SUPERFAMILY 1.75 HMM library and genome assignments server

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HMG-box family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HMG-box [ 47094]
Superfamily:   HMG-box [ 47095]
Family:   HMG-box [ 47096] (9)


Family statistics
Genomes (385) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,324 12,875 25
Proteins 3,462 10,657 24


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.000000007154Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000000003989Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0.8859Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.07083Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.07442Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.08534Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.09462Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1113Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1139Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1906Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2144Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2613Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.01101Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.03104Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.03589Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.05351Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.08736Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.09896Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1239Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.1601Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2025Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.23Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.3825Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.7971Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.002505InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.005177InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the extremities0.01206InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.05096InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.05499InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.07669InformativeInherited
Phenotypic Abnormality (PA)Hernia0.08572InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.1076InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.1321InformativeInherited
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.1804InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.2275InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.5378InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the diaphragm0.000037Highly InformativeDirect
Phenotypic Abnormality (PA)Dilatation of the renal pelvis0.00008274Highly InformativeDirect
Phenotypic Abnormality (PA)Cutis marmorata0.000282Highly InformativeDirect
Phenotypic Abnormality (PA)Cleft palate0.000347Highly InformativeDirect
Phenotypic Abnormality (PA)Lacrimation abnormality0.000418Highly InformativeDirect
Phenotypic Abnormality (PA)Slow-growing hair0.0006915Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the sense of smell0.0009968Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.004947Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the 5th toe0.01106Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the phalanges of the hand0.02214Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.03525Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal toenail morphology0.04126Highly InformativeInherited
Phenotypic Abnormality (PA)Hypogonadism0.1216Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal 5th finger morphology0.1551Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal fingernail morphology0.3045Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the nails0.3524Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.6158Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.008428Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.01852Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08968Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3754Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6139Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.0004593Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.005217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.008456Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.05225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1052Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.1677Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.1931Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.2993Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3086Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.32Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.004439InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.01365InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.02586InformativeInherited
Mammalian Phenotype (MP)abnormal testis morphology0.02772InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.04781InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.2472InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.2625InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.00008588Highly InformativeDirect
Mammalian Phenotype (MP)distended abdomen0.0004397Highly InformativeDirect
Mammalian Phenotype (MP)persistent truncus arteriosis0.000925Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.001371Highly InformativeInherited
Mammalian Phenotype (MP)abnormal optic nerve morphology0.001676Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb development0.002387Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seminiferous tubule morphology0.2127Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.002253Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3957Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.00009056Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001607Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2699Moderately InformativeInherited
Worm Phenotype (WP)vulva morphology variant0.00002187InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.04352InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.1327InformativeInherited
Worm Phenotype (WP)gonad development variant0.1379InformativeInherited
Worm Phenotype (WP)gonad arm morphology variant0.000002834Highly InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.0000205Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003579Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.006155Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)cell cycle progression0.0009667InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.03456Least InformativeInherited
Fly Anatomy (FA)adult0.03478Least InformativeInherited
Fly Anatomy (FA)segment0.08445Least InformativeInherited
Fly Anatomy (FA)tagma0.08582Least InformativeInherited
Fly Anatomy (FA)adult external thorax0.0002632Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0.0003354Moderately InformativeDirect
Fly Anatomy (FA)appendage0.001134Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.000965Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.03965Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.4642Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5514Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.07738Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.2693Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.6299Moderately InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.08594InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.1395InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.3354InformativeInherited
Zebrafish Anatomy (ZA)digestive system0.3553InformativeInherited
Zebrafish Anatomy (ZA)peripheral nervous system0.01765Highly InformativeInherited
Zebrafish Anatomy (ZA)pharynx0.06362Highly InformativeInherited
Zebrafish Anatomy (ZA)gill0.07573Highly InformativeInherited
Zebrafish Anatomy (ZA)endochondral element0.07681Highly InformativeInherited
Zebrafish Anatomy (ZA)replacement element0.0795Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.1661Highly InformativeInherited
Zebrafish Anatomy (ZA)ectoderm0.2356Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.002975Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.004837Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.01146Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.07066Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.07126Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.4903Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5242Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.00006502Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0001223Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.000187Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0.004581Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0696Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2107Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.3352Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.00000551InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000165InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.0002875InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0004844InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0006173InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.03832InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.06418InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.1546InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.00000004141Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0000006789Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00000306Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.00001041Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0001173Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0001947Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0003584Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0005618Highly InformativeDirect
Xenopus ANatomical entity (XAN)splanchnocranium0.0008625Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.01047Highly InformativeInherited
Xenopus ANatomical entity (XAN)blastopore lip0.1127Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant ovule0.0008035Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.006424Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.000001951Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000002009InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 28 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a HMG-box domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]