SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


ThiG-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   ThiG-like [ 110399]
Families:   ThiG-like [ 110400]


Superfamily statistics
Genomes (1,553) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,585 10,202 3
Proteins 1,584 10,197 3


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00000018740.0000004288Least InformativeDirect
Biological Process (BP)biosynthetic process0.00000075380.0000003963Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.00000051790.000001036Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.000010170.000003222Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00000019230.00000039Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00000044620.0000007874Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.0000073510.00001204Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0002130.001384Least InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0000000000039230.0000000000002271Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00000000025740.00000000009393Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.000000000080240.00000000006528Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00000000021560.000000000006725Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.00000000060830.0000000002719Moderately InformativeDirect
Biological Process (BP)water-soluble vitamin biosynthetic process00InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.000000000000014920InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process00InformativeDirect
Biological Process (BP)thiamine biosynthetic process00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0000004288 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000003963 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000001036 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000003222 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000039 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000007874 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00001204 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.001384 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.0000000000002271 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000000009393 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00000000006528 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000000006725 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000000002719 Moderately Informative Direct
Biological Process (BP) water-soluble vitamin biosynthetic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) thiamine biosynthetic process 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processThiamine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008867 SSF110399 Protein matches
Abstract This family consists of several bacterial thiazole biosynthesis protein G sequences. ThiG, together with ThiF and ThiH, is proposed to be involved in the synthesis of 4-methyl-5-(b-hydroxyethyl)thiazole (THZ) which is an intermediate in the thiazole production pathway [PubMed9371431].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ThiG-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the ThiG-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]