SUPERFAMILY 1.75 HMM library and genome assignments server

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post-HMGL domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   RuvA C-terminal domain-like [ 46928] (9)
Superfamily:   post-HMGL domain-like [ 89000] (2)
Families:   DmpG/LeuA communication domain-like [ 89001] (2)
  Conserved carboxylase domain [ 109725]


Superfamily statistics
Genomes (2,072) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,619 21,229 5
Proteins 3,594 21,166 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0000002021 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01962 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.8318 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2918 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0002337 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00008049 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.001095 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2556 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.00005232 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000002319 Informative Direct
Biological Process (BP) glucose metabolic process 0.0000000000118 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.00000000004014 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.0000000000001817 Highly Informative Direct
Molecular Function (MF) transferase activity 0.8646 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.000001057 Informative Direct
Molecular Function (MF) ligase activity 0.00000000004432 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.000000000001019 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001808 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.661 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.009072 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1993 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)2-isopropylmalate synthase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processGluconeogenesis0.0000000001405Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionPyruvate0.0000001868Highly InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a post-HMGL domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the post-HMGL domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]