SUPERFAMILY 1.75 HMM library and genome assignments server

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Paired domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Family:   Paired domain [ 46748] (3)


Family statistics
Genomes (145) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,391 4,077 3
Proteins 1,390 4,071 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.3044Least InformativeInherited
Disease Ontology (DO)physical disorder0.0002832InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00003355Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.00007082Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.004601Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.01197Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0000101Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.00002949Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0002339Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.0003044Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0.0003177Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.0006202Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.01335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.01348Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.05161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.3291Moderately InformativeInherited
Mammalian Phenotype (MP)postnatal lethality0InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.00002646InformativeDirect
Mammalian Phenotype (MP)decreased body size0.0001341InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0005584InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.01125InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.09718InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.2575InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.423InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.0001302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell morphology0.000204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.0002205Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate morphology0.0003187Highly InformativeDirect
Mammalian Phenotype (MP)pigmentation phenotype0.0005055Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thyroid gland morphology0.008116Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.003732Moderately InformativeInherited
Worm Phenotype (WP)cell number decreased0.00000002762Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)pair rule phenotype0.0000003911Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.01194Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.05331Least InformativeInherited
Fly Anatomy (FA)adult0.05346Least InformativeInherited
Fly Anatomy (FA)nervous system0.0784Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.08582Least InformativeInherited
Fly Anatomy (FA)larva0.1261Least InformativeInherited
Fly Anatomy (FA)somatic cell0.37Least InformativeInherited
Fly Anatomy (FA)larval tagma0.001722Moderately InformativeInherited
Fly Anatomy (FA)larval segment0.002898Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.02445Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.06603Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.08202Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.09654Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1667Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.01401InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.04728InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.09724InformativeInherited
Fly Anatomy (FA)anatomical cluster0.1132InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.2465InformativeInherited
Fly Anatomy (FA)EL neuron0.00001067Highly InformativeDirect
Fly Anatomy (FA)larval abdominal segment A2-70.00007214Highly InformativeDirect
Fly Anatomy (FA)RP neuron0.008371Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval motor neuron0.04312Highly InformativeInherited
Fly Anatomy (FA)abdominal segment 40.06608Highly InformativeInherited
Fly Anatomy (FA)trichome field0.09915Highly InformativeInherited
Fly Anatomy (FA)abdominal segment 80.111Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval cuticle0.4593Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.03472Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.06018Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6799Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1958Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.2195Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.06538InformativeInherited
Zebrafish Anatomy (ZA)pars superior ear0.0009898Highly InformativeDirect
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.03489Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.2136Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.2939Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9599Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.01875Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.06086Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.4039Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7397Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.00004608InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000183InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0002736InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0003472InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.001385InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.00496InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.04613InformativeInherited
Xenopus ANatomical entity (XAN)anterior neural fold0.000001554Highly InformativeDirect
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm0.000004397Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.00001475Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.00001512Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.00001943Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0001095Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0001099Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric mesenchyme0.0001108Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0001174Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0001177Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0004789Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0006693Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0009965Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.143Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.00006404Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 187 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Homeodomain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]