SUPERFAMILY 1.75 HMM library and genome assignments server

Polo-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Polo-box domain [ 82614]
Superfamily:   Polo-box domain [ 82615] (2)
Families:   Polo-box duplicated region [ 102856]
  Swapped Polo-box domain [ 82616]


Superfamily statistics
Genomes (405) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,599 1,828 7
Proteins 935 1,062 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000000002089 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000000000354 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000003514 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000000963 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00002226 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.00008612 Least Informative Direct
Biological Process (BP) localization 0.1935 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02022 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.03269 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.0544 Least Informative Inherited
Biological Process (BP) single-organism organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000000003262 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000000005075 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000005168 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000108 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00003049 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00003436 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00004567 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00006821 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0001031 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0007209 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0009818 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.2296 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.132 Moderately Informative Inherited
Biological Process (BP) organ development 0.9253 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2775 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.03099 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.03393 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08231 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8412 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001982 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.1122 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1774 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1427 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000000000000003707 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000000000004343 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000009465 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000002223 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000000005194 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000006662 Informative Direct
Biological Process (BP) cell division 0.00000005293 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00000008511 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000001011 Informative Direct
Biological Process (BP) organelle assembly 0.000003136 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00001135 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.00001172 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00002002 Informative Direct
Biological Process (BP) embryonic organ development 0.00002955 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0000439 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00009215 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0001137 Informative Direct
Biological Process (BP) organelle fission 0.0002598 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0004701 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.1553 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01261 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.4527 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.009748 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.09787 Informative Inherited
Biological Process (BP) single organism reproductive process 0.008711 Informative Inherited
Biological Process (BP) reproductive structure development 0.007889 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) nuclear division 0.000000000000003707 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.000000000000003707 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00000000008519 Highly Informative Direct
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.0000000007281 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.000000001497 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.000000006006 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.00000001243 Highly Informative Direct
Biological Process (BP) placenta development 0.0000003032 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000008062 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000009056 Highly Informative Direct
Biological Process (BP) in utero embryonic development 0.000005299 Highly Informative Direct
Biological Process (BP) spindle organization 0.000005466 Highly Informative Direct
Biological Process (BP) positive regulation of cell division 0.00001487 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00007698 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.0001182 Highly Informative Direct
Biological Process (BP) cytokinesis 0.09782 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.2259 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.3561 Highly Informative Inherited
Biological Process (BP) DNA integrity checkpoint 0.9638 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.05035 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) protein complex binding 0.0002318 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0022 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.001365 Informative Inherited
Molecular Function (MF) tubulin binding 0.0000001944 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00006207 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000000000000118 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000001938 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7038 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6381 Least Informative Inherited
Cellular Component (CC) protein complex 0.008529 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000000001724 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0 Informative Direct
Cellular Component (CC) chromosome 0.1244 Informative Inherited
Cellular Component (CC) microtubule organizing center 0 Highly Informative Direct
Cellular Component (CC) midbody 0.0000000000007901 Highly Informative Direct
Cellular Component (CC) chromosome, centromeric region 0.000000000002614 Highly Informative Direct
Cellular Component (CC) spindle 0.0000000271 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0000000000008382Moderately InformativeDirect
Biological processMitosis0.000000007277InformativeDirect
Cellular componentCytoplasm0.0000000001188Least InformativeDirect
Cellular componentNucleus0.00000008207Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.0000022Moderately InformativeDirect
Cellular componentChromosome0.000004754InformativeDirect
DiseaseTumor suppressor0.0000000001225Moderately InformativeDirect
DomainRepeat0.0000000000000801Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Polo-box domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Polo-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]