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Notch domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Notch domain [ 90192]
Superfamily:   Notch domain [ 90193]
Families:   Notch domain [ 90194]


Superfamily statistics
Genomes (149) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,123 1,266 1
Proteins 509 581 1


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0001336 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000002177 Least Informative Direct
Biological Process (BP) biological regulation 0.0003778 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000001255 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0108 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.009584 Least Informative Inherited
Biological Process (BP) immune system process 0.000000000003354 Moderately Informative Direct
Biological Process (BP) cell communication 0.00001625 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0004238 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00002941 Moderately Informative Direct
Biological Process (BP) signaling 0.000000000001148 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0004186 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0004119 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000002055 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00001203 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000331 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.7129 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.02857 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2509 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.2295 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01567 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.02333 Moderately Informative Inherited
Biological Process (BP) system development 0.009657 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.007666 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001379 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1222 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.07391 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.247 Moderately Informative Inherited
Biological Process (BP) response to stress 0.5006 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2406 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1799 Moderately Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 0.0008556 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00000004095 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000009407 Informative Direct
Biological Process (BP) generation of neurons 0.000000000001686 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0003072 Informative Direct
Biological Process (BP) organelle assembly 0.00003559 Informative Direct
Biological Process (BP) circulatory system development 0.000000000001166 Informative Direct
Biological Process (BP) regulation of nervous system development 0.02405 Informative Inherited
Biological Process (BP) cell development 0.04025 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.001899 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.001283 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.06313 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.006318 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.02387 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.00613 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0002969 Highly Informative Direct
Biological Process (BP) brain development 0.00002997 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0002007 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.00006267 Highly Informative Direct
Biological Process (BP) cell projection organization 0.0000000007449 Highly Informative Direct
Biological Process (BP) hemopoiesis 0 Highly Informative Direct
Biological Process (BP) regeneration 0.0000000003096 Highly Informative Direct
Biological Process (BP) wound healing 0 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00004863 Highly Informative Direct
Biological Process (BP) cell division 0.0004425 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0001547 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.002093 Highly Informative Inherited
Biological Process (BP) neuron development 0.06724 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03196 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.002882 Highly Informative Inherited
Molecular Function (MF) molecular transducer activity 0.000007573 Informative Direct
Cellular Component (CC) membrane 0.000004137 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0003415 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.01355 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.04321 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00009786 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000257 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000002978 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.2702 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.05871 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.001168 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.0004453 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000000004817 Informative Direct
Cellular Component (CC) cell surface 0.0000001606 Informative Direct
Cellular Component (CC) cell junction 0.000008255 Informative Direct
Cellular Component (CC) apical part of cell 0.000001537 Informative Direct
Cellular Component (CC) plasma membrane region 0.005799 Informative Inherited
Cellular Component (CC) apical plasma membrane 0.00005715 Highly Informative Direct
Cellular Component (CC) anchoring junction 0.0000000963 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.003428Least InformativeInherited
Disease Ontology (DO)organ system cancer0.05633Least InformativeInherited
Disease Ontology (DO)blood coagulation disease0.0000377Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.00005229Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0001742Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.02323Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.0000006781InformativeDirect
Disease Ontology (DO)kidney cancer0.00001378InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.00001682InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0000305InformativeDirect
Disease Ontology (DO)liver carcinoma0.00037InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.0006356InformativeDirect
Disease Ontology (DO)skin hemangioma0.0000000000003086Highly InformativeDirect
Disease Ontology (DO)hemangioma0.000000003094Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00000001423Highly InformativeDirect
Disease Ontology (DO)purpura0.000001957Highly InformativeDirect
Disease Ontology (DO)renal cell carcinoma0.000004237Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the oral cavity0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the orbital region0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nose0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0Moderately InformativeDirect
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of long bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2383Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper lip0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the mandible0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the forehead0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eyelid0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the thorax0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0InformativeDirect
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0InformativeDirect
Phenotypic Abnormality (PA)Localized skin lesion0InformativeDirect
Phenotypic Abnormality (PA)Cerebellar malformation0.0002851InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.0004531InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.0008715InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.001001InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the scalp hair0.01455InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the heart valves0.1038InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac ventricle0.148InformativeInherited
Phenotypic Abnormality (PA)Hernia of the abdominal wall0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.0003025Highly InformativeDirect
Phenotypic Abnormality (PA)Ventricular septal defect0.0009336Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital malformation of the great arteries0.04706Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.013Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.03312Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03717Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0002733Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0009391Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00169Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.003737Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.004378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.006692Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.006789Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.009388Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1112Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.234Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3896Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.4094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.4414Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0001919InformativeDirect
Mammalian Phenotype (MP)abnormal embryo development0.0004273InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0004734InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas morphology0.009376InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.04321InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.07052InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.08622InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08856InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2246InformativeInherited
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.0000006273Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin0.0000008282Highly InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence0.00000333Highly InformativeDirect
Mammalian Phenotype (MP)thick epidermis0.000005909Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pericardial cavity morphology0.00002229Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.00003127Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair follicle morphology0.00007185Highly InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0004252Highly InformativeDirect
Mammalian Phenotype (MP)edema0.0009596Highly InformativeDirect
Mammalian Phenotype (MP)abnormal holocrine gland morphology0.003606Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.006052Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.000000000003423Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainSignal0.000000003529Least InformativeDirect
DomainANK repeat0InformativeDirect
DomainEGF-like domain0InformativeDirect
Molecular functionCalcium0.0000000000000241Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000800 SSF90193 Protein matches
Abstract The Notch domain is also called the 'DSL' domain or the Lin-12/Notch repeat (LNR). The LNR region is present only in Notch related proteins C-terminal to EGF repeats. The lin-12/Notch proteins act as transmembrane receptors for intercellular signals that specify cell fates during animal development. In response to a ligand, proteolytic cleavages release the intracellular domain of Notch, which then gains access to the nucleus and acts as a transcriptional co-activator [PubMed3119223]. The LNR region is supposed to negatively regulate the Lin-12/Notch proteins activity. It is a triplication of an around 35-40 amino acids module present on the extracellular part of the protein [PubMed7697721, PubMed8139658]. Each module contains six cysteine residues engaged in three disulphide bonds and three conserved aspartate and asparagine residues [PubMed3119223]. The biochemical characterization of a recombinantly expressed LIN-12.1 module from the human Notch1 receptor indicate that the disulphide bonds are formed between the first and fifth, second and fourth, and third and sixth cysteines. The formation of this particular disulphide isomer is favored by the presence of Ca2+, which is also required to maintain the structural integrity of the rLIN-12.1 module. The conserved aspartate and asparagine residues are likely to be important for Ca2+ binding, and thereby contribute to the native fold.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Notch domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Notch domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]