SUPERFAMILY 1.75 HMM library and genome assignments server


GAT-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   GAT-like domain [ 89009] (2)
Families:   GAT domain [ 89010] (3)
  Phosphoinositide-binding clathrin adaptor, domain 2 [ 100929] (2)


Superfamily statistics
Genomes (474) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,994 3,653 11
Proteins 3,975 3,644 11


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 2.816e-09 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.3607 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002784 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01679 Least Informative Inherited
Biological Process (BP) cellular localization 2.898e-11 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.921e-05 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.06076 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4847 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.0416 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3421 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00171 Moderately Informative Inherited
Biological Process (BP) system process 0.01087 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.09625 Moderately Informative Inherited
Biological Process (BP) protein transport 1.11e-09 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 3.472e-08 Informative Direct
Biological Process (BP) vesicle-mediated transport 5.662e-06 Informative Direct
Biological Process (BP) synaptic transmission 2.018e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0.0005004 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0005866 Informative Direct
Biological Process (BP) protein localization to organelle 0.6158 Informative Inherited
Biological Process (BP) organelle localization 0.2592 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) vesicle organization 3.443e-11 Highly Informative Direct
Biological Process (BP) establishment of synaptic vesicle localization 7.964e-09 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 5.29e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0002672 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.06963 Highly Informative Inherited
Molecular Function (MF) binding 0.0004729 Least Informative Direct
Molecular Function (MF) anion binding 3.868e-05 Moderately Informative Direct
Molecular Function (MF) lipid binding 3.593e-07 Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.02497 Highly Informative Inherited
Cellular Component (CC) membrane 0.0003575 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0007187 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.6441 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3856 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 2.321e-06 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0001743 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.005277 Moderately Informative Inherited
Cellular Component (CC) coated vesicle 4.437e-12 Informative Direct
Cellular Component (CC) synapse part 9.118e-05 Informative Direct
Cellular Component (CC) cell cortex 0.000197 Informative Direct
Cellular Component (CC) endosome 0.0007081 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.02917 Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 2.094e-13 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 1.573e-07 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 2.884e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.05431Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1423Least InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.06924Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.001596InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0156InformativeInherited
Mammalian Phenotype (MP)decreased birth weight8.324e-06Highly InformativeDirect
Mammalian Phenotype (MP)hypoglycemia1.018e-05Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.05757Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0005217InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage4.35e-05Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage2.036e-05InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport3.237e-11Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Post-translational modificationPhosphoprotein7.218e-07Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GAT-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GAT-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]