SUPERFAMILY 1.75 HMM library and genome assignments server


C-terminal, gelsolin-like domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gelsolin-like [ 55752] (3)
Superfamily:   C-terminal, gelsolin-like domain of Sec23/24 [ 82754]
Families:   C-terminal, gelsolin-like domain of Sec23/24 [ 82755] (2)


Superfamily statistics
Genomes (444) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,877 2,403 4
Proteins 2,725 2,251 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 3.513e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.537e-07 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.8349 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.003662 Least Informative Inherited
Biological Process (BP) developmental process 0.5533 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9777 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9561 Least Informative Inherited
Biological Process (BP) organelle organization 6.801e-12 Moderately Informative Direct
Biological Process (BP) cellular localization 8.182e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 4.915e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 6.487e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 4.659e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 8.329e-05 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0007606 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.1306 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6255 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4654 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.7749 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.009756 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1582 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1432 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9592 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9108 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1452 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3578 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8642 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.006 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.5334 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.01881 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1331 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 4.912e-11 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.433e-07 Informative Direct
Biological Process (BP) regulation of anatomical structure size 6.105e-07 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 7.945e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 2.137e-06 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.346e-06 Informative Direct
Biological Process (BP) cellular component disassembly 6.404e-06 Informative Direct
Biological Process (BP) protein transport 0.0001485 Informative Direct
Biological Process (BP) cellular membrane organization 0.0004178 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.01807 Informative Inherited
Biological Process (BP) regulation of response to stress 0.03207 Informative Inherited
Biological Process (BP) positive regulation of transport 0.001953 Informative Inherited
Biological Process (BP) regulation of secretion 0.005479 Informative Inherited
Biological Process (BP) generation of neurons 0.0447 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1429 Informative Inherited
Biological Process (BP) regulation of cell development 0.7425 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.006832 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1198 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.05617 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.004027 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001444 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002412 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.132 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01664 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.4684 Informative Inherited
Biological Process (BP) cellular protein complex disassembly 6.073e-10 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 4.895e-09 Highly Informative Direct
Biological Process (BP) post-translational protein modification 5.948e-08 Highly Informative Direct
Biological Process (BP) protein glycosylation 5.38e-07 Highly Informative Direct
Biological Process (BP) actin filament organization 5.381e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 6.292e-07 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 9.969e-07 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 1.394e-06 Highly Informative Direct
Biological Process (BP) vesicle organization 1.563e-06 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 6.188e-06 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 1.009e-05 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 2.2e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 2.879e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 5.07e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron differentiation 0.0001034 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001384 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0003144 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0005675 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0009023 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 0.001998 Highly Informative Inherited
Biological Process (BP) organelle localization 0.1759 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.001389 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.001111 Highly Informative Inherited
Molecular Function (MF) binding 0.3012 Least Informative Inherited
Molecular Function (MF) cation binding 0.0007807 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0037 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.02939 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.01507 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 3.437e-11 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.535e-08 Informative Direct
Molecular Function (MF) lipid binding 1.079e-05 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0001695 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0009856 Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 2.177e-09 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 5.199e-09 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.461e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 2.236e-08 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.02545 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.00919 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2134 Least Informative Inherited
Cellular Component (CC) protein complex 0.349 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01301 Least Informative Inherited
Cellular Component (CC) membrane 0.7779 Least Informative Inherited
Cellular Component (CC) vesicle 2.458e-07 Moderately Informative Direct
Cellular Component (CC) endomembrane system 4.203e-07 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1.525e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 4.911e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0003896 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.01421 Moderately Informative Inherited
Cellular Component (CC) coated vesicle 1.443e-13 Informative Direct
Cellular Component (CC) actin cytoskeleton 4.838e-06 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0001556 Informative Direct
Cellular Component (CC) cell leading edge 0.0002125 Informative Direct
Cellular Component (CC) Golgi apparatus 0.008407 Informative Inherited
Cellular Component (CC) cell projection part 0.002243 Informative Inherited
Cellular Component (CC) transport vesicle 0 Highly Informative Direct
Cellular Component (CC) vesicle membrane 3.63e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 8.422e-09 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 7.451e-07 Highly Informative Direct
Cellular Component (CC) ruffle 0.0001906 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.0005894 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment size variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1.572e-10Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection5.899e-08Moderately InformativeDirect
Cellular componentCytoskeleton1.042e-07Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding2.318e-16Least InformativeDirect
Molecular functionCalcium5.241e-12Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0001297Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal, gelsolin-like domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal, gelsolin-like domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]