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BEACH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   BEACH domain [ 81836]
Superfamily:   BEACH domain [ 81837]
Families:   BEACH domain [ 81838] (2)


Superfamily statistics
Genomes (478) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,326 5,497 2
Proteins 2,291 5,432 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.2415 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.001881 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02128 Least Informative Inherited
Biological Process (BP) immune system process 0.00004581 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.04159 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0326 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.5036 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.0005179 Informative Direct
Biological Process (BP) immune response 0.000007002 Informative Direct
Biological Process (BP) cell development 0.0007415 Informative Direct
Biological Process (BP) vesicle organization 0.00000006253 Highly Informative Direct
Biological Process (BP) pigmentation 0.0000001261 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.9201 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.09115 Least Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Pace of progression0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.125Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02867Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03447Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.08477Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.001739InformativeInherited
Phenotypic Abnormality (PA)Subcutaneous hemorrhage0.0001973Highly InformativeDirect
Phenotypic Abnormality (PA)Thrombocytopenia0.0003805Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.008191Least InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.000587Least InformativeDirect
Cellular componentEndoplasmic reticulum0.0000229Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00000000000001122Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainWD repeat0InformativeDirect
Post-translational modificationPhosphoprotein0.00003911Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000409 SSF81837 Protein matches
Abstract

The "beige" mouse is established as an animal model of Chediak-Higashi Syndrome (CHS) [PubMed8896560]. The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein . It is also found in distantly related proteins like, for example, and which are factor associated with neutral sphingomyelinase activation [PubMed9620659].

The BEACH domain is usually followed by a series of WD repeats . The function of the BEACH domain is unknown.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BEACH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the BEACH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]