SUPERFAMILY 1.75 HMM library and genome assignments server

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Folate-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Folate-binding domain [ 103024]
Superfamily:   Folate-binding domain [ 103025] (2)
Families:   Aminomethyltransferase folate-binding domain [ 103026] (3)
  TrmE formyl-THF-binding domain [ 117997]


Superfamily statistics
Genomes (2,497) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,518 39,593 8
Proteins 6,479 39,417 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000001803 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000176 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03823 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000000000009834 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00000000534 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000004334 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000003632 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0008348 Moderately Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.000000001369 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0000003821 Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.000000000001909 Highly Informative Direct
Molecular Function (MF) transferase activity 0.06001 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.006397 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.00000000003626 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00002375 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0005641 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.8166 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.05181 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.000000004028 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.00004138Moderately InformativeDirect
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases0InformativeDirect
Enzyme Commission (EC)With other acceptors0.0000003397InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processtRNA processing0InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionPotassium0InformativeDirect
Molecular functionGTP-binding0.00002805InformativeDirect
Molecular functionFolate-binding0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Folate-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Folate-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]