SUPERFAMILY 1.75 HMM library and genome assignments server

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MIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   MIR domain [ 82109]
Families:   MIR domain [ 82110] (2)


Superfamily statistics
Genomes (584) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,322 10,747 2
Proteins 2,602 8,374 2


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Heterogeneous0.0002273InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1782Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2033Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.472Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.4844Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.6006Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7865Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.09021Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1179Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0.2138Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2168Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2282Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2312Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.2485Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2739Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.3539Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Fatigable weakness0.0004022InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.003249InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.04683InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.04857InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.1179InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.2366InformativeInherited
Phenotypic Abnormality (PA)Proximal amyotrophy0.000008199Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.00008113Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0001422Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.0001496Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.0002601Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.0004487Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal left ventricle morphology0.01302Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pinna0.04399Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.00004615Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland physiology0.05134InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)organism subdivision0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)embryo0Moderately InformativeDirect
Fly Anatomy (FA)muscle system0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.6936Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.09476Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1449Moderately InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.02468InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003608 SSF82109 Protein matches
Abstract This is a domain found in ryanodine, inositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1,4,5-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules [PubMed1645727]. The function is modulated by Ca2+, Mg2+, ATP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) [PubMed7829078]. protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the MIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]