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Metal cation-transporting ATPase, ATP-binding domain N superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
Superfamily:   Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
Families:   Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)


Superfamily statistics
Genomes (2,197) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 14,927 54,227 4
Proteins 14,900 54,108 4


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000007162 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0002297 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.03742 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04568 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000006842 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5326 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.832 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8186 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.005317 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9771 Moderately Informative Inherited
Biological Process (BP) tissue development 0.669 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.6751 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.6559 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.9621 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.03638 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5572 Moderately Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) system process 0.00000001072 Informative Direct
Biological Process (BP) metal ion transport 0.0000008942 Informative Direct
Biological Process (BP) regulation of ion transport 0.000001979 Informative Direct
Biological Process (BP) embryo development 0.00005787 Informative Direct
Biological Process (BP) transmembrane transport 0.0001987 Informative Direct
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.009069 Informative Inherited
Biological Process (BP) cellular response to lipid 0.1476 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4137 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.4815 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.8639 Informative Inherited
Biological Process (BP) generation of neurons 0.9095 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.0303 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001676 Informative Inherited
Biological Process (BP) circulatory system development 0.1351 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1447 Informative Inherited
Biological Process (BP) locomotion 0.1854 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) central nervous system development 0.03654 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3255 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) response to metal ion 0.09606 Informative Inherited
Biological Process (BP) behavior 0.006953 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.008103 Informative Inherited
Biological Process (BP) epithelium development 0.375 Informative Inherited
Biological Process (BP) post-embryonic development 0.2031 Informative Inherited
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.000000000000007296 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.00000000000395 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.0000001152 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.00001096 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00001482 Highly Informative Direct
Biological Process (BP) second-messenger-mediated signaling 0.000015 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.00001722 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00001898 Highly Informative Direct
Biological Process (BP) heart contraction 0.000399 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0004854 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0006437 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0007759 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.000781 Highly Informative Direct
Biological Process (BP) muscle system process 0.006188 Highly Informative Inherited
Biological Process (BP) heart development 0.02072 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.04783 Highly Informative Inherited
Biological Process (BP) neuron development 0.4694 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.01711 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.125 Highly Informative Inherited
Biological Process (BP) sodium ion transport 0.02827 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) nervous system process 0.7242 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.08364 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.07764 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000000000004916 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000000003566 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.00000002174 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00001002 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) active ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000000001617 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000001998 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000002349 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.000006253 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.005597 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000234 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1321 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.004409 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.0000002964 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00002246 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0005587 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1361 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.1164 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) transporter complex 0.00000004703 Informative Direct
Cellular Component (CC) vacuolar part 0.0000001791 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.00007629 Informative Direct
Cellular Component (CC) cilium 0.0004455 Informative Direct
Cellular Component (CC) neuron projection 0.1297 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.002906 Informative Inherited
Cellular Component (CC) plasma membrane region 0.1004 Informative Inherited
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.00000000000003647 Highly Informative Direct
Cellular Component (CC) sarcomere 0.00000007332 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0001188 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001389 Highly Informative Direct
Cellular Component (CC) dendrite 0.1101 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000000007761Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0.0000001689Moderately InformativeDirect
Cellular componentCell projection0.0003265Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001478Least InformativeDirect
DiseaseDisease mutation0.000000836Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0000006302InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metal cation-transporting ATPase, ATP-binding domain N domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Metal cation-transporting ATPase, ATP-binding domain N superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]