SUPERFAMILY 1.75 HMM library and genome assignments server

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GAT-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   GAT-like domain [ 89009] (2)
Families:   GAT domain [ 89010] (3)
  Phosphoinositide-binding clathrin adaptor, domain 2 [ 100929] (2)


Superfamily statistics
Genomes (475) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,006 3,653 11
Proteins 3,987 3,644 11


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.1614 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02091 Least Informative Inherited
Biological Process (BP) biological regulation 0.379 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6168 Least Informative Inherited
Biological Process (BP) regulation of localization 0.01985 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.0496 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.06398 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2596 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002721 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02504 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3973 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.06531 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.682 Moderately Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.0001523 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0005218 Informative Direct
Biological Process (BP) proteolysis 0.06944 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.002005 Informative Inherited
Biological Process (BP) vesicle organization 0.000001684 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0.00003635 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00001307 Highly Informative Direct
Biological Process (BP) endocytosis 0.1845 Highly Informative Inherited
Molecular Function (MF) binding 0.0001275 Least Informative Direct
Molecular Function (MF) protein binding 0.00000001244 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001033 Moderately Informative Direct
Molecular Function (MF) phospholipid binding 0.0000000006361 Informative Direct
Cellular Component (CC) membrane 0.0000001734 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000002477 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.2688 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.00000000002633 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00002178 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.08818 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.00002222 Informative Direct
Cellular Component (CC) organelle subcompartment 0.00001838 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0001931 Informative Direct
Cellular Component (CC) synapse 0.0003271 Informative Direct
Cellular Component (CC) membrane region 0.0000004694 Informative Direct
Cellular Component (CC) coated vesicle 0.0005012 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.06277Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.069Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1349Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.01135Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.03456InformativeInherited
Mammalian Phenotype (MP)perinatal lethality0.04771InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000007361Highly InformativeDirect
Mammalian Phenotype (MP)hypoglycemia0.000009386Highly InformativeDirect
Mammalian Phenotype (MP)neonatal lethality0.008123Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.000525InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00004365Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.00002043InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000000002943Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndosome3.293e-16Moderately InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.00000000573Least InformativeDirect
Post-translational modificationUbl conjugation0.0000007502Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GAT-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GAT-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]