SUPERFAMILY 1.75 HMM library and genome assignments server


Calcium ATPase, transduction domain A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   Calcium ATPase, transduction domain A [ 81653]
Families:   Calcium ATPase, transduction domain A [ 81652]


Superfamily statistics
Genomes (2,341) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 21,212 44,555 2
Proteins 21,077 44,253 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0003842 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9886 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8548 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7935 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9931 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5579 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02481 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.422 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 9.984e-13 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 4.156e-07 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 1.054e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.348e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 5.706e-05 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.807 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5418 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1846 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5675 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2032 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01049 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.7852 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.7927 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5135 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.261 Moderately Informative Inherited
Biological Process (BP) system process 0.02046 Moderately Informative Inherited
Biological Process (BP) reproduction 0.07091 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8013 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular cation homeostasis 1.472e-12 Informative Direct
Biological Process (BP) purine nucleotide metabolic process 1.8e-12 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 2.513e-12 Informative Direct
Biological Process (BP) ribonucleoside metabolic process 6.693e-09 Informative Direct
Biological Process (BP) response to inorganic substance 8.702e-08 Informative Direct
Biological Process (BP) organophosphate catabolic process 1.518e-07 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 1.077e-06 Informative Direct
Biological Process (BP) lipid transport 2.915e-06 Informative Direct
Biological Process (BP) regulation of ion transport 3.775e-06 Informative Direct
Biological Process (BP) cellular membrane organization 4.997e-06 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 5.67e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001024 Informative Direct
Biological Process (BP) metal ion transport 0.0001297 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0002256 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000478 Informative Direct
Biological Process (BP) positive regulation of transport 0.0005694 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0006222 Informative Direct
Biological Process (BP) generation of neurons 0.5393 Informative Inherited
Biological Process (BP) cell projection organization 0.986 Informative Inherited
Biological Process (BP) sensory organ development 0.03383 Informative Inherited
Biological Process (BP) embryonic organ development 0.05315 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7615 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2111 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.02267 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9669 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7349 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.8055 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.2191 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.9732 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) gland development 0.005002 Informative Inherited
Biological Process (BP) central nervous system development 0.01957 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5391 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) biological adhesion 0.4316 Informative Inherited
Biological Process (BP) response to other organism 0.1089 Informative Inherited
Biological Process (BP) response to light stimulus 0.1735 Informative Inherited
Biological Process (BP) response to wounding 0.3819 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3667 Informative Inherited
Biological Process (BP) purine nucleoside metabolic process 0.1752 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3659 Informative Inherited
Biological Process (BP) synaptic transmission 0.2201 Informative Inherited
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 3.156e-14 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 3.669e-11 Highly Informative Direct
Biological Process (BP) lactation 7.994e-11 Highly Informative Direct
Biological Process (BP) locomotory behavior 9.535e-11 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.051e-10 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 7.407e-08 Highly Informative Direct
Biological Process (BP) epidermis development 3.426e-07 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1.086e-05 Highly Informative Direct
Biological Process (BP) response to toxic substance 1.737e-05 Highly Informative Direct
Biological Process (BP) hydrogen transport 0.0001752 Highly Informative Direct
Biological Process (BP) adult behavior 0.0004321 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0006766 Highly Informative Direct
Biological Process (BP) inner ear development 0.0007257 Highly Informative Direct
Biological Process (BP) coagulation 0.0008574 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0008935 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.03966 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.3893 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 1 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001387 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.05395 Highly Informative Inherited
Biological Process (BP) sensory perception 0.2028 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.02242 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.8821 Highly Informative Inherited
Biological Process (BP) learning or memory 0.7272 Highly Informative Inherited
Biological Process (BP) wound healing 0.01721 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2458 Highly Informative Inherited
Biological Process (BP) nucleotide catabolic process 0.01795 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.1281 Highly Informative Inherited
Biological Process (BP) nucleoside triphosphate catabolic process 0.1524 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1936 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.005089 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.8109 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.9901 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.2462 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 1.096e-07 Moderately Informative Direct
Molecular Function (MF) anion binding 0.08633 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.02963 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.03893 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 1.462e-11 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1.444e-09 Informative Direct
Molecular Function (MF) transition metal ion binding 1 Informative Inherited
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 2.711e-05 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 4.921e-05 Highly Informative Direct
Molecular Function (MF) calcium ion binding 9.819e-05 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.1126 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.001031 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.2733 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 6.824e-08 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.8158 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.61e-11 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1.813e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 3.762e-05 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) vacuole 0.0001196 Informative Direct
Cellular Component (CC) endosome 0.0006412 Informative Direct
Cellular Component (CC) neuron part 0.5377 Informative Inherited
Cellular Component (CC) contractile fiber part 0.001634 Informative Inherited
Cellular Component (CC) integral to membrane 0.004019 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.7502 Informative Inherited
Cellular Component (CC) trans-Golgi network 0 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 3.574e-12 Highly Informative Direct
Cellular Component (CC) sarcomere 2.397e-05 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001019 Highly Informative Direct
Cellular Component (CC) cell body 0.004268 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase1.039e-13Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase6.865e-12Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase4.443e-10Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase7.143e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.01975Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0001686InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007914Least InformativeDirect
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant2.482e-09Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive1.86e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)cranium0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell1.053e-06Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.05167Least InformativeInherited
Plant ANatomical entity (PAN)androecium0.1872Least InformativeInherited
Plant ANatomical entity (PAN)guard cell6.941e-08Moderately InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue3.025e-06InformativeDirect
Plant ANatomical entity (PAN)parenchyma cell5.916e-09Highly InformativeDirect
Plant ANatomical entity (PAN)anther0.0007771Highly InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0003297Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport4.672e-11Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus1.397e-12Moderately InformativeDirect
Cellular componentCell membrane6.008e-07Moderately InformativeDirect
Cellular componentEndosome0.000814Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing5.652e-05Least InformativeDirect
DiseaseDisease mutation6.007e-05Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionCalcium transport0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration1.489e-06Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transduction domain A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transduction domain A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]