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Calcium ATPase, transduction domain A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   Calcium ATPase, transduction domain A [ 81653]
Families:   Calcium ATPase, transduction domain A [ 81652]


Superfamily statistics
Genomes (3,045) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,691 90,075 2
Proteins 25,533 89,686 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000007061 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.907 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5405 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01255 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.312 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000003346 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00002193 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00004228 Moderately Informative Direct
Biological Process (BP) system process 0.0003304 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.9173 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1922 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.001393 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.4016 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.3964 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3465 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.005277 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.8157 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5357 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7631 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8505 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5166 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2582 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1374 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000000003676 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0000000004853 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00000000122 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000000154 Informative Direct
Biological Process (BP) metal ion transport 0.000000002241 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00000005453 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000003034 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0000005743 Informative Direct
Biological Process (BP) cellular membrane organization 0.0000007768 Informative Direct
Biological Process (BP) response to inorganic substance 0.000001488 Informative Direct
Biological Process (BP) blood circulation 0.00001161 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00001377 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0001073 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001414 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002869 Informative Direct
Biological Process (BP) cation homeostasis 0.0004693 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0005432 Informative Direct
Biological Process (BP) muscle system process 0.06742 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.2481 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.3892 Informative Inherited
Biological Process (BP) response to lipid 0.5542 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.7808 Informative Inherited
Biological Process (BP) generation of neurons 0.4413 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.003876 Informative Inherited
Biological Process (BP) sensory organ development 0.004413 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7747 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.07793 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9152 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9907 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) gland development 0.001712 Informative Inherited
Biological Process (BP) central nervous system development 0.003821 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2306 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.516 Informative Inherited
Biological Process (BP) biological adhesion 0.381 Informative Inherited
Biological Process (BP) response to light stimulus 0.1074 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.01361 Informative Inherited
Biological Process (BP) response to wounding 0.4344 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3699 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1423 Informative Inherited
Biological Process (BP) synaptic transmission 0.2767 Informative Inherited
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.0000000000001005 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0.0000000000001736 Highly Informative Direct
Biological Process (BP) lactation 0.000000000002091 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.00000000004164 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000000003017 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0000001066 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0000002632 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0001014 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0002558 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0003382 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0003503 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0003812 Highly Informative Direct
Biological Process (BP) ear development 0.0005411 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0005745 Highly Informative Direct
Biological Process (BP) hydrogen transport 0.0008345 Highly Informative Direct
Biological Process (BP) adult behavior 0.0009885 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.03442 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.2428 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.2043 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01101 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.06778 Highly Informative Inherited
Biological Process (BP) sensory perception 0.008651 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.007845 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9675 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) learning or memory 0.8315 Highly Informative Inherited
Biological Process (BP) coagulation 0.001675 Highly Informative Inherited
Biological Process (BP) wound healing 0.02457 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2883 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.1702 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.2035 Highly Informative Inherited
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.8118 Highly Informative Inherited
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.8877 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.009965 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.3565 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.9048 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.1665 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00000005596 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1366 Moderately Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000000000752 Informative Direct
Molecular Function (MF) nucleotide binding 0.000000000000008977 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0000000002536 Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00001611 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.00002916 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.00007056 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.00008557 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.01191 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.2064 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.01092 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.2337 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00001802 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.5811 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000001283 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.00005862 Moderately Informative Direct
Cellular Component (CC) vesicle 0.02135 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) vacuolar part 0.0000001772 Informative Direct
Cellular Component (CC) contractile fiber part 0.001171 Informative Inherited
Cellular Component (CC) integral to membrane 0.003876 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.8266 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.00000000000001045 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.00000000004137 Highly Informative Direct
Cellular Component (CC) sarcomere 0.000007751 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0007556 Highly Informative Direct
Cellular Component (CC) cell body 0.008718 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.01517Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0003764InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007914Least InformativeDirect
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant0.000000002482Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.0000000186Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0001175Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.002441Least InformativeInherited
Plant ANatomical entity (PAN)flower0.03196Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.04703Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06103Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.0000005963InformativeDirect
Plant ANatomical entity (PAN)parenchyma cell0.000000003406Highly InformativeDirect
Plant ANatomical entity (PAN)anther0.0005621Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0002813Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0.00000000001115InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.00000000005253Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell membrane0.0000000003752Moderately InformativeDirect
Cellular componentEndosome0.00004492Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001092Least InformativeDirect
DiseaseDisease mutation0.000008845Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00001429InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transduction domain A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transduction domain A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]