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TAF(II)230 TBP-binding fragment superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   TAF(II)230 TBP-binding fragment [ 47054]
Superfamily:   TAF(II)230 TBP-binding fragment [ 47055]
Families:   TAF(II)230 TBP-binding fragment [ 47056]

Superfamily statistics
Genomes (153) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 219 491 1
Proteins 219 490 1

Functional annotation
General category General
Detailed category Protein interaction

Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000002216 Least Informative Direct
Biological Process (BP) animal organ development 0.000000000107 Moderately Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Molecular Function (MF) transferase activity 0.003686 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.00000001964 Informative Direct
Molecular Function (MF) acetyltransferase activity 0.0000000001899 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.3274 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.05974 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.001991 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.001843 Moderately Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.00000002809Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainBromodomain0Highly InformativeDirect
Post-translational modificationDNA-binding0.000002716Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009067 SSF47055 Protein matches

In eukaryotes, the general transcription factor TFIID helps to regulate transcription by RNA polymerase II from class II promoters. TFIID consists of TATA-box-binding proteins (TBP) and TBP-associated factors (TAFIIs), which together mediate both activation and inhibition of transcription. In Drosophila, the N-terminal region of TAFII-230 (the TFIID 230kDa subunit) binds directly to TBP, thereby inhibiting the binding of TBP to the TATA box. The structure of TAFII-230 is comprised of three short helices in an irregular array, which forms the core that occupies the DNA-binding surface of TBP [PubMed9741622]. Note, the Gene3D model in this entry is hitting fewer proteins than it should and is under revision.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a TAF(II)230 TBP-binding fragment domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the TAF(II)230 TBP-binding fragment superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]