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C-terminal, gelsolin-like domain of Sec23/24 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gelsolin-like [ 55752] (3)
Superfamily:   C-terminal, gelsolin-like domain of Sec23/24 [ 82754]
Families:   C-terminal, gelsolin-like domain of Sec23/24 [ 82755] (2)


Superfamily statistics
Genomes (504) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,257 7,705 4
Proteins 3,061 7,356 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000000001427 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.001734 Least Informative Inherited
Biological Process (BP) biological regulation 0.4818 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0000000002289 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000005681 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000001781 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000002569 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000004927 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000005384 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000009711 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.9178 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.605 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7776 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2055 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.03128 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02398 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.3372 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.556 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.3025 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5115 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.00142 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.002435 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.08153 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8698 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.00000000000002971 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000000000002222 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000001953 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000001586 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000114 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000001239 Informative Direct
Biological Process (BP) membrane organization 0.000005691 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00001327 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00005345 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00006581 Informative Direct
Biological Process (BP) embryo development 0.0001329 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0007258 Informative Direct
Biological Process (BP) regulation of locomotion 0.0173 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.02317 Informative Inherited
Biological Process (BP) intracellular protein transport 0.4734 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1404 Informative Inherited
Biological Process (BP) tissue development 0.6506 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.06658 Informative Inherited
Biological Process (BP) organelle localization 0.9142 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.002573 Informative Inherited
Biological Process (BP) generation of neurons 0.00996 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1442 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.06778 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01674 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.339 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.0353 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01498 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1198 Informative Inherited
Biological Process (BP) positive regulation of transport 0.001434 Informative Inherited
Biological Process (BP) regulation of secretion 0.01574 Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0000000000003254 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00000000001221 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.0000000002401 Highly Informative Direct
Biological Process (BP) protein polymerization 0.00000000321 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0.000000003253 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000000004153 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.00000002481 Highly Informative Direct
Biological Process (BP) vesicle organization 0.00000008626 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.00000009409 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000003763 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000004751 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0000005286 Highly Informative Direct
Biological Process (BP) vesicle localization 0.00001928 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00002649 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00005188 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00006054 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00007351 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.0000977 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0001423 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0002856 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0005114 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0005174 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0006284 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0007646 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.01358 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.007937 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.02972 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.008422 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.07208 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.004617 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.001484 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.05205 Highly Informative Inherited
Molecular Function (MF) binding 0.0002689 Least Informative Direct
Molecular Function (MF) molecular function regulator 0.00003108 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0006305 Moderately Informative Direct
Molecular Function (MF) anion binding 0.09304 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1482 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00000000000000324 Informative Direct
Molecular Function (MF) phospholipid binding 0.00000129 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000002637 Informative Direct
Molecular Function (MF) amide binding 0.0005013 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.1372 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.4579 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.02369 Informative Inherited
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.0000000000308 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.000000005189 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000008725 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00001512 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00001806 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00002482 Highly Informative Direct
Molecular Function (MF) actin filament binding 0.000311 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.0002024 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.02279 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01166 Least Informative Inherited
Cellular Component (CC) membrane 0.07959 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.5437 Least Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000000000001208 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.00000000000007855 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0000000008869 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00003706 Moderately Informative Direct
Cellular Component (CC) cell projection 0.06377 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000001305 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.2762 Informative Inherited
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0 Highly Informative Direct
Cellular Component (CC) ruffle 0.000005581 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.00004997 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0InformativeDirect
Worm Phenotype (WP)germ cell compartment size variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.000000000005413Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000001376Moderately InformativeDirect
Cellular componentCell projection0.0000000002813Moderately InformativeDirect
DomainRepeat0.0001168Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.000000000008141Least InformativeDirect
Molecular functionCalcium0.00000000000006467Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0.0001612Least InformativeDirect
Post-translational modificationPhosphoprotein0.0003427Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal, gelsolin-like domain of Sec23/24 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal, gelsolin-like domain of Sec23/24 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]