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Glycolipid transfer protein, GLTP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Glycolipid transfer protein, GLTP [ 110003]
Superfamily:   Glycolipid transfer protein, GLTP [ 110004]
Families:   Glycolipid transfer protein, GLTP [ 110005]


Superfamily statistics
Genomes (430) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,391 1,290 1
Proteins 1,377 1,281 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule localization0.0000000000057030.000000000000001945Moderately InformativeDirect
Biological Process (BP)organic substance transport0.00000000021110.000000000000001945Moderately InformativeDirect
Biological Process (BP)single-organism transport0.0000000021730.0000000000002117Moderately InformativeDirect
Biological Process (BP)nitrogen compound transport0.035150.0002377Moderately InformativeInherited
Biological Process (BP)ion transport0.012920.1514Moderately InformativeInherited
Biological Process (BP)lipid localization00InformativeDirect
Biological Process (BP)anion transport0.0000000047090.00000002011InformativeDirect
Biological Process (BP)organophosphate ester transport0.00000014380.0000007648Highly InformativeDirect
Molecular Function (MF)binding0.00027180.0006927Least InformativeDirect
Molecular Function (MF)transporter activity0.0000000000045910Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000064410.00000000001294Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.013160.0000004382Moderately InformativeInherited
Molecular Function (MF)amide binding0.000000000018570InformativeDirect
Molecular Function (MF)phospholipid binding0.000020.0000006284InformativeDirect
Molecular Function (MF)lipid transporter activity00Highly InformativeDirect
Molecular Function (MF)glycolipid binding0.00018340.0000000000007312Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity0.001410.000000004887Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule localization 0.000000000000001945 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000000000000001945 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000000000002117 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.0002377 Moderately Informative Direct
Biological Process (BP) cellular localization 0.5568 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1514 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) anion transport 0.00000002011 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.06566 Informative Inherited
Biological Process (BP) organophosphate ester transport 0.0000007648 Highly Informative Direct
Molecular Function (MF) binding 0.0006927 Least Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000000001294 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000004382 Moderately Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) phospholipid binding 0.0000006284 Informative Direct
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.0000000000007312 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.000000004887 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.2726 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2873 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.002706 Least Informative Inherited
Cellular Component (CC) Golgi apparatus 0.000002316 Informative Direct
Cellular Component (CC) Golgi subcompartment 0.0000001556 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid transport0InformativeDirect
Cellular componentMembrane0.0003624Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0.00000000001492Moderately InformativeDirect
DomainRepeat0.0005944Least InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR014830 SSF110004 Protein matches
Abstract

Glycolipid transfer protein (GLTP) is a cytosolic protein that catalyses the intermembrane transfer of glycolipids such as glycosphingolipids, glyceroglycolipids, and possibly glucosylceramides, but not of phospholipids. GLTP has a multi-helical structure consisting of two layers of orthogonally packed helices [PubMed15504043, PubMed16309699].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycolipid transfer protein, GLTP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Glycolipid transfer protein, GLTP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]