SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


beta-sandwich domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   beta-sandwich domain of Sec23/24 [ 81995]
Families:   beta-sandwich domain of Sec23/24 [ 81996] (2)


Superfamily statistics
Genomes (647) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,532 15,294 4
Proteins 5,417 15,023 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00001027 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000000438 Least Informative Direct
Biological Process (BP) biological regulation 0.009473 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001864 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0003303 Moderately Informative Direct
Biological Process (BP) tissue development 0.0003792 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001114 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000004076 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000004801 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.3838 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2624 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01286 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04269 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7248 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1669 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.06673 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.859 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.9932 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.8445 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1305 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7413 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9743 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.008714 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1293 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.006374 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.2749 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.007391 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1166 Moderately Informative Inherited
Biological Process (BP) embryo development 0.0001399 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00000009344 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000004558 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0002031 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000008738 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000001064 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00002432 Informative Direct
Biological Process (BP) intracellular transport 0.000009238 Informative Direct
Biological Process (BP) cell development 0.0005646 Informative Direct
Biological Process (BP) generation of neurons 0.00000007127 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0003617 Informative Direct
Biological Process (BP) regulation of cellular localization 0.0000000428 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00000001657 Informative Direct
Biological Process (BP) regulation of secretion 0.05617 Informative Inherited
Biological Process (BP) positive regulation of transport 0.09039 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.003498 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.03637 Informative Inherited
Biological Process (BP) hemopoiesis 0.01498 Informative Inherited
Biological Process (BP) circulatory system development 0.8245 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3771 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.144 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1416 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.04338 Informative Inherited
Biological Process (BP) organelle localization 0.8158 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4201 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.04657 Informative Inherited
Biological Process (BP) regulation of growth 0.004824 Informative Inherited
Biological Process (BP) negative regulation of transport 0.05444 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1556 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.003207 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0207 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5538 Informative Inherited
Biological Process (BP) epithelium development 0.1474 Informative Inherited
Biological Process (BP) single organism reproductive process 0.171 Informative Inherited
Biological Process (BP) central nervous system development 0.2319 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.5525 Informative Inherited
Biological Process (BP) locomotion 0.01447 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.02188 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.07387 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.5025 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01723 Informative Inherited
Biological Process (BP) post-embryonic development 0.003492 Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.0004282 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000004958 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0000008216 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.0002179 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000000000001233 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000000001834 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.000187 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00000001605 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000003262 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.000000000000001925 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.0000001496 Highly Informative Direct
Biological Process (BP) neuron development 0.0004952 Highly Informative Direct
Biological Process (BP) appendage development 0.0009105 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000000000008845 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00000000004717 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.0002337 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.01755 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.149 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.005161 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.6145 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.05622 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.01404 Highly Informative Inherited
Biological Process (BP) heart development 0.1118 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.1206 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.06559 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.02164 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.08074 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.002276 Highly Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.002664 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.003654 Highly Informative Inherited
Biological Process (BP) germ cell development 0.1223 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.001156 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.02132 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.01841 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.01481 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.4862 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.86 Highly Informative Inherited
Molecular Function (MF) binding 0.07032 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.002444 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.01021 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0005277 Informative Direct
Molecular Function (MF) zinc ion binding 0.0000001859 Informative Direct
Molecular Function (MF) receptor binding 0.07449 Informative Inherited
Molecular Function (MF) amide binding 0.007233 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.00001932 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.001031 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.04538 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.001953 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0009631 Least Informative Direct
Cellular Component (CC) protein complex 0.0000000003299 Least Informative Direct
Cellular Component (CC) membrane 0.006425 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.04078 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.001223 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.00000000000009368 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000000000000007429 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.000001033 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) Golgi-associated vesicle 0 Highly Informative Direct
Cellular Component (CC) membrane coat 0 Highly Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000000000004013 Highly Informative Direct
Cellular Component (CC) RNA polymerase II transcription factor complex 0.0000004176 Highly Informative Direct
Cellular Component (CC) receptor complex 0.09267 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000001415Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processTranscription regulation0.0002148Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00005046Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
DomainCoiled coil0.00000000000000942Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.00000000000216Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.0000000003817Moderately InformativeDirect
Post-translational modificationKinase0.0607Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.0000008771InformativeDirect
Post-translational modificationPhosphoprotein0.00001158Least InformativeDirect
Post-translational modificationAcetylation0.00006957Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-sandwich domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the beta-sandwich domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]