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ABC transporter transmembrane region superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   ABC transporter transmembrane region [ 90122]
Superfamily:   ABC transporter transmembrane region [ 90123]
Families:   ABC transporter transmembrane region [ 90124] (2)

Superfamily statistics
Genomes (3,121) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 48,658 0 4
Proteins 38,623 0 4

Functional annotation
General category Processes_IC
Detailed category Transport

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06722Least InformativeInherited
Disease Ontology (DO)nervous system disease0.1073Least InformativeInherited
Disease Ontology (DO)brain disease0.0004821Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.000826Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.03063Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1297Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.1661Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.2876Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4461Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.00001254InformativeDirect
Disease Ontology (DO)myeloid leukemia0.00006684InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.006984InformativeInherited
Disease Ontology (DO)liver disease0.8957InformativeInherited
Disease Ontology (DO)bronchiectasis0.000004024Highly InformativeDirect
Disease Ontology (DO)leukodystrophy0.000007689Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.0003831Highly InformativeDirect
Disease Ontology (DO)primary biliary cirrhosis0.0007385Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.007026Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09923Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.0004943Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3053Moderately InformativeInherited
Phenotypic Abnormality (PA)Jaundice0.0002593Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.8398Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.04048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0001654Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver lobule morphology0.000244Highly InformativeDirect
Mammalian Phenotype (MP)amyloid beta deposits0.0002632Highly InformativeDirect
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.0002685Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00006689Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.4441Least InformativeInherited
Worm Phenotype (WP)cell development variant0.9619Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.6218Moderately InformativeInherited
Worm Phenotype (WP)metal response variant0.000000006889InformativeDirect
Worm Phenotype (WP)alimentary system development variant0.001532InformativeInherited
Worm Phenotype (WP)lysosome organization biogenesis variant0.00000007301Highly InformativeDirect
Worm Phenotype (WP)gut granule development variant0.000001986Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.00006975Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.9033Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.0002663InformativeDirect
Plant ANatomical entity (PAN)portion of vascular tissue0.03417InformativeInherited
Plant ANatomical entity (PAN)vascular bundle0.0004551Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.0009121InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processImmunity0.0947Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport0InformativeDirect
Biological processAntibiotic resistance0.00000613InformativeDirect
Biological processAdaptive immunity0.000002891Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCell membrane0.000003569Moderately InformativeDirect
Cellular componentMitochondrion0.00145Moderately InformativeInherited
Cellular componentMitochondrion inner membrane0.0000000001143InformativeDirect
Cellular componentVacuole0.000000006903InformativeDirect
Cellular componentPeroxisome0.00000007447InformativeDirect
Cellular componentCell inner membrane0.0000007918InformativeDirect
DiseaseDisease mutation0.0002579Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionChloride0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Molecular functionChloride channel0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationThiol protease0.0000000009146InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0002354Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00000000005998Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000001162Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011527 SSF90123 Protein matches

ABC transporters minimally contain two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). In certain bacterial transporters, these regions are found on different polypeptides. The function of the integral inner-membrane protein is to translocate the substrate across the membrane, as well as in substrate recognition [PubMed9873074, PubMed10529352].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a ABC transporter transmembrane region domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the ABC transporter transmembrane region superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]