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Calcium ATPase, transduction domain A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   Calcium ATPase, transduction domain A [ 81653]
Families:   Calcium ATPase, transduction domain A [ 81652]


Superfamily statistics
Genomes (3,047) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,760 90,075 2
Proteins 25,602 89,686 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002686 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.01125 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3525 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000008 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.01806 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9681 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.9252 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.9075 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.177 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) ion homeostasis 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000000000000007239 Informative Direct
Biological Process (BP) transmembrane transport 0.000000002091 Informative Direct
Biological Process (BP) response to inorganic substance 0.0000006506 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000006883 Informative Direct
Biological Process (BP) system process 0.000008781 Informative Direct
Biological Process (BP) embryo development 0.0004287 Informative Direct
Biological Process (BP) metal ion transport 0.0007756 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) circulatory system development 0.1798 Informative Inherited
Biological Process (BP) generation of neurons 0.5179 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.006257 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3251 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01193 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.9684 Informative Inherited
Biological Process (BP) actin filament-based process 0.9734 Informative Inherited
Biological Process (BP) locomotion 0.3376 Informative Inherited
Biological Process (BP) central nervous system development 0.05708 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2744 Informative Inherited
Biological Process (BP) cell adhesion 0.1225 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) behavior 0.007072 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.2294 Informative Inherited
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) inner ear development 0.00000000137 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.00000001933 Highly Informative Direct
Biological Process (BP) detoxification 0.0000001719 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000007353 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000002148 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00000861 Highly Informative Direct
Biological Process (BP) response to copper ion 0.00001433 Highly Informative Direct
Biological Process (BP) hydrogen transport 0.00002662 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0001663 Highly Informative Direct
Biological Process (BP) heart contraction 0.0002118 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0003659 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.0007724 Highly Informative Direct
Biological Process (BP) muscle system process 0.0008542 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.3687 Highly Informative Inherited
Biological Process (BP) neuron development 0.1037 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9688 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2272 Highly Informative Inherited
Biological Process (BP) brain development 0.005947 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1494 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1058 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.01405 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1495 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.955 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000000000005931 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000000005007 Moderately Informative Direct
Molecular Function (MF) anion binding 0.03932 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.09652 Moderately Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine nucleoside binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) ribonucleoside binding 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000000008575 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000006914 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000000007242 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.0000000000003852 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.000002008 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.000009734 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000714 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.01604 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000000002976 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001132 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.01161 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.00000002023 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000001266 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0003521 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0006468 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.7889 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) organelle subcompartment 0.0000000002975 Informative Direct
Cellular Component (CC) vacuolar part 0.00000000361 Informative Direct
Cellular Component (CC) transporter complex 0.00000008928 Informative Direct
Cellular Component (CC) membrane region 0.6104 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00317 Informative Inherited
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.000000000003818 Highly Informative Direct
Cellular Component (CC) myofibril 0.000003083 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001153 Highly Informative Direct
Cellular Component (CC) sperm part 0.0001218 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0002805 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.08579Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0003034InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00002228Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.004993Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.006516Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.004645Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.06755Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.007485InformativeInherited
Worm Phenotype (WP)plasma membrane composition variant0.0000000000006324Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.000000001108Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.00000001786Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)integumentary system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0001185Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.002465Least InformativeInherited
Plant ANatomical entity (PAN)flower0.03209Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.04731Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06133Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.0000005989InformativeDirect
Plant ANatomical entity (PAN)parenchyma cell0.000000003417Highly InformativeDirect
Plant ANatomical entity (PAN)anther0.0005633Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0002825Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0.00000000006069InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.00000000009072Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell membrane0.00000000008104Moderately InformativeDirect
Cellular componentEndosome0.00000008135Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001247Least InformativeDirect
DiseaseDisease mutation0.00001914Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00002626InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transduction domain A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transduction domain A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]