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C-terminal, gelsolin-like domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gelsolin-like [ 55752] (3)
Superfamily:   C-terminal, gelsolin-like domain of Sec23/24 [ 82754]
Families:   C-terminal, gelsolin-like domain of Sec23/24 [ 82755] (2)


Superfamily statistics
Genomes (506) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,290 7,705 4
Proteins 3,094 7,356 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0006026 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00001946 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000000001925 Least Informative Direct
Biological Process (BP) biological regulation 0.5525 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.0000000433 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.00008594 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000001184 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000005656 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000008356 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000007959 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000005376 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000003364 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000008354 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2223 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7372 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9004 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.4979 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6199 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.1886 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3023 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1167 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.164 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6525 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.319 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01214 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02015 Moderately Informative Inherited
Biological Process (BP) embryo development 0.0001257 Informative Direct
Biological Process (BP) protein transport 0.0002022 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000000613 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.000001397 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001887 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0004398 Informative Direct
Biological Process (BP) intracellular transport 0.000000001409 Informative Direct
Biological Process (BP) positive regulation of transport 0.0001035 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000006266 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000341 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000008003 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000001133 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000002329 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0000000003303 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0000000005629 Informative Direct
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) generation of neurons 0.003183 Informative Inherited
Biological Process (BP) cell development 0.1859 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.004825 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.0405 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.05829 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.008144 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.002619 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1695 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.03593 Informative Inherited
Biological Process (BP) regulation of locomotion 0.02285 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02257 Informative Inherited
Biological Process (BP) hemopoiesis 0.006492 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.8832 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.002085 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.04796 Informative Inherited
Biological Process (BP) regulation of secretion 0.004574 Informative Inherited
Biological Process (BP) post-embryonic development 0.2122 Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.00004584 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00004531 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002038 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00000000006388 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000000000000001925 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0001837 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.0008823 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000000001818 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0004812 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.0000001159 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0009878 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.000004753 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.000000003185 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0001003 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.00001339 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.00006202 Highly Informative Direct
Biological Process (BP) protein polymerization 0.000000005051 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001156 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.00000009408 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000001165 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00002252 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0.000000003054 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.000004385 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000001928 Highly Informative Direct
Biological Process (BP) response to growth factor 0.00165 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.1137 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.4451 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.2602 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.001549 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.01597 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.3595 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.001035 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.002477 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.6145 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.007043 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.004461 Highly Informative Inherited
Molecular Function (MF) binding 0.00005198 Least Informative Direct
Molecular Function (MF) metal ion binding 0.000000000005814 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.000002758 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1735 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.000002888 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000000000007771 Informative Direct
Molecular Function (MF) zinc ion binding 0.0000000007442 Informative Direct
Molecular Function (MF) amide binding 0.0001692 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00001005 Informative Direct
Molecular Function (MF) enzyme activator activity 0.2481 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.05919 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.2721 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.00000000861 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.0000001318 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000004787 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00005999 Highly Informative Direct
Molecular Function (MF) actin filament binding 0.0003224 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol phosphate binding 0.000000005 Highly Informative Direct
Cellular Component (CC) membrane 0.0004003 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0006421 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000002694 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.9273 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9694 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0001265 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1487 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000008689 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.2643 Informative Inherited
Cellular Component (CC) ruffle 0.000004247 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.00006308 Highly Informative Direct
Cellular Component (CC) membrane coat 0 Highly Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0.0000000003108Moderately InformativeDirect
Cellular componentCytoskeleton0.000000001459Moderately InformativeDirect
DomainRepeat0.0001187Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding4.963e-16Least InformativeDirect
Molecular functionCalcium0.000000000003836Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0.0001523Least InformativeDirect
Post-translational modificationPhosphoprotein0.0003656Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal, gelsolin-like domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal, gelsolin-like domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]