SUPERFAMILY 1.75 HMM library and genome assignments server


Polo-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Polo-box domain [ 82614]
Superfamily:   Polo-box domain [ 82615] (2)
Families:   Polo-box duplicated region [ 102856]
  Swapped Polo-box domain [ 82616]


Superfamily statistics
Genomes (404) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,597 1,828 7
Proteins 934 1,062 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 1.086e-14 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.825e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.656e-13 Least Informative Direct
Biological Process (BP) protein metabolic process 8.034e-08 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.164e-05 Least Informative Direct
Biological Process (BP) developmental process 0.0328 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.07275 Least Informative Inherited
Biological Process (BP) localization 0.1771 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02023 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 9.3e-13 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 4.953e-11 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 5.04e-11 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 2.326e-10 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 3.794e-06 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.804e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.063e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 4.916e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 6.183e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 8.338e-05 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.01122 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.03451 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2479 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8415 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2288 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0204 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1288 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.05648 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.162 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.1446 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1392 Moderately Informative Inherited
Biological Process (BP) organ development 0.9407 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 5.747e-14 Informative Direct
Biological Process (BP) cytoskeleton organization 2.575e-10 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.057e-09 Informative Direct
Biological Process (BP) negative regulation of cell death 3.878e-09 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 6.689e-08 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 3.474e-06 Informative Direct
Biological Process (BP) embryonic organ development 7.827e-06 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1.078e-05 Informative Direct
Biological Process (BP) regulation of cell cycle process 2.16e-05 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 4.415e-05 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0001288 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0001952 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0003025 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0006234 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.1549 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01292 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.004324 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.5566 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 2.119e-14 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 3.27e-13 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 3.035e-10 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 3.742e-10 Highly Informative Direct
Biological Process (BP) chromosome segregation 4.586e-09 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 6.26e-09 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.069e-08 Highly Informative Direct
Biological Process (BP) placenta development 1.21e-07 Highly Informative Direct
Biological Process (BP) cell division 1.738e-06 Highly Informative Direct
Biological Process (BP) cellular component disassembly 2.067e-06 Highly Informative Direct
Biological Process (BP) spindle organization 5.852e-06 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 0.0001357 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.0001642 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0007975 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.0326 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.3632 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.04765 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.002214 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.001332 Informative Inherited
Molecular Function (MF) tubulin binding 1.912e-07 Highly Informative Direct
Molecular Function (MF) protein kinase activity 6.352e-05 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 8.984e-15 Least Informative Direct
Cellular Component (CC) intracellular organelle part 2.721e-10 Least Informative Direct
Cellular Component (CC) protein complex 9.089e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.6797 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7738 Least Informative Inherited
Cellular Component (CC) cytoskeleton 1.925e-11 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0 Informative Direct
Cellular Component (CC) chromosome 0.1502 Informative Inherited
Cellular Component (CC) centrosome 0 Highly Informative Direct
Cellular Component (CC) midbody 6.236e-13 Highly Informative Direct
Cellular Component (CC) spindle 5.342e-11 Highly Informative Direct
Cellular Component (CC) kinetochore 8.94e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle8.382e-13Moderately InformativeDirect
Biological processMitosis7.277e-09InformativeDirect
Cellular componentCytoplasm1.188e-10Least InformativeDirect
Cellular componentNucleus8.207e-08Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection2.2e-06Moderately InformativeDirect
Cellular componentChromosome4.754e-06InformativeDirect
DiseaseTumor suppressor1.225e-10Moderately InformativeDirect
DomainRepeat8.01e-14Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Polo-box domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Polo-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]