SUPERFAMILY 1.75 HMM library and genome assignments server


DPP6 N-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   DPP6 N-terminal domain-like [ 82171]
Families:   DPP6 N-terminal domain-like [ 82172] (2)


Superfamily statistics
Genomes (1,594) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 9,979 16,973 18
Proteins 9,685 16,522 18


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.9327 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4684 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.03524 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.715 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3012 Least Informative Inherited
Biological Process (BP) localization 0.3488 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.0002706 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.05553 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.002245 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9134 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8228 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2534 Moderately Informative Inherited
Biological Process (BP) system process 0.2111 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02223 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0139 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.003918 Moderately Informative Inherited
Biological Process (BP) gene expression 0.005098 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.0299 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.3662 Moderately Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1.237e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 2.702e-05 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.003261 Informative Inherited
Biological Process (BP) regulation of ion transport 0.003008 Informative Inherited
Biological Process (BP) localization of cell 0.002266 Informative Inherited
Biological Process (BP) cellular component movement 0.006012 Informative Inherited
Biological Process (BP) locomotion 0.006951 Informative Inherited
Biological Process (BP) regulation of translation 6.704e-12 Highly Informative Direct
Biological Process (BP) translational initiation 6.28e-09 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.699e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 7.749e-05 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0004978 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0002226 Least Informative Direct
Molecular Function (MF) binding 0.7932 Least Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.0008839 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.00111 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) RNA binding 1.421e-12 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0002138 Informative Direct
Molecular Function (MF) enzyme binding 0.002988 Informative Inherited
Molecular Function (MF) translation factor activity, nucleic acid binding 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 3.07e-15 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 8.727e-06 Highly Informative Direct
Cellular Component (CC) membrane 0.626 Least Informative Inherited
Cellular Component (CC) protein complex 0.03894 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01198 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2557 Least Informative Inherited
Cellular Component (CC) cell projection 4.831e-06 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.9466 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.04074 Moderately Informative Inherited
Cellular Component (CC) cell projection part 2.09e-08 Informative Direct
Cellular Component (CC) cell leading edge 2.65e-06 Informative Direct
Cellular Component (CC) lamellipodium 2.343e-05 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 2.924e-05 Highly Informative Direct
Cellular Component (CC) cell projection membrane 6.441e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.6546Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.008876Moderately InformativeInherited
Disease Ontology (DO)meningioma1.784e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant3.345e-06Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.136e-06InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.4749Least InformativeInherited
Plant ANatomical entity (PAN)guard cell0.0009556Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInitiation factor0InformativeDirect
Biological processVirulence3.656e-14InformativeDirect
Biological processCell adhesion6.21e-08InformativeDirect
Biological processTranslation regulation3.971e-05InformativeDirect
Biological processCilium biogenesis/degradation5.221e-09Highly InformativeDirect
Cellular componentMembrane4.636e-10Least InformativeDirect
Cellular componentCell projection1.531e-13Moderately InformativeDirect
Cellular componentSecreted6.29e-09Moderately InformativeDirect
Cellular componentCell junction5.335e-07Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainTransmembrane0.143Least InformativeInherited
DomainSignal-anchor0Moderately InformativeDirect
DomainWD repeat0InformativeDirect
Molecular functionRNA-binding0.0001284Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DPP6 N-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the DPP6 N-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]