SUPERFAMILY 1.75 HMM library and genome assignments server


Metal cation-transporting ATPase, ATP-binding domain N superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
Superfamily:   Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
Families:   Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)


Superfamily statistics
Genomes (2,179) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,309 34,983 4
Proteins 14,283 34,944 4


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.29e-13 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8803 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9353 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04361 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4225 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2964 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 8.86e-13 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.029e-08 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.468e-05 Moderately Informative Direct
Biological Process (BP) system process 2.91e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 9.601e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001686 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0007188 Moderately Informative Direct
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.08553 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6791 Moderately Informative Inherited
Biological Process (BP) organ development 0.6566 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9924 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3856 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8736 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5324 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1158 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1409 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.04737 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1119 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) metal ion transport 1.012e-13 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 3.447e-13 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 3.551e-11 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 6.293e-11 Informative Direct
Biological Process (BP) organophosphate catabolic process 2.132e-10 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 5.076e-10 Informative Direct
Biological Process (BP) regulation of ion transport 8.731e-10 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 1.517e-09 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.89e-09 Informative Direct
Biological Process (BP) cellular membrane organization 5.639e-08 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 1.316e-07 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 3.374e-06 Informative Direct
Biological Process (BP) blood circulation 9.465e-06 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.0001762 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002245 Informative Direct
Biological Process (BP) sensory organ development 0.0005886 Informative Direct
Biological Process (BP) embryonic organ development 0.0007423 Informative Direct
Biological Process (BP) metal ion homeostasis 0.0008522 Informative Direct
Biological Process (BP) generation of neurons 0.4423 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.916 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02125 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9656 Informative Inherited
Biological Process (BP) single-organism behavior 0.01947 Informative Inherited
Biological Process (BP) gland development 0.04001 Informative Inherited
Biological Process (BP) central nervous system development 0.005915 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2742 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7227 Informative Inherited
Biological Process (BP) response to other organism 0.0968 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.03809 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.002288 Informative Inherited
Biological Process (BP) response to wounding 0.2233 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.8423 Informative Inherited
Biological Process (BP) epithelium development 0.5036 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1672 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.4528 Informative Inherited
Biological Process (BP) cell-cell signaling 0.4653 Informative Inherited
Biological Process (BP) ion transmembrane transport 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 1.922e-15 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 7.281e-15 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.077e-14 Highly Informative Direct
Biological Process (BP) ATP metabolic process 1.761e-14 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 4.866e-12 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 1.247e-11 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 1.68e-11 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 1.508e-08 Highly Informative Direct
Biological Process (BP) lactation 1.497e-07 Highly Informative Direct
Biological Process (BP) response to drug 5.281e-07 Highly Informative Direct
Biological Process (BP) inner ear development 7.553e-07 Highly Informative Direct
Biological Process (BP) locomotory behavior 9.688e-07 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 1.512e-05 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 3.306e-05 Highly Informative Direct
Biological Process (BP) adult behavior 5.061e-05 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0003145 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0004254 Highly Informative Direct
Biological Process (BP) coagulation 0.0004814 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0005167 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.01269 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.01892 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.3642 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.05133 Highly Informative Inherited
Biological Process (BP) sensory perception 0.02765 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.00618 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) cellular transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) learning or memory 0.4673 Highly Informative Inherited
Biological Process (BP) wound healing 0.007517 Highly Informative Inherited
Biological Process (BP) hemostasis 0.7833 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.00402 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1161 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.743 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.978 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.1403 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 2.746e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001174 Moderately Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 1.698e-13 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 1.518e-12 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1.652e-09 Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.498e-07 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 3.036e-06 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.004175 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.001124 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.01532 Highly Informative Inherited
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.2553 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 5.07e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.5951 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 4.588e-13 Moderately Informative Direct
Cellular Component (CC) organelle membrane 4.619e-07 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.007888 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) Golgi apparatus 5.683e-14 Informative Direct
Cellular Component (CC) vacuolar part 3.375e-06 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 9.308e-06 Informative Direct
Cellular Component (CC) contractile fiber part 0.0003302 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 1.4e-12 Highly Informative Direct
Cellular Component (CC) sarcomere 7.461e-07 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 8.336e-06 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 9.744e-05 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0004471 Highly Informative Direct
Cellular Component (CC) cell body 0.03512 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase7.761e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.07236Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0002661InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00137Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1559Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.06673InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant6.327e-11Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive2.47e-08Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant1.572e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome1.691e-07Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001726Least InformativeDirect
DiseaseDisease mutation1.052e-07Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration2.505e-07InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metal cation-transporting ATPase, ATP-binding domain N domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Metal cation-transporting ATPase, ATP-binding domain N superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]