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Metal cation-transporting ATPase, ATP-binding domain N superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
Superfamily:   Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
Families:   Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)


Superfamily statistics
Genomes (2,197) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 14,927 54,227 4
Proteins 14,900 54,108 4


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000139 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.003606 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2167 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000008359 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4186 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7146 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001099 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.573 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.9219 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.989 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1125 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) ion homeostasis 0 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000000000000003764 Informative Direct
Biological Process (BP) metal ion transport 0.0000009038 Informative Direct
Biological Process (BP) regulation of ion transport 0.000002134 Informative Direct
Biological Process (BP) system process 0.00001149 Informative Direct
Biological Process (BP) transmembrane transport 0.00003642 Informative Direct
Biological Process (BP) embryo development 0.00008892 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0007693 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.1218 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.3524 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.4569 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.7825 Informative Inherited
Biological Process (BP) sensory organ development 0.00537 Informative Inherited
Biological Process (BP) tissue development 0.848 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.147 Informative Inherited
Biological Process (BP) locomotion 0.1602 Informative Inherited
Biological Process (BP) central nervous system development 0.04061 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2261 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) response to metal ion 0.02418 Informative Inherited
Biological Process (BP) behavior 0.003291 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.04368 Informative Inherited
Biological Process (BP) circulatory system development 0.1402 Informative Inherited
Biological Process (BP) post-embryonic development 0.1717 Informative Inherited
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.000000000000001945 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.00000001099 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.0000002504 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000003212 Highly Informative Direct
Biological Process (BP) inner ear development 0.000007031 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000009978 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.00001128 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.0000214 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00002732 Highly Informative Direct
Biological Process (BP) heart contraction 0.0002635 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0004418 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0004884 Highly Informative Direct
Biological Process (BP) muscle system process 0.0005685 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0005715 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.06322 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.01583 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2206 Highly Informative Inherited
Biological Process (BP) sodium ion transport 0.02633 Highly Informative Inherited
Biological Process (BP) brain development 0.004286 Highly Informative Inherited
Biological Process (BP) neurological system process 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2105 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.0588 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.002461 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.08494 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000000739 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000000001353 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000000005919 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00001272 Moderately Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000000002558 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000006847 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 8.425e-16 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000002288 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.00003541 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.003231 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000009392 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.005445 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.09398 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00002289 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0005443 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.06079 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) transporter complex 0.00000002113 Informative Direct
Cellular Component (CC) vacuolar part 0.0000002221 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.00005057 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00144 Informative Inherited
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.00000000000003768 Highly Informative Direct
Cellular Component (CC) myofibril 0.0000000835 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.00001476 Highly Informative Direct
Cellular Component (CC) sperm part 0.00007677 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001086 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000000007761Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.6309Least InformativeInherited
Phenotypic Abnormality (PA)Decreased facial expression0.0006885InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.001848Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0001552InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00008146Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003075Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.003534Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.07445Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.001083Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.06045Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.006732InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.2007InformativeInherited
Worm Phenotype (WP)plasma membrane composition variant0.000000000000002601Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.00000000001806Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.00000002373Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.000005327Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)integumentary system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0.0000001659Moderately InformativeDirect
Cellular componentCell projection0.000314Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001739Least InformativeDirect
DiseaseDisease mutation0.0000008259Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0000006594InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metal cation-transporting ATPase, ATP-binding domain N domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Metal cation-transporting ATPase, ATP-binding domain N superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]