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Acyl-CoA binding protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Acyl-CoA binding protein [ 47027]
Families:   Acyl-CoA binding protein [ 47028]


Superfamily statistics
Genomes (656) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,551 6,774 2
Proteins 2,536 6,723 2


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.24910.0003501Least InformativeInherited
Biological Process (BP)primary metabolic process0.25180.465Least InformativeInherited
Biological Process (BP)lipid metabolic process0.00015520.00000000000288Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.0031080.00007216Moderately InformativeInherited
Biological Process (BP)lipid localization0.000000094130.00000000000002102InformativeDirect
Molecular Function (MF)binding0.03770.2594Least InformativeInherited
Molecular Function (MF)anion binding0.000000007880.0000000000004249Moderately InformativeDirect
Molecular Function (MF)sulfur compound binding00InformativeDirect
Molecular Function (MF)coenzyme binding0.0000000000000013860InformativeDirect
Molecular Function (MF)fatty acid derivative binding00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0003501 Least Informative Direct
Biological Process (BP) primary metabolic process 0.465 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1711 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.00000000000288 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00007216 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00000000009516 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.03812 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01179 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.06984 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.0154 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01029 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.00000000000002102 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000001801 Informative Direct
Biological Process (BP) lipid catabolic process 0.000589 Informative Direct
Molecular Function (MF) binding 0.2594 Least Informative Inherited
Molecular Function (MF) anion binding 0.0000000000004249 Moderately Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) fatty acid derivative binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.005146 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1598 Least Informative Inherited
Cellular Component (CC) microbody 0.000000000001859 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAutophagy0InformativeDirect
Cellular componentGolgi apparatus3.314e-16Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000000000004575Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
DomainCoiled coil0.00000000008149Moderately InformativeDirect
DomainANK repeat0.00000000000008397InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.0000000002144Least InformativeDirect
Post-translational modificationAcetylation0.00000001833Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000582 SSF47027 Protein matches
Abstract

Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters [PubMed1454809]. ACBP is also known as diazepam binding inhibitor (DBI) or endozepine (EP) because of its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor [PubMed1649940].

ACBP is a highly conserved protein of about 90 residues that is found in all four eukaryotic kingdoms, Animalia, Plantae, Fungi and Protista, and in some eubacterial species [PubMed16018771].

Although ACBP occurs as a completely independent protein, intact ACB domains have been identified in a number of large, multifunctional proteins in a variety of eukaryotic species. These include large membrane-associated proteins with N-terminal ACB domains, multifunctional enzymes with both ACB and peroxisomal enoyl-CoA Delta(3), Delta(2)-enoyl-CoA isomerase domains, and proteins with both an ACB domain and ankyrin repeats [PubMed16018771].

The ACB domain consists of four alpha-helices arranged in a bowl shape with a highly exposed acyl-CoA-binding site. The ligand is bound through specific interactions with residues on the protein, most notably several conserved positive charges that interact with the phosphate group on the adenosine-3'phosphate moiety, and the acyl chain is sandwiched between the hydrophobic surfaces of CoA and the protein [PubMed11491287].

Other proteins containing an ACB domain include:

  • Endozepine-like peptide (ELP) (gene DBIL5) from mouse [PubMed8898349]. ELP is a testis- specific ACBP homolog that may be involved in the energy metabolism of the mature sperm.
  • MA-DBI, a transmembrane protein of unknown function which has been found in mammals. MA-DBI contains a N-terminal ACB domain.
  • DRS-1 [PubMed10354522], a human protein of unknown function that contains a N-terminal ACB domain and a C-terminal enoyl-CoA isomerase/hydratase domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA binding protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Acyl-CoA binding protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]