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Glycolipid transfer protein, GLTP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Glycolipid transfer protein, GLTP [ 110003]
Superfamily:   Glycolipid transfer protein, GLTP [ 110004]
Families:   Glycolipid transfer protein, GLTP [ 110005]


Superfamily statistics
Genomes (433) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,404 2,927 1
Proteins 1,390 2,899 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule localization0.00000000000021040Moderately InformativeDirect
Biological Process (BP)organic substance transport0.0000000000096510Moderately InformativeDirect
Biological Process (BP)single-organism transport0.00000000013570.00000000000002769Moderately InformativeDirect
Biological Process (BP)nitrogen compound transport0.0660.0005199Moderately InformativeInherited
Biological Process (BP)ion transport0.029110.2093Moderately InformativeInherited
Biological Process (BP)lipid localization00InformativeDirect
Biological Process (BP)anion transport0.000000006960.00000003056InformativeDirect
Biological Process (BP)organophosphate ester transport0.00000056790.00000177Highly InformativeDirect
Molecular Function (MF)binding0.00067420.002431Least InformativeInherited
Molecular Function (MF)transporter activity0.0000000000090980Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000090150.00000000002974Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.011180.0000001984Moderately InformativeInherited
Molecular Function (MF)amide binding0.000000000013620InformativeDirect
Molecular Function (MF)phospholipid binding0.000020.0000007932InformativeDirect
Molecular Function (MF)lipid transporter activity00Highly InformativeDirect
Molecular Function (MF)glycolipid binding0.00017830.0000000000008391Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule localization 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.00000000000002769 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.0005199 Moderately Informative Direct
Biological Process (BP) cellular localization 0.6552 Moderately Informative Inherited
Biological Process (BP) ion transport 0.2093 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) anion transport 0.00000003056 Informative Direct
Biological Process (BP) single-organism cellular localization 0.09585 Informative Inherited
Biological Process (BP) intracellular transport 0.3172 Informative Inherited
Biological Process (BP) organophosphate ester transport 0.00000177 Highly Informative Direct
Molecular Function (MF) binding 0.002431 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000000002974 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000001984 Moderately Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) phospholipid binding 0.0000007932 Informative Direct
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.0000000000008391 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol phosphate binding 0.0000000005577 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.000002248 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.243 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1836 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.001536 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0002884 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000003087 Informative Direct
Cellular Component (CC) Golgi subcompartment 0.0000002204 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid transport0InformativeDirect
Cellular componentMembrane0.0003791Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0.00000000001538Moderately InformativeDirect
DomainRepeat0.0005986Least InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR014830 SSF110004 Protein matches
Abstract

Glycolipid transfer protein (GLTP) is a cytosolic protein that catalyses the intermembrane transfer of glycolipids such as glycosphingolipids, glyceroglycolipids, and possibly glucosylceramides, but not of phospholipids. GLTP has a multi-helical structure consisting of two layers of orthogonally packed helices [PubMed15504043, PubMed16309699].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycolipid transfer protein, GLTP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Glycolipid transfer protein, GLTP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]