SUPERFAMILY 1.75 HMM library and genome assignments server

C-terminal, gelsolin-like domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gelsolin-like [ 55752] (3)
Superfamily:   C-terminal, gelsolin-like domain of Sec23/24 [ 82754]
Families:   C-terminal, gelsolin-like domain of Sec23/24 [ 82755] (2)


Superfamily statistics
Genomes (498) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,226 3,346 4
Proteins 3,031 3,163 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0000000005579 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000002226 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0004152 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1033 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.206 Least Informative Inherited
Biological Process (BP) developmental process 0.02765 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1029 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9624 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism organelle organization 0.0000000000235 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000002174 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000001385 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000001714 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000001195 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00002804 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00005286 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.513 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1394 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.643 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2468 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9674 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.001176 Moderately Informative Inherited
Biological Process (BP) organ development 0.7356 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01619 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7842 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.004769 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.0654 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.0392 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01148 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.142 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4423 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1508 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0.000000000001639 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000001137 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000001676 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000001418 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000002368 Informative Direct
Biological Process (BP) positive regulation of transport 0.00000739 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00001545 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00008853 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001118 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0001137 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0001657 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0008482 Informative Direct
Biological Process (BP) regulation of secretion 0.001861 Informative Inherited
Biological Process (BP) organelle localization 0.6165 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.002999 Informative Inherited
Biological Process (BP) embryonic organ development 0.008125 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.05553 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1828 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.08752 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1351 Informative Inherited
Biological Process (BP) tube development 0.00401 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02151 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.003161 Informative Inherited
Biological Process (BP) regulation of locomotion 0.006072 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.03891 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.2516 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.00508 Informative Inherited
Biological Process (BP) regulation of cell development 0.3662 Informative Inherited
Biological Process (BP) generation of neurons 0.005716 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.005716 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03477 Informative Inherited
Biological Process (BP) muscle structure development 0.003192 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.005176 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.02057 Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.00000000006352 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.00000001298 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.0000000297 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.00000004151 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.000000124 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000001076 Highly Informative Direct
Biological Process (BP) protein glycosylation 0.000001349 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000001673 Highly Informative Direct
Biological Process (BP) respiratory system development 0.000002098 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000002569 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000031 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0.000003922 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.000007041 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000007434 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000009079 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.00004518 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00007545 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0001681 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0003185 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0003413 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0005726 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0005859 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0006673 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0007118 Highly Informative Direct
Biological Process (BP) protein polymerization 0.003683 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.6555 Highly Informative Inherited
Molecular Function (MF) binding 0.009429 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.000117 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0006587 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02614 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.009729 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.004578 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.00000001065 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00000157 Informative Direct
Molecular Function (MF) lipid binding 0.00007941 Informative Direct
Molecular Function (MF) protein complex binding 0.00433 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.00134 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.009373 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.000000001359 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.000000006956 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000009349 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.000000651 Highly Informative Direct
Molecular Function (MF) actin filament binding 0.0001455 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.0178 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0001531 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.7673 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.001614 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.1815 Least Informative Inherited
Cellular Component (CC) protein complex 0.02052 Least Informative Inherited
Cellular Component (CC) vesicle 0.0000000000000118 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.000000000002926 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000001083 Moderately Informative Direct
Cellular Component (CC) membrane region 0.0178 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.0135 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.0104 Moderately Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.000003262 Informative Direct
Cellular Component (CC) cell leading edge 0.0004266 Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) transport vesicle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000004682 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00002441 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment size variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.00000000007663Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0.0000001896Moderately InformativeDirect
Cellular componentCytoskeleton0.0000002142Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.000000000000002286Least InformativeDirect
Molecular functionCalcium0.000000000009818Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0.0006186Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal, gelsolin-like domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal, gelsolin-like domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]