SUPERFAMILY 1.75 HMM library and genome assignments server

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Hypoxia-inducible factor Hif2a, C-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Family:   Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]


Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 248 918 1
Proteins 248 918 1


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)female reproductive system disease0.002265InformativeInherited
Disease Ontology (DO)endometriosis0.0008472Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1364Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.02503Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.03535Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.04246Moderately InformativeInherited
Phenotypic Abnormality (PA)Obesity0.0007081InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.0007176InformativeDirect
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.002435InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.002294Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007064Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1375Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3474Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3659Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3791Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0004571Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.001804Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.004344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.0358Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.05022Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.07187Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1203Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1989Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.2147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2407Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.4984Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.0002754InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.00286InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.003363InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.003763InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.01613InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.05654InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.07021InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.09202InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.1187InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.1451InformativeInherited
Mammalian Phenotype (MP)decreased heart rate0.00005899Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.0002761Highly InformativeDirect
Mammalian Phenotype (MP)enlarged brain ventricles0.0006518Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.0006718Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart weight0.0009236Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.001908Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sleep behavior0.002078Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.003284Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.2437Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)circadian rhythm defective0.0005226InformativeDirect
Fly Phenotype (FP)behavior defective0.1071InformativeInherited
Fly Phenotype (FP)locomotor rhythm defective0.00004552Highly InformativeDirect
Fly Phenotype (FP)semi-sterile0.0001032Highly InformativeDirect
Fly Phenotype (FP)sleep defective0.0001659Highly InformativeDirect
Fly Phenotype (FP)decreased fecundity0.0006446Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)circulatory system0.01731Moderately InformativeInherited
Fly Anatomy (FA)adult heart0.0009325InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.2353Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3009Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3617Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.4072Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5027Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.6887Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8233Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.005232Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.01761Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1001Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0006021InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.001273InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.002734InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01396InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0215InformativeInherited
Xenopus ANatomical entity (XAN)trunk musculature0.00001582Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.000158Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.0003527Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]