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DUSP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DUSP-like [ 143790]
Superfamily:   DUSP-like [ 143791]
Families:   DUSP, domain in ubiquitin-specific proteases [ 143792]


Superfamily statistics
Genomes (446) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,905 4,476 1
Proteins 1,624 3,815 1


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0006802 Least Informative Direct
Biological Process (BP) response to stimulus 0.6037 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.001738 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3488 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signaling 0.0001344 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0004593 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9741 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2117 Moderately Informative Inherited
Biological Process (BP) cell communication 0.8889 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.23 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1621 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1247 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1473 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2704 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6818 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2183 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01044 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9232 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001281 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.002208 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.05289 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.2568 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1465 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.7231 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2438 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0.000001054 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0002355 Informative Direct
Biological Process (BP) microtubule-based process 0.0003884 Informative Direct
Biological Process (BP) regulation of protein modification process 0.004974 Informative Inherited
Biological Process (BP) generation of neurons 0.006847 Informative Inherited
Biological Process (BP) cell development 0.0561 Informative Inherited
Biological Process (BP) phosphorylation 0.003846 Informative Inherited
Biological Process (BP) cell cycle process 0.009868 Informative Inherited
Biological Process (BP) chromosome organization 0.2041 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.01489 Informative Inherited
Biological Process (BP) localization of cell 0.006432 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.003657 Informative Inherited
Biological Process (BP) locomotion 0.005736 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.007056 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.0179 Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000000002612 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000001335 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0000008491 Highly Informative Direct
Biological Process (BP) RNA splicing 0.000005436 Highly Informative Direct
Biological Process (BP) mRNA processing 0.000008296 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000009543 Highly Informative Direct
Biological Process (BP) response to growth factor 0.00002582 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00009744 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0001326 Highly Informative Direct
Biological Process (BP) neuron development 0.0004929 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0007688 Highly Informative Direct
Biological Process (BP) histone modification 0.5239 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.9494 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.0006172 Moderately Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.0000005672 Informative Direct
Molecular Function (MF) cysteine-type endopeptidase activity 0.00000003419 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0562 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2098 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00001213 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0000000000006479 Informative Direct
Cellular Component (CC) microtubule organizing center 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Cellular componentNucleus0.00000000004541Least InformativeDirect
Cellular componentCytoplasm0.000004529Least InformativeDirect
Cellular componentCytoskeleton0.000000000007374Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0.0000001219Moderately InformativeDirect
Molecular functionZinc0.0000000002199Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000000005218Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DUSP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the DUSP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]