SUPERFAMILY 1.75 HMM library and genome assignments server

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Plexin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Trefoil/Plexin domain-like [ 57491] (3)
Superfamily:   Plexin repeat [ 103575]
Families:   Plexin repeat [ 103576] (3)

Superfamily statistics
Genomes (152) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,100 11,027 5
Proteins 3,860 10,407 5

Functional annotation
General category Regulation
Detailed category Receptor activity

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hypersensitivity reaction type II disease0.1089Moderately InformativeInherited
Disease Ontology (DO)skin disease0.2538Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00009261InformativeDirect
Disease Ontology (DO)bullous skin disease0.0004078InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0005612Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.02741Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0003212Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.0009748Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002956Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08152Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4323Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4586Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.6819Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.000213InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.002243InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.005401InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.01379InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.04097InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.07436InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.115InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.1385InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.1436InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.00000000002702Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal inner plexiform layer morphology0.000003716Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.00002876Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.00003375Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hippocampal mossy fiber morphology0.00004611Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.0001512Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal migration0.0007477Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.004841Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.00003744Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.03901Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.000000002321InformativeDirect
Worm Phenotype (WP)male morphology variant0.00000003329InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.0000015InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00001063InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.000000002436Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000002101Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.09826Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.0003093Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.008974Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02182Moderately InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.00001667InformativeDirect
Fly Anatomy (FA)abdominal segment0.00007909InformativeDirect
Fly Anatomy (FA)larval abdomen0.0001924InformativeDirect
Fly Anatomy (FA)larval segment0.002776InformativeInherited
Fly Anatomy (FA)nerve0.008409InformativeInherited
Fly Anatomy (FA)gut section0.07712InformativeInherited
Fly Anatomy (FA)tract0.1386InformativeInherited
Fly Anatomy (FA)fascicle0.00000007784Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.0003576Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.4719Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5854Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.0802Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.451Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.02153InformativeInherited
Zebrafish Anatomy (ZA)primary germ layer0.02295InformativeInherited
Zebrafish Anatomy (ZA)primary motor neuron0.00006454Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.5634Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.769Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.00007848Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0009526Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.01074Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1683Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.837Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.00000001107InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.08847InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.7343InformativeInherited
Xenopus ANatomical entity (XAN)otic placode0.00003647Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.00007682Highly InformativeDirect
Xenopus ANatomical entity (XAN)branchial arch0.0003581Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0004512Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0009783Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.1217Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Plexin repeat domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Plexin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]