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Transmembrane di-heme cytochromes superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Heme-binding four-helical bundle [ 81344] (3)
Superfamily:   Transmembrane di-heme cytochromes [ 81342] (2)
Families:   Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [ 81642] (2)
  Formate dehydrogenase N, cytochrome (gamma) subunit [ 75645]


Superfamily statistics
Genomes (1,905) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,453 167,695 8
Proteins 6,451 167,592 8


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.22350.002338Least InformativeInherited
Biological Process (BP)single-organism cellular process0.81940.9975Least InformativeInherited
Biological Process (BP)oxidation-reduction process0.000016290.0000000000000446Moderately InformativeDirect
Biological Process (BP)generation of precursor metabolites and energy0.000056530.00000000001013Moderately InformativeDirect
Biological Process (BP)cellular respiration0.000072120.0000000000002086InformativeDirect
Molecular Function (MF)binding0.97081Least InformativeInherited
Molecular Function (MF)electron carrier activity0.000000000000054180InformativeDirect
Molecular Function (MF)tetrapyrrole binding0.00014210.0000001163InformativeDirect
Molecular Function (MF)heme binding0.000012130.00000004095Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 0.07547 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.002338 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.04655 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.04257 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.961 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9975 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.05499 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0.0000000000000446 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.00000000001013 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.0001201 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0004367 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.009772 Moderately Informative Inherited
Biological Process (BP) cellular respiration 0.0000000000002086 Informative Direct
Biological Process (BP) electron transport chain 0.00000000003334 Informative Direct
Biological Process (BP) ATP metabolic process 0.000002478 Informative Direct
Biological Process (BP) phosphorylation 0.007234 Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.00000001305 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.00000208 Moderately Informative Direct
Molecular Function (MF) electron carrier activity 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0000001163 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000000000001829 Informative Direct
Molecular Function (MF) heme binding 0.00000004095 Highly Informative Direct
Cellular Component (CC) membrane 0.0004683 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.00242 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1676 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2841 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4817 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0000001308 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.000004604 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000008965 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0006815 Moderately Informative Direct
Cellular Component (CC) oxidoreductase complex 0.000000000000003141 Informative Direct
Cellular Component (CC) cytochrome complex 0.0000000000007487 Informative Direct
Cellular Component (CC) respiratory chain complex 0.000000001216 Informative Direct
Cellular Component (CC) transporter complex 0.0000009695 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0001274 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain 0.0002322 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain complex III 0.0000009448 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processRespiratory chain0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Coding sequence diversityRNA editing0.00000002434Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transmembrane di-heme cytochromes domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transmembrane di-heme cytochromes superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]