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ABC transporter transmembrane region superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   ABC transporter transmembrane region [ 90122]
Superfamily:   ABC transporter transmembrane region [ 90123]
Families:   ABC transporter transmembrane region [ 90124] (2)


Superfamily statistics
Genomes (3,114) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,149 177,294 4
Proteins 38,291 165,477 4


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.4029 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4643 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000000001243 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000002506 Moderately Informative Direct
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3274 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.002579 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.003519 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1471 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6088 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9744 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.7271 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.116 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.05139 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.4497 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.07901 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1125 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.000000000000009009 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000000000001409 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.0000000000009875 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000000006343 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000000007562 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00000005409 Informative Direct
Biological Process (BP) organic acid transport 0.000000111 Informative Direct
Biological Process (BP) anion transport 0.0000006025 Informative Direct
Biological Process (BP) cell development 0.000008169 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00003275 Informative Direct
Biological Process (BP) nitrogen compound transport 0.00004525 Informative Direct
Biological Process (BP) ion homeostasis 0.00006598 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.00008069 Informative Direct
Biological Process (BP) response to acid chemical 0.0004168 Informative Direct
Biological Process (BP) response to inorganic substance 0.07901 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.0543 Informative Inherited
Biological Process (BP) cellular response to lipid 0.6232 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01858 Informative Inherited
Biological Process (BP) positive regulation of transport 0.3484 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.06384 Informative Inherited
Biological Process (BP) secretion 0.7914 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.06629 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.06649 Informative Inherited
Biological Process (BP) lipid catabolic process 0.002802 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.003926 Informative Inherited
Biological Process (BP) post-embryonic development 0.5931 Informative Inherited
Biological Process (BP) reproductive system development 0.1438 Informative Inherited
Biological Process (BP) metal ion transport 0.9519 Informative Inherited
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) germ cell development 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0 Highly Informative Direct
Biological Process (BP) cell maturation 0 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00000000001037 Highly Informative Direct
Biological Process (BP) response to drug 0.0000000000716 Highly Informative Direct
Biological Process (BP) detoxification 0.000000005546 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0000001427 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.0000006994 Highly Informative Direct
Biological Process (BP) cellular response to external stimulus 0.000001292 Highly Informative Direct
Biological Process (BP) amide transport 0.0000127 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.00004674 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.0001179 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.000132 Highly Informative Direct
Biological Process (BP) modified amino acid transport 0.0001675 Highly Informative Direct
Biological Process (BP) lipid modification 0.0007621 Highly Informative Direct
Biological Process (BP) cellular response to corticosteroid stimulus 0.0008756 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0009517 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.0009574 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0.001168 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.008142 Highly Informative Inherited
Biological Process (BP) ammonium transport 0.1864 Highly Informative Inherited
Biological Process (BP) gene silencing 0.001992 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.003337 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.002684 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00000000000001095 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000000117 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000001415 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000003281 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.0000000000002117 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.0000000000002261 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000001955 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000008814 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0001215 Informative Direct
Molecular Function (MF) receptor binding 0.8683 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.000001187 Highly Informative Direct
Molecular Function (MF) drug transporter activity 0.0000046 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.00013 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0.6437 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.007848 Least Informative Inherited
Cellular Component (CC) protein complex 0.9894 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000000000000175 Moderately Informative Direct
Cellular Component (CC) vacuole 0.00000000000006921 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000008183 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00006404 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0007268 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.4859 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.005874 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.007738 Moderately Informative Inherited
Cellular Component (CC) endosome 0.000000000000003057 Informative Direct
Cellular Component (CC) vacuolar part 0.000000000000008925 Informative Direct
Cellular Component (CC) apical part of cell 0.00000000000009276 Informative Direct
Cellular Component (CC) microbody 0.00000000001088 Informative Direct
Cellular Component (CC) transporter complex 0.0000000001155 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.0134 Informative Inherited
Cellular Component (CC) plasma membrane region 0.02409 Informative Inherited
Cellular Component (CC) cell projection part 1 Informative Inherited
Cellular Component (CC) cell junction 0.009887 Informative Inherited
Cellular Component (CC) lytic vacuole 1 Informative Inherited
Cellular Component (CC) early endosome 0.000000000000003057 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.00000000000006794 Highly Informative Direct
Cellular Component (CC) ATP-binding cassette (ABC) transporter complex 0.000000002822 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.00000001068 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.0000002046 Highly Informative Direct
Cellular Component (CC) brush border membrane 0.000001543 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00002098 Highly Informative Direct
Cellular Component (CC) symplast 0.00004365 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.00009495 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.00003459Least InformativeDirect
Disease Ontology (DO)organ system cancer0.06682Least InformativeInherited
Disease Ontology (DO)nervous system disease0.1129Least InformativeInherited
Disease Ontology (DO)genetic disease0.000875Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.03076Moderately InformativeInherited
Disease Ontology (DO)bone marrow disease0.0763Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1281Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.1651Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.2817Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4387Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.00001418InformativeDirect
Disease Ontology (DO)myeloid leukemia0.00006748InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.00673InformativeInherited
Disease Ontology (DO)liver disease0.8984InformativeInherited
Disease Ontology (DO)bronchiectasis0.000004209Highly InformativeDirect
Disease Ontology (DO)leukodystrophy0.000007181Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.0003963Highly InformativeDirect
Disease Ontology (DO)primary biliary cirrhosis0.0007546Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.3915Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.67Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.2236InformativeInherited
Phenotypic Abnormality (PA)Ectopia lentis0.0007315Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.847Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.043Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0001639Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver lobule morphology0.0002586Highly InformativeDirect
Mammalian Phenotype (MP)amyloid beta deposits0.0002595Highly InformativeDirect
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.0003019Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0006652Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.5319Least InformativeInherited
Worm Phenotype (WP)cell development variant0.9593Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.6774Moderately InformativeInherited
Worm Phenotype (WP)metal response variant0.0000000004192InformativeDirect
Worm Phenotype (WP)alimentary system development variant0.001526InformativeInherited
Worm Phenotype (WP)lysosome organization biogenesis variant0.0000000625Highly InformativeDirect
Worm Phenotype (WP)gut granule development variant0.00000194Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.00005844Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.9033Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.0002663InformativeDirect
Plant ANatomical entity (PAN)portion of vascular tissue0.03417InformativeInherited
Plant ANatomical entity (PAN)vascular bundle0.0004551Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.0009121InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.05582Least InformativeInherited
Drugbank ATC_code (DB)drugs used in diabetes0.0000009201Moderately InformativeDirect
Drugbank ATC_code (DB)glibenclamide0.000000003445InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processImmunity0.04692Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport0InformativeDirect
Biological processAntibiotic resistance0.000004976InformativeDirect
Biological processCytolysis0.0007963InformativeDirect
Biological processAdaptive immunity0.0000002096Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCell membrane0.000001089Moderately InformativeDirect
Cellular componentMitochondrion0.001028Moderately InformativeInherited
Cellular componentMitochondrion inner membrane0.000000000108InformativeDirect
Cellular componentVacuole0.00000004051InformativeDirect
Cellular componentPeroxisome0.00000006196InformativeDirect
Cellular componentCell inner membrane0.0000003105InformativeDirect
DiseaseDisease mutation0.0001031Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionIron transport0Highly InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationThiol protease0.0000000007445InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationIsopeptide bond9.502e-16Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000000008075Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011527 SSF90123 Protein matches
Abstract

ABC transporters minimally contain two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). In certain bacterial transporters, these regions are found on different polypeptides. The function of the integral inner-membrane protein is to translocate the substrate across the membrane, as well as in substrate recognition [PubMed9873074, PubMed10529352].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ABC transporter transmembrane region domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the ABC transporter transmembrane region superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]