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Ligand-binding domain in the NO signalling and Golgi transport superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ligand-binding domain in the NO signalling and Golgi transport [ 111125]
Superfamily:   Ligand-binding domain in the NO signalling and Golgi transport [ 111126] (3)
Families:   H-NOX domain [ 111127]
  TRAPP components [ 118076] (2)
  MJ1460-like [ 160689]


Superfamily statistics
Genomes (1,242) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,608 12,184 7
Proteins 3,583 12,070 7


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.17131Least InformativeInherited
Biological Process (BP)cellular localization0.00010080.00001025Moderately InformativeDirect
Biological Process (BP)organelle organization0.0075150.3602Moderately InformativeInherited
Biological Process (BP)vesicle-mediated transport0.000000087240.0000001526InformativeDirect
Biological Process (BP)intracellular transport0.00001520.0000001495InformativeDirect
Biological Process (BP)Golgi vesicle transport00Highly InformativeDirect
Biological Process (BP)vesicle organization0.0000000077140.000001485Highly InformativeDirect
Molecular Function (MF)molecular function regulator0.000000081510.000002491Moderately InformativeDirect
Molecular Function (MF)guanyl-nucleotide exchange factor activity00.0000000000000123Highly InformativeDirect
Cellular Component (CC)protein complex0.0000025710.000000000000008837Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.96041Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.60860.003716Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.22291Least InformativeInherited
Cellular Component (CC)endomembrane system0.0006630.01822Moderately InformativeInherited
Cellular Component (CC)vesicle0.130.1719Moderately InformativeInherited
Cellular Component (CC)Golgi apparatus0.000000039890.000007318InformativeDirect
Cellular Component (CC)cytoplasmic vesicle part0.0023290.004646InformativeInherited
Cellular Component (CC)endosome0.056970.02335InformativeInherited
Cellular Component (CC)tethering complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.0008994 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0009198 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2049 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.001026 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4109 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.002355 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01397 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.7212 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.03159 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.001281 Least Informative Inherited
Biological Process (BP) cellular localization 0.00001025 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.00000000000004411 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0000000000002301 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000000000001467 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000000005057 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000000009778 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000006621 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000000107 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.646 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.0105 Moderately Informative Inherited
Biological Process (BP) cell communication 0.07988 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1773 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.04584 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3602 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.01135 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.0000001526 Informative Direct
Biological Process (BP) intracellular transport 0.0000001495 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0.000001241 Informative Direct
Biological Process (BP) cellular response to inorganic substance 0.00001412 Informative Direct
Biological Process (BP) response to nitrogen compound 0.06932 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.02789 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.001897 Informative Inherited
Biological Process (BP) Golgi vesicle transport 0 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000001485 Highly Informative Direct
Biological Process (BP) second-messenger-mediated signaling 0.0000000003726 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0001569 Highly Informative Direct
Molecular Function (MF) binding 0.2871 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.000002491 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.000000000000001615 Moderately Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000000008052 Informative Direct
Molecular Function (MF) protein dimerization activity 0.01571 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0000000000000123 Highly Informative Direct
Molecular Function (MF) heme binding 0.00000000572 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.000009707 Highly Informative Direct
Cellular Component (CC) protein complex 0.000000000000008837 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.003716 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0.000000000002069 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.01822 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.1719 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.000007318 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.004646 Informative Inherited
Cellular Component (CC) endosome 0.02335 Informative Inherited
Cellular Component (CC) tethering complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000000006216Least InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
DomainCoiled coil0.0000001624Moderately InformativeDirect
Molecular functionNucleotide-binding0.00000794Least InformativeDirect
Molecular functionMetal-binding0.1016Least InformativeInherited
Molecular functionIron0.000000002448Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationPalmitate0.0000000001062Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011644 SSF111126 Protein matches
Abstract The HNOB (Heme NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ligand-binding domain in the NO signalling and Golgi transport domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Ligand-binding domain in the NO signalling and Golgi transport superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]