SUPERFAMILY 1.75 HMM library and genome assignments server

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Sema domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Sema domain [ 101912]
Family:   Sema domain [ 101913] (3)


Family statistics
Genomes (135) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,823 7,646 3
Proteins 2,789 7,610 3


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0.2758Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3083Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.01299Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01717Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.02602InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.05703InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.0001626Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the sense of smell0.0004205Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0003228Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.1586Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.00232Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.006331Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.01215Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.2873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4243Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.00002168InformativeDirect
Mammalian Phenotype (MP)abnormal cell migration0.00008708InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.001462InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.007211InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.01406InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.02505InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.0277InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.04482InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.07484InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.08749InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.1149InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.3129InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule epithelium morphology0.0000009593Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.000003272Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.000004786Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal migration0.0002321Highly InformativeDirect
Mammalian Phenotype (MP)ectopic neuron0.0005833Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary system development0.08288Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cerebellar layer morphology0.567Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.001895Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0002252Moderately InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0InformativeDirect
Worm Phenotype (WP)male morphology variant0InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00000005028InformativeDirect
Worm Phenotype (WP)male ray morphology variant0Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.000000000889Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000000006549Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)abdomen0Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0Moderately InformativeDirect
Fly Anatomy (FA)larval segment0Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)ganglion0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0Moderately InformativeDirect
Fly Anatomy (FA)ventral nerve cord0InformativeDirect
Fly Anatomy (FA)larval abdominal segment0InformativeDirect
Fly Anatomy (FA)nerve0InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0.002834InformativeInherited
Fly Anatomy (FA)tract0.1876InformativeInherited
Fly Anatomy (FA)intersegmental nerve0Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0Highly InformativeDirect
Fly Anatomy (FA)fascicle0.0000006468Highly InformativeDirect
Fly Anatomy (FA)connective0.00001956Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00004505Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0007416Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.2817Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.4357Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.04379Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.3224Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.0123InformativeInherited
Zebrafish Anatomy (ZA)ectoderm0.0008857Highly InformativeDirect
Zebrafish Anatomy (ZA)motor neuron0.001499Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.1039Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3462Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.428Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.5392Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.000002344Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0003376Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0003888Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.006112Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.3175Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.000004046InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.05601InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.5541InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.000002865Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.000005706Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0001625Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0002047Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0009444Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode1Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Sema domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]