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Neurotransmitter-gated ion-channel transmembrane pore superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Neurotransmitter-gated ion-channel transmembrane pore [ 90111]
Superfamily:   Neurotransmitter-gated ion-channel transmembrane pore [ 90112]
Families:   Neurotransmitter-gated ion-channel transmembrane pore [ 90113] (4)


Superfamily statistics
Genomes (211) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,765 23,543 8
Proteins 7,593 22,910 8


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0007635Least InformativeDirect
Disease Ontology (DO)disease of mental health0.00000000000003045Moderately InformativeDirect
Disease Ontology (DO)brain disease0.001353Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.3696Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease1Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.00000000000005049InformativeDirect
Disease Ontology (DO)schizophrenia0.00005896InformativeDirect
Disease Ontology (DO)focal epilepsy0.07799InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1294InformativeInherited
Disease Ontology (DO)autistic disorder0.00000001846Highly InformativeDirect
Disease Ontology (DO)cocaine dependence0.000001023Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.00001145Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.00004495Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.00008902Highly InformativeDirect
Disease Ontology (DO)frontal lobe epilepsy0.000723Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0002003Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.01786Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.08584Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.08866Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.2633Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6211Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.8386Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.9421Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9858Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.01445Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.02937Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.1358Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1538Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.329Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.3885Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.4104Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.657Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.6853Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.7009Moderately InformativeInherited
Phenotypic Abnormality (PA)Epileptic encephalopathy0.0008221InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.004121InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.009395InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.02041InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.02501InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.02629InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.05636InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.08173InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.1327InformativeInherited
Phenotypic Abnormality (PA)Scoliosis0.1366InformativeInherited
Phenotypic Abnormality (PA)Seizures0.1412InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.1505InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.1513InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.167InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.2415InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.5489InformativeInherited
Phenotypic Abnormality (PA)Fatigable weakness of neck muscles0.0000001418Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased miniature endplate potentials0.0000002162Highly InformativeDirect
Phenotypic Abnormality (PA)Orthopnea0.0000002162Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia0.0000002624Highly InformativeDirect
Phenotypic Abnormality (PA)Amyoplasia0.0000002624Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals0.0000003184Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of jaw muscles0.0000004551Highly InformativeDirect
Phenotypic Abnormality (PA)Thoracic kyphoscoliosis0.0000006354Highly InformativeDirect
Phenotypic Abnormality (PA)Weakness of long finger extensor muscles0.0000008688Highly InformativeDirect
Phenotypic Abnormality (PA)Triceps weakness0.000001158Highly InformativeDirect
Phenotypic Abnormality (PA)Ankle weakness0.0000015Highly InformativeDirect
Phenotypic Abnormality (PA)Weakness of the intrinsic hand muscles0.000001965Highly InformativeDirect
Phenotypic Abnormality (PA)Uncontrolled eye movements0.000002354Highly InformativeDirect
Phenotypic Abnormality (PA)Jerky head movements0.000005873Highly InformativeDirect
Phenotypic Abnormality (PA)Low self esteem0.00001368Highly InformativeDirect
Phenotypic Abnormality (PA)EEG with generalized epileptiform discharges0.00002952Highly InformativeDirect
Phenotypic Abnormality (PA)Absence seizure0.0001108Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia0.0001513Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of respiratory muscles0.0001732Highly InformativeDirect
Phenotypic Abnormality (PA)Reduced vital capacity0.000252Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of binocular vision0.0004362Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.0004974Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.0004974Highly InformativeDirect
Phenotypic Abnormality (PA)Febrile seizures0.0006199Highly InformativeDirect
Phenotypic Abnormality (PA)Exertional dyspnea0.0006231Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0008768Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.001234Highly InformativeInherited
Phenotypic Abnormality (PA)Stereotypy0.01672Highly InformativeInherited
Phenotypic Abnormality (PA)EMG abnormality0.02864Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.1509Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip-girdle musculature1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0000000003603Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.0003911Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.01301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05743Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.09047Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.3008Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3453Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.4787Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.6846Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.7474Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000000001856InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.000968InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.001211InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.001276InformativeInherited
Mammalian Phenotype (MP)seizures0.001585InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.004554InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.01144InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.0214InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.0334InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2967InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.3022InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.5403InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.6954InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7802InformativeInherited
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.00000000306Highly InformativeDirect
Mammalian Phenotype (MP)urinary incontinence0.00000005686Highly InformativeDirect
Mammalian Phenotype (MP)abnormal type IV spiral ligament fibrocytes0.0000006317Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder0.000002916Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.000006335Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology0.000008879Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00001891Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.00001891Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis0.00003312Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception0.0001031Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001312Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0001321Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.0002032Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0002358Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear outer hair cell morphology0.0004933Highly InformativeDirect
Mammalian Phenotype (MP)decreased fear-related response0.0008873Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.01176Highly InformativeInherited
Mammalian Phenotype (MP)renal/urinary system inflammation0.01351Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.01425Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.02456Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.09011Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.1014Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.2654Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.6808Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000000000003766Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.000000000009503Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000000000009662Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00002196Least InformativeDirect
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)drug response variant0.0000009448Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00003037Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00003037Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00003083Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0000313Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.00004461Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00007461Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0InformativeDirect
Worm Phenotype (WP)body bend variant9.238e-16InformativeDirect
Worm Phenotype (WP)body posture variant0.00000000000006605InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0000000002973InformativeDirect
Worm Phenotype (WP)localized movement variant0.0000000006288InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00000001624InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00000007271InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.000001031InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001638InformativeDirect
Worm Phenotype (WP)positive chemotaxis variant0.0008821InformativeDirect
Worm Phenotype (WP)pesticide response variant0.008666InformativeInherited
Worm Phenotype (WP)directionality variant0.01936InformativeInherited
Worm Phenotype (WP)locomotion reduced0.12InformativeInherited
Worm Phenotype (WP)metal response variant0.3222InformativeInherited
Worm Phenotype (WP)nicotine response variant0.4536InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)small1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)antihelmintic response variant0.0000000000003047Highly InformativeDirect
Worm Phenotype (WP)synaptic transmission variant0.00000001664Highly InformativeDirect
Worm Phenotype (WP)fat0.000004087Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.000006115Highly InformativeDirect
Worm Phenotype (WP)short0.000006763Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.000007305Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.00002827Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0004683Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0005706Highly InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.05683Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)circadian rhythm defective0.00006744InformativeDirect
Fly Phenotype (FP)chemical resistant0.000001866Highly InformativeDirect
Fly Phenotype (FP)phototaxis defective0.0001147Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.06362Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5024Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3451Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.00008143Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)late tailbud stage0.3711InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.00001134Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 400.0008699Highly InformativeDirect

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR006029 SSF90112 Protein matches
Abstract

This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Neurotransmitter-gated ion-channel transmembrane pore domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Neurotransmitter-gated ion-channel transmembrane pore superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]