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1rlr A:10-221 PDB entry domain

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   R1 subunit of ribonucleotide reductase, N-terminal domain [ 48167]
Superfamily:   R1 subunit of ribonucleotide reductase, N-terminal domain [ 48168]
Family:   R1 subunit of ribonucleotide reductase, N-terminal domain [ 48169]
Protein:   R1 subunit of ribonucleotide reductase, N-terminal domain [48170]
   
PDB Entry Domain:   1rlr A:10-221 [ 18753]
  SUPERFAMILY domain annotation for 1rlra10-221
  PDB structure summary for 1rlr


InterPro annotation
Cross references IPR008926 SSF48168 Protein matches
Abstract

The large subunit (R1) of ribonucleotide reductase (RNR), is an essential enzyme required for DNA replication and DNA repair. In both Escherichia coli and higher organisms, the enzyme consists of two non-identical subunits, a dimer of an 85-kDa protein, R1, and a dimer of a 45-kDa protein, R2. Both subunits are essential for RNR enzyme activity - R1 contains, in the substrate binding site, the reducing active cysteine pair and R2 provides a catalytically essential organic radical. R1 is able to bind and reduce the four common ribonucleoside diphosphates. Substrate specificity is determined by nucleoside triphosphates binding to a protein site different from the active site and acting as allosteric effectors. Thus the presence of ATP makes the enzyme reduce CDP and UDP, dGTP favours ADP reduction and dTTP favours GDP reduction. dATP is a general inhibitor. This provides a mechanism for a balanced enzymatic production of building blocks for DNA synthesis [PubMed10542051].


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a R1 subunit of ribonucleotide reductase, N-terminal domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Internal database links ]