SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


C-terminal, gelsolin-like domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gelsolin-like [ 55752] (3)
Superfamily:   C-terminal, gelsolin-like domain of Sec23/24 [ 82754]
Families:   C-terminal, gelsolin-like domain of Sec23/24 [ 82755] (2)


Superfamily statistics
Genomes (499) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,227 3,346 4
Proteins 3,032 3,163 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000000005671 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01643 Least Informative Inherited
Biological Process (BP) biological regulation 0.3529 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0000000001757 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000005769 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000001093 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000001339 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000004234 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000008951 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0001036 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0007713 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.9511 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.607 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5348 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7467 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02181 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.3092 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.222 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2149 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02733 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01345 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.00000000000001068 Informative Direct
Biological Process (BP) actin filament-based process 0.000000000004076 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000006459 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000008696 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000009 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000013 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000008947 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00004001 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00006673 Informative Direct
Biological Process (BP) embryo development 0.00008356 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.01618 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01742 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.01025 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1303 Informative Inherited
Biological Process (BP) positive regulation of transport 0.001452 Informative Inherited
Biological Process (BP) generation of neurons 0.009027 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.07456 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.002269 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1337 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1182 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.06879 Informative Inherited
Biological Process (BP) secretion 0.109 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.04719 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0213 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.1312 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.02846 Informative Inherited
Biological Process (BP) protein targeting 0.1956 Informative Inherited
Biological Process (BP) regulation of secretion 0.01468 Informative Inherited
Biological Process (BP) regulation of actin filament polymerization 0 Highly Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0000000000003376 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.000000000108 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.0000000002409 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000000001388 Highly Informative Direct
Biological Process (BP) protein polymerization 0.000000003023 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00000002819 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0000003333 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000003385 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000003584 Highly Informative Direct
Biological Process (BP) antigen processing and presentation of exogenous peptide antigen 0.0000004013 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000000518 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.000001578 Highly Informative Direct
Biological Process (BP) negative regulation of protein polymerization 0.00000498 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000138 Highly Informative Direct
Biological Process (BP) vesicle localization 0.00001496 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000323 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000753 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000269 Highly Informative Direct
Biological Process (BP) establishment of protein localization to membrane 0.0002868 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0005069 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0007156 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0007292 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00088 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.01405 Highly Informative Inherited
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.002783 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.007619 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.07233 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.006234 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1344 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.007501 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.1044 Highly Informative Inherited
Molecular Function (MF) binding 0.000151 Least Informative Direct
Molecular Function (MF) molecular function regulator 0.00002909 Moderately Informative Direct
Molecular Function (MF) protein binding 0.0001529 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0005097 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.1502 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.09066 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.000000000000004807 Informative Direct
Molecular Function (MF) phospholipid binding 0.000001195 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0002103 Informative Direct
Molecular Function (MF) amide binding 0.0004952 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.1358 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.451 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.024 Informative Inherited
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.00000000003384 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.000000005115 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000006454 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00001691 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00001764 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00002283 Highly Informative Direct
Molecular Function (MF) actin filament binding 0.0004156 Highly Informative Direct
Cellular Component (CC) protein complex 0.0000003983 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00007343 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.004094 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.05312 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3438 Least Informative Inherited
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.00000000000001182 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0000000003967 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0002979 Moderately Informative Direct
Cellular Component (CC) cell projection 0.05692 Moderately Informative Inherited
Cellular Component (CC) transport vesicle 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000001409 Informative Direct
Cellular Component (CC) cell projection part 0.04606 Informative Inherited
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0 Highly Informative Direct
Cellular Component (CC) ruffle 0.00000482 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.00004276 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0InformativeDirect
Worm Phenotype (WP)organelle organization biogenesis variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment size variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)portion of tissue0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.000000000005127Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000001087Moderately InformativeDirect
Cellular componentCell projection0.000000000143Moderately InformativeDirect
DomainRepeat0.0001145Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding4.676e-16Least InformativeDirect
Molecular functionCalcium0.000000000000001857Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0.0001565Least InformativeDirect
Post-translational modificationPhosphoprotein0.0003479Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal, gelsolin-like domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal, gelsolin-like domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]