SUPERFAMILY 1.75 HMM library and genome assignments server

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post-HMGL domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   RuvA C-terminal domain-like [ 46928] (9)
Superfamily:   post-HMGL domain-like [ 89000] (2)
Families:   DmpG/LeuA communication domain-like [ 89001] (2)
  Conserved carboxylase domain [ 109725]


Superfamily statistics
Genomes (2,064) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,598 19,390 5
Proteins 3,573 19,374 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.2416 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.00475 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.006523 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.000005326 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.0003832 Moderately Informative Direct
Biological Process (BP) hexose metabolic process 0.00000007485 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000119 Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.00000000004774 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.00000001562 Highly Informative Direct
Molecular Function (MF) transferase activity 0.2905 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.0000000429 Informative Direct
Molecular Function (MF) ligase activity 0.00009991 Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000001163 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001069 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.03362 Least Informative Inherited
Cellular Component (CC) membrane 0.02086 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00000001776 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0000008245 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.00003637 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)2-isopropylmalate synthase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processGluconeogenesis0.00000000001381Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionPyruvate0.00000003029Highly InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.000000000000001792Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.7828Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.927Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.00000000003728Moderately InformativeDirect
UniPathway (UP)gluconeogenesis0.000000000000005322InformativeDirect
UniPathway (UP)phenylpropanoid degradation0.000004467InformativeDirect
UniPathway (UP)L-leucine biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a post-HMGL domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the post-HMGL domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]