SUPERFAMILY 1.75 HMM library and genome assignments server

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ets domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   ets domain [ 46859] (8)


Family statistics
Genomes (145) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,075 5,776 14
Proteins 2,075 5,768 14


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.005064Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.008586Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02584Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.05147Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.09583Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.309Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.001194Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.001847Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.004541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.007176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.01378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.01762Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.08401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.08923Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1164Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.197Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2252Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3492Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.3787Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.6665Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.7853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000112InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0.01585InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.01907InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06709InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.4047InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.00003597Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0006206Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.0007524Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.003953Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.0004229Moderately InformativeDirect
Worm Phenotype (WP)nervous system development variant0.00002304Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)pupa0.0008799Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.1529Least InformativeInherited
Zebrafish Anatomy (ZA)motile cell0.01071InformativeInherited
Zebrafish Anatomy (ZA)immune system0.01717InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.01914InformativeInherited
Zebrafish Anatomy (ZA)granulocyte0.0003729Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.09412Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1215Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.4145Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000000004055Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.00000004918Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.000001303Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.552Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.00000000004472InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00000000239InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0000009076InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00001617InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00007336InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0002993InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.0003176InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0003896InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0005124InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.002125InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.002983InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.01667InformativeInherited
Xenopus ANatomical entity (XAN)ventral blood island0.000000000007855Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0000000006763Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000001224Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.00004757Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.00007125Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]