SUPERFAMILY 1.75 HMM library and genome assignments server

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ASF1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   ASF1-like [ 101546]
Families:   ASF1-like [ 101547]


Superfamily statistics
Genomes (494) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 736 1,733 7
Proteins 727 1,708 7


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000001137 Least Informative Direct
Biological Process (BP) biological regulation 0.08635 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1864 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.00734 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.01103 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.005869 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.03384 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.006843 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.009749 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.00006644 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.001826 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.04632 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.005937 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.00006599 Informative Direct
Biological Process (BP) chromosome organization 0.00000000005455 Informative Direct
Biological Process (BP) chromatin assembly or disassembly 0 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.0000000000001572 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.07932 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2049 Least Informative Inherited
Cellular Component (CC) chromosome 0.0000009439 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainCoiled coil0.000000001357Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006818 SSF101546 Protein matches
Abstract This family includes the yeast ASF1 protein, which derepresses transcriptionally silenced genes. The human ASF1 homologue has been found to possess histone chaperone activity, which may explain the derepressing function of this family [PubMed10759893].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ASF1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the ASF1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]