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MIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   MIR domain [ 82109]
Families:   MIR domain [ 82110] (2)


Superfamily statistics
Genomes (584) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,322 10,747 2
Proteins 2,602 8,374 2


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.06937Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.247Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.3087Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.3412Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4005Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4079Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6368Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.03089Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.05948Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1155Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0.1226Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1401Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1567Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1773Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.1851Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.187Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.1982Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2236Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Fatigable weakness0.0001688InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.01023InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.02939InformativeInherited
Phenotypic Abnormality (PA)Abnormal tendon morphology0.03362InformativeInherited
Phenotypic Abnormality (PA)Abnormal cerebellum morphology0.03727InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.0758InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.1012InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.2554InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.4013InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.00004267Highly InformativeDirect
Phenotypic Abnormality (PA)Bifid uvula0.00007225Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.00007589Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.0002326Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.0002508Highly InformativeDirect
Phenotypic Abnormality (PA)Respiratory failure0.000613Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.0006619Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomyopathy0.0009242Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.00101Highly InformativeInherited
Phenotypic Abnormality (PA)Cranial nerve paralysis0.002253Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pinna0.02648Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.00004623Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland physiology0.05127InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.001775Moderately InformativeInherited
Fly Phenotype (FP)locomotor behavior defective0.0002834InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.6865Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.0863Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.141Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.001882InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.006599InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003608 SSF82109 Protein matches
Abstract This is a domain found in ryanodine, inositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1,4,5-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules [PubMed1645727]. The function is modulated by Ca2+, Mg2+, ATP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) [PubMed7829078]. protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the MIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]