SUPERFAMILY 1.75 HMM library and genome assignments server

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post-HMGL domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   RuvA C-terminal domain-like [ 46928] (9)
Superfamily:   post-HMGL domain-like [ 89000] (2)
Families:   DmpG/LeuA communication domain-like [ 89001] (2)
  Conserved carboxylase domain [ 109725]


Superfamily statistics
Genomes (2,070) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,608 21,229 5
Proteins 3,583 21,166 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000009709 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1983 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.8256 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01967 Least Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.00008231 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.0002443 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.001106 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2609 Moderately Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.000002264 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.00005408 Informative Direct
Biological Process (BP) glucose metabolic process 0.00000000001014 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.00000000003217 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000001831 Highly Informative Direct
Molecular Function (MF) transferase activity 0.7934 Least Informative Inherited
Molecular Function (MF) ligase activity 0.0000000005308 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0000007369 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.0000000000006619 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000006408 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.6633 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00494 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00004313 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.1973 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)2-isopropylmalate synthase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Forming carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processGluconeogenesis0.0000000001466Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionPyruvate0.0000001915Highly InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.000000000000001821Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.7903Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.928Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.00000000004Moderately InformativeDirect
UniPathway (UP)gluconeogenesis0.00000000000000585InformativeDirect
UniPathway (UP)phenylpropanoid degradation0.000003701InformativeDirect
UniPathway (UP)L-leucine biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a post-HMGL domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the post-HMGL domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]