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Helical domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ERP29 C domain-like [ 47932] (2)
Superfamily:   Helical domain of Sec23/24 [ 81811]
Families:   Helical domain of Sec23/24 [ 81812] (2)


Superfamily statistics
Genomes (501) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,552 6,248 4
Proteins 2,549 6,230 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0001405 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1006 Least Informative Inherited
Biological Process (BP) biological regulation 0.9124 Least Informative Inherited
Biological Process (BP) cellular localization 0.00000000379 Moderately Informative Direct
Biological Process (BP) immune system process 0.0003553 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0004467 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0007787 Moderately Informative Direct
Biological Process (BP) organelle organization 0.01875 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.02866 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.1943 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.04296 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2755 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001631 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.05389 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2119 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7128 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.02402 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4681 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0032 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.2986 Moderately Informative Inherited
Biological Process (BP) membrane organization 0.0000000000875 Informative Direct
Biological Process (BP) embryo development 0.0000001561 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00007582 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001061 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001169 Informative Direct
Biological Process (BP) positive regulation of transport 0.0001281 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.01604 Informative Inherited
Biological Process (BP) intracellular protein transport 0.3442 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.0112 Informative Inherited
Biological Process (BP) tissue development 0.3014 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.009528 Informative Inherited
Biological Process (BP) organelle localization 0.8347 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.007187 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01543 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04027 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.004361 Informative Inherited
Biological Process (BP) regulation of secretion 0.05543 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03494 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.000000000001444 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000000000002435 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000000001672 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000000005428 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000000279 Highly Informative Direct
Biological Process (BP) vesicle localization 0.0000008756 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000008931 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000008561 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000009079 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00005064 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.0001874 Highly Informative Direct
Biological Process (BP) muscle structure development 0.01313 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.001149 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.03133 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00000002315 Least Informative Direct
Cellular Component (CC) membrane 0.00003687 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.0001076 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.002553 Least Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.00000000000002355 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000000000005146 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.00000000006501 Moderately Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0 Highly Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment size variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)female genitalia0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)egg0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)kidney0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.00000004582Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationAcetylation0.00002959Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006900 SSF81811 Protein matches
Abstract

COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex [PubMed11535824]. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerisation and membrane deformation [PubMed12239560].

Sec23 p and Sec24p are structurally related, folding into five distinct domains: a beta-barrel, a zinc-finger , an alpha/beta trunk domain , an all-helical region, and a C-terminal gelsolin-like domain . This entry describes the all-helical domain, which forms an approximately 105-residue segment with the C-terminal 30 residues. The linker between alpha-M and alpha-N contacts Sar1.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Helical domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Helical domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]