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HCP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   HCP-like [ 81901]
Families:   HCP-like [ 81902] (2)


Superfamily statistics
Genomes (2,158) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,848 71,958 2
Proteins 16,748 51,950 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9953 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.1428 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9943 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9872 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3916 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.5208 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.6264 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.5111 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.1596 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.309 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7821 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9893 Moderately Informative Inherited
Biological Process (BP) response to nitrogen compound 0.05423 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1081 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.7285 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.8611 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8263 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.9214 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.2736 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.09981 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.4231 Informative Inherited
Biological Process (BP) embryo development 0.03533 Informative Inherited
Biological Process (BP) gastrulation 0.0005201 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0009548 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00001278 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.3528 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.75 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.7907 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.6576 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9647 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.000000236 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.9487 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.9745 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.06244 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00001422 Informative Direct
Cellular Component (CC) chromosome 0.07953 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.2916 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.03177 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.001441 Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.0000000001391 Highly Informative Direct
Cellular Component (CC) chromatin 0.002714 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In cyclic amides0InformativeDirect
Enzyme Commission (EC)Beta-lactamase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01305Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.05374Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2003Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.008429Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.00926Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.0136Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0216Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.02633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.0005402InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0006351InformativeDirect
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.000005587Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primary cilium morphology0.000006324Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.1541Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00005123Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0459Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.000000000009385Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000004293Moderately InformativeDirect
Enzyme Commission (EC)In cyclic amides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0.0000000006512InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0004826Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.00000000000005761Moderately InformativeDirect
DomainTPR repeat0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.01295Least InformativeInherited
UniPathway (UP)glycan metabolism0.00000004398Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0.00003207Moderately InformativeDirect
UniPathway (UP)alginate biosynthesis0.000000001433Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HCP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HCP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]