SUPERFAMILY 1.75 HMM library and genome assignments server

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Plexin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Trefoil/Plexin domain-like [ 57491] (3)
Superfamily:   Plexin repeat [ 103575]
Families:   Plexin repeat [ 103576] (3)


Superfamily statistics
Genomes (152) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,100 11,027 5
Proteins 3,860 10,407 5


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hypersensitivity reaction type II disease0.1089Moderately InformativeInherited
Disease Ontology (DO)skin disease0.2538Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00009262InformativeDirect
Disease Ontology (DO)bullous skin disease0.0004081InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.005413Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1729Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the endocrine system0.02317InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.195InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0002901Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.01895Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0002206Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.0009602Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.007157Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08138Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4341Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4591Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.7614Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.0001741InformativeDirect
Mammalian Phenotype (MP)abnormal cerebellum morphology0.001166InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01463InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.03759InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.04098InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.1088InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.1149InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.1385InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.1431InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.00000000002127Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal inner plexiform layer morphology0.000003721Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.00003411Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hippocampal mossy fiber morphology0.00004615Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0001827Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal migration0.0007456Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.001292Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.005575Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.00003869Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0003437Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0003437Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.000345Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0003463Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0003825Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.03966Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.000000002416InformativeDirect
Worm Phenotype (WP)male morphology variant0.00000003463InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.000001577InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00001101InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.000000002536Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000002179Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.09906Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.0003277Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.009526Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02257Moderately InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.00001695InformativeDirect
Fly Anatomy (FA)abdominal segment0.00007854InformativeDirect
Fly Anatomy (FA)larval abdomen0.0001971InformativeDirect
Fly Anatomy (FA)larval segment0.002796InformativeInherited
Fly Anatomy (FA)nerve0.008652InformativeInherited
Fly Anatomy (FA)gut section0.07768InformativeInherited
Fly Anatomy (FA)tract0.1353InformativeInherited
Fly Anatomy (FA)fascicle0.00000007732Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.0003819Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.4881Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5902Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.07815Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4804Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.02059InformativeInherited
Zebrafish Anatomy (ZA)primary germ layer0.02337InformativeInherited
Zebrafish Anatomy (ZA)primary motor neuron0.00006012Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.5815Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7691Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0000912Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.001307Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01335Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.177Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8449Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.00000001635InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.1113InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.7781InformativeInherited
Xenopus ANatomical entity (XAN)periocular region0.00002054Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic placode0.00003233Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.000082Highly InformativeDirect
Xenopus ANatomical entity (XAN)branchial arch0.0003887Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0004559Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0009648Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.1185Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Plexin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Plexin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]