SUPERFAMILY 1.75 HMM library and genome assignments server

C-terminal, gelsolin-like domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gelsolin-like [ 55752] (3)
Superfamily:   C-terminal, gelsolin-like domain of Sec23/24 [ 82754]
Families:   C-terminal, gelsolin-like domain of Sec23/24 [ 82755] (2)


Superfamily statistics
Genomes (498) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,226 3,346 4
Proteins 3,031 3,163 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0000000002976 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000001137 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0005028 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.09416 Least Informative Inherited
Biological Process (BP) developmental process 0.02704 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2643 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9891 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9618 Least Informative Inherited
Biological Process (BP) organelle organization 0.0000000001649 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000001189 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000001624 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000006786 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000001662 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000002796 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000006871 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0001486 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.1374 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6397 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5108 Moderately Informative Inherited
Biological Process (BP) organ development 0.7626 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.06038 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9386 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01623 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8373 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.005266 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2767 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1502 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01109 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4399 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.03282 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1412 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0.000000000234 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000001194 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000005883 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000001264 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000001204 Informative Direct
Biological Process (BP) positive regulation of transport 0.000005181 Informative Direct
Biological Process (BP) cellular membrane organization 0.0001308 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001621 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0001637 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.002567 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.02054 Informative Inherited
Biological Process (BP) embryonic organ development 0.01033 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.07615 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2273 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.04064 Informative Inherited
Biological Process (BP) generation of neurons 0.00556 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1275 Informative Inherited
Biological Process (BP) regulation of cell development 0.4563 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.005177 Informative Inherited
Biological Process (BP) tube development 0.001124 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02102 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.2739 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.05578 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03902 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.004874 Informative Inherited
Biological Process (BP) muscle structure development 0.006287 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.00576 Informative Inherited
Biological Process (BP) regulation of locomotion 0.006001 Informative Inherited
Biological Process (BP) organelle localization 0.6003 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01203 Informative Inherited
Biological Process (BP) regulation of secretion 0.001875 Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.000000000006696 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.00000001319 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.00000003186 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.00000004093 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0000001252 Highly Informative Direct
Biological Process (BP) protein glycosylation 0.0000005652 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000001457 Highly Informative Direct
Biological Process (BP) respiratory system development 0.000001987 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000002615 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000003142 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0.000003957 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000125 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00002195 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0000333 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0000449 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0001709 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0003013 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0005797 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0006715 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0007922 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00278 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.001088 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.001466 Highly Informative Inherited
Molecular Function (MF) binding 0.008279 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0004654 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0006493 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0261 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.0000000103 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000001604 Informative Direct
Molecular Function (MF) lipid binding 0.00007963 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0004131 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.002939 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.000000001344 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.000000006908 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0000000092 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000001904 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.01798 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0001197 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.002007 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.02162 Least Informative Inherited
Cellular Component (CC) membrane 0.182 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000000000008984 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000000000008055 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000000001588 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0000008711 Moderately Informative Direct
Cellular Component (CC) cell projection 0.008801 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.0112 Moderately Informative Inherited
Cellular Component (CC) coated vesicle 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000003286 Informative Direct
Cellular Component (CC) cell leading edge 0.0004323 Informative Direct
Cellular Component (CC) Golgi apparatus 0.02122 Informative Inherited
Cellular Component (CC) transport vesicle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.00002087 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00002413 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment size variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.00000000007663Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0.0000001896Moderately InformativeDirect
Cellular componentCytoskeleton0.0000002142Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.000000000000002286Least InformativeDirect
Molecular functionCalcium0.000000000009818Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0.0006186Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal, gelsolin-like domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal, gelsolin-like domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]