SUPERFAMILY 1.75 HMM library and genome assignments server


C-terminal, gelsolin-like domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gelsolin-like [ 55752] (3)
Superfamily:   C-terminal, gelsolin-like domain of Sec23/24 [ 82754]
Families:   C-terminal, gelsolin-like domain of Sec23/24 [ 82755] (2)


Superfamily statistics
Genomes (486) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,084 3,346 4
Proteins 2,906 3,163 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 3.193e-09 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 9.463e-09 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0005091 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.1776 Least Informative Inherited
Biological Process (BP) developmental process 0.05925 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.404 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 1.577e-10 Moderately Informative Direct
Biological Process (BP) cellular localization 1.076e-09 Moderately Informative Direct
Biological Process (BP) regulation of localization 4.673e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.078e-08 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.644e-07 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 7.116e-06 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 7.481e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0003406 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.1555 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6941 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5745 Moderately Informative Inherited
Biological Process (BP) organ development 0.7612 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.05923 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4053 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5485 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01597 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.835 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2627 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1943 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01654 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.5327 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.04533 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1865 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 2.082e-10 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.956e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.098e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 9.937e-07 Informative Direct
Biological Process (BP) positive regulation of transport 5.079e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 7.519e-06 Informative Direct
Biological Process (BP) cellular component disassembly 1.477e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 2.851e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0.0001207 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001618 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.000302 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0256 Informative Inherited
Biological Process (BP) regulation of response to stress 0.05203 Informative Inherited
Biological Process (BP) protein complex assembly 0.2027 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.3043 Informative Inherited
Biological Process (BP) embryonic organ development 0.01049 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.07601 Informative Inherited
Biological Process (BP) organ morphogenesis 0.231 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.04462 Informative Inherited
Biological Process (BP) generation of neurons 0.009128 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1282 Informative Inherited
Biological Process (BP) regulation of cell development 0.4501 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.006626 Informative Inherited
Biological Process (BP) tube development 0.001181 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01933 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.05496 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.04204 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.006795 Informative Inherited
Biological Process (BP) muscle structure development 0.005944 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.005848 Informative Inherited
Biological Process (BP) regulation of locomotion 0.006041 Informative Inherited
Biological Process (BP) organelle localization 0.6024 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01197 Informative Inherited
Biological Process (BP) regulation of secretion 0.001601 Informative Inherited
Biological Process (BP) Golgi vesicle transport 5.327e-12 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 1.667e-09 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 3.15e-09 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 4.073e-09 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1.682e-08 Highly Informative Direct
Biological Process (BP) post-translational protein modification 6.371e-08 Highly Informative Direct
Biological Process (BP) regulation of wound healing 1.992e-07 Highly Informative Direct
Biological Process (BP) protein glycosylation 9.831e-07 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 1.33e-06 Highly Informative Direct
Biological Process (BP) respiratory system development 2.313e-06 Highly Informative Direct
Biological Process (BP) vesicle organization 2.649e-06 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 4.444e-06 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 6.079e-06 Highly Informative Direct
Biological Process (BP) actin filament organization 2.198e-05 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 3.156e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 6.427e-05 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0002542 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000354 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0005177 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0008851 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0009437 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0009709 Highly Informative Direct
Biological Process (BP) muscle organ development 0.002405 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.02907 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.001492 Highly Informative Inherited
Molecular Function (MF) binding 0.02698 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0007419 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0009112 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0274 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 1.543e-08 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 1.601e-06 Informative Direct
Molecular Function (MF) lipid binding 8.099e-05 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0004258 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.003005 Informative Inherited
Molecular Function (MF) actin binding 1.474e-12 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 2.185e-09 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1.079e-08 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.572e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 2.025e-07 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.01917 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 9.517e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.002262 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.04047 Least Informative Inherited
Cellular Component (CC) membrane 0.2617 Least Informative Inherited
Cellular Component (CC) vesicle 1.206e-14 Moderately Informative Direct
Cellular Component (CC) endomembrane system 3.139e-13 Moderately Informative Direct
Cellular Component (CC) organelle membrane 6.097e-09 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 8.323e-07 Moderately Informative Direct
Cellular Component (CC) cell projection 0.007809 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.01729 Moderately Informative Inherited
Cellular Component (CC) coated vesicle 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 5.461e-06 Informative Direct
Cellular Component (CC) cell leading edge 0.0004227 Informative Direct
Cellular Component (CC) Golgi apparatus 0.02226 Informative Inherited
Cellular Component (CC) transport vesicle 0 Highly Informative Direct
Cellular Component (CC) microvillus 7.372e-09 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 2.008e-05 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.117e-05 Highly Informative Direct
Cellular Component (CC) ruffle 6.409e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment size variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm8.02e-11Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection1.816e-07Moderately InformativeDirect
Cellular componentCytoskeleton2.105e-07Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding1.383e-15Least InformativeDirect
Molecular functionCalcium8.5e-12Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0.0005783Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal, gelsolin-like domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal, gelsolin-like domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]