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MIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   MIR domain [ 82109]
Families:   MIR domain [ 82110] (2)


Superfamily statistics
Genomes (584) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,322 10,747 2
Proteins 2,602 8,374 2


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Heterogeneous0.0002459InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1743Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.197Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.4647Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.4753Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.5872Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7795Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.0859Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1164Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0.2064Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2096Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2282Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.229Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.245Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2707Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.3435Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Fatigable weakness0.0003846InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.01708InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.04544InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.04802InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.1154InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.128InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.2298InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.00008334Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.0001394Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0001464Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.0002565Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.0004472Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal left ventricle morphology0.01326Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pinna0.04121Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.00004622Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland physiology0.05133InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)embryo0Moderately InformativeDirect
Fly Anatomy (FA)embryonic/larval muscle system0InformativeDirect
Fly Anatomy (FA)muscle cell0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.684Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.09433Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1409Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.001739InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.006494InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003608 SSF82109 Protein matches
Abstract This is a domain found in ryanodine, inositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1,4,5-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules [PubMed1645727]. The function is modulated by Ca2+, Mg2+, ATP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) [PubMed7829078]. protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the MIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]