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Calcium ATPase, transduction domain A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   Calcium ATPase, transduction domain A [ 81653]
Families:   Calcium ATPase, transduction domain A [ 81652]


Superfamily statistics
Genomes (3,052) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 25,907 115,282 2
Proteins 25,748 114,570 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000005603 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.02392 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2368 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00003131 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.9591 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.0346 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.9303 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7084 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3857 Moderately Informative Inherited
Biological Process (BP) ion homeostasis 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000000000109 Informative Direct
Biological Process (BP) transmembrane transport 0.0000003109 Informative Direct
Biological Process (BP) system process 0.0000006033 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000008329 Informative Direct
Biological Process (BP) sensory organ development 0.0003516 Informative Direct
Biological Process (BP) metal ion transport 0.0004157 Informative Direct
Biological Process (BP) response to metal ion 0.0007268 Informative Direct
Biological Process (BP) embryo development 0.0008809 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) generation of neurons 0.6278 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) tissue development 0.3372 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.0119 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.9341 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.9827 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3575 Informative Inherited
Biological Process (BP) locomotion 0.4098 Informative Inherited
Biological Process (BP) central nervous system development 0.0776 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3349 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) behavior 0.007215 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01269 Informative Inherited
Biological Process (BP) circulatory system development 0.2154 Informative Inherited
Biological Process (BP) post-embryonic development 0.2182 Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) inner ear development 0.000000001612 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.00000006666 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000003513 Highly Informative Direct
Biological Process (BP) response to copper ion 0.000005195 Highly Informative Direct
Biological Process (BP) detoxification 0.000006689 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00001056 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.0001485 Highly Informative Direct
Biological Process (BP) heart contraction 0.0002635 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0002644 Highly Informative Direct
Biological Process (BP) neuron development 0.1471 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.8928 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001749 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.01982 Highly Informative Inherited
Biological Process (BP) sodium ion transport 0.2006 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2578 Highly Informative Inherited
Biological Process (BP) brain development 0.008639 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.263 Highly Informative Inherited
Biological Process (BP) proton transport 0.088 Highly Informative Inherited
Biological Process (BP) neurological system process 0.8814 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.3838 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.003637 Highly Informative Inherited
Biological Process (BP) muscle system process 0.003317 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1199 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.01187 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1337 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.9462 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000000085 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000003264 Moderately Informative Direct
Molecular Function (MF) anion binding 0.03378 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.09449 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000000001997 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.000000000003633 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000000003279 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.0000000000004701 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.000001314 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.00001711 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0007686 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.01115 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.01617 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000005074 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0004574 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.00988 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0000001706 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001331 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.6608 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.001185 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) vacuolar part 0.000000001168 Informative Direct
Cellular Component (CC) transporter complex 0.0000002652 Informative Direct
Cellular Component (CC) membrane region 0.654 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.001709 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.01787 Informative Inherited
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.000000000007465 Highly Informative Direct
Cellular Component (CC) myofibril 0.000004664 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001104 Highly Informative Direct
Cellular Component (CC) sperm part 0.0002247 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0003524 Highly Informative Direct
Cellular Component (CC) symplast 0.0005007 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.2396 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.08728Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.000285InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00003611Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.007049Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.009248Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.004821Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.06045Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.006732InformativeInherited
Worm Phenotype (WP)plasma membrane composition variant0.0000000000004982Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.000000001286Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.00000001817Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)integumentary system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0001185Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.002465Least InformativeInherited
Plant ANatomical entity (PAN)flower0.03209Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.04731Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06133Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.0000005989InformativeDirect
Plant ANatomical entity (PAN)parenchyma cell0.000000003417Highly InformativeDirect
Plant ANatomical entity (PAN)anther0.0005633Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0002825Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0.0000000001243InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.0000000002453Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell membrane0.00000000004517Moderately InformativeDirect
Cellular componentEndosome0.0000001236Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001284Least InformativeDirect
DiseaseDisease mutation0.00002659Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionZinc transport0.00000001083Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00002817InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transduction domain A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transduction domain A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]