SUPERFAMILY 1.75 HMM library and genome assignments server


Metal cation-transporting ATPase, ATP-binding domain N superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
Superfamily:   Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
Families:   Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)


Superfamily statistics
Genomes (2,142) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 13,718 20,261 4
Proteins 13,698 20,236 4


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 4.698e-11 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1035 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4975 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3008 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 4.021e-12 Moderately Informative Direct
Biological Process (BP) regulation of localization 4.69e-07 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 1.473e-05 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 4.485e-05 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0001733 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0002976 Moderately Informative Direct
Biological Process (BP) system process 0.0005473 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0005551 Moderately Informative Direct
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1165 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.8763 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7734 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5676 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4626 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.003493 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.232 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1222 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1215 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.968 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 3.749e-15 Informative Direct
Biological Process (BP) lipid localization 5.591e-15 Informative Direct
Biological Process (BP) metal ion transport 1.262e-14 Informative Direct
Biological Process (BP) membrane organization 1.088e-11 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 1.366e-11 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 1.075e-09 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 1.652e-09 Informative Direct
Biological Process (BP) organophosphate catabolic process 5.638e-09 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1.085e-08 Informative Direct
Biological Process (BP) regulation of ion transport 3.258e-08 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 3.373e-08 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 3.45e-08 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 1.314e-06 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 2.011e-06 Informative Direct
Biological Process (BP) blood circulation 4.544e-05 Informative Direct
Biological Process (BP) cation homeostasis 0.002004 Informative Inherited
Biological Process (BP) generation of neurons 0.6855 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.00664 Informative Inherited
Biological Process (BP) sensory organ development 0.009469 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.9593 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.09159 Informative Inherited
Biological Process (BP) positive regulation of transport 0.002522 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.4915 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.03026 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8681 Informative Inherited
Biological Process (BP) central nervous system development 0.01206 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7041 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8915 Informative Inherited
Biological Process (BP) response to light stimulus 0.08612 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.004082 Informative Inherited
Biological Process (BP) response to wounding 0.2264 Informative Inherited
Biological Process (BP) gland development 0.1044 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.9121 Informative Inherited
Biological Process (BP) epithelium development 0.6354 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3404 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.3165 Informative Inherited
Biological Process (BP) cell-cell signaling 0.4503 Informative Inherited
Biological Process (BP) ion transmembrane transport 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.085e-14 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 9.076e-14 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 3.261e-13 Highly Informative Direct
Biological Process (BP) ATP metabolic process 7.866e-13 Highly Informative Direct
Biological Process (BP) locomotory behavior 7.88e-12 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 1.72e-10 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 4.071e-10 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 5.368e-10 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 1.948e-08 Highly Informative Direct
Biological Process (BP) response to drug 2.631e-06 Highly Informative Direct
Biological Process (BP) lactation 3.355e-06 Highly Informative Direct
Biological Process (BP) adult behavior 3.297e-05 Highly Informative Direct
Biological Process (BP) inner ear development 0.0001591 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0002047 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0003178 Highly Informative Direct
Biological Process (BP) regulation of sodium ion transport 0.0004314 Highly Informative Direct
Biological Process (BP) coagulation 0.0004318 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.000562 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.001713 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.03434 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.03954 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4943 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.09293 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1281 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.008464 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.00637 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.007388 Highly Informative Inherited
Biological Process (BP) hemostasis 0.649 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.08292 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.6564 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.9254 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.1596 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 2e-06 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00245 Moderately Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 5.623e-13 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 5.081e-09 Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.772e-07 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.002847 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.01364 Highly Informative Inherited
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.2845 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 2.969e-15 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 6.948e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.5339 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 9.779e-11 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1.684e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 4.746e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.001528 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) Golgi apparatus 6.618e-10 Informative Direct
Cellular Component (CC) vacuolar part 1.694e-06 Informative Direct
Cellular Component (CC) contractile fiber part 0.0001631 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0003664 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 9.323e-13 Highly Informative Direct
Cellular Component (CC) sarcomere 6.398e-07 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 2.323e-05 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 4.962e-05 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001207 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase7.761e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.0719Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0002621InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00137Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1559Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.06673InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant6.327e-11Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive2.47e-08Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant1.572e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus1.363e-08Moderately InformativeDirect
Cellular componentEndosome4.359e-05Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001227Least InformativeDirect
DiseaseDisease mutation6.807e-07Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration2.601e-07InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metal cation-transporting ATPase, ATP-binding domain N domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Metal cation-transporting ATPase, ATP-binding domain N superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]