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F-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   F-box domain [ 81385]
Superfamily:   F-box domain [ 81383]
Families:   F-box domain [ 81381] (4)


Superfamily statistics
Genomes (530) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 52,586 103,863 6
Proteins 51,553 102,221 6


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)transferase complex0.00014230Moderately InformativeDirect
Cellular Component (CC)ubiquitin ligase complex0.00000064920InformativeDirect
Cellular Component (CC)SCF ubiquitin ligase complex0.0000000011690Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.00005179 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.001782 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4931 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1164 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.6316 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) regulation of cell cycle 0.000001015 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00002897 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0002686 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.1783 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.9271 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.9456 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.059 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1263 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.9546 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.9697 Informative Inherited
Biological Process (BP) cell cycle process 0.002304 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.2554 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.2945 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.001503 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.9738 Informative Inherited
Biological Process (BP) response to radiation 0.6367 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) regulation of system process 0.7072 Informative Inherited
Biological Process (BP) regulation of growth 0.4183 Informative Inherited
Biological Process (BP) post-translational protein modification 0 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.000000000001075 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000000002979 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.000000003898 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.000000008643 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000004008 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.000008601 Highly Informative Direct
Biological Process (BP) photoperiodism 0.00001577 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00004383 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0001322 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0006132 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.004275 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.03391 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.005401 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.1049 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.7815 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.01981 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.9588 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.1119 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.7172 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.004101 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.01098 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02265 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.2252 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.4205 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.1835 Least Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.937 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.4658 Informative Inherited
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0009393 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.5231 Informative Inherited
Cellular Component (CC) SCF ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.136 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processCell cycle0.00001496Moderately InformativeDirect
Biological processBiological rhythms0.00000000000000357InformativeDirect
Biological processNeurogenesis0.00000000002843InformativeDirect
Biological processMitosis0.0000000001687InformativeDirect
Biological processWnt signaling pathway0.00001042InformativeDirect
Biological processSporulation0.0006979InformativeDirect
Biological processFlowering0.000000976Highly InformativeDirect
Biological processAuxin signaling pathway0.000002385Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCell junction0.000000002958Moderately InformativeDirect
Cellular componentSynapse0.00002757InformativeDirect
Coding sequence diversityAlternative splicing0.0000009108Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainWD repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Post-translational modificationReceptor1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0.0002921InformativeDirect
Post-translational modificationPhotoreceptor protein0.000006531Highly InformativeDirect
Post-translational modificationUbl conjugation0.00005265Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a F-box domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the F-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]