SUPERFAMILY 1.75 HMM library and genome assignments server

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WWE domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   WWE domain [ 117838]
Superfamily:   WWE domain [ 117839]
Families:   WWE domain [ 117840] (2)


Superfamily statistics
Genomes (214) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,065 5,478 3
Proteins 1,714 4,637 2


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.1731Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1808Least InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.02898Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.04161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.05619Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001954InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.007961InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.06606InformativeInherited
Mammalian Phenotype (MP)abnormal spleen marginal zone morphology0.0001149Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0007454Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05826Least InformativeInherited
Worm Phenotype (WP)protein interaction variant0.0002656Moderately InformativeDirect
Worm Phenotype (WP)neuron migration variant0InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Aminoacyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.00002359Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WWE domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the WWE domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]