SUPERFAMILY 1.75 HMM library and genome assignments server

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BAR/IMD domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   BAR/IMD domain-like [ 116747]
Superfamily:   BAR/IMD domain-like [ 103657] (4)
Families:   BAR domain [ 103658] (3)
  Arfaptin, Rac-binding fragment [ 64599]
  IMD domain [ 140703]
  FCH domain [ 158645] (2)


Superfamily statistics
Genomes (547) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,083 43,150 12
Proteins 13,876 42,731 12


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.531Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.6393Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.9251Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4251Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.5384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.562Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.6526Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1095InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.2127InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.2709InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.2769InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling0.00000007846Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.0000123Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.003491Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hematocrit0.01211Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.004107Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.004598Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03202Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.0001868Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.002797Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.206Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.5439Moderately InformativeInherited
Worm Phenotype (WP)accumulated germline cell corpses0.00001776InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.008568InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.08329InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.4883InformativeInherited
Worm Phenotype (WP)gut granule development variant0.0001886Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective0.0007797Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.005119Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.4051Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4075Least InformativeInherited
Fly Anatomy (FA)somatic cell0.538Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08628Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1795Moderately InformativeInherited
Fly Anatomy (FA)cell component0.004054InformativeInherited
Fly Anatomy (FA)bouton0.00002156Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.00004939Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BAR/IMD domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the BAR/IMD domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]