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F-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   F-box domain [ 81385]
Superfamily:   F-box domain [ 81383]
Families:   F-box domain [ 81381] (4)


Superfamily statistics
Genomes (530) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 52,586 103,863 6
Proteins 51,553 102,221 6


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)macromolecular complex0.074540.00000003347Least InformativeInherited
Cellular Component (CC)transferase complex0.000064990Moderately InformativeDirect
Cellular Component (CC)ubiquitin ligase complex0.0000002930InformativeDirect
Cellular Component (CC)SCF ubiquitin ligase complex0.0000000005230Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.00003762 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.001282 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4496 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1145 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) regulation of cell cycle 0.000001488 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00002504 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0001661 Informative Direct
Biological Process (BP) regulation of catabolic process 0.1431 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) ion homeostasis 0.9856 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3425 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02038 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.9462 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.9534 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.3276 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1311 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8263 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.8941 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.895 Informative Inherited
Biological Process (BP) cell cycle process 0.003404 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.9712 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.001915 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) regulation of system process 0.3624 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1473 Informative Inherited
Biological Process (BP) response to radiation 0.5231 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.3935 Informative Inherited
Biological Process (BP) post-translational protein modification 0 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.000000000001585 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000000001946 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.000000008437 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.00000001212 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000003515 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0000009696 Highly Informative Direct
Biological Process (BP) photoperiodism 0.00001278 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0000951 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0001071 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0003812 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.6697 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.2284 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.004147 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.1038 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.768 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.01343 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.01479 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.01619 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.1154 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.007175 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.01809 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) trans-synaptic signaling 0.001958 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.174 Least Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.9247 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.4626 Informative Inherited
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0007152 Highly Informative Direct
Cellular Component (CC) macromolecular complex 0.00000003347 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) synapse 0.1626 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.4744 Informative Inherited
Cellular Component (CC) SCF ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.1247 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0.09036Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1068Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nose0.2066Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.7816Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.2386InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.251InformativeInherited
Phenotypic Abnormality (PA)Prominent nasal bridge0.0004973Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hallux0.0005131Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.8687Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell cycle0.02737Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9702Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant1Moderately InformativeInherited
Worm Phenotype (WP)protein protein interaction variant1Moderately InformativeInherited
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001499Highly InformativeDirect
Worm Phenotype (WP)sex determination variant0.01492Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.06735Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.3976Least InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.05254Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1677Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00004604Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0004022Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.01241Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.00008192Moderately InformativeDirect
Enzyme Commission (EC)DNA helicase0.0000002053InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processCell cycle0.00001459Moderately InformativeDirect
Biological processBiological rhythms0.000000000000003804InformativeDirect
Biological processNeurogenesis0.00000000002793InformativeDirect
Biological processMitosis0.0000000001156InformativeDirect
Biological processWnt signaling pathway0.00001047InformativeDirect
Biological processSporulation0.0006569InformativeDirect
Biological processFlowering0.0000009895Highly InformativeDirect
Biological processAuxin signaling pathway0.000002286Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCell junction0.000000002907Moderately InformativeDirect
Cellular componentSynapse0.00002859InformativeDirect
Coding sequence diversityAlternative splicing0.000001205Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainWD repeat0InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Post-translational modificationReceptor1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0.0002962InformativeDirect
Post-translational modificationPhotoreceptor protein0.000006518Highly InformativeDirect
Post-translational modificationUbl conjugation0.00005238Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a F-box domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the F-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]