SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Polo-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Polo-box domain [ 82614]
Superfamily:   Polo-box domain [ 82615] (2)
Families:   Polo-box duplicated region [ 102856]
  Swapped Polo-box domain [ 82616]


Superfamily statistics
Genomes (413) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,659 4,020 7
Proteins 967 2,314 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000000000001185 Least Informative Direct
Biological Process (BP) biological regulation 0.00000001312 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000001467 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000004782 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00001414 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.001222 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006841 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.001258 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000000000009222 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000001882 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000689 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000002381 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00001458 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00003766 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00009812 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0005421 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.09636 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1409 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.08229 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02454 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.9507 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4052 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1976 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.5403 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6971 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6143 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2504 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2329 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.2385 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.002019 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2156 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.193 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1981 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6304 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000000000004293 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000000671 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0000000001568 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000001089 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000002429 Informative Direct
Biological Process (BP) regulation of cellular localization 0.000007838 Informative Direct
Biological Process (BP) epithelium development 0.000007881 Informative Direct
Biological Process (BP) single organism reproductive process 0.000009127 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000009204 Informative Direct
Biological Process (BP) regulation of protein localization 0.00001718 Informative Direct
Biological Process (BP) organelle assembly 0.00002074 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00007935 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.0001121 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.0001616 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0001765 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0002312 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0003322 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0003552 Informative Direct
Biological Process (BP) reproductive system development 0.0004923 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0005907 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0008759 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.05021 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.8782 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01115 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.005976 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.002575 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.04434 Informative Inherited
Biological Process (BP) embryo development 0.001048 Informative Inherited
Biological Process (BP) chromosome organization 0.7064 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0 Highly Informative Direct
Biological Process (BP) nuclear division 0.0000000000002963 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00000000005742 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000000001323 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0.000000002929 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000007244 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0000001402 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0000008742 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.000003763 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000009419 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00002589 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.00004189 Highly Informative Direct
Biological Process (BP) nucleus organization 0.00006513 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00007104 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.0001987 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0008027 Highly Informative Direct
Biological Process (BP) cytokinesis 0.05238 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04374 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.09608 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.7349 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.7926 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.00669 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.06505 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.1091 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0003032 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.001849 Informative Inherited
Molecular Function (MF) tubulin binding 0.0000001767 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000135 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000001917 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.6539 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9872 Least Informative Inherited
Cellular Component (CC) protein complex 0.01652 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000000001859 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0009498 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1051 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.04039 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0 Informative Direct
Cellular Component (CC) neuron projection 0.0007862 Informative Direct
Cellular Component (CC) chromosome 0.07107 Informative Inherited
Cellular Component (CC) microtubule organizing center 0.00000000000001309 Highly Informative Direct
Cellular Component (CC) midbody 0.000000000001748 Highly Informative Direct
Cellular Component (CC) kinetochore 0.00000008047 Highly Informative Direct
Cellular Component (CC) spindle 0.000002224 Highly Informative Direct
Cellular Component (CC) dendrite 0.000007187 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.00000000000004829Moderately InformativeDirect
Biological processMitosis0.000000002881InformativeDirect
Cellular componentCytoplasm0.000000000002377Least InformativeDirect
Cellular componentNucleus0.0000001527Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.00001453Moderately InformativeDirect
Cellular componentChromosome0.00000001495InformativeDirect
Cellular componentKinetochore0.000000000000001304Highly InformativeDirect
Cellular componentCentromere0.00000000000004847Highly InformativeDirect
DiseaseTumor suppressor0.000001428Moderately InformativeDirect
DomainRepeat0.0000000000001394Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Polo-box domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Polo-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]