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Notch domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Notch domain [ 90192]
Superfamily:   Notch domain [ 90193]
Families:   Notch domain [ 90194]


Superfamily statistics
Genomes (153) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,138 1,266 1
Proteins 516 581 1


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000000005454 Least Informative Direct
Biological Process (BP) biological regulation 0.000008951 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000001663 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.004005 Least Informative Inherited
Biological Process (BP) immune system process 0.0000000000113 Moderately Informative Direct
Biological Process (BP) cell communication 0.00000004846 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0003995 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00001031 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.00002629 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000003412 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0003748 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000131 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00001201 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000286 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.0005058 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.01097 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.01366 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01563 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4794 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3163 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001651 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01113 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1158 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.0672 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.2393 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1349 Moderately Informative Inherited
Biological Process (BP) system development 0.008286 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2227 Moderately Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) tissue development 0.00001234 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0002175 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00000005054 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00000000897 Informative Direct
Biological Process (BP) generation of neurons 0.00000000000239 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0002949 Informative Direct
Biological Process (BP) organelle assembly 0.00009355 Informative Direct
Biological Process (BP) circulatory system development 0.000000000001548 Informative Direct
Biological Process (BP) regulation of nervous system development 0.02665 Informative Inherited
Biological Process (BP) cell development 0.04846 Informative Inherited
Biological Process (BP) central nervous system development 0.001066 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.002365 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.03519 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.01455 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.06414 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.0189 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0003354 Highly Informative Direct
Biological Process (BP) kidney development 0.0004073 Highly Informative Direct
Biological Process (BP) brain development 0.00003688 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0001678 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.00006866 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0001742 Highly Informative Direct
Biological Process (BP) regeneration 0.0000000007961 Highly Informative Direct
Biological Process (BP) wound healing 0 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00008206 Highly Informative Direct
Biological Process (BP) cell division 0.0003454 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.000004476 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0001519 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) neuron development 0.07091 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.00357 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.01763 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.01251 Highly Informative Inherited
Molecular Function (MF) molecular transducer activity 0.000008016 Informative Direct
Cellular Component (CC) membrane 0.000006263 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001423 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0008349 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.07559 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0001132 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000003896 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.000000009356 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.2762 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.0005689 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000000003367 Informative Direct
Cellular Component (CC) cell surface 0.0000001742 Informative Direct
Cellular Component (CC) apical part of cell 0.000001461 Informative Direct
Cellular Component (CC) plasma membrane region 0.005929 Informative Inherited
Cellular Component (CC) apical plasma membrane 0.00000005576 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.0003477 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.05644Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.00005358Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0001802Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00167Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.02305Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.0000006981InformativeDirect
Disease Ontology (DO)kidney cancer0.00001376InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.00001691InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.00003118InformativeDirect
Disease Ontology (DO)liver carcinoma0.0003747InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.0006178InformativeDirect
Disease Ontology (DO)skin hemangioma0.0000000000002948Highly InformativeDirect
Disease Ontology (DO)hemangioma0.000000002967Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00000001401Highly InformativeDirect
Disease Ontology (DO)purpura0.000001882Highly InformativeDirect
Disease Ontology (DO)renal cell carcinoma0.000004131Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the oral cavity0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the orbital region0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nose0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0Moderately InformativeDirect
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of long bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2389Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper lip0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the forehead0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the thorax0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0InformativeDirect
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0InformativeDirect
Phenotypic Abnormality (PA)Localized skin lesion0InformativeDirect
Phenotypic Abnormality (PA)Abnormal jaw morphology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.0004549InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.0008826InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.001008InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the scalp hair0.01482InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebellum0.01759InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the heart valves0.1041InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac ventricle0.1486InformativeInherited
Phenotypic Abnormality (PA)Hernia of the abdominal wall0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.0003061Highly InformativeDirect
Phenotypic Abnormality (PA)Ventricular septal defect0.0009551Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital malformation of the great arteries0.04681Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01447Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.03613Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03819Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0002899Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0008937Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.001577Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001626Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.003592Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.004537Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.006454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.006739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.00918Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.09941Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1654Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.226Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3895Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4888Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.00002428InformativeDirect
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0001806InformativeDirect
Mammalian Phenotype (MP)abnormal embryo development0.0004042InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0004495InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.0009939InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas morphology0.009108InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.03922InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.06613InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.08201InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.0907InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2184InformativeInherited
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.0000005896Highly InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence0.00000312Highly InformativeDirect
Mammalian Phenotype (MP)thick epidermis0.000005569Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.00002948Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair follicle morphology0.00006935Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney size0.0002922Highly InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0004004Highly InformativeDirect
Mammalian Phenotype (MP)edema0.0009535Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pericardial cavity morphology0.002645Highly InformativeInherited
Mammalian Phenotype (MP)abnormal holocrine gland morphology0.003272Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.006202Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect
Zebrafish Anatomy (ZA)cell0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.000000000003826Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainSignal0.000000003742Least InformativeDirect
DomainANK repeat0InformativeDirect
DomainEGF-like domain0InformativeDirect
Molecular functionCalcium0.0000000000000264Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000800 SSF90193 Protein matches
Abstract The Notch domain is also called the 'DSL' domain or the Lin-12/Notch repeat (LNR). The LNR region is present only in Notch related proteins C-terminal to EGF repeats. The lin-12/Notch proteins act as transmembrane receptors for intercellular signals that specify cell fates during animal development. In response to a ligand, proteolytic cleavages release the intracellular domain of Notch, which then gains access to the nucleus and acts as a transcriptional co-activator [PubMed3119223]. The LNR region is supposed to negatively regulate the Lin-12/Notch proteins activity. It is a triplication of an around 35-40 amino acids module present on the extracellular part of the protein [PubMed7697721, PubMed8139658]. Each module contains six cysteine residues engaged in three disulphide bonds and three conserved aspartate and asparagine residues [PubMed3119223]. The biochemical characterization of a recombinantly expressed LIN-12.1 module from the human Notch1 receptor indicate that the disulphide bonds are formed between the first and fifth, second and fourth, and third and sixth cysteines. The formation of this particular disulphide isomer is favored by the presence of Ca2+, which is also required to maintain the structural integrity of the rLIN-12.1 module. The conserved aspartate and asparagine residues are likely to be important for Ca2+ binding, and thereby contribute to the native fold.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Notch domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Notch domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]