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Calcium ATPase, transmembrane domain M superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Calcium ATPase, transmembrane domain M [ 81666]
Superfamily:   Calcium ATPase, transmembrane domain M [ 81665]
Families:   Calcium ATPase, transmembrane domain M [ 81664]


Superfamily statistics
Genomes (3,051) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 27,877 122,390 2
Proteins 27,632 121,870 2


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.00000000000006022 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000006717 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.1456 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.005154 Least Informative Inherited
Biological Process (BP) response to stimulus 0.07136 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000002274 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8519 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1853 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9467 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.05115 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7845 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.3326 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2008 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.04336 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) system process 0.0000000001271 Informative Direct
Biological Process (BP) transmembrane transport 0.000000431 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000007696 Informative Direct
Biological Process (BP) metal ion transport 0.0001987 Informative Direct
Biological Process (BP) embryo development 0.0007043 Informative Direct
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) response to metal ion 0.003176 Informative Inherited
Biological Process (BP) cation homeostasis 0.001888 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.8567 Informative Inherited
Biological Process (BP) generation of neurons 0.6595 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.008974 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.004448 Informative Inherited
Biological Process (BP) circulatory system development 0.1801 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.6904 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4285 Informative Inherited
Biological Process (BP) locomotion 0.4546 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) central nervous system development 0.03287 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5346 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) behavior 0.01132 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.002555 Informative Inherited
Biological Process (BP) post-embryonic development 0.2776 Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000001916 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.000001895 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000002654 Highly Informative Direct
Biological Process (BP) response to copper ion 0.000004995 Highly Informative Direct
Biological Process (BP) detoxification 0.00001301 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.00006614 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0001065 Highly Informative Direct
Biological Process (BP) second-messenger-mediated signaling 0.0001077 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.0001688 Highly Informative Direct
Biological Process (BP) heart contraction 0.000399 Highly Informative Direct
Biological Process (BP) muscle system process 0.004164 Highly Informative Inherited
Biological Process (BP) heart development 0.04347 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.03907 Highly Informative Inherited
Biological Process (BP) neuron development 0.1273 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001265 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.02472 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2101 Highly Informative Inherited
Biological Process (BP) sodium ion transport 0.2073 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9152 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.3758 Highly Informative Inherited
Biological Process (BP) proton transport 0.1129 Highly Informative Inherited
Biological Process (BP) nervous system process 0.5839 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2061 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1892 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.002587 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1016 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000000000004592 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000009715 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02281 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.06535 Moderately Informative Inherited
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) active ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000000000004728 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.000000000000901 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000000006394 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.0000009183 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.00002582 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0004079 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.008909 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.0016 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000004985 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0002274 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.01463 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.00000000287 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0000001647 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0002391 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.7216 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.006961 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.2983 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) vacuolar part 0.000000001104 Informative Direct
Cellular Component (CC) transporter complex 0.0000009889 Informative Direct
Cellular Component (CC) membrane region 0.5612 Informative Inherited
Cellular Component (CC) neuron projection 0.1511 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.001467 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.01946 Informative Inherited
Cellular Component (CC) plasma membrane region 0.4885 Informative Inherited
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.0000000000003398 Highly Informative Direct
Cellular Component (CC) sarcomere 0.000001091 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00004992 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0002797 Highly Informative Direct
Cellular Component (CC) symplast 0.0007467 Highly Informative Direct
Cellular Component (CC) dendrite 0.2177 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.2428 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001092Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000007156Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004596Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007355Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0.000000000128InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.0000000004579Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell membrane0.00000000008943Moderately InformativeDirect
Cellular componentEndosome0.0000001972Moderately InformativeDirect
Cellular componentVacuole0.0008873InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0002667Least InformativeDirect
DiseaseDisease mutation0.0000003024Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionZinc transport0.00000001344Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0000285InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transmembrane domain M domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transmembrane domain M superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]