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Plexin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Trefoil/Plexin domain-like [ 57491] (3)
Superfamily:   Plexin repeat [ 103575]
Families:   Plexin repeat [ 103576] (3)


Superfamily statistics
Genomes (152) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,100 11,027 5
Proteins 3,860 10,407 5


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hypersensitivity reaction type II disease0.1089Moderately InformativeInherited
Disease Ontology (DO)skin disease0.2538Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00009262InformativeDirect
Disease Ontology (DO)bullous skin disease0.0004081InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.01422Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1014Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the endocrine system0.03339InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.1795InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0005589Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.02729Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.000321Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.0009568Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002942Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08156Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4324Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.457Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.682Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.000213InformativeDirect
Mammalian Phenotype (MP)abnormal cerebellum morphology0.001392InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.005387InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.01377InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.04096InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.07436InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.115InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.1385InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.144InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.000000000027Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal inner plexiform layer morphology0.000003716Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.00002873Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.00003372Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hippocampal mossy fiber morphology0.00004607Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.000151Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal migration0.0007454Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.005584Least InformativeInherited
Worm Phenotype (WP)neuron development variant0.000003324Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00004282Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.04283Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.000000002542InformativeDirect
Worm Phenotype (WP)male morphology variant0.00000003854InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0000001301InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.000001906InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.000000002938Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00000001802Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.09088Least InformativeInherited
Fly Anatomy (FA)organism subdivision0.1484Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.0003411Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.01038Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02424Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.00001215InformativeDirect
Fly Anatomy (FA)ventral nerve cord0.00001813InformativeDirect
Fly Anatomy (FA)abdominal segment0.00008164InformativeDirect
Fly Anatomy (FA)nerve0.0005623InformativeDirect
Fly Anatomy (FA)larval segment0.001923InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.0324InformativeInherited
Fly Anatomy (FA)gut section0.07808InformativeInherited
Fly Anatomy (FA)tract0.1343InformativeInherited
Fly Anatomy (FA)fascicle0.00000008533Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.0003952Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.4836Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5985Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4825Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.02361InformativeInherited
Zebrafish Anatomy (ZA)primary germ layer0.02479InformativeInherited
Zebrafish Anatomy (ZA)primary motor neuron0.0000546Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.5369Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.5861Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7701Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0001138Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.003622Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01399Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1802Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8058Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.00000001465InformativeDirect
Xenopus ANatomical entity (XAN)neural crest0.0000004269InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.1239InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.7531InformativeInherited
Xenopus ANatomical entity (XAN)periocular region0.00002282Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.00007931Highly InformativeDirect
Xenopus ANatomical entity (XAN)branchial arch0.0004059Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0004378Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0009248Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.118Highly InformativeInherited
Xenopus ANatomical entity (XAN)neurogenic placode1Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Plexin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Plexin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]