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Orange domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Orange domain-like [ 158456]
Superfamily:   Orange domain-like [ 158457]
Families:   Hairy Orange domain [ 158458]


Superfamily statistics
Genomes (128) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,153 3,047 1
Proteins 1,148 3,037 1


Functional annotation
Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00832Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2333Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1658Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1854Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.01043InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.04783InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.06801InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.000003514Highly InformativeDirect
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.00001476Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.00001476Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.00001939Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.0001916Highly InformativeDirect
Mammalian Phenotype (MP)increased heart ventricle size0.000272Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0004463Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.001994Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.01109InformativeInherited
Fly Phenotype (FP)increased cell number0.0002438Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organism subdivision0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)nervous system0.4155Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4226Least InformativeInherited
Fly Anatomy (FA)larva0.6518Least InformativeInherited
Fly Anatomy (FA)cell0.7587Least InformativeInherited
Fly Anatomy (FA)ganglion0.04678Moderately InformativeInherited
Fly Anatomy (FA)thorax0.04729Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.151Moderately InformativeInherited
Fly Anatomy (FA)embryo0.1769Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1901Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.004939InformativeInherited
Fly Anatomy (FA)larval segment0.06163InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.07472InformativeInherited
Fly Anatomy (FA)neuromere0.1864InformativeInherited
Fly Anatomy (FA)EL neuron0.00002134Highly InformativeDirect
Fly Anatomy (FA)larval neuromere0.001443Highly InformativeInherited
Fly Anatomy (FA)embryonic thorax0.01865Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.1775Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1807Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2246Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2616Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.2686Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.5266Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0005483Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0008134Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.001202Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.004149Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.04289Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.05031Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.000003284InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.000004115InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00001217InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00001524InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00003567InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0001974InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0003546InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.002723InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.004438InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.006596InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.007971InformativeInherited
Xenopus ANatomical entity (XAN)tail0.009067InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.03161InformativeInherited
Xenopus ANatomical entity (XAN)intermediate mesoderm0.000000217Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.000002416Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.00002363Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0001152Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0001958Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.0002105Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0009174Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.001218Highly InformativeInherited
Xenopus ANatomical entity (XAN)tail bud0.001337Highly InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Orange domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Orange domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]