SUPERFAMILY 1.75 HMM library and genome assignments server

DPP6 N-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   DPP6 N-terminal domain-like [ 82171]
Families:   DPP6 N-terminal domain-like [ 82172] (2)


Superfamily statistics
Genomes (2,018) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,632 27,656 18
Proteins 11,287 26,942 18


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.9155 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.779 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8045 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.02189 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.9386 Least Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5841 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.897 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1607 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.003154 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6738 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1644 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1697 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.03956 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.06504 Moderately Informative Inherited
Biological Process (BP) gene expression 0.006081 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2118 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.0000002271 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0008163 Informative Direct
Biological Process (BP) positive regulation of transport 0.006215 Informative Inherited
Biological Process (BP) regulation of cell activation 0.001746 Informative Inherited
Biological Process (BP) cell projection organization 0.09656 Informative Inherited
Biological Process (BP) regulation of ion transport 0.00389 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.03246 Informative Inherited
Biological Process (BP) neurological system process 0.05708 Informative Inherited
Biological Process (BP) cellular component movement 0.00544 Informative Inherited
Biological Process (BP) localization of cell 0.017 Informative Inherited
Biological Process (BP) locomotion 0.05507 Informative Inherited
Biological Process (BP) regulation of translation 0.00000000007146 Highly Informative Direct
Biological Process (BP) translational initiation 0.00000004089 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.000000822 Highly Informative Direct
Biological Process (BP) cilium organization 0.000006699 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00003191 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0001308 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0001338 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0008137 Highly Informative Direct
Biological Process (BP) regulation of ion transmembrane transport 0.00641 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00006267 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.005922 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) RNA binding 0.00000001105 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0006964 Informative Direct
Molecular Function (MF) enzyme binding 0.02815 Informative Inherited
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0004281 Highly Informative Direct
Cellular Component (CC) membrane 0.9589 Least Informative Inherited
Cellular Component (CC) protein complex 0.0149 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.06606 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.0002351 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0734 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.4233 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0.000008877 Informative Direct
Cellular Component (CC) intraciliary transport particle 0.000000000009343 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.000000755 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0002556 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5144Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.001899Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1662Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0000004995InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.007738InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.000003345Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001136InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.00000000000009165InformativeDirect
Biological processProtein biosynthesis0.0000000000004154InformativeDirect
Biological processCell adhesion0.00000003371InformativeDirect
Biological processTranslation regulation0.00004686InformativeDirect
Biological processCilium biogenesis/degradation0.0000000122Highly InformativeDirect
Cellular componentMembrane0.0000000003849Least InformativeDirect
Cellular componentCell projection0.00000000000136Moderately InformativeDirect
Cellular componentSecreted0.000000006618Moderately InformativeDirect
Cellular componentCell junction0.000001115Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainTransmembrane0.04194Least InformativeInherited
DomainSignal-anchor0InformativeDirect
DomainWD repeat0InformativeDirect
Molecular functionRNA-binding0.0001658Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DPP6 N-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the DPP6 N-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]