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Spectrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Families:   Spectrin repeat [ 46967] (3)


Superfamily statistics
Genomes (400) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 41,692 159,518 22
Proteins 5,171 21,102 11


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.02088Moderately InformativeInherited
Disease Ontology (DO)muscle tissue disease0.0001095InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.000194Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.05319Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.05758Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.09443Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1446Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1887Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.02367Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.04276Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.148Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2069Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2566Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.3068Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.4799Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0006388InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.004364InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.02573InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00001295Highly InformativeDirect
Phenotypic Abnormality (PA)Epidermal thickening0.0003206Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0003393Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.0004962Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomyopathy0.0008277Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.001855Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0001251Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.06238Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01924Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.07573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.142Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5071Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.002634InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.00003684Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01234Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.02429Highly InformativeInherited
Mammalian Phenotype (MP)abnormal physical strength0.06255Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000403Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0006649Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.004139Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.004391Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02871Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.06926Least InformativeInherited
Worm Phenotype (WP)larval lethal0.1122Least InformativeInherited
Worm Phenotype (WP)movement variant0.0001455Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001735Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0001778Moderately InformativeDirect
Worm Phenotype (WP)drug response variant0.0002492Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.01046Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.0155Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.04524Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4044Moderately InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.00006951InformativeDirect
Worm Phenotype (WP)brood size variant0.0001135InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0003874InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0004651InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0004839InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0008633InformativeDirect
Worm Phenotype (WP)cell component localization variant0.03779InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000002627Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000004734Highly InformativeDirect
Worm Phenotype (WP)reduced brood size0.00005753Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.0001202Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0004621Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1091Least InformativeInherited
Fly Phenotype (FP)lethal0.006221Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of larval stage0.0002938InformativeDirect
Fly Phenotype (FP)hypoactive0.0001934Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.1148Least InformativeInherited
Fly Anatomy (FA)larva0.1168Least InformativeInherited
Fly Anatomy (FA)nervous system0.1709Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2629Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.299Least InformativeInherited
Fly Anatomy (FA)gonad0.009375Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01045Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.02806Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.03914Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.07208Moderately InformativeInherited
Fly Anatomy (FA)tract0.0004778InformativeDirect
Fly Anatomy (FA)epithelial tube0.0113InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.01154InformativeInherited
Fly Anatomy (FA)epithelial cell0.02236InformativeInherited
Fly Anatomy (FA)gut section0.03268InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.07353InformativeInherited
Fly Anatomy (FA)germline cyst0.08201InformativeInherited
Fly Anatomy (FA)germline cell0.09075InformativeInherited
Fly Anatomy (FA)connective0.00008401Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0005125Highly InformativeDirect
Fly Anatomy (FA)oocyte0.0009551Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.01932Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1235Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2412Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7366Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.04661Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.6238Moderately InformativeInherited
Xenopus ANatomical entity (XAN)limb0.0004226InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.003973InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.02724InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.08109InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.1312InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.0007488Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.1328Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.03588Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 660.0006281InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Spectrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]