Biological Process (BP)generation of precursor metabolites and energy0.000044530.000000000005926Moderately InformativeDirect
Biological Process (BP)cellular respiration0.000062390.0000000000001678InformativeDirect
Molecular Function (MF)binding0.94231Least InformativeInherited
Molecular Function (MF)electron carrier activity0.000000000000060440InformativeDirect
Molecular Function (MF)tetrapyrrole binding0.00017770.0000001554InformativeDirect
Molecular Function (MF)heme binding0.0000099510.00000003551Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.05145 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.1047 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.04721 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.04757 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.001554 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1871 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0.00000000000002741 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000000000005926 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0.00006269 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.0001211 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0003384 Moderately Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.001912 Moderately Informative Inherited
Biological Process (BP) cellular respiration 0.0000000000001678 Informative Direct
Biological Process (BP) electron transport chain 0.00000000002893 Informative Direct
Biological Process (BP) ATP metabolic process 0.000001913 Informative Direct
Biological Process (BP) phosphorylation 0.006841 Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.000000009129 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.000002031 Moderately Informative Direct
Molecular Function (MF) electron carrier activity 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0000001554 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.000000000000134 Informative Direct
Molecular Function (MF) heme binding 0.00000003551 Highly Informative Direct
Cellular Component (CC) membrane 0.0007216 Least Informative Direct
Cellular Component (CC) protein complex 0.1798 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3118 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5532 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1385 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.00000007271 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.000003014 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000006049 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0002839 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0005607 Moderately Informative Direct
Cellular Component (CC) oxidoreductase complex 0.000000000000001578 Informative Direct
Cellular Component (CC) cytochrome complex 0.0000000000009312 Informative Direct
Cellular Component (CC) respiratory chain complex 0.000000001063 Informative Direct
Cellular Component (CC) transporter complex 0.0000006887 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0001409 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain 0.0002364 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain complex III 0.00000000009921 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processRespiratory chain0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Coding sequence diversityRNA editing0.00000002544Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transmembrane di-heme cytochromes domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transmembrane di-heme cytochromes superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]