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BAR/IMD domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   BAR/IMD domain-like [ 116747]
Superfamily:   BAR/IMD domain-like [ 103657] (4)
Families:   BAR domain [ 103658] (3)
  Arfaptin, Rac-binding fragment [ 64599]
  IMD domain [ 140703]
  FCH domain [ 158645] (2)


Superfamily statistics
Genomes (545) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 13,946 35,343 12
Proteins 13,739 34,982 12


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.000048990Least InformativeDirect
Biological Process (BP)single-organism cellular process0.052370.00000000000005114Least InformativeInherited
Biological Process (BP)organelle organization0.060071Moderately InformativeInherited
Biological Process (BP)actin filament-based process0.00055230.0000000003818InformativeDirect
Biological Process (BP)vesicle-mediated transport0.0035340InformativeInherited
Cellular Component (CC)cell projection0.0015430.0000000001422Moderately InformativeInherited
Cellular Component (CC)cilium0.00066150.3983InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.16240.2568InformativeInherited
Cellular Component (CC)ciliary base0.00000000069310.0000008935Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000005114 Least Informative Direct
Biological Process (BP) biological regulation 0.00000000000002636 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5433 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.000000988 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000000238 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000006198 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0006218 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9203 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3257 Moderately Informative Inherited
Biological Process (BP) system development 0.7946 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1917 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.04834 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03034 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3549 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3128 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08142 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.204 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08602 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05619 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.008467 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1798 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.007269 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.422 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.3109 Moderately Informative Inherited
Biological Process (BP) cell communication 0.05726 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0.0000000003818 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000006088 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000000002647 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000000001386 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000004251 Informative Direct
Biological Process (BP) regulation of growth 0.000006944 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0006129 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0007181 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.1605 Informative Inherited
Biological Process (BP) regulation of locomotion 0.3052 Informative Inherited
Biological Process (BP) organelle assembly 0.0763 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.153 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9446 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.01162 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1354 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.7414 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.02151 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2987 Informative Inherited
Biological Process (BP) negative regulation of transport 0.09697 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.2221 Informative Inherited
Biological Process (BP) organelle localization 0.4508 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.01499 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) tissue development 0.2134 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.4095 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.003861 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.7363 Informative Inherited
Biological Process (BP) phosphorylation 0.5803 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.4096 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4463 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.9971 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02576 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5498 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.7095 Informative Inherited
Biological Process (BP) cell-cell signaling 0.1349 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5201 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.8235 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.07582 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001032 Informative Inherited
Biological Process (BP) positive regulation of transport 0.001729 Informative Inherited
Biological Process (BP) cell development 0.002951 Informative Inherited
Biological Process (BP) cell cycle process 0.6194 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1325 Informative Inherited
Biological Process (BP) cell projection assembly 0.00001506 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.000000000004879 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00000000001745 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0000000002588 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000000001954 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.000000003945 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.000000004121 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.00000001403 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.00000002697 Highly Informative Direct
Biological Process (BP) lysosome organization 0.000001441 Highly Informative Direct
Biological Process (BP) trans-synaptic signaling 0.000001689 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000007609 Highly Informative Direct
Biological Process (BP) vesicle localization 0.000009683 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00001148 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000016 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.00003362 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell proliferation 0.00003957 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.00004356 Highly Informative Direct
Biological Process (BP) appendage development 0.00004517 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00006019 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00006068 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00006411 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.00007929 Highly Informative Direct
Biological Process (BP) kidney development 0.0002772 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.0004347 Highly Informative Direct
Biological Process (BP) germ cell development 0.0005697 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0006627 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.001333 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.05366 Highly Informative Inherited
Biological Process (BP) single-organism membrane fusion 1 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.001325 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.5867 Highly Informative Inherited
Biological Process (BP) heart contraction 0.001393 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.00114 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.006551 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.05405 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.3123 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.04232 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.2422 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.9787 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.001484 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.8904 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.1486 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.1602 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.2395 Highly Informative Inherited
Biological Process (BP) muscle system process 0.01599 Highly Informative Inherited
Biological Process (BP) cell division 0.04056 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.000000000000006357 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000000001537 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00000008427 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.1209 Informative Inherited
Molecular Function (MF) enzyme binding 0.1183 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.003484 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0000875 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0001984 Highly Informative Direct
Molecular Function (MF) small GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.8202 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.9711 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9011 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000000001422 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000000000001135 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.000000002518 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000003633 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.09978 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.09455 Moderately Informative Inherited
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00000000000001496 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000001518 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000007615 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000001202 Informative Direct
Cellular Component (CC) membrane region 0.0002741 Informative Direct
Cellular Component (CC) Golgi apparatus 0.007792 Informative Inherited
Cellular Component (CC) cell surface 0.0278 Informative Inherited
Cellular Component (CC) cilium 0.3983 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.2568 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) side of membrane 0.01019 Informative Inherited
Cellular Component (CC) ciliary base 0.0000008935 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.000000000044 Highly Informative Direct
Cellular Component (CC) midbody 0.000000001789 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.000000008007 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.0001936 Highly Informative Direct
Cellular Component (CC) ruffle 0.0003408 Highly Informative Direct
Cellular Component (CC) dendrite 0.7113 Highly Informative Inherited
Cellular Component (CC) cortical actin cytoskeleton 0.004737 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.5308Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.6408Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.9256Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2281Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3983Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4256Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.538Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.5609Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.6529Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.0191InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1091InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.2119InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.2703InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.2763InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling0.00000007855Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.00001225Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.003566Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hematocrit0.01212Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.008849Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.008934Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2449Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.0007886Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.03127Moderately InformativeInherited
Worm Phenotype (WP)accumulated germline cell corpses0.0001528InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.009985InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.04364InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.1052InformativeInherited
Worm Phenotype (WP)gut granule development variant0.0001611Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.3841Least InformativeInherited
Fly Anatomy (FA)nervous system0.4544Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6536Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1419Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2053Moderately InformativeInherited
Fly Anatomy (FA)cell component0.01651InformativeInherited
Fly Anatomy (FA)bouton0.0003585Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.0005749Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00392Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle0.0009642Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processAutophagy0.00000000000003504InformativeDirect
Biological processNeurogenesis0.0000000000001988InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processSeptation0.00008981Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentLysosome0.0000003738InformativeDirect
Cellular componentMitochondrion outer membrane0.00003907InformativeDirect
Cellular componentCoated pit0.0000000000009568Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00008567Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.0002081InformativeDirect
DiseaseProto-oncogene0.00003355Moderately InformativeDirect
DiseaseTumor suppressor0.0003476Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainANK repeat0.000000000000193InformativeDirect
DomainSH2 domain0.00000002744InformativeDirect
DomainSH3-binding0.00007817InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.8963Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationActin-binding0.00000000002162InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000004453InformativeDirect
Post-translational modificationTyrosine-protein kinase0.000000000002561Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BAR/IMD domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the BAR/IMD domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]