SUPERFAMILY 1.75 HMM library and genome assignments server

GAT-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   GAT-like domain [ 89009] (2)
Families:   GAT domain [ 89010] (3)
  Phosphoinositide-binding clathrin adaptor, domain 2 [ 100929] (2)


Superfamily statistics
Genomes (474) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,994 3,653 11
Proteins 3,975 3,644 11


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0000000001918 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.02096 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.02814 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4008 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7392 Least Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.00006887 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00003013 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.008494 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2604 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4587 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4275 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.05841 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 0.0004641 Informative Direct
Biological Process (BP) protein transport 0.000009198 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00002761 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0006872 Informative Direct
Biological Process (BP) organelle localization 0.2708 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.008516 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.0581 Informative Inherited
Biological Process (BP) protein localization to organelle 0.6101 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.08766 Informative Inherited
Biological Process (BP) vesicle organization 0.00000000003359 Highly Informative Direct
Biological Process (BP) establishment of synaptic vesicle localization 0.000000008224 Highly Informative Direct
Molecular Function (MF) binding 0.0005306 Least Informative Direct
Molecular Function (MF) anion binding 0.00003885 Moderately Informative Direct
Molecular Function (MF) lipid binding 0.0000003588 Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.02515 Highly Informative Inherited
Cellular Component (CC) membrane 0.0003608 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000004579 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.5047 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.02626 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000002511 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.005138 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.00003347 Informative Direct
Cellular Component (CC) cell cortex 0.0003954 Informative Direct
Cellular Component (CC) synapse 0.001378 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.02491 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.0000001958 Highly Informative Direct
Cellular Component (CC) coated vesicle 0.00002734 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.00002518 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.05431Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1423Least InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.06924Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.001596InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0156InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000008324Highly InformativeDirect
Mammalian Phenotype (MP)hypoglycemia0.00001018Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.05757Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0005217InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0000435Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.00002036InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000000003237Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000007218Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GAT-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GAT-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]