SUPERFAMILY 1.75 HMM library and genome assignments server

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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (400) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 41,692 159,518 22
Proteins 5,171 21,102 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.02088Moderately InformativeInherited
Disease Ontology (DO)muscle tissue disease0.0001095InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.000194Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.04941Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.05497Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.09027Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1393Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1799Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.02203Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.0419Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1455Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2048Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2561Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.3054Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.4686Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0006715InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.004424InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.02547InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00001335Highly InformativeDirect
Phenotypic Abnormality (PA)Epidermal thickening0.0003238Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0003742Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.0004406Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomyopathy0.0008445Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.00181Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0001251Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.06238Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01924Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.07573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.142Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5071Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.002634InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.00003684Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01234Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.02429Highly InformativeInherited
Mammalian Phenotype (MP)abnormal physical strength0.06255Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)blast cell physiology variant0.0004576Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000459Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0005953Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.003961Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.006778Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01291Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.05542Least InformativeInherited
Worm Phenotype (WP)larval lethal0.1049Least InformativeInherited
Worm Phenotype (WP)drug response variant0.0001501Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0005976Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0005976Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0006003Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0006031Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0006714Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.00072Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00449Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.008871Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.01826Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3453Moderately InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.00006654InformativeDirect
Worm Phenotype (WP)brood size variant0.0001008InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0002319InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0002488InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0004046InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0008378InformativeDirect
Worm Phenotype (WP)cell component localization variant0.03783InformativeInherited
Worm Phenotype (WP)drug resistant0.07337InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000002475Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00000438Highly InformativeDirect
Worm Phenotype (WP)reduced brood size0.00005106Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.0001143Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.000139Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0004368Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1115Least InformativeInherited
Fly Phenotype (FP)lethal0.006327Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of larval stage0.0002946InformativeDirect
Fly Phenotype (FP)hypoactive0.0001965Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.07381Least InformativeInherited
Fly Anatomy (FA)larva0.1078Least InformativeInherited
Fly Anatomy (FA)nervous system0.1825Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2793Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3111Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01092Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.02915Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.07137Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.2994Moderately InformativeInherited
Fly Anatomy (FA)tract0.0004941InformativeDirect
Fly Anatomy (FA)epithelial tube0.01183InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.01207InformativeInherited
Fly Anatomy (FA)epithelial cell0.02273InformativeInherited
Fly Anatomy (FA)gut section0.03313InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.07139InformativeInherited
Fly Anatomy (FA)connective0.00008982Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0005084Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.0196Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.2404Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7341Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.05523Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.607Moderately InformativeInherited
Xenopus ANatomical entity (XAN)limb0.0004238InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.004814InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.027InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.08192InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.1293InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.000749Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.1351Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.0365Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 660.0006317InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]