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DPP6 N-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   DPP6 N-terminal domain-like [ 82171]
Families:   DPP6 N-terminal domain-like [ 82172] (2)


Superfamily statistics
Genomes (2,026) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,770 63,553 18
Proteins 11,423 61,685 18


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.8961 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.03539 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6379 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.05632 Least Informative Inherited
Biological Process (BP) biological regulation 0.7801 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2648 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8462 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.0001976 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.009637 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.5641 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001662 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6557 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4528 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02544 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.004106 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.004184 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001136 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.02089 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.002297 Moderately Informative Inherited
Biological Process (BP) gene expression 0.007393 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.3213 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.005744 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00007936 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000000002208 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.00000000003177 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00004278 Informative Direct
Biological Process (BP) ribosome biogenesis 0.0005314 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00001241 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0006066 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0000002216 Informative Direct
Biological Process (BP) regulation of ion transport 0.001945 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.01954 Informative Inherited
Biological Process (BP) locomotion 0.05275 Informative Inherited
Biological Process (BP) localization of cell 0.08584 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.003676 Informative Inherited
Biological Process (BP) translational initiation 0.0000004543 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000001002 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0003371 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0002933 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.00003228 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.0000346 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.00000008606 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.002995 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.04716 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000008139 Least Informative Direct
Molecular Function (MF) binding 0.8722 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0008654 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.001404 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.00000000002438 Informative Direct
Molecular Function (MF) identical protein binding 0.00001161 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0001271 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.3632 Informative Inherited
Molecular Function (MF) enzyme binding 0.04152 Informative Inherited
Molecular Function (MF) protease binding 0.0000000002972 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0.9525 Least Informative Inherited
Cellular Component (CC) protein complex 0.003746 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01255 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.4058 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.828 Least Informative Inherited
Cellular Component (CC) cell projection 0.00007666 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.6771 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.2855 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.5532 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.478 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.0005871 Informative Direct
Cellular Component (CC) plasma membrane region 0.00008641 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.0005634 Informative Direct
Cellular Component (CC) transporter complex 0.008254 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.1083 Informative Inherited
Cellular Component (CC) lamellipodium 0.00002755 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0001325 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.3072 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.007572 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.00000000000082Moderately InformativeDirect
Biological processProtein biosynthesis0.00000000000111InformativeDirect
Biological processCell adhesion0.00000000002293InformativeDirect
Biological processTranslation regulation0.00008108InformativeDirect
Biological processCilium biogenesis/degradation0.00000008271Highly InformativeDirect
Cellular componentMembrane0.000000003987Least InformativeDirect
Cellular componentCell projection0.00000000003344Moderately InformativeDirect
Cellular componentSecreted0.000000001609Moderately InformativeDirect
Cellular componentCell junction0.0000007929Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentPeriplasm0.00007582InformativeDirect
DomainTransmembrane0.05281Least InformativeInherited
DomainSignal-anchor0InformativeDirect
DomainWD repeat0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationRNA-binding0.0004175Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DPP6 N-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the DPP6 N-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]