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MIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   MIR domain [ 82109]
Families:   MIR domain [ 82110] (2)


Superfamily statistics
Genomes (584) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,322 8,598 2
Proteins 2,602 6,795 2


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular membrane-bounded organelle0.0058780.003893Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.011890.000000000004512Least InformativeInherited
Cellular Component (CC)endomembrane system0.00000035060Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.000000005036 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00006153 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0001885 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000004549 Least Informative Direct
Biological Process (BP) biological regulation 0.00008355 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000007856 Least Informative Direct
Biological Process (BP) response to stimulus 0.001147 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.001255 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01934 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.007537 Least Informative Inherited
Biological Process (BP) ion transport 0.000000000000148 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00005951 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000001738 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000253 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000001215 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000002617 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.003439 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3289 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.09799 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0863 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.001677 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3379 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.01916 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1181 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001487 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1329 Moderately Informative Inherited
Biological Process (BP) tissue development 0.142 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1784 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.02728 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.009102 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02933 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.03885 Moderately Informative Inherited
Biological Process (BP) system process 0.000001629 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0001125 Informative Direct
Biological Process (BP) response to metal ion 0.000000003479 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000001789 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) regulation of system process 0.0000000001611 Informative Direct
Biological Process (BP) protein oligomerization 0.000000002405 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) transmembrane transport 0.00000000001249 Informative Direct
Biological Process (BP) cellular response to inorganic substance 0.0006012 Informative Direct
Biological Process (BP) circulatory system development 0.0005299 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0000002548 Informative Direct
Biological Process (BP) regulation of protein localization 0.771 Informative Inherited
Biological Process (BP) cell development 0.08441 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0606 Informative Inherited
Biological Process (BP) regulation of secretion 0.01124 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.07973 Informative Inherited
Biological Process (BP) growth 0.004259 Informative Inherited
Biological Process (BP) cell death 0.00694 Informative Inherited
Biological Process (BP) response to hypoxia 0.000009474 Highly Informative Direct
Biological Process (BP) muscle system process 0.0000000002875 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) heart development 0.000003927 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0000000005703 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000000000001015 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00001715 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.000000775 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000007611 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.0000001553 Highly Informative Direct
Biological Process (BP) muscle tissue development 0.000002788 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.00004031 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.000000001477 Highly Informative Direct
Biological Process (BP) anatomical structure maturation 0.0000001418 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0.0000001102 Least Informative Direct
Molecular Function (MF) binding 0.01406 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000002902 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.07598 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.0145 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.003846 Moderately Informative Inherited
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) phospholipid binding 0.03097 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.002041 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.002304 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.5363 Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0000005685 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0001532 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000004512 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00003831 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.003893 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.4281 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.6846 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.001081 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.02913 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.9977 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00001115 Informative Direct
Cellular Component (CC) transporter complex 0.000002287 Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) sarcomere 0.000000001998 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.00002802 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000000000001544Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000003331Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0.0002761Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0.0001582Least InformativeDirect
Post-translational modificationS-nitrosylation0.000001131InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003608 SSF82109 Protein matches
Abstract This is a domain found in ryanodine, inositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1,4,5-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules [PubMed1645727]. The function is modulated by Ca2+, Mg2+, ATP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) [PubMed7829078]. protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]