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Polo-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Polo-box domain [ 82614]
Superfamily:   Polo-box domain [ 82615] (2)
Families:   Polo-box duplicated region [ 102856]
  Swapped Polo-box domain [ 82616]


Superfamily statistics
Genomes (404) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,597 1,828 7
Proteins 934 1,062 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000000001086 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000000000002825 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000000006656 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00000008034 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00002164 Least Informative Direct
Biological Process (BP) developmental process 0.0328 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.07275 Least Informative Inherited
Biological Process (BP) localization 0.1771 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02023 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.00000000000093 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000000004953 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000000504 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000002326 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000003794 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00002804 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00003063 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00004916 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00006183 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00008338 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.01122 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.03451 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2479 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8415 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2288 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0204 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1288 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.05648 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.162 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.1446 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1392 Moderately Informative Inherited
Biological Process (BP) organ development 0.9407 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00000000000005747 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000002575 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000001057 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000000003878 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00000006689 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.000003474 Informative Direct
Biological Process (BP) embryonic organ development 0.000007827 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00001078 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.0000216 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.00004415 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0001288 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0001952 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0003025 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0006234 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.1549 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01292 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.004324 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.5566 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00000000000002119 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000000000000327 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0000000003035 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.0000000003742 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.000000004586 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.00000000626 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.00000001069 Highly Informative Direct
Biological Process (BP) placenta development 0.000000121 Highly Informative Direct
Biological Process (BP) cell division 0.000001738 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000002067 Highly Informative Direct
Biological Process (BP) spindle organization 0.000005852 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 0.0001357 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.0001642 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0007975 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.0326 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.3632 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.04765 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.002214 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.001332 Informative Inherited
Molecular Function (MF) tubulin binding 0.0000001912 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00006352 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.000000000000008984 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000002721 Least Informative Direct
Cellular Component (CC) protein complex 0.000009089 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.6797 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7738 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000000001925 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0 Informative Direct
Cellular Component (CC) chromosome 0.1502 Informative Inherited
Cellular Component (CC) centrosome 0 Highly Informative Direct
Cellular Component (CC) midbody 0.0000000000006236 Highly Informative Direct
Cellular Component (CC) spindle 0.00000000005342 Highly Informative Direct
Cellular Component (CC) kinetochore 0.00000000894 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0000000000008382Moderately InformativeDirect
Biological processMitosis0.000000007277InformativeDirect
Cellular componentCytoplasm0.0000000001188Least InformativeDirect
Cellular componentNucleus0.00000008207Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.0000022Moderately InformativeDirect
Cellular componentChromosome0.000004754InformativeDirect
DiseaseTumor suppressor0.0000000001225Moderately InformativeDirect
DomainRepeat0.0000000000000801Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Polo-box domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Polo-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]