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Polo-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Polo-box domain [ 82614]
Superfamily:   Polo-box domain [ 82615] (2)
Families:   Polo-box duplicated region [ 102856]
  Swapped Polo-box domain [ 82616]


Superfamily statistics
Genomes (411) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,619 4,020 7
Proteins 945 2,314 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000000000001267 Least Informative Direct
Biological Process (BP) biological regulation 0.00000001342 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000001625 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000682 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00001955 Least Informative Direct
Biological Process (BP) primary metabolic process 0.001712 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006406 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000000000124 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000001819 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000007758 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00001603 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00004545 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001037 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001096 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.2116 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1981 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4201 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2493 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1017 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.004569 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.02919 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.5503 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.7033 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6214 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1408 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2319 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.2497 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2195 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.08242 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6227 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2027 Moderately Informative Inherited
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000000000005537 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000007433 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0000000001424 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000001291 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000003031 Informative Direct
Biological Process (BP) regulation of cellular localization 0.000008417 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000108 Informative Direct
Biological Process (BP) organelle assembly 0.00001677 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00008657 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.0001218 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.0001737 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0001796 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002509 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.000304 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0003881 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000594 Informative Direct
Biological Process (BP) reproductive system development 0.0006318 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0008822 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.05066 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.8689 Informative Inherited
Biological Process (BP) tissue development 0.0238 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.007217 Informative Inherited
Biological Process (BP) embryo development 0.001076 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.001565 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.04221 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01144 Informative Inherited
Biological Process (BP) membrane organization 0.1025 Informative Inherited
Biological Process (BP) chromosome organization 0.709 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.00000000000002124 Highly Informative Direct
Biological Process (BP) nuclear division 0.0000000000003926 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000000001337 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000000008368 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000000844 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0000001457 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0000009582 Highly Informative Direct
Biological Process (BP) cell division 0.0000021 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.000004266 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000009202 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000009765 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00003281 Highly Informative Direct
Biological Process (BP) nucleus organization 0.00006414 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0000822 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.00009949 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0009486 Highly Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.08432 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.1812 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.7883 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.003291 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.06694 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.09228 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00032 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.001987 Informative Inherited
Molecular Function (MF) tubulin binding 0.0000001868 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00001204 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000002108 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.6792 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9844 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.5681 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000000001144 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0009383 Moderately Informative Direct
Cellular Component (CC) cell projection 0.09714 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.03849 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0 Informative Direct
Cellular Component (CC) neuron projection 0.0006852 Informative Direct
Cellular Component (CC) chromosome 0.07979 Informative Inherited
Cellular Component (CC) microtubule organizing center 0.00000000000002918 Highly Informative Direct
Cellular Component (CC) midbody 0.000000000002017 Highly Informative Direct
Cellular Component (CC) kinetochore 0.0000001012 Highly Informative Direct
Cellular Component (CC) spindle 0.0000024 Highly Informative Direct
Cellular Component (CC) dendrite 0.000005397 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.00000000000004775Moderately InformativeDirect
Biological processMitosis0.000000002189InformativeDirect
Cellular componentCytoplasm0.000000000002647Least InformativeDirect
Cellular componentNucleus0.0000001463Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.00001384Moderately InformativeDirect
Cellular componentChromosome0.0000000149InformativeDirect
Cellular componentKinetochore0.000000000000001304Highly InformativeDirect
Cellular componentCentromere0.0000000000000477Highly InformativeDirect
DiseaseTumor suppressor0.000001466Moderately InformativeDirect
DomainRepeat0.0000000000001363Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Polo-box domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Polo-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]