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FCH domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   BAR/IMD domain-like [ 116747]
Superfamily:   BAR/IMD domain-like [ 103657] (4)
Family:   FCH domain [ 158645] (2)


Family statistics
Genomes (141) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 447 1,170 2
Proteins 443 1,166 2


Gene Ontology (high-quality)

(
show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000001625 Least Informative Direct
Biological Process (BP) biological regulation 0.000000003696 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0003356 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000005893 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00001209 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00005311 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.01243 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.08615 Moderately Informative Inherited
Biological Process (BP) cell communication 0.0696 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01163 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.03763 Moderately Informative Inherited
Biological Process (BP) negative regulation of biological process 0.006992 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6173 Moderately Informative Inherited
Biological Process (BP) single-organism localization 0.1461 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.001836 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9383 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.9202 Moderately Informative Inherited
Biological Process (BP) transport 0.4724 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6774 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.181 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.4774 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule metabolic process 0.6109 Moderately Informative Inherited
Biological Process (BP) regulation of primary metabolic process 0.5547 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.508 Moderately Informative Inherited
Biological Process (BP) system development 0.7215 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 0.00003425 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000001941 Informative Direct
Biological Process (BP) nervous system development 0.000000003364 Informative Direct
Biological Process (BP) post-embryonic development 0.0001599 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) sexual reproduction 0.00000001511 Informative Direct
Biological Process (BP) actin filament-based process 0.00002255 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.0002156 Informative Direct
Biological Process (BP) cellular protein localization 0.00000000000003226 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.000001824 Informative Direct
Biological Process (BP) regulation of growth 0.00000000003283 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cell development 0.00006098 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000335 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) regulation of multicellular organismal development 0.00002061 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.6061 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.07609 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) embryo development 0.3872 Informative Inherited
Biological Process (BP) intracellular transport 0.5779 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.02186 Informative Inherited
Biological Process (BP) negative regulation of transport 0.06296 Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.0451 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.03887 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.001897 Informative Inherited
Biological Process (BP) single organism reproductive process 0.004025 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.03424 Informative Inherited
Biological Process (BP) tissue development 0.1337 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.211 Informative Inherited
Biological Process (BP) cell morphogenesis 0.0000003188 Highly Informative Direct
Biological Process (BP) endocytosis 0.0000384 Highly Informative Direct
Biological Process (BP) microtubule-based process 0.0006141 Highly Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00007731 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.000002248 Highly Informative Direct
Biological Process (BP) cell projection organization 0.0000000000009648 Highly Informative Direct
Biological Process (BP) neuron differentiation 0.000002677 Highly Informative Direct
Biological Process (BP) regulation of actin filament length 0.000000001784 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.000001231 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.0006348 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) tube development 0.0006336 Highly Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00000000134 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.000000000006566 Highly Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0000000004462 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000001023 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.00002945 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00007724 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00003814 Highly Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000105 Highly Informative Direct
Biological Process (BP) regulation of supramolecular fiber organization 0.00000000003304 Highly Informative Direct
Biological Process (BP) regulation of cell migration 0.9773 Highly Informative Inherited
Biological Process (BP) regulation of neurogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.5657 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.004389 Highly Informative Inherited
Biological Process (BP) negative regulation of organelle organization 0.2369 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.003817 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.05395 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.009628 Highly Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.04745 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.005716 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000000002541 Least Informative Direct
Molecular Function (MF) protein binding 0.0004199 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000134 Moderately Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.1372 Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.01017 Informative Inherited
Molecular Function (MF) phospholipid binding 0.00004171 Highly Informative Direct
Molecular Function (MF) enzyme activator activity 6.585e-16 Highly Informative Direct
Cellular Component (CC) membrane 0.0000000000007428 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00008289 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0004689 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000000306 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell periphery 0.0000000000004521 Moderately Informative Direct
Cellular Component (CC) cell projection 0.005601 Moderately Informative Inherited
Cellular Component (CC) neuron part 0.005894 Informative Inherited
Cellular Component (CC) whole membrane 0.0242 Informative Inherited
Cellular Component (CC) endosome 0.003719 Informative Inherited
Cellular Component (CC) plasma membrane part 0.003208 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.004188 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.03012 Informative Inherited
Cellular Component (CC) cytoskeletal part 0.08871 Informative Inherited
Cellular Component (CC) midbody 0.000000000000008448 Highly Informative Direct
Cellular Component (CC) synapse part 0.0000001544 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0502 Highly Informative Inherited
Cellular Component (CC) cell cortex part 0.01131 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis1.916e-16InformativeDirect
Biological processDifferentiation0.00007102InformativeDirect
Biological processAutophagy0.00000002602Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.0000000001897Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0.0000003506Moderately InformativeDirect
Cellular componentGolgi apparatus0.00004816Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0InformativeDirect
Cellular componentLysosome0.0000000000006881InformativeDirect
Cellular componentEndosome0.0000002567InformativeDirect
Cellular componentSynapse0.7663InformativeInherited
Cellular componentCoated pit0Highly InformativeDirect
Cellular componentSynaptosome0.0003431Highly InformativeDirect
DiseaseProto-oncogene0.00001499Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain0.0000005481InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.06846Moderately InformativeInherited
Post-translational modificationGTPase activation0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0000000000188Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a BAR/IMD domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]