SUPERFAMILY 1.75 HMM library and genome assignments server


DPP6 N-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   DPP6 N-terminal domain-like [ 82171]
Families:   DPP6 N-terminal domain-like [ 82172] (2)


Superfamily statistics
Genomes (2,016) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,599 27,656 18
Proteins 11,256 26,942 18


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.873 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7171 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.03136 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.8881 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.0006759 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.1382 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3972 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6723 Moderately Informative Inherited
Biological Process (BP) system process 0.3924 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1238 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.09921 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.06982 Moderately Informative Inherited
Biological Process (BP) gene expression 0.01831 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2062 Moderately Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 2.672e-07 Informative Direct
Biological Process (BP) translation 6.194e-05 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0004385 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.01918 Informative Inherited
Biological Process (BP) cell projection organization 0.09285 Informative Inherited
Biological Process (BP) regulation of ion transport 0.003632 Informative Inherited
Biological Process (BP) positive regulation of transport 0.004357 Informative Inherited
Biological Process (BP) cellular component movement 0.005401 Informative Inherited
Biological Process (BP) localization of cell 0.01627 Informative Inherited
Biological Process (BP) locomotion 0.05473 Informative Inherited
Biological Process (BP) regulation of translation 7.442e-11 Highly Informative Direct
Biological Process (BP) translational initiation 4.143e-08 Highly Informative Direct
Biological Process (BP) cilium organization 4.018e-06 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 9.259e-06 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 8.511e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000119 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0001277 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.003332 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0001384 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.005574 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) RNA binding 2.719e-09 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0006715 Informative Direct
Molecular Function (MF) enzyme binding 0.02482 Informative Inherited
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 8.007e-16 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0004304 Highly Informative Direct
Cellular Component (CC) membrane 0.9636 Least Informative Inherited
Cellular Component (CC) protein complex 0.03428 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.2128 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8879 Least Informative Inherited
Cellular Component (CC) cell projection 1.246e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.4123 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 8.578e-06 Informative Direct
Cellular Component (CC) intraflagellar transport particle 9.28e-12 Highly Informative Direct
Cellular Component (CC) cell projection membrane 1.199e-05 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0002562 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5071Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.001717Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1638Moderately InformativeInherited
Disease Ontology (DO)meningioma4.992e-07InformativeDirect
Disease Ontology (DO)chronic leukemia0.004102InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.007247InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.000592Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant3.345e-06Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.136e-06InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence9.215e-14InformativeDirect
Biological processProtein biosynthesis4.207e-13InformativeDirect
Biological processCell adhesion3.349e-08InformativeDirect
Biological processTranslation regulation4.669e-05InformativeDirect
Biological processCilium biogenesis/degradation1.123e-08Highly InformativeDirect
Cellular componentMembrane3.63e-10Least InformativeDirect
Cellular componentCell projection1.242e-12Moderately InformativeDirect
Cellular componentSecreted6.714e-09Moderately InformativeDirect
Cellular componentCell junction1.109e-06Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainTransmembrane0.04241Least InformativeInherited
DomainSignal-anchor0InformativeDirect
DomainWD repeat0InformativeDirect
Molecular functionRNA-binding0.000163Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DPP6 N-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the DPP6 N-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]