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Metal cation-transporting ATPase, ATP-binding domain N superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
Superfamily:   Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
Families:   Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)


Superfamily statistics
Genomes (2,192) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,788 34,983 4
Proteins 14,762 34,944 4


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001096 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.001532 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3276 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000004584 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.001446 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3501 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7632 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7994 Moderately Informative Inherited
Biological Process (BP) response to stress 0.592 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.8937 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.03457 Moderately Informative Inherited
Biological Process (BP) ion homeostasis 0 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000000000000003692 Informative Direct
Biological Process (BP) transmembrane transport 0.000001361 Informative Direct
Biological Process (BP) regulation of ion transport 0.00000178 Informative Direct
Biological Process (BP) metal ion transport 0.000002174 Informative Direct
Biological Process (BP) embryo development 0.00005328 Informative Direct
Biological Process (BP) system process 0.0001028 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0006179 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.08788 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.354 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.4597 Informative Inherited
Biological Process (BP) circulatory system development 0.1255 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.6809 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1507 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.05124 Informative Inherited
Biological Process (BP) locomotion 0.1247 Informative Inherited
Biological Process (BP) central nervous system development 0.03285 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1956 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.07543 Informative Inherited
Biological Process (BP) behavior 0.003313 Informative Inherited
Biological Process (BP) epithelium development 0.2919 Informative Inherited
Biological Process (BP) post-embryonic development 0.1807 Informative Inherited
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.000000000000001902 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000000000106 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.000000003641 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000002344 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.000001855 Highly Informative Direct
Biological Process (BP) inner ear development 0.000006311 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000006643 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0000226 Highly Informative Direct
Biological Process (BP) muscle system process 0.0001302 Highly Informative Direct
Biological Process (BP) heart contraction 0.0002118 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.0003054 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0003868 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.07023 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.01914 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1864 Highly Informative Inherited
Biological Process (BP) brain development 0.003519 Highly Informative Inherited
Biological Process (BP) steroid metabolic process 0.001118 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4296 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.05457 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.003457 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1039 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000001093 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000004817 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000000001612 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00001771 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) ribonucleoside binding 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine nucleoside binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000001039 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000001466 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000002101 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.00003653 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000000745 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0009442 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2038 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.0000004672 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000325 Moderately Informative Direct
Cellular Component (CC) vesicle 0.003411 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.03577 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) transporter complex 0.000000008475 Informative Direct
Cellular Component (CC) vacuolar part 0.0000003135 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0001348 Informative Direct
Cellular Component (CC) organelle subcompartment 0.0007443 Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.00000000000002585 Highly Informative Direct
Cellular Component (CC) myofibril 0.00000006257 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.00001583 Highly Informative Direct
Cellular Component (CC) sperm part 0.00004711 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000175 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000000007761Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.6298Least InformativeInherited
Phenotypic Abnormality (PA)Decreased facial expression0.0006714InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.00197Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.000166InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00005075Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002089Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.002359Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.06166Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.001035Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.06755Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.007485InformativeInherited
Worm Phenotype (WP)plasma membrane composition variant0.000000000000002994Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.00000000001521Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.00000002332Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.000005262Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)integumentary system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0.0000001198Moderately InformativeDirect
Cellular componentCell projection0.000183Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001692Least InformativeDirect
DiseaseDisease mutation0.0000004817Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0000006186InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metal cation-transporting ATPase, ATP-binding domain N domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Metal cation-transporting ATPase, ATP-binding domain N superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]