SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [ 47212]
Families:   FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [ 47213]


Superfamily statistics
Genomes (458) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 617 1,650 3
Proteins 615 1,647 3


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0002596 Least Informative Direct
Biological Process (BP) biological regulation 0.000003303 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.01815 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.02095 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.00214 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5795 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.2236 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.007868 Least Informative Inherited
Biological Process (BP) reproduction 0.0003882 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0001114 Moderately Informative Direct
Biological Process (BP) cell communication 0.000001751 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0002498 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000992 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.03513 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.009522 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.003996 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.09271 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2524 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02555 Moderately Informative Inherited
Biological Process (BP) regulation of catabolic process 0.00000001414 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.000206 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00001228 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0003322 Informative Direct
Biological Process (BP) growth 0.0000596 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00003673 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0001549 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00003581 Informative Direct
Biological Process (BP) regulation of system process 0.001724 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02624 Informative Inherited
Biological Process (BP) phosphorylation 0.01411 Informative Inherited
Biological Process (BP) regulation of growth 0.002174 Informative Inherited
Biological Process (BP) regulation of cell growth 0.000292 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000000007609 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.00000000004611 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.000000000000009084 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0000001063 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.0004545 Highly Informative Direct
Molecular Function (MF) transferase activity 0.0000003807 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000001039 Moderately Informative Direct
Molecular Function (MF) kinase activity 0.00000000001059 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000000284 Informative Direct
Cellular Component (CC) membrane 0.2486 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1203 Least Informative Inherited
Cellular Component (CC) protein complex 0.004406 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.003547 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1283 Least Informative Inherited
Cellular Component (CC) vacuole 0.000000003353 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00003611 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00003719 Moderately Informative Direct
Cellular Component (CC) lytic vacuole 0.000000000002664 Informative Direct
Cellular Component (CC) vacuolar part 0.000002031 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000007787Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.000000005278Moderately InformativeDirect
Cellular componentNucleus0.0004116Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0.000000003887Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000002431InformativeDirect
Post-translational modificationPhosphoprotein0.000005346Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009076 SSF47212 Protein matches
Abstract

Rapamycin and FK506 are potent immunosuppressive agents that bind to the FK506-binding protein (FKBP12), inhibiting its peptidyl-prolyl isomerase activity. The rapamycin-FKBP12 complex can then bind to and inhibit the FKBP12-rapamycin-associated protein (FRAP) in humans and RAFT1 in rats, causing cell-cycle arrest [PubMed10089303]. The FK506-FKBP12 complex cannot bind FRAP, but can bind to and inhibit calcineurin. Rapamycin is able to bind to two proteins, FKBP12 and FRAP, by simultaneously occupying two hydrophobic binding pockets, thereby linking these two proteins together to form a dimer [PubMed8662507]. The structure of the FKBP12-rapamycin-binding domain of FRAP consists of a core bundle of four helices arranged up-and-down in a left-handed twist.

FRAP has been shown to interact in vitro with CLIP-170, a protein involved in microtubule organisation and function [PubMed12231510]. FRAP is thought to act as a kinase to phosphorylate CLIP-170, thereby regulating its binding to microtubules. FRAP is also thought to cooperate with p85/p110 phosphatidylinositol 3-kinase (PI3K) to induce the activation of the serine/threonine kinase p70 S6 kinase (p70S6K), which in turn phosphorylates the 40S ribosomal protein S6, thereby altering the translation of ribosomal proteins and translation elongation factors [PubMed11684675].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]