SUPERFAMILY 1.75 HMM library and genome assignments server

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F-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   F-box domain [ 81385]
Superfamily:   F-box domain [ 81383]
Families:   F-box domain [ 81381] (4)

Superfamily statistics
Genomes (532) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 52,703 0 6
Proteins 51,670 0 6

Functional annotation
General category General
Detailed category Protein interaction

Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.8684Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell cycle0.02748Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9723Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant1Moderately InformativeInherited
Worm Phenotype (WP)protein protein interaction variant1Moderately InformativeInherited
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001686Highly InformativeDirect
Worm Phenotype (WP)sex determination variant0.01437Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.3366Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3612Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.05114Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1644Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00009001Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0007077Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.01251Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.00008245Moderately InformativeDirect
Enzyme Commission (EC)DNA helicase0.0000002036InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processCell cycle0.00002805Moderately InformativeDirect
Biological processBiological rhythms0.000000000000003827InformativeDirect
Biological processNeurogenesis0.00000000004032InformativeDirect
Biological processMitosis0.0000000001971InformativeDirect
Biological processWnt signaling pathway0.00001143InformativeDirect
Biological processSporulation0.0007074InformativeDirect
Biological processFlowering0.00000113Highly InformativeDirect
Biological processAuxin signaling pathway0.000002418Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCell junction0.000000005803Moderately InformativeDirect
Cellular componentSynapse0.00003288InformativeDirect
Coding sequence diversityAlternative splicing0.0000007361Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainWD repeat0InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Post-translational modificationReceptor1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0.0003032InformativeDirect
Post-translational modificationPhotoreceptor protein0.000006671Highly InformativeDirect
Post-translational modificationUbl conjugation0.0005597Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a F-box domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the F-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]