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BEACH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   BEACH domain [ 81836]
Superfamily:   BEACH domain [ 81837]
Families:   BEACH domain [ 81838] (2)


Superfamily statistics
Genomes (480) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,356 5,497 2
Proteins 2,321 5,432 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000323 Least Informative Direct
Biological Process (BP) biological regulation 0.2218 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3795 Least Informative Inherited
Biological Process (BP) response to stimulus 0.09247 Least Informative Inherited
Biological Process (BP) immune system process 0.000005158 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00833 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001359 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.06131 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.462 Moderately Informative Inherited
Biological Process (BP) immune response 0.00002079 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0003872 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000002495 Informative Direct
Biological Process (BP) intracellular transport 0.000005499 Informative Direct
Biological Process (BP) cell development 0.0001336 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000155 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.002688 Informative Inherited
Biological Process (BP) vesicle organization 0.000001459 Highly Informative Direct
Biological Process (BP) pigmentation 0.0000002452 Highly Informative Direct
Molecular Function (MF) molecular function regulator 0.000003773 Moderately Informative Direct
Molecular Function (MF) kinase regulator activity 0.001662 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5723 Least Informative Inherited
Cellular Component (CC) membrane 0.007039 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0202 Least Informative Inherited
Cellular Component (CC) vacuole 0.0000195 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0007922 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00003344 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.000005396 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.0001776 Moderately Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000000003669 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00001261 Informative Direct
Cellular Component (CC) endosome 0.07713 Informative Inherited
Cellular Component (CC) late endosome 0.0000000797 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.0008954 Highly Informative Direct
Cellular Component (CC) extrinsic component of organelle membrane 0.000000000001853 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.0006164Least InformativeDirect
Cellular componentEndoplasmic reticulum0.00002951Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.0000000000002192Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainWD repeat0InformativeDirect
Post-translational modificationPhosphoprotein0.00004116Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000409 SSF81837 Protein matches
Abstract

The "beige" mouse is established as an animal model of Chediak-Higashi Syndrome (CHS) [PubMed8896560]. The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein . It is also found in distantly related proteins like, for example, and which are factor associated with neutral sphingomyelinase activation [PubMed9620659].

The BEACH domain is usually followed by a series of WD repeats . The function of the BEACH domain is unknown.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BEACH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the BEACH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]