SUPERFAMILY 1.75 HMM library and genome assignments server

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(2r)-phospho-3-sulfolactate synthase ComA superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (2r)-phospho-3-sulfolactate synthase ComA [ 102110]
Families:   (2r)-phospho-3-sulfolactate synthase ComA [ 102111]


Superfamily statistics
Genomes (265) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 327 1,189 2
Proteins 325 1,187 2


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR003830 SSF102110 Protein matches
Abstract

Methanogenic archaea produce methane via the anaerobic reduction of acetate or single carbon compounds [PubMed12440773]. Coenzyme M (CoM; 2-mercaptoethanesulphonic acid) serves as the terminal methyl carrier for this process. Previously thought to be unique to methanogenic archaea, CoM has also been found in methylotrophic bacteria.

Biosynthesis of CoM begins with the Michael addition of sulphite to phosphoenolpyruvate, forming 2-phospho-3-sulpholactate (PSL). This reaction is catalyzed by members of this family, PSL synthase (ComA) [PubMed11830598]. Subsequently, PSL is dephosphorylated by phosphosulpholactate phosphatase (ComB) to form 3-sulpholactate [PubMed11589710], which is then converted to 3-sulphopyruvate by L-sulpholactate dehydrogenase (ComC) [PubMed10850983]. Sulphopyruvate decarboxylase (ComDE) converts 3-sulphopyruvate to sulphoacetaldehyde [PubMed10940029]. Reductive thiolation of sulphoacetaldehyde is the final step.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (2r)-phospho-3-sulfolactate synthase ComA domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the (2r)-phospho-3-sulfolactate synthase ComA superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]