| Root: | SCOP hierarchy in SUPERFAMILY [ 0] (11) |
| Class: | All alpha proteins [ 46456] (258) |
| Fold: | DNA/RNA-binding 3-helical bundle [ 46688] (14) |
| | core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down |
| Superfamily: | "Winged helix" DNA-binding domain [ 46785] (68) |
| Families: | Biotin repressor-like [ 46786] (2) |
| | LexA repressor, N-terminal DNA-binding domain [ 46789] |
| | Arginine repressor (ArgR), N-terminal DNA-binding domain [ 46792] |
| | Transcriptional repressor Rex, N-terminal domain [ 101007] |
| | CAP C-terminal domain-like [ 46796] (6) |
| | Lrp/AsnC-like transcriptional regulator N-terminal domain [ 68967] (4) |
| | Swapped dimer with the "wing" C-terminal strands |
| | ArsR-like transcriptional regulators [ 46801] (4) |
| | The N- and C-terminal helical extensions to the common fold form the dimer interface |
| | Transcriptional regulator IclR, N-terminal domain [ 74676] |
| | MarR-like transcriptional regulators [ 63379] (16) |
| | The N- and C-terminal helical extensions to the common fold form the dimer interface |
| | DNA-binding protein Mj223 [ 81690] |
| | homologous to the MarR-like family in the DNA-binding region but dimerizes differently through the N- and C-terminal helical extensions to the common fold |
| | Penicillinase repressor [ 101016] (2) |
| | homologous to the MarR-like family in the DNA-binding region but has a different dimerisation subdomain |
| | GntR-like transcriptional regulators [ 46804] (2) |
| | N-terminal domain of Bacillus PurR [ 101021] |
| | Replication terminator protein (RTP) [ 46807] |
| | LysR-like transcriptional regulators [ 88979] (2) |
| | contains long helix in the C-terminal extension; forms dimer similar to the RTP dimer |
| | N-terminal domain of molybdate-dependent transcriptional regulator ModE [ 46810] |
| | contains beta-hairpin in the N-terminal extension and two helices in the C-terminal extension |
| | Transcription factor MotA, activation domain [ 46813] |
| | The N- and C-terminal helical extensions to the common fold form the dimer interface (distinct from that of ArsR-like family) |
| | Transcription factor E/IIe-alpha, N-terminal domain [ 101024] |
| | contains extra N-terminal helix |
| | FUR-like [ 101027] |
| | contains extra N-terminal helix and an alpha+beta dimerisation subdomain |
| | Replication initiation protein [ 46816] (2) |
| | duplication: tandem repeat of two "winged helix" domains arranged with the pseudo twofold symmetry |
| | Helicase DNA-binding domain [ 46819] (4) |
| | follows the extended AAA-ATPase domain |
| | RecQ helicase DNA-binding domain-like [ 101030] (2) |
| | follows the tandem AAA-ATPase domain |
| | SCF ubiquitin ligase complex WHB domain [ 74679] (2) |
| | C-terminal fragment of elongation factor SelB [ 74683] |
| | Restriction endonuclease FokI, N-terminal (recognition) domain [ 46824] |
| | TnsA endonuclease, C-terminal domain [ 46782] |
| | Plant O-methyltransferase, N-terminal domain [ 63475] (5) |
| | unknown function |
| | Linker histone H1/H5 [ 46827] (3) |
| | Forkhead DNA-binding domain [ 46832] (6) |
| | DNA-binding domain from rap30 [ 46841] |
| | C-terminal domain of the rap74 subunit of TFIIF [ 63480] |
| | C-terminal domain of RPA32 [ 46844] |
| | DEP domain [ 63483] (4) |
| | membrane-binding domain |
| | Cell cycle transcription factor e2f-dp [ 46847] (2) |
| | heterodimer of two homologous chains |
| | The central core domain of TFIIE beta [ 46850] |
| | Z-DNA binding domain [ 46853] (4) |
| | Pfam 02295 |
| | P4 origin-binding domain-like [ 46856] (2) |
| | C-terminus passes through the first loop |
| | ets domain [ 46859] (8) |
| | Heat-shock transcription factor [ 46873] |
| | Interferon regulatory factor [ 46877] (3) |
| | Pfam 00605 |
| | 39 kda initiator binding protein, IBP39, N-terminal domain [ 101045] |
| | Iron-dependent repressor protein [ 46882] (3) |
| | Dissimilatory sulfite reductase DsvD [ 101048] |
| | La domain [ 101051] (2) |
| | Pfam 05383; RNA-binding domain |
| | Methionine aminopeptidase, insert domain [ 46887] |
| | circularly permuted version of the "winged helix" fold |
| | PCI domain (PINT motif) [ 109671] (2) |
| | Pfam 01399 |
| | Hypothetical protein F93 [ 109674] |
| | contains long helix in the C-terminal extension; forms dimer similar to the RTP and LysR dimers |
| | Archaeal DNA-binding protein [ 109677] |
| | contains long helix in the C-terminal extension; forms dimer similar to the RTP and LysR dimers |
| | TrmB-like [ 109680] (2) |
| | The N- and C-terminal helical extensions to the common fold form the dimer interface, distinct from other known families |
| | Heat-inducible transcription repressor HrcA, N-terminal domain [ 109683] |
| | similar domain organization to the transcriptional regulator IclR |
| | DNA replication factor Cdt1 [ 109686] |
| | Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain [ 109689] |
| | C-terminal part of Pfam 06272 |
| | Vacuolar sorting protein domain [ 109692] (3) |
| | duplication: tandem repeat of two "winged-helix" domains |
| | Transcriptional regulator Rrf2 [ 109699] (2) |
| | Pfam 02082 |
| | Rio2 serine protein kinase N-terminal domain [ 109702] |
| | Rad21/Rec8-like [ 116795] |
| | Pfam 04824 |
| | Hypothetical protein PH1932 [ 116798] |
| | contains new dimerisation all-alpha C-terminal subdomain |
| | An Obfc1 domain [ 116801] |
| | helix-loop insertion in the HTH motif |
| | ScpB/YpuH-like [ 116804] |
| | Pfam 04079
duplication: tandem repeat of two 'winged helix' domains; forms a dimer via the C-terminal domain |
| | PadR-like [ 116807] (3) |
| | Pfam 03551; related to the MarR-like family (Pfam 01047) |
| | Hypothetical protein YhgG [ 116812] |
| | ROK associated domain [ 140279] (3) |
| | found N-terminal to ROK domain in some proteins |
| | PF1790-like [ 140286] |
| | sequence similarity to PH1932 in the N-terminal domain; the C-terminal domain provides new dimerisation interface made of a beta-hairpin and a coiled coil |
| | MukF N-terminal domain-like [ 140289] |
| | N-terminal part of Pfam 03882 |
| | CodY HTH domain [ 140292] |
| | Pfam 08222 |
| | FtsK C-terminal domain-like [ 140295] |
| | PfamB 000224 |
| | Nudix-associated domain [ 140299] (2) |
| | PfamB 002148; this domain is C-terminal to the Nudix domain in some bacterial proteins |
| | HxlR-like [ 140304] (4) |
| | Pfam 01638; DUF24; the N- and C-terminal helical extensions to the common fold form the dimer interface similar to that of the ArsR-like family (scop_fa 46801) |
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 173 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a "Winged helix" DNA-binding domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 173 hidden Markov models representing the "Winged helix" DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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