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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (400) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 41,692 159,518 22
Proteins 5,171 21,102 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.02088Moderately InformativeInherited
Disease Ontology (DO)muscle tissue disease0.0001095InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.000194Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.05334Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.05773Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.09428Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1447Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1889Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.02377Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.04286Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1478Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2075Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2559Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.3074Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.48Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0006382InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.004332InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.02569InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00001296Highly InformativeDirect
Phenotypic Abnormality (PA)Epidermal thickening0.0003279Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0003395Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.0004959Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomyopathy0.0008275Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.001853Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0001248Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.06249Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01924Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.07586Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2852Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5063Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.002617InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.00003677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01234Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.0243Highly InformativeInherited
Mammalian Phenotype (MP)abnormal physical strength0.06255Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0004054Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.00067Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.004183Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.004406Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02894Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.06973Least InformativeInherited
Worm Phenotype (WP)larval lethal0.1122Least InformativeInherited
Worm Phenotype (WP)movement variant0.0001472Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001754Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0001796Moderately InformativeDirect
Worm Phenotype (WP)drug response variant0.0002514Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.01047Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.01552Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.04509Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4052Moderately InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.00007003InformativeDirect
Worm Phenotype (WP)brood size variant0.0001147InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0003888InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0004675InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0004868InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0008655InformativeDirect
Worm Phenotype (WP)cell component localization variant0.03784InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000002647Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00000477Highly InformativeDirect
Worm Phenotype (WP)reduced brood size0.00005811Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.0001209Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.000465Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1053Least InformativeInherited
Fly Phenotype (FP)lethal0.006135Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of larval stage0.0003015InformativeDirect
Fly Phenotype (FP)hypoactive0.0002025Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.1084Least InformativeInherited
Fly Anatomy (FA)larva0.121Least InformativeInherited
Fly Anatomy (FA)nervous system0.1573Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2517Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2883Least InformativeInherited
Fly Anatomy (FA)gonad0.00902Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01024Moderately InformativeInherited
Fly Anatomy (FA)female-specific anatomical entity0.017Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.0275Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.0726Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.4482Moderately InformativeInherited
Fly Anatomy (FA)tract0.0004582InformativeDirect
Fly Anatomy (FA)epithelial tube0.01092InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.01937InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.02532InformativeInherited
Fly Anatomy (FA)female germline cyst0.03219InformativeInherited
Fly Anatomy (FA)gut section0.03279InformativeInherited
Fly Anatomy (FA)epithelial cell0.04913InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.07472InformativeInherited
Fly Anatomy (FA)germline cell0.09059InformativeInherited
Fly Anatomy (FA)fat body0.1668InformativeInherited
Fly Anatomy (FA)fat cell0.00002719Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.00007293Highly InformativeDirect
Fly Anatomy (FA)connective0.00008029Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0005081Highly InformativeDirect
Fly Anatomy (FA)oocyte0.0009394Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1237Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2409Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7367Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.04644Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.6233Moderately InformativeInherited
Xenopus ANatomical entity (XAN)limb0.0004238InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.003963InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.02753InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.08121InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.1309InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.0007507Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.1328Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.0358Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 660.0006264InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]