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Transmembrane di-heme cytochromes superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Heme-binding four-helical bundle [ 81344] (3)
Superfamily:   Transmembrane di-heme cytochromes [ 81342] (2)
Families:   Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [ 81642] (2)
  Formate dehydrogenase N, cytochrome (gamma) subunit [ 75645]


Superfamily statistics
Genomes (1,906) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,454 219,794 8
Proteins 6,452 219,647 8


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.20810.001778Least InformativeInherited
Biological Process (BP)single-organism cellular process0.810.9926Least InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.000053160.000000000007196Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.000015020.00000000000002937Moderately InformativeDirect
Biological Process (BP)cellular respiration0.000066110.0000000000001387InformativeDirect
Molecular Function (MF)binding0.98851Least InformativeInherited
Molecular Function (MF)electron carrier activity0.000000000000046690InformativeDirect
Molecular Function (MF)tetrapyrrole binding0.00013430.00000009658InformativeDirect
Molecular Function (MF)heme binding0.000010850.00000003219Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.9435 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.04706 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.07398 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9926 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.04522 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.04148 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.001778 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.000000000007196 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0003744 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00000000000002937 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.0001026 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.008996 Moderately Informative Inherited
Biological Process (BP) electron transport chain 0.00000000002448 Informative Direct
Biological Process (BP) cellular respiration 0.0000000000001387 Informative Direct
Biological Process (BP) ATP metabolic process 0.000001985 Informative Direct
Biological Process (BP) phosphorylation 0.006554 Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.000001958 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.000000009183 Moderately Informative Direct
Molecular Function (MF) electron carrier activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000000000001976 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00000009658 Informative Direct
Molecular Function (MF) heme binding 0.00000003219 Highly Informative Direct
Cellular Component (CC) membrane 0.000405 Least Informative Direct
Cellular Component (CC) protein complex 0.1839 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4653 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2661 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1505 Least Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.00000008138 Moderately Informative Direct
Cellular Component (CC) organelle inner membrane 0.000000007187 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0000001119 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0007187 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0.000001163 Moderately Informative Direct
Cellular Component (CC) mitochondrial respiratory chain 0.0003402 Informative Direct
Cellular Component (CC) cytochrome complex 0.0000000000006614 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0001473 Informative Direct
Cellular Component (CC) respiratory chain complex 0.000000001112 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.000000000000003036 Informative Direct
Cellular Component (CC) transporter complex 0.000001012 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain complex III 0.0000009789 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processRespiratory chain0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Coding sequence diversityRNA editing0.00000002355Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transmembrane di-heme cytochromes domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transmembrane di-heme cytochromes superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]