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Notch domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Notch domain [ 90192]
Superfamily:   Notch domain [ 90193]
Families:   Notch domain [ 90194]


Superfamily statistics
Genomes (156) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,149 3,287 1
Proteins 520 1,477 1


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.05701Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.00005519Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0001872Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00168Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.02347Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.0000007135InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.00001719InformativeDirect
Disease Ontology (DO)urinary system cancer0.00001968InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.00003207InformativeDirect
Disease Ontology (DO)liver carcinoma0.0003848InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.000636InformativeDirect
Disease Ontology (DO)skin hemangioma0.0000000000002972Highly InformativeDirect
Disease Ontology (DO)hemangioma0.000000003031Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00000001425Highly InformativeDirect
Disease Ontology (DO)purpura0.000001922Highly InformativeDirect
Disease Ontology (DO)renal cell carcinoma0.000004281Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skeletal system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.07402Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2141Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the calvaria0InformativeDirect
Phenotypic Abnormality (PA)Localized skin lesion0InformativeDirect
Phenotypic Abnormality (PA)Hernia0InformativeDirect
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.000912InformativeDirect
Phenotypic Abnormality (PA)Abnormal spleen morphology0.001416InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.004215InformativeInherited
Phenotypic Abnormality (PA)Abnormal lip morphology0.01168InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.029InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0Highly InformativeDirect
Phenotypic Abnormality (PA)Hernia of the abdominal wall0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal aortic valve physiology0.00002445Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.0003032Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertension0.000706Highly InformativeDirect
Phenotypic Abnormality (PA)Kyphosis0.0008128Highly InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.0008437Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.000922Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the philtrum0.001981Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01431Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.03599Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03803Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0002888Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.000881Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.001563Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001607Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.003577Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.004504Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.006465Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.006704Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.009148Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.09953Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2265Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3895Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.4419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4888Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.00002438InformativeDirect
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0001809InformativeDirect
Mammalian Phenotype (MP)abnormal embryo development0.0004067InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0004458InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.0009829InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas morphology0.00918InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.03937InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.06605InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.08294InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.09035InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2209InformativeInherited
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.0000005926Highly InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence0.000003126Highly InformativeDirect
Mammalian Phenotype (MP)thick epidermis0.000005585Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.00002963Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair follicle morphology0.00006965Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney size0.0002923Highly InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0004017Highly InformativeDirect
Mammalian Phenotype (MP)edema0.0009555Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pericardial cavity morphology0.002662Highly InformativeInherited
Mammalian Phenotype (MP)abnormal holocrine gland morphology0.003305Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.005773Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR000800 SSF90193 Protein matches
Abstract The Notch domain is also called the 'DSL' domain or the Lin-12/Notch repeat (LNR). The LNR region is present only in Notch related proteins C-terminal to EGF repeats. The lin-12/Notch proteins act as transmembrane receptors for intercellular signals that specify cell fates during animal development. In response to a ligand, proteolytic cleavages release the intracellular domain of Notch, which then gains access to the nucleus and acts as a transcriptional co-activator [PubMed3119223]. The LNR region is supposed to negatively regulate the Lin-12/Notch proteins activity. It is a triplication of an around 35-40 amino acids module present on the extracellular part of the protein [PubMed7697721, PubMed8139658]. Each module contains six cysteine residues engaged in three disulphide bonds and three conserved aspartate and asparagine residues [PubMed3119223]. The biochemical characterization of a recombinantly expressed LIN-12.1 module from the human Notch1 receptor indicate that the disulphide bonds are formed between the first and fifth, second and fourth, and third and sixth cysteines. The formation of this particular disulphide isomer is favored by the presence of Ca2+, which is also required to maintain the structural integrity of the rLIN-12.1 module. The conserved aspartate and asparagine residues are likely to be important for Ca2+ binding, and thereby contribute to the native fold.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Notch domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Notch domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]