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Kelch motif superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Kelch motif [ 117281]
Families:   Kelch motif [ 117282]


Superfamily statistics
Genomes (957) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 20,144 51,892 4
Proteins 17,777 45,641 4


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.00000000963 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000002059 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.5138 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.7875 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.6919 Least Informative Inherited
Biological Process (BP) biological regulation 0.02398 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.06029 Least Informative Inherited
Biological Process (BP) tissue development 0.0000001714 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000002361 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000005537 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000009507 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000003079 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001888 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002915 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0003872 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0004258 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7121 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02507 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02452 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4237 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1035 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4446 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5395 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.7889 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.296 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4626 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8983 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.8928 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.3709 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.002431 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.1541 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.05935 Moderately Informative Inherited
Biological Process (BP) cell development 0.0000000004045 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000008888 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000001531 Informative Direct
Biological Process (BP) regulation of growth 0.000006347 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000009397 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00001641 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00005987 Informative Direct
Biological Process (BP) embryo development 0.00006517 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.000247 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0002921 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0004885 Informative Direct
Biological Process (BP) regulation of locomotion 0.0005898 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.4389 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.05177 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.02467 Informative Inherited
Biological Process (BP) epithelium development 0.873 Informative Inherited
Biological Process (BP) cell cycle process 0.1441 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.1296 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.007846 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.488 Informative Inherited
Biological Process (BP) generation of neurons 0.01574 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.001083 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.02023 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.008497 Informative Inherited
Biological Process (BP) protein localization to organelle 0.09489 Informative Inherited
Biological Process (BP) circulatory system development 0.003938 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.001975 Informative Inherited
Biological Process (BP) secondary metabolic process 0.01759 Informative Inherited
Biological Process (BP) growth 0.003049 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02602 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.03681 Informative Inherited
Biological Process (BP) proteolysis 0.007894 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.002106 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) metal ion transport 0.2098 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.07614 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.128 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of cell size 0.00000000000001254 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000000000004192 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000000000004206 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0000000005602 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.0000000008337 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000000002928 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000000005927 Highly Informative Direct
Biological Process (BP) appendage development 0.00000001021 Highly Informative Direct
Biological Process (BP) response to growth factor 0.00000008471 Highly Informative Direct
Biological Process (BP) cell growth 0.00000008642 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.0000001298 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0000001452 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0000002843 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000003891 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.0000007062 Highly Informative Direct
Biological Process (BP) heart development 0.000003014 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.000003524 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.00001621 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00004332 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.00006399 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle phase transition 0.0001113 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.0001323 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0002297 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0003219 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0005136 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0008137 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0008636 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.001548 Highly Informative Inherited
Biological Process (BP) neuron development 0.5788 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.001287 Highly Informative Inherited
Biological Process (BP) kidney development 0.0905 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.05369 Highly Informative Inherited
Biological Process (BP) regulation of chromosome segregation 0.003223 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.02431 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.002602 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.02719 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.001027 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.01501 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.01438 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.04916 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00002892 Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.00000001387 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.02516 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000682 Moderately Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0.000009509 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.3278 Informative Inherited
Cellular Component (CC) spindle 0.00002147 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.007019Least InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000004386Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.0000000001653InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.0000000006671Moderately InformativeDirect
Biological processHost-virus interaction0.00006994Moderately InformativeDirect
Biological processCell cycle0.0000717Moderately InformativeDirect
Biological processDifferentiation0.002756Moderately InformativeInherited
Biological processMitosis2.442e-16InformativeDirect
Biological processMeiosis0.000003553InformativeDirect
Biological processTranslation regulation0.0000194InformativeDirect
Biological processSpermatogenesis0.00003097Highly InformativeDirect
Cellular componentNucleus0.0003752Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.00000001953Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0.0000001976InformativeDirect
Cellular componentSarcoplasmic reticulum0.00000006437Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainKelch repeat0Highly InformativeDirect
DomainLaminin EGF-like domain0.00000001644Highly InformativeDirect
Molecular functionLectin0.0002085InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.0003156Moderately InformativeDirect
Post-translational modificationIsomerase0.0003325Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0.0004813InformativeDirect
Post-translational modificationPhosphoprotein0.0005358Least InformativeDirect
Post-translational modificationUbl conjugation0.0001567Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kelch motif domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Kelch motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]