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DPP6 N-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   DPP6 N-terminal domain-like [ 82171]
Families:   DPP6 N-terminal domain-like [ 82172] (2)


Superfamily statistics
Genomes (2,019) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,629 27,656 18
Proteins 11,284 26,942 18


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.02893 Least Informative Inherited
Biological Process (BP) biological regulation 0.7878 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.219 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.6767 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.7248 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.658 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.0004694 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0008842 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.06769 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.802 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9742 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.003273 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.01264 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.3677 Moderately Informative Inherited
Biological Process (BP) immune system process 0.3447 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.03825 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01786 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.01012 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.008356 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.007305 Moderately Informative Inherited
Biological Process (BP) gene expression 0.007502 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.3136 Moderately Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.000000000136 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00000001673 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.000002157 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000004848 Informative Direct
Biological Process (BP) proteolysis 0.0001436 Informative Direct
Biological Process (BP) regulation of ion transport 0.0001807 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0003544 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.01407 Informative Inherited
Biological Process (BP) locomotion 0.03504 Informative Inherited
Biological Process (BP) ribonucleoprotein complex biogenesis 0.001623 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.001592 Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.00000003411 Highly Informative Direct
Biological Process (BP) translational initiation 0.0000005716 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000001059 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.00002703 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.00003157 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0002733 Highly Informative Direct
Biological Process (BP) cell projection organization 0.07326 Highly Informative Inherited
Biological Process (BP) cell migration 0.007194 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000005571 Least Informative Direct
Molecular Function (MF) binding 0.7872 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0005737 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.001243 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.00000000004179 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00004069 Informative Direct
Molecular Function (MF) identical protein binding 0.0000424 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.3731 Informative Inherited
Molecular Function (MF) enzyme binding 0.03364 Informative Inherited
Molecular Function (MF) translation factor activity, RNA binding 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0001055 Highly Informative Direct
Cellular Component (CC) membrane 0.8844 Least Informative Inherited
Cellular Component (CC) protein complex 0.00364 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.03582 Least Informative Inherited
Cellular Component (CC) cell projection 0.00004692 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.6664 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.2407 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.3397 Moderately Informative Inherited
Cellular Component (CC) cell projection part 0.0000001458 Informative Direct
Cellular Component (CC) plasma membrane region 0.00005846 Informative Direct
Cellular Component (CC) cell surface 0.0004362 Informative Direct
Cellular Component (CC) transporter complex 0.006241 Informative Inherited
Cellular Component (CC) lamellipodium 0.00001598 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0001378 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0287 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5293Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.001884Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1623Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0000003622InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.007163InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.0006008Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09988Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1086Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1351Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1551Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.1944Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the foot0.009155Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.01504Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.02752Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.03644Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.04433Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.04901Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.08406Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.1318Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1981Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.4016Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.01056InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01274InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb bone0.1001InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.1479InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.2643InformativeInherited
Phenotypic Abnormality (PA)Broad toe0.000007347Highly InformativeDirect
Phenotypic Abnormality (PA)Protruding ear0.00004266Highly InformativeDirect
Phenotypic Abnormality (PA)Reduced number of teeth0.0005396Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of globe location0.08971Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.0000001887Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.0000000000006238Moderately InformativeDirect
Biological processProtein biosynthesis0.000000000001305InformativeDirect
Biological processCell adhesion0.00000000002225InformativeDirect
Biological processTranslation regulation0.00007542InformativeDirect
Biological processCilium biogenesis/degradation0.0000000584Highly InformativeDirect
Cellular componentMembrane0.000000003232Least InformativeDirect
Cellular componentCell projection0.00000000001254Moderately InformativeDirect
Cellular componentSecreted0.000000001021Moderately InformativeDirect
Cellular componentCell junction0.0000007014Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentPeriplasm0.00007848InformativeDirect
DomainTransmembrane0.05186Least InformativeInherited
DomainSignal-anchor0InformativeDirect
DomainWD repeat0InformativeDirect
Molecular functionRNA-binding0.0004494Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DPP6 N-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the DPP6 N-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]