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HCP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   HCP-like [ 81901]
Families:   HCP-like [ 81902] (2)


Superfamily statistics
Genomes (2,154) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,696 71,958 2
Proteins 16,613 51,950 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.08425 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.8735 Least Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5048 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3232 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.05379 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1634 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7419 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3183 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2721 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9869 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.3049 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.3438 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.03754 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.02786 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.674 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.7984 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.7692 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.7909 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.3999 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.0801 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.2513 Informative Inherited
Biological Process (BP) embryo development 0.03118 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.002283 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.007429 Informative Inherited
Biological Process (BP) gastrulation 0.0005168 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00008925 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000001031 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.1514 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.004311 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.6912 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9728 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.7891 Least Informative Inherited
Cellular Component (CC) protein complex 0.332 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9326 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9838 Least Informative Inherited
Cellular Component (CC) transferase complex 0.00000003337 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.711 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.7226 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.09106 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.000001372 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0.000001393 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0008746 Informative Direct
Cellular Component (CC) chromosome 0.06045 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.009496 Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.0000000001218 Highly Informative Direct
Cellular Component (CC) cell division site 0.00001601 Highly Informative Direct
Cellular Component (CC) chromatin 0.00161 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In cyclic amides0InformativeDirect
Enzyme Commission (EC)Beta-lactamase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01413Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.05495Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2129Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.008792Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.009055Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.02078Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.02732Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.0005588InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0006636InformativeDirect
Mammalian Phenotype (MP)embryonic lethality0.407InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.000005926Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primary cilium morphology0.000006712Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.003562Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00005377Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.04743Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.000000000009662Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000004334Moderately InformativeDirect
Enzyme Commission (EC)In cyclic amides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0.0000000005854InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0003863Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.0000000000001421Moderately InformativeDirect
DomainTPR repeat0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.01296Least InformativeInherited
UniPathway (UP)glycan metabolism0.00000004417Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0.00003139Moderately InformativeDirect
UniPathway (UP)alginate biosynthesis0.000000001445Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HCP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HCP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]