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ABC transporter transmembrane region superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   ABC transporter transmembrane region [ 90122]
Superfamily:   ABC transporter transmembrane region [ 90123]
Families:   ABC transporter transmembrane region [ 90124] (2)


Superfamily statistics
Genomes (3,119) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 48,465 220,054 4
Proteins 38,482 194,452 4


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.8903 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003763 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8639 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000002343 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.000004417 Moderately Informative Direct
Biological Process (BP) ion transport 0.00033 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0005667 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9719 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.153 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7078 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.6795 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.5122 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.003413 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.09596 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.716 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001134 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.1125 Moderately Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0 Informative Direct
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) cellular response to lipid 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.0000000002224 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000002535 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00000001618 Informative Direct
Biological Process (BP) response to metal ion 0.000007563 Informative Direct
Biological Process (BP) cell development 0.000007723 Informative Direct
Biological Process (BP) system process 0.0000228 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.000103 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0002115 Informative Direct
Biological Process (BP) organic acid transport 0.0004354 Informative Direct
Biological Process (BP) lipid catabolic process 0.0009755 Informative Direct
Biological Process (BP) regulation of system process 0.06217 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01567 Informative Inherited
Biological Process (BP) positive regulation of transport 0.171 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.00223 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.005932 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.02233 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1114 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.0482 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.1716 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.09972 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01223 Informative Inherited
Biological Process (BP) reproductive system development 0.1009 Informative Inherited
Biological Process (BP) metal ion transport 0.906 Informative Inherited
Biological Process (BP) response to organophosphorus 0 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0 Highly Informative Direct
Biological Process (BP) cell maturation 0 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0 Highly Informative Direct
Biological Process (BP) germ cell development 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0 Highly Informative Direct
Biological Process (BP) response to ketone 0 Highly Informative Direct
Biological Process (BP) response to drug 0.00000000002701 Highly Informative Direct
Biological Process (BP) detoxification 0.0000000001903 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.0000002838 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.00002803 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.00003168 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00003729 Highly Informative Direct
Biological Process (BP) pathogenesis 0.000177 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0002614 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.0003696 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0005136 Highly Informative Direct
Biological Process (BP) lipid modification 0.0009476 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.0009944 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.02441 Highly Informative Inherited
Biological Process (BP) response to amino acid 0.1236 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2899 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.5814 Highly Informative Inherited
Biological Process (BP) response to antibiotic 0.06194 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001382 Highly Informative Inherited
Biological Process (BP) carbohydrate derivative transport 0.01992 Highly Informative Inherited
Biological Process (BP) ammonium transport 0.05467 Highly Informative Inherited
Biological Process (BP) organic cation transport 0.1365 Highly Informative Inherited
Biological Process (BP) sulfur compound transport 0.003498 Highly Informative Inherited
Biological Process (BP) modified amino acid transport 0.005795 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.4184 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.01275 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.005765 Highly Informative Inherited
Biological Process (BP) gene silencing 0.002944 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.02644 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00000000000008696 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000005524 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000467 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00004149 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000000000003113 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000002381 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000003464 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000115 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) active ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) drug transporter activity 0.00000004497 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.000005137 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.00003403 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.00004032 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.0004243 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0007479 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0.6815 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000000000156 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000002695 Least Informative Direct
Cellular Component (CC) protein complex 0.8819 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.0000000000000228 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00000000000002419 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000009771 Moderately Informative Direct
Cellular Component (CC) organelle inner membrane 0.000002105 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00002287 Moderately Informative Direct
Cellular Component (CC) mitochondrial envelope 0.00004968 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.1176 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.01647 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.005999 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0.000000000000003036 Informative Direct
Cellular Component (CC) transporter complex 0.0000000000001492 Informative Direct
Cellular Component (CC) endosome 0.0000000000004625 Informative Direct
Cellular Component (CC) apical part of cell 0.000000000002592 Informative Direct
Cellular Component (CC) microbody 0.000000000003164 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.00000000001014 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.01055 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.528 Informative Inherited
Cellular Component (CC) plasma membrane region 0.07416 Informative Inherited
Cellular Component (CC) lytic vacuole 1 Informative Inherited
Cellular Component (CC) microbody membrane 0.00000000000002419 Highly Informative Direct
Cellular Component (CC) ATP-binding cassette (ABC) transporter complex 0.00000000001687 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.000000005787 Highly Informative Direct
Cellular Component (CC) brush border membrane 0.00000007712 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000009948 Highly Informative Direct
Cellular Component (CC) symplast 0.00001344 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00003804 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.00009215 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.001343 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processImmunity0.06289Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport0InformativeDirect
Biological processAntibiotic resistance0.00000533InformativeDirect
Biological processAdaptive immunity0.0000008981Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell membrane0.000001995Moderately InformativeDirect
Cellular componentMitochondrion0.001127Moderately InformativeInherited
Cellular componentMitochondrion inner membrane0.00000000009908InformativeDirect
Cellular componentVacuole0.00000000628InformativeDirect
Cellular componentPeroxisome0.00000007132InformativeDirect
Cellular componentCell inner membrane0.0000008378InformativeDirect
DiseaseDisease mutation0.0001726Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionChloride0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Molecular functionChloride channel0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationThiol protease0.0000000007658InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000000000000001892Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000000002525Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011527 SSF90123 Protein matches
Abstract

ABC transporters minimally contain two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). In certain bacterial transporters, these regions are found on different polypeptides. The function of the integral inner-membrane protein is to translocate the substrate across the membrane, as well as in substrate recognition [PubMed9873074, PubMed10529352].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ABC transporter transmembrane region domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the ABC transporter transmembrane region superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]