SUPERFAMILY 1.75 HMM library and genome assignments server


beta-sandwich domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   beta-sandwich domain of Sec23/24 [ 81995]
Families:   beta-sandwich domain of Sec23/24 [ 81996] (2)


Superfamily statistics
Genomes (627) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,268 7,084 4
Proteins 5,164 6,950 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 6.383e-12 Least Informative Direct
Biological Process (BP) developmental process 7.742e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.205e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 7.244e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.1025 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9932 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1926 Least Informative Inherited
Biological Process (BP) cellular localization 2.228e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.267e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001682 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0004029 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0004046 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.9938 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.001777 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2552 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8734 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2082 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1558 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8438 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1723 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7885 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.001064 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6097 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2457 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.008043 Moderately Informative Inherited
Biological Process (BP) reproduction 0.114 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.05935 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2532 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.2179 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.08733 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.07984 Moderately Informative Inherited
Biological Process (BP) organ development 0.006027 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7595 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 2.885e-08 Informative Direct
Biological Process (BP) cell projection organization 1.122e-07 Informative Direct
Biological Process (BP) organ morphogenesis 1.929e-06 Informative Direct
Biological Process (BP) embryonic organ development 1.154e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.802e-05 Informative Direct
Biological Process (BP) cellular membrane organization 6.947e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure size 8.59e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001471 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0002722 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0003149 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0007708 Informative Direct
Biological Process (BP) regulation of response to stress 0.05693 Informative Inherited
Biological Process (BP) regulation of system process 0.3664 Informative Inherited
Biological Process (BP) regulation of secretion 0.008707 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.002271 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.03347 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.3509 Informative Inherited
Biological Process (BP) tube development 0.002106 Informative Inherited
Biological Process (BP) sensory organ development 0.3283 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1774 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.4983 Informative Inherited
Biological Process (BP) regulation of cell development 0.8956 Informative Inherited
Biological Process (BP) cardiovascular system development 0.6815 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.002307 Informative Inherited
Biological Process (BP) protein complex assembly 0.3003 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00106 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.002982 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.08 Informative Inherited
Biological Process (BP) leukocyte activation 0.07194 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.6713 Informative Inherited
Biological Process (BP) generation of neurons 0.1634 Informative Inherited
Biological Process (BP) central nervous system development 0.3352 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.008492 Informative Inherited
Biological Process (BP) muscle structure development 0.2632 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4085 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.0621 Informative Inherited
Biological Process (BP) sexual reproduction 0.07498 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2715 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.2994 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3671 Informative Inherited
Biological Process (BP) organelle localization 0.211 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.03245 Informative Inherited
Biological Process (BP) positive regulation of transport 0.02923 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.08704 Informative Inherited
Biological Process (BP) epithelium development 0.8713 Informative Inherited
Biological Process (BP) locomotion 0.005298 Informative Inherited
Biological Process (BP) cellular component movement 0.01443 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) Golgi vesicle transport 8.506e-09 Highly Informative Direct
Biological Process (BP) artery morphogenesis 5.308e-08 Highly Informative Direct
Biological Process (BP) respiratory system development 1.942e-07 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 8.608e-07 Highly Informative Direct
Biological Process (BP) protein glycosylation 3.962e-06 Highly Informative Direct
Biological Process (BP) vesicle organization 7.551e-06 Highly Informative Direct
Biological Process (BP) post-translational protein modification 1.437e-05 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.985e-05 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 2.385e-05 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 5.541e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0001266 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0001387 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0001576 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0002181 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0002832 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0004872 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0007089 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.000735 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0.0009511 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.07212 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.06356 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.001333 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.006275 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.08474 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.006034 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.07953 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.3929 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.02644 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.004489 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.121 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.3327 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1226 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.1103 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.006424 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.02766 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.3072 Highly Informative Inherited
Biological Process (BP) inner ear development 0.00465 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.02747 Highly Informative Inherited
Biological Process (BP) ossification 0.01248 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.001917 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.007326 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.03393 Highly Informative Inherited
Molecular Function (MF) binding 0.2381 Least Informative Inherited
Molecular Function (MF) receptor binding 0.08312 Informative Inherited
Molecular Function (MF) transcription factor binding 0.002347 Highly Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.01255 Highly Informative Inherited
Cellular Component (CC) protein complex 0.01622 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.04316 Least Informative Inherited
Cellular Component (CC) membrane 0.5515 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.00379 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.05131 Least Informative Inherited
Cellular Component (CC) endomembrane system 5.322e-12 Moderately Informative Direct
Cellular Component (CC) vesicle 8.135e-12 Moderately Informative Direct
Cellular Component (CC) organelle membrane 4.111e-07 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.001998 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9344 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) coated vesicle 1.107e-10 Informative Direct
Cellular Component (CC) nucleoplasm part 6.983e-05 Informative Direct
Cellular Component (CC) Golgi apparatus 0.04939 Informative Inherited
Cellular Component (CC) transport vesicle 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 4.659e-08 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 1.902e-05 Highly Informative Direct
Cellular Component (CC) transcription factor complex 3.734e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 0.02827 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases1.415e-09Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0.411Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.004687Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01092Least InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant7.425e-05Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant7.938e-05Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0002493Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00121Moderately InformativeInherited
Worm Phenotype (WP)germline nuclear positioning variant6.218e-07InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant3.777e-06InformativeDirect
Worm Phenotype (WP)germ cell compartment size variant1.995e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1045Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.02805Moderately InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.03334Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.6905Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0.01921Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon0.0009963Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups7.89e-05Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.3459Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases1.698e-10Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.008842Moderately InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processTranscription regulation0.0001295Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus2.448e-05Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
DomainCoiled coil1.076e-14Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding8.51e-07Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein2.089e-10Moderately InformativeDirect
Post-translational modificationKinase0.05749Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase6.043e-07InformativeDirect
Post-translational modificationPhosphoprotein3.592e-06Least InformativeDirect
Post-translational modificationAcetylation0.0001492Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-sandwich domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the beta-sandwich domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]