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DPP6 N-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   DPP6 N-terminal domain-like [ 82171]
Families:   DPP6 N-terminal domain-like [ 82172] (2)


Superfamily statistics
Genomes (2,024) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,705 63,553 18
Proteins 11,358 61,685 18


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2468 Least Informative Inherited
Biological Process (BP) biological regulation 0.7376 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.06797 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6926 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.04304 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8782 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.0002534 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00161 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.678 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.00126 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4382 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.563 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01068 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02495 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.004341 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.004472 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.02008 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.002407 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.006519 Moderately Informative Inherited
Biological Process (BP) gene expression 0.00701 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.3332 Moderately Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.00000000004551 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000000003233 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00004294 Informative Direct
Biological Process (BP) proteolysis 0.0001094 Informative Direct
Biological Process (BP) membrane organization 0.0002277 Informative Direct
Biological Process (BP) ribosome biogenesis 0.0005965 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0006022 Informative Direct
Biological Process (BP) organelle assembly 0.000925 Informative Direct
Biological Process (BP) regulation of ion transport 0.002006 Informative Inherited
Biological Process (BP) locomotion 0.04465 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.002835 Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.0000000933 Highly Informative Direct
Biological Process (BP) translational initiation 0.0000005613 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00000126 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.00003295 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.00003831 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0003225 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0003553 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.04181 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.002797 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000001184 Least Informative Direct
Molecular Function (MF) binding 0.8156 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0007627 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.001187 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.00000000003349 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00009342 Informative Direct
Molecular Function (MF) identical protein binding 0.0001113 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.3835 Informative Inherited
Molecular Function (MF) enzyme binding 0.04341 Informative Inherited
Molecular Function (MF) translation factor activity, RNA binding 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) protease binding 0.0000000002253 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0001217 Highly Informative Direct
Cellular Component (CC) macromolecular complex 0.0005167 Least Informative Direct
Cellular Component (CC) membrane 0.9629 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01518 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.4068 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8312 Least Informative Inherited
Cellular Component (CC) cell projection 0.000059 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.2793 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.6761 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.5809 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.4527 Moderately Informative Inherited
Cellular Component (CC) plasma membrane region 0.00009017 Informative Direct
Cellular Component (CC) cell surface 0.0005179 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.0006713 Informative Direct
Cellular Component (CC) transporter complex 0.00794 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.1103 Informative Inherited
Cellular Component (CC) lamellipodium 0.00001975 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0001664 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.3027 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.008074 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5293Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.001907Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1611Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0000004004InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.007077InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.0006033Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.101Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1094Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1362Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1552Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.1948Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the foot0.009322Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.01518Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.0282Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.0368Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.04476Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.04899Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.08406Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.1319Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1851Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.4192Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.01062InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01287InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb bone0.1006InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.1508InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.1817InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.2633InformativeInherited
Phenotypic Abnormality (PA)Broad toe0.00000844Highly InformativeDirect
Phenotypic Abnormality (PA)Protruding ear0.00004342Highly InformativeDirect
Phenotypic Abnormality (PA)Pneumonia0.0001922Highly InformativeDirect
Phenotypic Abnormality (PA)Reduced number of teeth0.0005631Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of globe location0.09117Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.0000001876Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.0000000000006702Moderately InformativeDirect
Biological processProtein biosynthesis0.000000000001217InformativeDirect
Biological processCell adhesion0.00000000002233InformativeDirect
Biological processTranslation regulation0.00008149InformativeDirect
Biological processCilium biogenesis/degradation0.00000008152Highly InformativeDirect
Cellular componentMembrane0.00000000328Least InformativeDirect
Cellular componentCell projection0.0000000000295Moderately InformativeDirect
Cellular componentSecreted0.000000001041Moderately InformativeDirect
Cellular componentCell junction0.000000773Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentPeriplasm0.00007771InformativeDirect
DomainTransmembrane0.05512Least InformativeInherited
DomainSignal-anchor0InformativeDirect
DomainWD repeat0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationRNA-binding0.0004356Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DPP6 N-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the DPP6 N-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]