SUPERFAMILY 1.75 HMM library and genome assignments server


Neurotransmitter-gated ion-channel transmembrane pore superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Neurotransmitter-gated ion-channel transmembrane pore [ 90111]
Superfamily:   Neurotransmitter-gated ion-channel transmembrane pore [ 90112]
Families:   Neurotransmitter-gated ion-channel transmembrane pore [ 90113] (4)


Superfamily statistics
Genomes (175) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 6,902 6,799 8
Proteins 6,764 6,695 8


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus0.011830Least InformativeInherited
Biological Process (BP)multicellular organismal process0.016630Least InformativeInherited
Biological Process (BP)homeostatic process2.287e-050Moderately InformativeDirect
Biological Process (BP)system process3.573e-050Moderately InformativeDirect
Biological Process (BP)single-organism behavior4.673e-091.331e-05InformativeDirect
Biological Process (BP)synaptic transmission2.357e-070InformativeDirect
Biological Process (BP)regulation of membrane potential2.727e-081.052e-13Highly InformativeDirect
Cellular Component (CC)membrane0.0016150Least InformativeInherited
Cellular Component (CC)synapse1.44e-070InformativeDirect
Cellular Component (CC)synaptic membrane2.321e-090Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.05535 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) homeostatic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) signal transduction 4.375e-12 Moderately Informative Direct
Biological Process (BP) nervous system development 3.297e-09 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0001199 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6254 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.8532 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.08042 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4743 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.006946 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.04163 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3989 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3327 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.5328 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1312 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.03177 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1984 Moderately Informative Inherited
Biological Process (BP) single-organism behavior 1.331e-05 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) response to organic nitrogen 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 7.835e-15 Informative Direct
Biological Process (BP) regulation of secretion 3.616e-11 Informative Direct
Biological Process (BP) transmembrane transport 1.024e-09 Informative Direct
Biological Process (BP) regulation of system process 5.903e-09 Informative Direct
Biological Process (BP) regulation of ion transport 5.269e-06 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0003372 Informative Direct
Biological Process (BP) locomotion 0.0006023 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000852 Informative Direct
Biological Process (BP) metal ion transport 0.9282 Informative Inherited
Biological Process (BP) response to external stimulus 0.1705 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3953 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.4221 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.5947 Informative Inherited
Biological Process (BP) protein oligomerization 0.04332 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2036 Informative Inherited
Biological Process (BP) regulation of cell development 0.002597 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.8151 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.08942 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.007108 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 0.01046 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.03694 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.05081 Informative Inherited
Biological Process (BP) cell activation 0.2004 Informative Inherited
Biological Process (BP) regulation of reproductive process 0.004405 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01999 Informative Inherited
Biological Process (BP) positive regulation of transport 0.05863 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.9831 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3932 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7564 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.03344 Informative Inherited
Biological Process (BP) response to light stimulus 0.002524 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1199 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle system process 0.4727 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) regulation of membrane potential 1.052e-13 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 4.032e-14 Highly Informative Direct
Biological Process (BP) response to hypoxia 5.564e-10 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 5.679e-10 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.525e-09 Highly Informative Direct
Biological Process (BP) B cell activation 3.484e-09 Highly Informative Direct
Biological Process (BP) response to ethanol 9.973e-08 Highly Informative Direct
Biological Process (BP) response to toxic substance 1.478e-07 Highly Informative Direct
Biological Process (BP) regulation of neuron differentiation 1.878e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 3.675e-06 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 5.108e-06 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 5.567e-06 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 5.8e-05 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 0.0001082 Highly Informative Direct
Biological Process (BP) diencephalon development 0.0002163 Highly Informative Direct
Biological Process (BP) exocytosis 0.000717 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 0.01202 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.005789 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.1945 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.309 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.4564 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.05304 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01952 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.001244 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.001183 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte activation 0.01758 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.2806 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.003914 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.1057 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.359 Highly Informative Inherited
Molecular Function (MF) binding 0.9128 Least Informative Inherited
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.751e-13 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.8992 Informative Inherited
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 9.932e-11 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 6.546e-09 Moderately Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) neuron part 0 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) cell surface 0.0003576 Informative Direct
Cellular Component (CC) synaptic membrane 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) cell body 1.929e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0003656Least InformativeDirect
Disease Ontology (DO)brain disease0.01826Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.5784Moderately InformativeInherited
Disease Ontology (DO)cognitive disorder1Moderately InformativeInherited
Disease Ontology (DO)substance dependence1.561e-13InformativeDirect
Disease Ontology (DO)leukodystrophy0.004896InformativeInherited
Disease Ontology (DO)focal epilepsy0.05124InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1138InformativeInherited
Disease Ontology (DO)cocaine dependence5.315e-07Highly InformativeDirect
Disease Ontology (DO)autistic disorder8.506e-07Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.0001296Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.0005043Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.0005541Highly InformativeDirect
Disease Ontology (DO)frontal lobe epilepsy0.0008764Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the central nervous system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2906Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01597Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.01948Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1417Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.3215Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.3981Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4624Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.002177InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.00317InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.01149InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01568InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.05844InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.0626InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.3892InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents4.084e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness4.084e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals2.991e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy1.097e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness8.42e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement9.088e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita9.088e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement2.567e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Gower sign4.454e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability5.494e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness8.836e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry0.0001143Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype3.612e-10Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9847Least InformativeInherited
Mammalian Phenotype (MP)behavior/neurological phenotype2.801e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0.004719Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.06149Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.06341Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2245Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5438Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6399Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic3.157e-05InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.001488InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.001939InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.004083InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.004083InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.01137InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.01488InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.01665InformativeInherited
Mammalian Phenotype (MP)seizures0.02632InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.06676InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.06976InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.06982InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1083InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1426InformativeInherited
Mammalian Phenotype (MP)abnormal motor capabilities/coordination/movement0.4822InformativeInherited
Mammalian Phenotype (MP)increased inflammatory response0.4973InformativeInherited
Mammalian Phenotype (MP)urinary incontinence1.986e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents3.011e-08Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder7.489e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology2.257e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential6.519e-06Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures1.519e-05Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open2.337e-05Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis2.337e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception8.68e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0001031Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001623Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.0002458Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0002662Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.0005743Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.00366Highly InformativeInherited
Mammalian Phenotype (MP)renal/urinary system inflammation0.01Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.02616Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.1421Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3669Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.4932Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.5966Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant2.736e-13Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant4.156e-09Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant1.422e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.001275Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant3.373e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002419InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0003623InformativeDirect
Worm Phenotype (WP)neuron development variant0.01251InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant1.637e-06Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant2.574e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0001783Highly InformativeDirect
Worm Phenotype (WP)organism starvation response variant0.002109Highly InformativeInherited
Worm Phenotype (WP)pesticide response variant0.006343Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.03953Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant4.432e-08InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage0.09858Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.0004963InformativeDirect
Xenopus DEvelopment stage (XDE)gastrula0.9847InformativeInherited

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.09661Least InformativeInherited
Drugbank ATC_code (DB)nervous system6.706e-05Moderately InformativeDirect
Drugbank ATC_code (DB)dermatologicals0.01672Moderately InformativeInherited
Drugbank ATC_code (DB)antidotes0.07735Moderately InformativeInherited
Drugbank ATC_code (DB)carbamates9.89e-11InformativeDirect
Drugbank ATC_code (DB)2-(4-chlorphenoxy)-ethanol9.164e-06InformativeDirect
Drugbank ATC_code (DB)ethanol9.164e-06InformativeDirect
Drugbank ATC_code (DB)ethanol9.164e-06InformativeDirect
Drugbank ATC_code (DB)nerve depressants9.164e-06InformativeDirect
Drugbank ATC_code (DB)ferrous glycine sulfate0.0005491InformativeDirect
Drugbank ATC_code (DB)other irrigating solutions0.0005491InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLigand-gated ion channel0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentPostsynaptic cell membrane0InformativeDirect
Cellular componentSynapse0InformativeDirect
DiseaseDisease mutation3.831e-13Least InformativeDirect
DiseaseEpilepsy2.755e-09InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionCalcium0.1302Moderately InformativeInherited
Molecular functionChloride0Highly InformativeDirect
Molecular functionCalcium channel1.343e-10Highly InformativeDirect
Molecular functionCalcium transport3.794e-09Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate2.217e-11Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006029 SSF90112 Protein matches
Abstract

This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Neurotransmitter-gated ion-channel transmembrane pore domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Neurotransmitter-gated ion-channel transmembrane pore superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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