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Polo-box domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Polo-box domain [ 82614]
Superfamily:   Polo-box domain [ 82615] (2)
Families:   Polo-box duplicated region [ 102856]
  Swapped Polo-box domain [ 82616]


Superfamily statistics
Genomes (406) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,599 1,828 7
Proteins 934 1,062 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000000000000005508 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000008428 Least Informative Direct
Biological Process (BP) biological regulation 0.00000000405 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000007425 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0006646 Least Informative Direct
Biological Process (BP) response to stimulus 0.006079 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000000000003049 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000001586 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000009658 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00001742 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00003534 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0003549 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.1096 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.02142 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1679 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.007086 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1881 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2083 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.311 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.5758 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.7187 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8735 Moderately Informative Inherited
Biological Process (BP) response to stress 0.006444 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4207 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0783 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.5727 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.2742 Moderately Informative Inherited
Biological Process (BP) signaling 0.006516 Moderately Informative Inherited
Biological Process (BP) cell communication 0.7243 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000000000002179 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000004294 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00000000007063 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000007422 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00000008001 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000001324 Informative Direct
Biological Process (BP) epithelium development 0.000004635 Informative Direct
Biological Process (BP) regulation of cellular localization 0.000004732 Informative Direct
Biological Process (BP) single organism reproductive process 0.000009036 Informative Direct
Biological Process (BP) regulation of protein localization 0.00001054 Informative Direct
Biological Process (BP) organelle assembly 0.00005839 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00006522 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.00008183 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0001231 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0001279 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0001283 Informative Direct
Biological Process (BP) organelle fission 0.0001687 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002297 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0002381 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000496 Informative Direct
Biological Process (BP) reproductive system development 0.0005396 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.0008095 Informative Direct
Biological Process (BP) embryo development 0.0008447 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.04959 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.8932 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.001082 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.00631 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.04634 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01762 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.003361 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000000000005193 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00000000006758 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000000004282 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0000000005469 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000005577 Highly Informative Direct
Biological Process (BP) cell cycle phase transition 0.0000009803 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.000001146 Highly Informative Direct
Biological Process (BP) cell division 0.000001206 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000004737 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000005733 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00004443 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.00004771 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00006504 Highly Informative Direct
Biological Process (BP) nucleus organization 0.0002259 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0007814 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.01603 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.08351 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.1545 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.2897 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.001356 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.08593 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.06811 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.0007878 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0003117 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.002234 Informative Inherited
Molecular Function (MF) tubulin binding 0.0000001391 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000132 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000006401 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.6271 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.639 Least Informative Inherited
Cellular Component (CC) protein complex 0.07487 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000000002582 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.00005219 Moderately Informative Direct
Cellular Component (CC) cell projection 0.07647 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.005742 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0 Informative Direct
Cellular Component (CC) chromosome 0.000000001845 Informative Direct
Cellular Component (CC) neuron projection 0.0002576 Informative Direct
Cellular Component (CC) centrosome 0 Highly Informative Direct
Cellular Component (CC) midbody 0.00000000000101 Highly Informative Direct
Cellular Component (CC) kinetochore 0.00000004718 Highly Informative Direct
Cellular Component (CC) spindle 0.0000009133 Highly Informative Direct
Cellular Component (CC) dendrite 0.000003059 Highly Informative Direct
Cellular Component (CC) nucleolus 0.00001245 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.00000000000004814Moderately InformativeDirect
Biological processMitosis0.000000002018InformativeDirect
Cellular componentCytoplasm0.000000000002561Least InformativeDirect
Cellular componentNucleus0.000000131Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.00001017Moderately InformativeDirect
Cellular componentChromosome0.00000001257InformativeDirect
Cellular componentKinetochore9.774e-16Highly InformativeDirect
Cellular componentCentromere0.00000000000004239Highly InformativeDirect
DiseaseTumor suppressor0.000001594Moderately InformativeDirect
DomainRepeat0.000000000000133Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Polo-box domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Polo-box domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]