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BAR/IMD domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   BAR/IMD domain-like [ 116747]
Superfamily:   BAR/IMD domain-like [ 103657] (4)
Families:   BAR domain [ 103658] (3)
  Arfaptin, Rac-binding fragment [ 64599]
  IMD domain [ 140703]
  FCH domain [ 158645] (2)


Superfamily statistics
Genomes (545) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 13,946 35,343 12
Proteins 13,739 34,982 12


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.0001620Least InformativeDirect
Biological Process (BP)single-organism cellular process0.11130Least InformativeInherited
Biological Process (BP)organelle organization0.058841Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.090770.02342Moderately InformativeInherited
Biological Process (BP)vesicle-mediated transport0.0053270InformativeInherited
Biological Process (BP)cell projection assembly0.0026230.000000000992Highly InformativeInherited
Biological Process (BP)plasma membrane bounded cell projection organization0.00029540.9535Highly InformativeInherited
Cellular Component (CC)cell projection0.002420.00000000003114Moderately InformativeInherited
Cellular Component (CC)cilium0.0010490.4555InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.16090.06711InformativeInherited
Cellular Component (CC)ciliary base0.0000000010620.0000007778Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000000052 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8522 Least Informative Inherited
Biological Process (BP) reproduction 0.0009517 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000006088 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000008736 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0003441 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.4486 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1614 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9772 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01265 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.02342 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3899 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.03508 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.005504 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.009342 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.009453 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.1002 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.6284 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.2338 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.3168 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1213 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.5666 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1217 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2617 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.00001676 Informative Direct
Biological Process (BP) regulation of growth 0.000004787 Informative Direct
Biological Process (BP) locomotion 0.0001206 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000000007952 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) intracellular transport 0.00003818 Informative Direct
Biological Process (BP) negative regulation of transport 0.00004952 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0003585 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000000000002856 Informative Direct
Biological Process (BP) epithelium development 0.000000401 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.341 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1782 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1947 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1219 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.06699 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.03809 Informative Inherited
Biological Process (BP) organelle localization 0.3209 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.6548 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.2268 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.02361 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.2413 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.00755 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1031 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.1609 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.01231 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.5596 Informative Inherited
Biological Process (BP) regulation of immune response 0.8077 Informative Inherited
Biological Process (BP) cell cycle process 0.6949 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02262 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.8951 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.8625 Informative Inherited
Biological Process (BP) phosphorylation 0.7645 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.5641 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.534 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6192 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8118 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.2039 Informative Inherited
Biological Process (BP) localization of cell 0.9036 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7057 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.003671 Informative Inherited
Biological Process (BP) positive regulation of transport 0.008141 Informative Inherited
Biological Process (BP) cell development 0.003623 Informative Inherited
Biological Process (BP) organelle assembly 0.1115 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4967 Informative Inherited
Biological Process (BP) cytokinesis 0.000007947 Highly Informative Direct
Biological Process (BP) lysosome organization 0.000002549 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.00009364 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.0009296 Highly Informative Direct
Biological Process (BP) germ cell development 0.0000002851 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000023 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.0000212 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000284 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0001479 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000000000992 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00000000001515 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.00000001633 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000009135 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.0008958 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0000000001019 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000002159 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.00000004015 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000000006926 Highly Informative Direct
Biological Process (BP) appendage development 0.0008274 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell proliferation 0.0001132 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000006989 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.000264 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.000000000004362 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Highly Informative Direct
Biological Process (BP) response to growth factor 0.00001762 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0001204 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.03306 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.001669 Highly Informative Inherited
Biological Process (BP) single-organism membrane fusion 1 Highly Informative Inherited
Biological Process (BP) kidney development 0.002494 Highly Informative Inherited
Biological Process (BP) heart contraction 0.001854 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.04427 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.006612 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.01021 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.5651 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.00268 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.05587 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.3101 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.9535 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.002606 Highly Informative Inherited
Biological Process (BP) embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.003948 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.08759 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.2781 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.2037 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.03735 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.879 Highly Informative Inherited
Biological Process (BP) muscle system process 0.02618 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.702 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000000000117 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000006488 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.1136 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.008939 Informative Inherited
Molecular Function (MF) enzyme binding 0.1372 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) protein domain specific binding 0.0001338 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0003628 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0001142 Highly Informative Direct
Molecular Function (MF) small GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1332 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000000006048 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000074 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000003114 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.000000007152 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.2067 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.09417 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000009726 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000181 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0000000000002733 Informative Direct
Cellular Component (CC) membrane region 0.0001602 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000009291 Informative Direct
Cellular Component (CC) Golgi apparatus 0.01516 Informative Inherited
Cellular Component (CC) side of membrane 0.01597 Informative Inherited
Cellular Component (CC) cell surface 0.01022 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.06711 Informative Inherited
Cellular Component (CC) cilium 0.4555 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) ruffle 0.0001479 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.00000000009207 Highly Informative Direct
Cellular Component (CC) midbody 0.0000000005782 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.00000001382 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) ciliary base 0.0000007778 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.0001511 Highly Informative Direct
Cellular Component (CC) presynapse 0.00000001382 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.05457 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.004517Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle0.001046Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0.00000000000001382InformativeDirect
Biological processAutophagy0.00000000000003736InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processSeptation0.00008742Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentLysosome0.0000004042InformativeDirect
Cellular componentMitochondrion outer membrane0.00004342InformativeDirect
Cellular componentCoated pit0.0000000000009434Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00005644Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000215InformativeDirect
DiseaseProto-oncogene0.00003238Moderately InformativeDirect
DiseaseTumor suppressor0.0003371Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainANK repeat0.00000000000002406InformativeDirect
DomainSH2 domain0.00000002922InformativeDirect
DomainSH3-binding0.00008068InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.9037Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationActin-binding0.00000000002316InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000004609InformativeDirect
Post-translational modificationTyrosine-protein kinase0.000000000002653Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BAR/IMD domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the BAR/IMD domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]