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MIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   MIR domain [ 82109]
Families:   MIR domain [ 82110] (2)


Superfamily statistics
Genomes (582) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,281 8,598 2
Proteins 2,572 6,795 2


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular membrane-bounded organelle0.0062140.007084Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.012420.000000000000004679Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0000089860Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0004266 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000000022 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000002109 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000007508 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00005599 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00009648 Least Informative Direct
Biological Process (BP) biological regulation 0.0003221 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0006517 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.01206 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) ion transport 0.0000000000004061 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000002461 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000005209 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000001763 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000006159 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.1395 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.02734 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.001757 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1411 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1192 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.01586 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.101 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001409 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.141 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3339 Moderately Informative Inherited
Biological Process (BP) system development 0.08046 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.003444 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02651 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.07401 Moderately Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) ion homeostasis 0 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) transmembrane transport 0.00000000004317 Informative Direct
Biological Process (BP) regulation of system process 0.0000000001962 Informative Direct
Biological Process (BP) protein oligomerization 0.000000001454 Informative Direct
Biological Process (BP) response to metal ion 0.000000002208 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0000002792 Informative Direct
Biological Process (BP) system process 0.000001762 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000001801 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.000006286 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0001014 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0002526 Informative Direct
Biological Process (BP) circulatory system development 0.0004794 Informative Direct
Biological Process (BP) cellular response to inorganic substance 0.0006244 Informative Direct
Biological Process (BP) cell development 0.07967 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.06464 Informative Inherited
Biological Process (BP) tissue development 0.1385 Informative Inherited
Biological Process (BP) regulation of secretion 0.01051 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.0463 Informative Inherited
Biological Process (BP) growth 0.00244 Informative Inherited
Biological Process (BP) cell death 0.005234 Informative Inherited
Biological Process (BP) divalent metal ion transport 0 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000000000001639 Highly Informative Direct
Biological Process (BP) muscle system process 0.0000000004088 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.000000003185 Highly Informative Direct
Biological Process (BP) muscle structure development 0.00000001132 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000009508 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000007068 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000009534 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00001825 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.00004461 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00000004782 Least Informative Direct
Molecular Function (MF) binding 0.02362 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000001716 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.07392 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.009638 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.002907 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) phospholipid binding 0.02781 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.001823 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.002056 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.5544 Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0000003968 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0001367 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000000004679 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000009182 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.007084 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.001725 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.001095 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.3047 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.5845 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.0359 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.9956 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) transporter complex 0.000002175 Informative Direct
Cellular Component (CC) supramolecular polymer 0.000006323 Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) myofibril 0.000000002383 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.000004415 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.00002957 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Pace of progression0.04403Moderately InformativeInherited
Slow progression0.0005768InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1772Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2429Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3335Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.3571Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4276Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.5786Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6192Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.01523Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.1532Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1604Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1797Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.2175Moderately InformativeInherited
Phenotypic Abnormality (PA)Decreased facial expression0.00007357InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0001202InformativeDirect
Phenotypic Abnormality (PA)Proximal muscle weakness0.0001338InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.0007308InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hip bone0.01024InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.0119InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.02627InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.02975InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal muscles0.03369InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebellum0.08901InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.1639InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.3043InformativeInherited
Phenotypic Abnormality (PA)Myopathic facies0.000000968Highly InformativeDirect
Phenotypic Abnormality (PA)Myalgia0.0001915Highly InformativeDirect
Phenotypic Abnormality (PA)Hip dislocation0.000345Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle cramps0.0003556Highly InformativeDirect
Phenotypic Abnormality (PA)Skeletal muscle hypertrophy0.0003817Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0004817Highly InformativeDirect
Phenotypic Abnormality (PA)Neonatal hypotonia0.0005631Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cranial nerves0.004142Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.00004634Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland physiology0.05187InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)behavior defective0.000644Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1253Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell0.4701Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle0.01865InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle cell0.0003305Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000000000001495Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000003237Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0.0002797Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0.0001706Least InformativeDirect
Post-translational modificationS-nitrosylation0.000000955InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein glycosylation0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR003608 SSF82109 Protein matches
Abstract This is a domain found in ryanodine, inositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1,4,5-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules [PubMed1645727]. The function is modulated by Ca2+, Mg2+, ATP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) [PubMed7829078]. protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]