SUPERFAMILY 1.75 HMM library and genome assignments server

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Orange domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Orange domain-like [ 158456]
Superfamily:   Orange domain-like [ 158457]
Families:   Hairy Orange domain [ 158458]


Superfamily statistics
Genomes (128) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,153 3,047 1
Proteins 1,148 3,037 1


Functional annotation
Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.008328Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2331Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06339Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1658Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1854Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.01043InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.04783InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.06801InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.000003522Highly InformativeDirect
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.00001478Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.00001478Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.00001942Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.0001917Highly InformativeDirect
Mammalian Phenotype (MP)increased heart ventricle size0.0002721Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0004463Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.001994Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.0111InformativeInherited
Fly Phenotype (FP)increased cell number0.000244Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.4532Least InformativeInherited
Fly Anatomy (FA)nervous system0.4632Least InformativeInherited
Fly Anatomy (FA)larva0.6299Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6603Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)thorax0.04821Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.04906Moderately InformativeInherited
Fly Anatomy (FA)embryo0.138Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1485Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2003Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.004731InformativeInherited
Fly Anatomy (FA)larval segment0.06908InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.07139InformativeInherited
Fly Anatomy (FA)neuromere0.1881InformativeInherited
Fly Anatomy (FA)EL neuron0.00002328Highly InformativeDirect
Fly Anatomy (FA)larval neuromere0.001445Highly InformativeInherited
Fly Anatomy (FA)embryonic thorax0.01879Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.1774Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.1782Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2229Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.263Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.2693Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.5266Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0005558Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0006285Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0007172Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.004203Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.04326Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.05047Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.000003336InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.000004223InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00001226InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00001517InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00003484InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0001447InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0003484InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.002745InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.004416InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.006543InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.007922InformativeInherited
Xenopus ANatomical entity (XAN)tail0.008984InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.0315InformativeInherited
Xenopus ANatomical entity (XAN)intermediate mesoderm0.0000002037Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.000002424Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.00002285Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0001138Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0001935Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.0002082Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0009613Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.001186Highly InformativeInherited
Xenopus ANatomical entity (XAN)tail bud0.001557Highly InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Orange domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Orange domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]