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Calcium ATPase, transmembrane domain M superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Calcium ATPase, transmembrane domain M [ 81666]
Superfamily:   Calcium ATPase, transmembrane domain M [ 81665]
Families:   Calcium ATPase, transmembrane domain M [ 81664]


Superfamily statistics
Genomes (3,046) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 27,670 95,033 2
Proteins 27,429 94,861 2


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0003484 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0153 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4209 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000301 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.01059 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9162 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.9883 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.8924 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.0761 Moderately Informative Inherited
Biological Process (BP) ion homeostasis 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000000000000001902 Informative Direct
Biological Process (BP) transmembrane transport 0.0000000002022 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000006883 Informative Direct
Biological Process (BP) response to inorganic substance 0.0000009603 Informative Direct
Biological Process (BP) system process 0.000002384 Informative Direct
Biological Process (BP) metal ion transport 0.0003642 Informative Direct
Biological Process (BP) embryo development 0.0005072 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0009647 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) circulatory system development 0.1492 Informative Inherited
Biological Process (BP) generation of neurons 0.6302 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.295 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01216 Informative Inherited
Biological Process (BP) actin filament-based process 0.9953 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) locomotion 0.331 Informative Inherited
Biological Process (BP) central nervous system development 0.04656 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3487 Informative Inherited
Biological Process (BP) cell adhesion 0.1607 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) behavior 0.01183 Informative Inherited
Biological Process (BP) epithelium development 0.9607 Informative Inherited
Biological Process (BP) post-embryonic development 0.2451 Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) inner ear development 0.000000000186 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.00000003341 Highly Informative Direct
Biological Process (BP) detoxification 0.0000002637 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000003014 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000009182 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00000861 Highly Informative Direct
Biological Process (BP) response to copper ion 0.00001433 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.00004482 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00004899 Highly Informative Direct
Biological Process (BP) muscle system process 0.00009747 Highly Informative Direct
Biological Process (BP) hydrogen transport 0.0001764 Highly Informative Direct
Biological Process (BP) heart contraction 0.0002118 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0002142 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.253 Highly Informative Inherited
Biological Process (BP) neuron development 0.1461 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.039 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2906 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2456 Highly Informative Inherited
Biological Process (BP) brain development 0.004104 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1494 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1299 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.009727 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.122 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000000000007928 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000000006952 Moderately Informative Direct
Molecular Function (MF) anion binding 0.03137 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.0912 Moderately Informative Inherited
Molecular Function (MF) ribonucleoside binding 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) purine nucleoside binding 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000000003255 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000001171 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000000003963 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.0000000000002329 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.000002008 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.00001358 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0003682 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.0107 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000001251 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000454 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.008054 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.00000001259 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000003304 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0009638 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0009666 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.8333 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) organelle subcompartment 0.0000000006922 Informative Direct
Cellular Component (CC) vacuolar part 0.000000006608 Informative Direct
Cellular Component (CC) transporter complex 0.0000001905 Informative Direct
Cellular Component (CC) membrane region 0.6344 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.001921 Informative Inherited
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.0000000000002255 Highly Informative Direct
Cellular Component (CC) myofibril 0.000000932 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00004438 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.00009593 Highly Informative Direct
Cellular Component (CC) sperm part 0.000149 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001092Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000007156Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004596Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007355Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.08579Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0005137InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0001061Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003518Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.003591Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.09185Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.001406Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.06755Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.007485InformativeInherited
Worm Phenotype (WP)plasma membrane composition variant0.000000000000002994Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.00000000002218Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.00000003003Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.000006387Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)integumentary system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0001185Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.002465Least InformativeInherited
Plant ANatomical entity (PAN)flower0.03209Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.04731Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06133Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.0000005989InformativeDirect
Plant ANatomical entity (PAN)parenchyma cell0.000000003417Highly InformativeDirect
Plant ANatomical entity (PAN)anther0.0005633Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0002825Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0.00000000001628InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.0000000001192Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell membrane0.00000000009848Moderately InformativeDirect
Cellular componentEndosome0.0000001093Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000307Least InformativeDirect
DiseaseDisease mutation0.0000001203Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00002775InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transmembrane domain M domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transmembrane domain M superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]