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Calcium ATPase, transduction domain A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   Calcium ATPase, transduction domain A [ 81653]
Families:   Calcium ATPase, transduction domain A [ 81652]


Superfamily statistics
Genomes (3,054) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 26,042 115,282 2
Proteins 25,880 114,570 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.00000003593 Least Informative Direct
Biological Process (BP) biological regulation 0.000000000000001925 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.002766 Least Informative Inherited
Biological Process (BP) response to stimulus 0.06096 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.102 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000005674 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9551 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.4208 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1767 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7799 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.08067 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2183 Moderately Informative Inherited
Biological Process (BP) system process 0.0000000004542 Informative Direct
Biological Process (BP) embryo development 0.0006246 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) metal ion transport 0.0004343 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000007696 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000000000000003734 Informative Direct
Biological Process (BP) transmembrane transport 0.000002402 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) response to metal ion 0.003176 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.02231 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4569 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) generation of neurons 0.554 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.002505 Informative Inherited
Biological Process (BP) circulatory system development 0.2147 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.6318 Informative Inherited
Biological Process (BP) locomotion 0.4433 Informative Inherited
Biological Process (BP) central nervous system development 0.07234 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4531 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) behavior 0.01358 Informative Inherited
Biological Process (BP) cation homeostasis 0.002196 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.01009 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.2462 Informative Inherited
Biological Process (BP) response to osmotic stress 0.00004831 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000007119 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) second-messenger-mediated signaling 0.00007102 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0003501 Highly Informative Direct
Biological Process (BP) response to copper ion 0.000004995 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.0001116 Highly Informative Direct
Biological Process (BP) heart contraction 0.000399 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000004679 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) detoxification 0.000008382 Highly Informative Direct
Biological Process (BP) neuron development 0.09119 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001972 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.02035 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.3053 Highly Informative Inherited
Biological Process (BP) sodium ion transport 0.2073 Highly Informative Inherited
Biological Process (BP) heart development 0.06379 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.8683 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.31 Highly Informative Inherited
Biological Process (BP) proton transport 0.06803 Highly Informative Inherited
Biological Process (BP) nervous system process 0.4093 Highly Informative Inherited
Biological Process (BP) muscle system process 0.01912 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.19 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1603 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1272 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.00391 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000007879 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000000000004164 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02886 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.06966 Moderately Informative Inherited
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) active ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000001137 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000000001156 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.00000000001064 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.0000009183 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0007882 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.00001937 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0176 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.006069 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0003218 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000001301 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.01275 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.000000008035 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001524 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0000001647 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.6729 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.005124 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.2661 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) vacuolar part 0.0000000009752 Informative Direct
Cellular Component (CC) transporter complex 0.0000005173 Informative Direct
Cellular Component (CC) membrane region 0.5381 Informative Inherited
Cellular Component (CC) neuron projection 0.1511 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.002392 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.02947 Informative Inherited
Cellular Component (CC) plasma membrane region 0.4501 Informative Inherited
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.000000000007456 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0002797 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) sarcomere 0.000003853 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001415 Highly Informative Direct
Cellular Component (CC) symplast 0.0005784 Highly Informative Direct
Cellular Component (CC) dendrite 0.2177 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.2052 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0.0000000004395InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processSodium transport0.0000000003524Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell membrane0.00000000007339Moderately InformativeDirect
Cellular componentEndosome0.0000001534Moderately InformativeDirect
Cellular componentVacuole0.0007737InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000106Least InformativeDirect
DiseaseDisease mutation0.00002784Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionZinc transport0.00000001142Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00003299InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transduction domain A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transduction domain A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]